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Clinical Genomics to Drug Discovery Using Machine Learning for Neurodegenerative Disorders: A Future Perspective

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AI and Neuro-Degenerative Diseases

Part of the book series: Studies in Computational Intelligence ((SCI,volume 1131))

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Abstract

Neurodegenerative diseases affect the central nervous system and lead to death of neuronal cells. Development of therapeutics for neurodegenerative diseases is more challenging as compared to other diseases. Exploring the association of neurodegenerative diseases with human gut microbiome can lead to development of microbiome-based therapeutics. Advancement in tools and techniques has changed the face of traditional clinical genomics. Integration of omics approach with computer-aided drug discovery and artificial intelligence gives a multi-dimensional insight into diagnosis and prognosis of neurodegenerative diseases. Faecal samples of patients of neurodegenerative diseases can be analysed using Next Generation Sequencing approach and can be further integrate with drug discovery approach to get insight into the important genes of highly abundant microbes in human gut. Furthermore, Magnetic Resonance Imaging (MRI), Single-photon emission computed tomography (SPECT), and positron emission tomography (PET) of patients can be analysed using various Artificial Intelligence approach to develop models for prediction and analysis of the neurodegenerative disease as well as classification of diseases.

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Author information

Authors and Affiliations

  1. Department of Bioinformatics, Centre for Post Graduate Studies, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha, India

    Abhishek Kumar Sahu

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

    Rosaleen Sahoo

  3. Biochemical Science Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India

    Rosaleen Sahoo

  4. Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Lingaraj Jena

  5. Central Molecular Laboratory, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India

    Sundeep Singh Saluja & Parameswar Sahu

  6. Department of Gastrointestinal Surgery, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India

    Sundeep Singh Saluja

Authors
  1. Abhishek Kumar Sahu
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  2. Rosaleen Sahoo
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  3. Lingaraj Jena
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  4. Sundeep Singh Saluja
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  5. Parameswar Sahu
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Correspondence to Sundeep Singh Saluja or Parameswar Sahu .

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Editors and Affiliations

  1. Amity International Business School, Amity University, Noida, India

    Loveleen Gaur

  2. Machine Intelligence Research Labs, Auburn, AL, USA

    Ajith Abraham

  3. Machine Intelligence Research Labs, Auburn, AL, USA

    Reuel Ajith

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Sahu, A.K., Sahoo, R., Jena, L., Saluja, S.S., Sahu, P. (2024). Clinical Genomics to Drug Discovery Using Machine Learning for Neurodegenerative Disorders: A Future Perspective. In: Gaur, L., Abraham, A., Ajith, R. (eds) AI and Neuro-Degenerative Diseases. Studies in Computational Intelligence, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-031-53148-4_4

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