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A New Animal Model for Anticipatory Anxiety?

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Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

Mice removed last from their home cage have a higher rectal temperature (hyperthermia) compared to those removed first from the same cage. This phenomenon was interpreted as a state of anxiety: anticipatory anxiety. This increase in rectal temperature was prevented in a dose dependent way by diazepam and serotonin-1A agonists. Several non-anxiolytic compounds did not affect the hyperthermia.

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Author information

Authors and Affiliations

  1. CNS Pharmacology, Duphar B.V., P.O.Box 900, 1380, DA, Weesp, The Netherlands

    T. J. J. Zethof, J. A. M. van der Heyden & B. Olivier

Authors
  1. T. J. J. Zethof
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  2. J. A. M. van der Heyden
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  3. B. Olivier
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Editor information

Editors and Affiliations

  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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© 1991 Springer Basel AG

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Zethof, T.J.J., van der Heyden, J.A.M., Olivier, B. (1991). A New Animal Model for Anticipatory Anxiety?. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_6

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_6

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6421-3

  • Online ISBN: 978-3-0348-6419-0

  • eBook Packages: Springer Book Archive

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