How Inherited Thrombophilia Affects Success Rate of IVF Treatment in Women

Abstract

The inclination towards conception, is one that has proven to be innate to human beings through generations. Unfortunately, as natural and earnest a desire it might be, so many willing couples and individuals find it difficult and sometimes impossible to conceive naturally. With the advancement of medical science, significant headway has been made, enough to provide a solution for individuals or couples who are unable to conceive naturally, using a series of technique called Assisted Reproductive Technique (ART) which refers to any treatment or procedure for assisting reproduction that includes the handling of human eggs, sperm, or embryos. In-vitro fertilization (IVF) is an example of an assisted reproductive method. In recent years, IVF has steadily become the most popular assisted reproductive procedure and, in most cases, the last resort for infertility therapy. Several factors have been identified as impacting IVF–embryo transfer success or failure rates. Factors to consider include age, parity, previous successful pregnancy, basal hormonal levels, number of antral follicles before stimulation, endometrial thickness, embryo grade, position and length of uterus, and embryo transfer technique. For decades, inherited thrombophilia has been suspected in spontaneous miscarriages during in vitro fertilization procedures. This work investigates the impact of inherited thrombophilia on IVF success rates. The IVF process and what causes couples to need IVF are discussed. The molecular characteristics of thrombophilia are thoroughly studied, and existing articles are evaluated and contrasted to provide additional clarity. Finally, a conclusion is reached regarding the effect of inherited.