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Bile acids, cell proliferation and protein phosphorylation

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Cell Growth and Oncogenesis

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

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Abstract

Bile acids are endogenous compounds with amphiphilic properties normally present in human body fluid. Cholic and chenodeoxycholic acids, the so-called “primary” bile acids, are synthesised in the liver from cholesterol. Under normal physiological conditions, 90–95% of these bile acids are then conjugated in the liver with glycine or taurine and secreted to the duodenum. Here, they facilitate lipid absorption and participate in a complex enterohepatic circulation. Cholic and chenodeoxycholic acids can also reach the colon where they are converted by the bacterial enzyme 7α-dehydroxylase, to the “secondary” bile acids, deoxycholic and lithocholic acids respectively.

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Author information

Authors and Affiliations

  1. Institute of Medical Biochemistry and Chemistry, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    F. Capuano, E. Russo, N. D’Eri & S. Papa

  2. Department of Gastroenterology, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    M. Barone & A. Francavilla

Authors
  1. F. Capuano
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  2. M. Barone
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  3. E. Russo
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  4. N. D’Eri
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  5. A. Francavilla
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  6. S. Papa
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Editor information

Editors and Affiliations

  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Peter Bannasch (Head Division of Cell Pathology) (Head Division of Cell Pathology)

  2. Institute of Medical Biochemistry and Chemistry, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    Darja Kanduc  & Sergio Papa  & 

  3. E.C. Slater Institute Faculty of Chemistry, University of Amsterdam, Plantage Muidergracht 12, NL-1018 TV, Amsterdam, The Netherlands

    J. M. Tager

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© 1998 Springer Basel AG

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Capuano, F., Barone, M., Russo, E., D’Eri, N., Francavilla, A., Papa, S. (1998). Bile acids, cell proliferation and protein phosphorylation. In: Bannasch, P., Kanduc, D., Papa, S., Tager, J.M. (eds) Cell Growth and Oncogenesis. Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8950-6_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8950-6_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9841-6

  • Online ISBN: 978-3-0348-8950-6

  • eBook Packages: Springer Book Archive

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