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Melting Point Certified Reference Materials for Organic Substances: Development Prospects

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Reference Materials in Measurement and Technology (RMMT 2022)

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Abstract

Measurements of the melting point of high-purity organic substances are crucial in various fields, such as medicine, biology, and perfumery and cosmetic production. This research was aimed at developing melting point certified reference materials (CRMs) for organic substances, with metrological traceability to the SI base units for “temperature” (°C). The study analyzes the metrological assurance in the field of melting point measurements, including a reference complex used to measure the melting point and purity of organic substances in the range of + 40 to + 250 °C. The research also identifies the basic requirements for substances eligible as CRMs. The study presents the results of determining the melting point of benzophenone, benzoic acid, succinic acid, anthracene, and caffeine, along with interlaboratory comparisons. To harmonize the results, a method is suggested, which involves presenting the certified value of the melting point determined by direct measurements and certified values of the optical transparency temperature at various heating rates in the certificates of the developed CRMs. These results have theoretical significance in improving the accuracy of measurements in the field of thermal analysis to a higher quality level. The study also outlines research directions for future work.

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Notes

  1. 1.

    Federal Information Fund for Ensuring the Uniformity of Measurements. Available via FIF EUM. https://fgis.gost.ru/fundmetrology. Accessed 7 October 2022.

  2. 2.

    GSO 7895-2001 Caffeine melting point reference material. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/392091. Accessed 7 October 2022.

    GSO 11070-2018 Reference material for the melting point of benzophenone. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/593689. Accessed 7 October 2022.

    GSO 11071-2018 Standard sample of the melting point of benzoic acid. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/394949. Accessed 7 October 2022.

  3. 3.

    GET 34-2020 State primary standard of temperature unit in the range from 0 to 3200 °C: D. I. Mendeleyev Institute for Metrology. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/12/items/1385580. Accessed 7 October 2022.

Abbreviations

ILC:

Interlaboratory comparison

MI:

Measuring instrument

CRM:

Certified reference material

FIF EUM:

Federal Information Fund for Ensuring the Uniformity of Measurements in Russia

References

  1. Aleksandrov Yu (1975) Accurate cryometry of organic substances. Khimiia Publ, Leningrad, p 160 (in Russian)

    Google Scholar 

  2. Aleksandrov YuI (2003) Controversial issues of modern metrology in chemical analysis. Izd-vo im NI Novikova, St. Petersburg, p 303 (in Russian)

    Google Scholar 

  3. Yalkowsky SH, Alantary D (2018) Estimation of melting points of organics. J Pharm Sci 107(5):1211–1227. https://doi.org/10.1016/j.xphs.2017.12.013

    Article  Google Scholar 

  4. Giani S, Riesen R, Schawe JEK (2018) An indirect method for vapor pressure and phase change enthalpy determination by thermogravimetry. Int J Thermophys 39(84):84. https://doi.org/10.1007/s10765-018-2407-y

    Article  ADS  Google Scholar 

  5. Feist M (2015) Thermal analysis: basics, applications, and benefit. ChemTexts 1:8. https://doi.org/10.1007/s40828-015-0008-y

    Article  Google Scholar 

  6. Jain A, Yalkowsky SH (2007) Comparison of two methods for estimation of melting points of organic compounds. Ind Eng Chem Res 46:8. https://doi.org/10.1021/ie0614428

    Article  Google Scholar 

  7. Kazartcev YaV, Korchagina EN, Mishina KA, Shehovtsov DA (2018) On the development of certified reference materials for melting point of high-purity organic substances. In: Collection of works Ith International scientific conference Reference materials in measurement and technology, UNIIM, Ekaterinburg, Russia, 11–14 Sept 2018, pp 79–80 (in Russian)

    Google Scholar 

  8. Tiers GVD (1990) Calibration of capillary melting-point apparatus to the international temperature scale of 1990 (ITS-90) by use of fluxed highly pure metals. Anal Chim Acta 237:241–244. https://doi.org/10.1016/S0003-2670(00)83924-0

    Article  Google Scholar 

  9. Monte MJS, Santos LMNBF, Fulem M, Fonseca JMS, Sousa CAD (2006) New static apparatus and vapor pressure of reference materials: naphthalene, benzoic acid, benzophenone, and ferrocene. J Chem Eng Data 51(2):757–766. https://doi.org/10.1021/je050502y

    Article  Google Scholar 

  10. Kazartcev Ia, Mishina K, Korchagina E, Varganov V (2018) Measuring complex for simultaneous determination of purity and melting point of high-purity organic substances. In: Abstracts 12th European symposium thermal analysis and calorimetry, Brasov, Romania, 27–30 Aug 2018, p 459

    Google Scholar 

  11. Moiseeva NP (2001) Methods of constructing an individual calibration characteristic for working platinum resistance thermometers. Meas Tech 44:502–507. https://doi.org/10.1023/A:1012314420995

    Article  Google Scholar 

  12. Gronvold F (1967) Adiabatic calorimeter for the investigation of reactive substances from 25 to 775 degrees C. Heat capacity of alpha-aluminum oxide. Acta Chememica Scandinavica 21:1695–1713. https://doi.org/10.3891/acta.chem.scand.21-1695

    Article  Google Scholar 

  13. Gronvold F (1993) Adiabatic calorimetry and solid-state properties above ambient temperature. Pure Appl Chem 65(5):927–934. https://doi.org/10.1351/pac199365050927

    Article  Google Scholar 

  14. GOST R 50779.60-2017 (ISO 13528:2015) (2017) Statistical methods. Use in proficiency testing by interlaboratory comparison. Standartinform, Moscow, p 83 (in Russian)

    Google Scholar 

  15. GOST 8.558-2009 (2020) State system for ensuring the uniformity of measurements. State verification schedule for means measuring temperature. Standartinform, Moscow, p 13 (in Russian)

    Google Scholar 

  16. Korchagina EN, Kazartsev IaV, Varganov VP, Solovev IV (2019) On the creation of a standard complex for the development of melting temperature measures based on pure organic substances. In: Proceedings of the V international scientific and technical conference modern methods and tools for studying the thermophysical properties of substances, St. Petersburg, 23–24 May 2019, Federal State Autonomous Educational Institution of Higher Education National Research University ITMO, St. Petersburg, Russia, pp 125–131 (in Russian)

    Google Scholar 

  17. Kazartsev IaV, Varganov VP, Korchagina EN, Solovev IV (2020) Standard complex for measuring the melting temperature and the degree of purity of organic substances. Devices 11:48–54 (in Russian)

    Google Scholar 

  18. Aleksandrov IuI, Varganov VP, Frenkel IM (1986) Method for determining the parameters of the phase transition solid—liquid and a device for its implementation. RF Patent, SU 1221566 A1 (in Russian)

    Google Scholar 

  19. GOST ISO/IEC 17043-2013 (2020) Conformity assessment. General requirements for proficiency testing. Standartinform, Moscow, p 36 (in Russian)

    Google Scholar 

  20. GOST 18995.4-73 (2009) Organic chemical products. Methods for determination of melting point interval. IPK Izdatel’stvo standartov, Moscow, p 5 (in Russian)

    Google Scholar 

  21. GOST 21553-76 (2001) Plastics. Methods for determination of melting temperature. IPK Izdatel’stvo standartov, Moscow, p 14 (in Russian)

    Google Scholar 

  22. OFS.1.2.1.0011.15 Melting point: general pharmacopoeial article: approved and put into effect by the Ministry of Health of the Russian Federation (Order of 29 October 2015 no. 771): date of introduction 01.01.2016. Available via Pharmacopoeia.ru. https://pharmacopoeia.ru/ofs-1-2-1-0011-15-temperatura-plavleniya. Accessed 7 Oct 2022 (in Russian)

  23. GOST R ISO 5725-5-2002 (2002) Accuracy (trueness and precision) of measurement methods and results. Part 5. Alternative methods for the determination of the precision of a standard measurement method. Gosstandart of Russia, Moscow, p 50 (in Russian)

    Google Scholar 

  24. GOST R ISO 5725-6-2002 (2002) Accuracy (trueness and precision) of measurement methods and results. Part 6. Use in practice of accuracy values. Gosstandart of Russia, Moscow, p 43 (in Russian)

    Google Scholar 

  25. RMG 103-2010 (2011) State system for ensuring the uniformity of measurements. Proficiency testing of test (measurement) laboratories, conducting the tests of substances, materials and environmental objects (for composition and physico-chemical properties) by means of interlaboratory comparisonsй. Standartinform, Moscow, p 39 (in Russian)

    Google Scholar 

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Acknowledgements

The research was carried out within the research work “Development and study of melting point measurements based on high-purity organic substances” and development work “Creation of a reference complex for measuring the melting point and purity of organic substances” at the D. I. Mendeleyev Institute for Metrology. All measurements were carried out using the equipment of the D. I. Mendeleyev Institute for Metrology.

Contribution of the Authors

Kazartsev Ya. V.—development of measurement methodology, programming, conducting research, carrying out a formal analysis of the data obtained, writing a draft of the article, preparation and creation of visual materials; Korchagina E. N.—development of the idea (concept) of the study, management of research and development work, obtaining funding, revision of the article; Solovev I. V.—conducting research, carrying out a formal analysis of the data obtained, revision of the article.

Conflict of Interest

The article was prepared on the basis of a report presented at the V International Scientific Conference “Reference Materials in Measurement and Technology” (Yekaterinburg, September 13–16, 2022). The article was admitted for publication after the abstract was revised, the article was formalized, and the review procedure was carried out.

The version in the Russian language is published in the journal “Measurement Standards. Reference Materials” 2023;19(1):29–40. (In Russ.). https://doi.org/10.20915/2077-1177-2023-19-1-29-40.

Author information

Authors and Affiliations

  1. D. I. Mendeleyev Institute for Metrology (VNIIM), Saint Petersburg, Russia

    Yaroslav V. Kazartsev, Elena N. Korchagina & Igor V. Solovev

Authors
  1. Yaroslav V. Kazartsev
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  2. Elena N. Korchagina
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  3. Igor V. Solovev
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Corresponding author

Correspondence to Yaroslav V. Kazartsev .

Editor information

Editors and Affiliations

  1. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Egor P. Sobina

  2. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Sergey V. Medvedevskikh

  3. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Olga N. Kremleva

  4. All-Russian Scientific Research Institute for Optical and Physical Measurements, Moscow, Russia

    Ivan S. Filimonov

  5. All-Russian Scientific Research Institute for Metrological Service, Moscow, Russia

    Elena V. Kulyabina

  6. D. I. Mendeleyev Institute for Metrology, Saint Petersburg, Russia

    Anna V. Kolobova

  7. Saint Petersburg State University, PetroAnalytica LLC, Saint Petersburg, Russia

    Andrey V. Bulatov

  8. All-Russian Scientific Research Institute of Physicotechnical and Radio Engineering Measurements, Moscow, Russia

    Vladimir I. Dobrovolskiy

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Kazartsev, Y.V., Korchagina, E.N., Solovev, I.V. (2024). Melting Point Certified Reference Materials for Organic Substances: Development Prospects. In: Sobina, E.P., et al. Reference Materials in Measurement and Technology . RMMT 2022. Springer, Cham. https://doi.org/10.1007/978-3-031-49200-6_18

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