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Chromosomes Today pp 93–104Cite as

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Igf2 imprinting in development and disease

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Abstract

Insuline-like growth factor 2 gene (Igf2) was one of the first imprinted genes to be discovered and occupies a centre stage in the study of imprinting. This is because it has dramatic effects on the control of fetal growth, it is involved in growth disorders and in cancer, it interacts with products of other imprinted genes, and its imprinting status is under complex regulation in a cluster of tightly linked imprinted genes. Here we review briefly the key features of Igf2 imprinting in normal development and in disease, and hope to show what a fascinating subject of study this gene and its biology provides.

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Author information

Authors and Affiliations

  1. Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK

    W. Reik, M. Constancia, W. Dean, K. Davies, L. Bowden, A. Murrell, R. Feil & G. Kelsey

  2. Max-Planck Institute of Molecular Genetics, Berlin, Germany

    J. Walter

Authors
  1. W. Reik
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  2. M. Constancia
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  3. W. Dean
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  4. K. Davies
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  5. L. Bowden
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  6. A. Murrell
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  7. R. Feil
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  8. J. Walter
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  9. G. Kelsey
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Editor information

Editors and Affiliations

  1. Istituto di Biologia e Genetica, Via Brecce Bianche, Ancona, 60131, Italy

    Ettore Olmo

  2. Dipartimento di Biologia animale / Centro di Studio per l’Istochimica — CNR, University of Pavia, Piazza Botta 9, Pavia, 27100, Italy

    Carlo Alberto Redi

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© 2000 Springer Basel AG

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Reik, W. et al. (2000). Igf2 imprinting in development and disease. In: Olmo, E., Redi, C.A. (eds) Chromosomes Today. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8484-6_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8484-6_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9587-3

  • Online ISBN: 978-3-0348-8484-6

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