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Role of Cell Therapy in Autoimmune Disease

  • Living reference work entry
  • First Online:
Encyclopedia of Inflammatory Diseases

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Synonyms

Allogeneic transplant; Autologous transplant; Crohn’s disease; IBD; Inflammatory arthritis; Mesenchymal stem cells; MS; MSC; Multiple sclerosis; Rheumatoid arthritis; Scleroderma; SLE; SSC

Definition

Cell therapy has developed in the last two decades as a more acceptable therapy for patients with inflammatory diseases. This entry addresses the published studies using stem cell transplant and MSC therapy in the most common inflammatory disorders.

Introduction

The potential role of stem transplantation in autoimmune disease (AID) was first suggested in the 1960s and 1970s based on xenograft studies in immunodeficient mice. These studies indicated that lupus could be induced in an irradiated mouse following transplant of spleen or marrow cells from a mouse with murine lupus (Denman et al. 1969). Furthermore, subsequent studies have documented that stem cell transplant from healthy mice is capable of curing murine lupus (Good 2002). The clinical benefit of stem cell transplant in...

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Pediatrics, Virginia Commonwealth University Medical Centre, P.O. Box 980121, 23298-0121, Richmond, VA, USA

    Christina M. Wiedl

  2. Blood and Marrow Transplant Program, Kidz Medical Services at Nicklaus Children’s hospital, P.O. Box 980121, 33155, Miami, FL, USA

    Kamar Godder

Authors
  1. Christina M. Wiedl
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  2. Kamar Godder
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Correspondence to Christina M. Wiedl .

Editor information

Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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Wiedl, C.M., Godder, K. (2014). Role of Cell Therapy in Autoimmune Disease. In: Parnham, M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_187-1

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_187-1

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  • Online ISBN: 978-3-0348-0620-6

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