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The Role of Exosomes in Regenerative Medicine

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Essentials of Regenerative Medicine in Interventional Pain Management

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Abstract

Exosomes are small vesicles that are released by cells, including medicinal signaling cells (MSCs), and play a role in intercellular communication. In regenerative medicine, exosomes are being explored as potential therapeutic agents due to their ability to transfer biomolecules between cells. For example, exosomes have been used to deliver small interfering ribonucleic acid (RNA) molecules to target cells, which can silence specific genes and modulate cell function. Additionally, exosomes can contain non-coding RNA, which plays a significant role in epigenetic control and can influence tumor metastasis. The goal of regenerative medicine is to take advantage of the epigenetic effect of exosomes while promoting repair and regeneration in targeted areas of the body. Exosomes have also been shown to improve symptoms of sarcopenia and have shown potential in applications such as knee osteoarthritis (OA), cartilage restoration, and tendon regeneration. Further research is needed to fully understand the mechanisms of exosomes in promoting tissue repair and to develop new strategies for the treatment of musculoskeletal injuries.

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Acknowledgments

This book chapter is modified and updated from a previous book chapter, “The Role of Exosomes in Regenerative Medicine” by Doug Spiel, MD, in Essentials of Regenerative Medicine in Interventional Pain Management published by ASIPP Publishing.

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Authors and Affiliations

  1. Neurological Associates of West Los Angeles, Santa Monica, CA, USA

    Sheldon Jordan & Jonathan Haroon

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  1. Sheldon Jordan
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  2. Jonathan Haroon
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Correspondence to Sheldon Jordan .

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Editors and Affiliations

  1. Comprehensive Spine & Sports Center, Campbell, CA, USA

    Annu Navani

  2. Tri-State Spine Care Institute, Cincinnati, OH, USA

    Sairam Atluri

  3. Pain Management Centers Of America, Evansville, IN, USA

    Mahendra Sanapati

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© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Jordan, S., Haroon, J. (2024). The Role of Exosomes in Regenerative Medicine. In: Navani, A., Atluri, S., Sanapati, M. (eds) Essentials of Regenerative Medicine in Interventional Pain Management. Springer, Cham. https://doi.org/10.1007/978-3-031-50357-3_13

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  • DOI: https://doi.org/10.1007/978-3-031-50357-3_13

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  • Online ISBN: 978-3-031-50357-3

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