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Regional selectivity of antipsychotic drugs

  • Chapter
Atypical Antipsychotics

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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Abstract

Antipsychotic drugs have been in clinical practice for more than 40 years, and it is now well established that at comparable levels of antipsychotic efficacy, the incidence of side-effects (especially the extrapyramidal side-effects) differs between individual drugs. This has already been known for a long time, but the earlier studies were largely overlooked. Among the earlier papers were a number of clinical studies comparing several phenothiazine antipsychotics, such as the large multicentre double blind study conducted by the National Institute of Mental Health in 1964 [1]. This study showed that in therapeutically equivalent doses, thioridazine produced significantly less rigidity and dystonia than chlorpromazine and fluphenazine. Comparable findings were also reported by other groups [2–4]. After the introduction of clozapine, it became even more apparent that antipsychotic drugs not necessarily had to induce extrapyramidal side-effects [5-8], see also Naber et al., this volume. This drugs seems to be almost completely free of extrapyramidal side-effects, including tardive dyskinesia.

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  1. Department of Psychoneuropharmacology, University of Nijmegen, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands

    Bart A. Ellenbroek & Alexander R. Cools

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Ellenbroek, B.A., Cools, A.R. (2000). Regional selectivity of antipsychotic drugs. In: Ellenbroek, B.A., Cools, A.R. (eds) Atypical Antipsychotics. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8448-8_5

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