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Roles of carbonic anhydrases in the alimentary tract

  • Chapter
The Carbonic Anhydrases

Part of the book series: EXS 90 ((EXS,volume 90))

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Abstract

Insight into the physiological role of carbonic anhydrases (CAs) can be derived from a knowledge of the cell types expressing the enzyme and by correlating the activity of the enzyme with the particular function at the cellular or subcellular site of its presence. Several approaches have been used to determine the location of CA at the tissue and intracellular levels. The specific activity of CA can be visualized by trapping the reaction product with a heavy metal. Hansson’s histochemical method, depending on cobalt trapping of CO2 produced by CA, has served to identify the enzyme at a number of sites (Korhonen et al., 1966; Hansson, 1967; O’Brien et al., 1977; Parkkila et al., 1989; Ridderstråle, 1991). The availability of specific antibodies to different isoenzymes, the development of modern immunocytochemical techniques and developments in molecular biology have also helped considerably to increase our understanding of the distribution and role of CA isoenzymes in the alimentary tract. Studies of the effects of CA inhibitors have implicated CAs in a variety of physiological processes, although several problems have been encountered with these inhibitors due to their unspecific mode of action. In addition, human and animal CA deficiencies may provide substantial improvements to our understanding of the individual contributions of each isoenzyme to physiological processes.

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  1. Departments of Anatomy and Clinical Chemistry, University of Oulu, FIN-90220, Oulu, Finland

    Seppo Parkkila

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  1. Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA, 16509, USA

    W. Richard Chegwidden

  2. Medical Genetics Unit, St George’s Hospital Medical School, London, SW17 0RE, UK

    Nicholas D. Carter

  3. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, 4, Stephenson Way, London, NW1 2HE, UK

    Yvonne H. Edwards

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Parkkila, S. (2000). Roles of carbonic anhydrases in the alimentary tract. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_23

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  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_23

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