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The Effect of Exo- and Endopyrogens on Serotonin Metabolism in the Nucleus Raphe Dorsalis of the Rat

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Thermal Balance in Health and Disease

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

Abstract

The effects of immune stimulants and cytokines on sleep and body temperature have recently been summarized (1). However, the exact mechanism how and where cytokines may control sleep regulation and temperature in the central nervous system is still not well understood. The serotoninergic transmitter system of the nucleus raphe dorsalis (NRD) has been shown to be involved in sleep and temperature regulation. Although serotonin (5-HT) release was found to be high in most brain areas during wakefulness, the NRD differed in that a high release of 5-HT could be observed during sleep (2). The aim of our study was to examine whether 5-HT metabolism, as measured by the extracellular serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the NRD, could be altered by immune stimulants and cytokines. In addition, the effect of normal light-dark cycle, immobilization and the application of drugs on body temperature and 5-HT metabolism in the NRD was included for comparison with the effect of cytokines.

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References

  1. Krueger, JM, Opp, MR, Kapás, L, Kimura-Takeuchi, M, Toth, L (1993): Muramyl Peptides and Interkeukin-1 in Sleep Regulation. In: Endocrine and Nutritional Control of Basic Biological Functions. Lehnert, H, Murison, R, Weiner, H, Hellhammer, D, Beyer, J eds. Seattle: Hogrefe & Huber, 347–354.

    Google Scholar 

  2. Cespuglio, R, Sarda, N, Gharib, A, Chastrette, N, Houdouin, F, Rampin, C, Jouvet, M (1990): Voltammetric detection of the release of 5-hydroxyindole compounds throughout the sleep-waking cycle of the rat. Exp Brain Res, 80, 121–128.

    Article  PubMed  CAS  Google Scholar 

  3. Paxinos, G, Watson, C (1982): The rat brain in stereotaxic coordinates. New York: Academic Press.

    Google Scholar 

  4. Clement, HW, Schäfer, F, Ruwe, C, Gemsa, D, Wesemann, W (1993): Stress-induced changes of extracellular 5-hydroxyindoleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat. Brain Res 614, 117–124.

    Article  PubMed  CAS  Google Scholar 

  5. Alföldi, P, Rubicsek, G, Cserni, G, Obál, F (1990): Brain and core temperatures and peripheral vasomotion during sleep and wakefulness at various ambient temperatures in the rat. Eur J Physiol 417, 336–341.

    Article  Google Scholar 

  6. Jacob, JJ, Suaudeau, C, Vidal, C (1983): Temperature changes induced by non painful stress in the rat. In: Environment, Drugs and Thermoregulation. Lomax, P, Schönbaum, E eds. Basel: Karger, 121–124.

    Google Scholar 

  7. Morgan, WW, Rudeen, PK, Pfeil, KA (1975): Effect of immobilization stress on serotonin content and turnover in regions of the rat brain. Life Sci 17, 143–150.

    Article  PubMed  CAS  Google Scholar 

  8. Hjorth, S, Magnusson, T (1988): The 5-HTi a receptor agonist, 8-OHDPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo. Naunyn-Schmiedebergs Arch Pharmacol 338, 463–471.

    PubMed  CAS  Google Scholar 

  9. Houdouin, F, Cespuglio, R, Gharib, A, Sarda, N, Jouvet, M (1991): Detection of the release of 5-hydroxyindole compounds in the hypothalamus and the n. raphe dorsalis throughout the sleep-waking cycle and during stressful situations in the rat: a polygraphic and voltammetric approach. Exp Brain Res 85, 153–162.

    Article  PubMed  CAS  Google Scholar 

  10. Zeisberger, E, Roth, J (1993): Neurobiologies concepts of fever generation and suppression. Neuropsychobiol 28, 106–109.

    Article  CAS  Google Scholar 

  11. Dunn, AJ (1993): Infection as a stressor: a cytokine-mediated activation of the hypothalamo-pituitary-adrenal axis? Ciba-Found Symp 172, 226–239.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Neurochemistry, Institute of Physiological Chemistry, Hans-Meerwein-Str., D-35033, Marburg, Germany

    H. W. Clement, C. Ruwe & W. Wesemann

  2. Institute of Immunology, Philipps-University, D-35033, Marburg, Germany

    D. Gemsa

Authors
  1. H. W. Clement
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  2. C. Ruwe
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  3. D. Gemsa
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  4. W. Wesemann
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Klinikum der Justus Liebig Universität, Aulweg 129, D-35392, Giessen, Germany

    Eugen Zeisberger

  2. Department of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, State University of Leiden, Leiden, The Netherlands

    Eduard Schönbaum

  3. Peelkensweg 4, 5428 NM, Venhorst, N.BR., The Netherlands

    Eduard Schönbaum

  4. Department of Pharmacology, UCLA School of Medicine, University of California, Los Angeles, CA, 90024-1735, USA

    Peter Lomax

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© 1994 Birkhäuser Verlag Basel

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Clement, H.W., Ruwe, C., Gemsa, D., Wesemann, W. (1994). The Effect of Exo- and Endopyrogens on Serotonin Metabolism in the Nucleus Raphe Dorsalis of the Rat. In: Zeisberger, E., Schönbaum, E., Lomax, P. (eds) Thermal Balance in Health and Disease. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7429-8_51

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  • DOI: https://doi.org/10.1007/978-3-0348-7429-8_51

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7431-1

  • Online ISBN: 978-3-0348-7429-8

  • eBook Packages: Springer Book Archive

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