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Pharmacology of Fear, Induced by Periaqueductal Gray Stimulation in the Rat

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Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

The effect of drugs on escape induced by aversive stimulation of the periaqueductal gray (PAG) matter is reviewed. Strongest influences were observed with compounds influencing GABA-ergic and serotonergic neurotransmission. Activation of the 5-HT1C-receptor is an effective way towards inhibition of the aversive effect of brain stimulation. An opposite effect was obtained by stimulation of 5-HT1A and 5-HT2-receptors. Dopaminergic D2-receptor activation seems to have weak enhancing effects on the stimulation induced aversive state. In view of these pharmacological characteristics it is not possible to conclude that there is a straight forward parallelism between brain stimulation-induced fear and a particular anxiety disorder.

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Author information

Authors and Affiliations

  1. CNS-Pharmacology Department, Organon, P.O.Box 20, Oss, The Netherlands

    C. L. Broekkamp, C. Dortmans, H. H. G. Berendsen & F. Jenck

Authors
  1. C. L. Broekkamp
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  2. C. Dortmans
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  3. H. H. G. Berendsen
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  4. F. Jenck
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Editor information

Editors and Affiliations

  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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© 1991 Springer Basel AG

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Broekkamp, C.L., Dortmans, C., Berendsen, H.H.G., Jenck, F. (1991). Pharmacology of Fear, Induced by Periaqueductal Gray Stimulation in the Rat. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_7

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6421-3

  • Online ISBN: 978-3-0348-6419-0

  • eBook Packages: Springer Book Archive

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