Abstract
Curcumin is a polyphenolic compound recently studied as a potential therapeutic agent for cancer treatment. However, this molecule possesses low solubility in water which complicates its direct use in the organism, making it essential to find a drug delivery system to carry this molecule through hydrophilic environments. To achieve this, carbon dots (CDs) with a polar surface were synthesized from citric acid and urea by solvothermal method, followed by the surface functionalization of the CDs via the adsorption of curcumin molecules (CD-Cur). This nanoplatform was encapsulated inside an electro-responsive hydrogel based on dextran and aniline (Dex/HDI/AT), which acts as a vehicle for CD-Cur. To evaluate the improvement of solubility of curcumin, a drug encapsulation test was carried out to compare its encapsulation rate to a molecule of great hydrophilicity, fluorescein. The results of FTIR, UV-Vis spectroscopy and zeta potential tests enabled to identify the composition of CDs and the functionalization of CD-Cur. The composition and structure of Dex/HDI/AT was confirmed by FTIR and SEM. Finally, the drug encapsulation test demonstrated the capacity of CDs to improve the interaction of hydrophobic curcumin molecules with aqueous-based environments such as the one offered by the DEX/HDI/AT hydrogel.
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Acknowledgements
D.C.R.B., D.F.M. and S.R.C., are grateful to the Universidad del Rosario for financial support. M.D.S.F acknowledges financial support from MinCiencias under Convocatoria 874 - Jovenes Talento.
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Bonilla Fajardo, N.J. et al. (2024). Synthesis and Evaluation of the Potential Use of an Electro-Responsive Hydrogel for the Encapsulation of Carbon Dot-Curcumin Nanoplatforms. In: Marques, J.L.B., Rodrigues, C.R., Suzuki, D.O.H., Marino Neto, J., García Ojeda, R. (eds) IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering. CLAIB CBEB 2022 2022. IFMBE Proceedings, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-031-49401-7_41
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