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Proteases, Coagulation, and Inflammation

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Proteases and Their Receptors in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

It is now widely accepted that inflammation and coagulation are two intimately linked processes. Pre-clinical evidence on this cross-talk have accumulated since 1961 when it was demonstrated that coagulation factors could cause an inflammatory response in in vivo pre-clinical studies. The discovery of thrombin receptors has been instrumental in clarifying several molecular aspects at the basis of the cross-talk between the coagulation and inflammation pathways. At the present stage we know that the coagulation–inflammation axis plays an important pathological role in many cardiovascular inflammatory-based disease. This chapter will address the role played by the thrombin receptors in the inflammation–coagulation axis and summarize the more recent pre-clinical and clinical findings.

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Authors and Affiliations

  1. Department of Experimental Pharmacology, University of Naples “Federico II”, via Domenico Montesano 49, 80131, Naples, Italy

    Giuseppe Cirino & Mariarosaria Bucci

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  1. Giuseppe Cirino
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  2. Mariarosaria Bucci
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Correspondence to Giuseppe Cirino .

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Editors and Affiliations

  1. CHU Purpan, INSERM U 563, BP 3028, Toulouse Cedex, 31024, France

    Nathalie Vergnolle

  2. Institut Pasteur, Unite de Defense Innee et Inflammation, INSERM U 874, Rue du Dr. Roux 25, Paris Cedex 15, 75724, France

    Michel Chignard

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Cirino, G., Bucci, M. (2011). Proteases, Coagulation, and Inflammation. In: Vergnolle, N., Chignard, M. (eds) Proteases and Their Receptors in Inflammation. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0157-7_10

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  • DOI: https://doi.org/10.1007/978-3-0348-0157-7_10

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