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Medical Care and Common Medical Comorbidities in ASD

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Adolescents and Adults with Autism Spectrum Disorders

Abstract

Provision of medical care to adults with autism has been complicated for a host of reasons. These include issues of lack of research data, insufficient guidance on best practices and information on approaches to the person with ASD, problems with insurance, and others. The limited data available suggest potential increased risk for certain medical and mental health problems. Clearly, costs for good medical care are increased even at a time when insurance reimbursement is limited and education for individuals with ASD on getting quality care has been minimal.

As a result of these problems, medical care is often delivered in emergency department settings, and the absence of primary care providers can mean that conditions are overlooked at a time when they are most treatable. Available data suggest increased rates of morbidity in the ASD population. In this chapter, we outline some of the current obstacles and directions for future research and clinical service.

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References

  • Abrahams, B. S., & Geschwind, D. H. (2008). Advances in autism genetics: on the threshold of a new neurobiology.[erratum appears in Nat Rev Genet. 2008 Jun;9(6):493]. Nature Reviews Genetics, 9(5), 341–355.

    Article  PubMed  PubMed Central  Google Scholar 

  • Amanullah, S., Rajeh, A., & Sivakumar, K. (2020). An overview of autism in the elderly. [Review]. Asian Journal of Psychiatry, 48, 101897. https://doi.org/10.1016/j.ajp.2019.101897

    Article  PubMed  Google Scholar 

  • Andersen, A. M., Law, J. K., Marvin, A. R., & Lipkin, P. H. (2020). Elopement patterns and caregiver strategies. Journal of Autism & Developmental Disorders, 50(6), 2053–2063.

    Article  Google Scholar 

  • Antezana, L., Scarpa, A., Valdespino, A., Albright, J., & Richey, J. A. (2017). Rural trends in diagnosis and services for autism spectrum disorder. Frontiers in Psychology, 8, 590.

    Article  PubMed  PubMed Central  Google Scholar 

  • Austin, J., et al. (2016). Improving access to care at autism treatment centers: A system analysis approach. Pediatrics, 137(Supplement_2), S149–S157.

    Article  PubMed  Google Scholar 

  • Badgett, N. M., et al. (2022). Emergency department utilization among youth with autism Spectrum disorder: Exploring the role of preventive care, medical home, and mental health access. Journal of Autism and Developmental Disorders, 1–9.

    Google Scholar 

  • Bemmer, E. R., Boulton, K. A., Thomas, E. E., Larke, B., Lah, S., Hickie, I. B., & Guastella, A. J. (2021). Modified CBT for social anxiety and social functioning in young adults with autism spectrum disorder. Molecular Autism, 12(1), 11.

    Article  PubMed  PubMed Central  Google Scholar 

  • Borremans, E., Rintala, P., & McCubbin, J. A. (2010). Physical fitness and physical activity in adolescents with Asperger syndrome: A comparative study. Adapted Physical Activity Quarterly, 27(4), 308–320.

    Article  PubMed  Google Scholar 

  • Borumandnia, N., Majd, H. A., Doosti, H., & Olazadeh, K. (2022). The trend analysis of neurological disorders as major causes of death and disability according to human development, 1990–2019. Environmental Science & Pollution Research, 29(10), 14348–14354.

    Article  Google Scholar 

  • Boulton, K. A., & Guastella, A. J. (2021). Social anxiety symptoms in autism spectrum disorder and social anxiety disorder: Considering the reliability of self-report instruments in adult cohorts. Autism research: Official Journal of the International Society for Autism Research, 14(11), 2383–2392.

    Article  PubMed  Google Scholar 

  • Brewer, A. T., Strickland-Cohen, K., Dotson, W., & Williams, D. C. (2014). Advance notice for transition-related problem behavior: Practice guidelines. Behavior Analysis in Practice, 7(2), 117–125.

    Article  PubMed  PubMed Central  Google Scholar 

  • Broder-Fingert, S., Brazauskas, K., Lindgren, K., Iannuzzi, D., & Van Cleave, J. (2014). Prevalence of overweight and obesity in a large clinical sample of children with autism. Academic Pediatrics, 14(4), 408–414.

    Article  PubMed  Google Scholar 

  • Buckley, A. W., Hirtz, D., Oskoui, M., Armstrong, M. J., Batra, A., Bridgemohan, C., Coury, D., Dawson, G., Donley, D., Findling, R. L., Gaughan, T., Gloss, D., Gronseth, G., Kessler, R., Merillat, S., Michelson, D., Owens, J., Pringsheim, T., Sikich, L., Stahmer, A., Thurm, A., Tuchman, R., Warren, Z., Wetherby, A., Wiznitzer, M., & Ashwal, S. (2020). Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology, 94(9), 392–404.

    Article  Google Scholar 

  • Budimirovic, D. B., Protic, D. D., Delahunty, C. M., Andrews, H. F., Choo, T. H., Xu, Q., Berry-Kravis, E., Kaufmann, W. E., & Consortium, F. (2022). Sleep problems in fragile X syndrome: Cross-sectional analysis of a large clinic-based cohort. American Journal of Medical Genetics. Part A, 188(4), 1029–1039.

    Article  PubMed  Google Scholar 

  • Burdo-Hartman, W. A., & Patel, D. R. (2008). Medical home and transition planning for children and youth with special health care needs. Pediatric Clinics of North America, 55(6), 1287–1297. vii–viii.

    Article  PubMed  Google Scholar 

  • Burke, L., & Stoddart, K. P. (2014). Medical and health problems in adults with high-functioning autism and Asperger syndrome. In Adolescents and adults with autism spectrum disorders (pp. 239–267). Springer Science + Business Media.

    Chapter  Google Scholar 

  • Capriola-Hall, N. N., Brewe, A. M., Golt, J., & White, S. W. (2020). Anxiety and depression reduction as distal outcomes of a college transition readiness program for adults with autism. Journal of Autism & Developmental Disorders, 28, 28.

    Google Scholar 

  • Carbone, P. S. (2013). Moving from research to practice in the primary care of children with autism spectrum disorders. Academic Pediatrics, 13(5), 390–399.

    Article  PubMed  Google Scholar 

  • Caron, C., & Rutter, M. (1991). Comorbidity in child psychopathology: Concepts, issues and research strategies. Journal of Child Psychology & Psychiatry & Allied Disciplines, 32(7), 1063–1080.

    Article  Google Scholar 

  • Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014). Gastrointestinal problems in children with autism, developmental delays or typical development. Journal of Autism & Developmental Disorders, 44(5), 1117–1127.

    Article  Google Scholar 

  • Chancel, R., Miot, S., Dellapiazza, F., & Baghdadli, A. (2022). Group-based educational interventions in adolescents and young adults with ASD without ID: A systematic review focusing on the transition to adulthood. European Child & Adolescent Psychiatry, 31(7), 1–21.

    Article  Google Scholar 

  • Chandler, S., Carcani-Rathwell, I., Charman, T., Pickles, A., Loucas, T., Meldrum, D., Simonoff, E., Sullivan, P., & Baird, G. (2013). Parent-reported gastro-intestinal symptoms in children with autism spectrum disorders. Journal of Autism & Developmental Disorders, 43(12), 2737–2747.

    Article  Google Scholar 

  • Clarke, T., Tickle, A., & Gillott, A. (2016). Substance use disorder in Asperger syndrome: An investigation into the development and maintenance of substance use disorder by individuals with a diagnosis of Asperger syndrome. International Journal of Drug Policy, 27, 154–163.

    Article  PubMed  Google Scholar 

  • Coury, D. (2010). Medical treatment of autism spectrum disorders. [Research support, U.S. Gov’t, P.H.S. Review]. Current Opinion in Neurology, 23(2), 131–136. https://doi.org/10.1097/WCO.0b013e32833722fa

    Article  PubMed  Google Scholar 

  • Curtin, C., Jojic, M., & Bandini, L. G. (2014). Obesity in children with autism spectrum disorder. Harvard Review of Psychiatry, 22(2), 93–103.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dalton, N., Chandler, S., Turner, C., Charman, T., Pickles, A., Loucas, T., Simonoff, E., Sullivan, P., & Baird, G. (2014). Gut permeability in autism spectrum disorders. Autism research: Official Journal of the International Society for Autism Research, 7(3), 305–313.

    Article  PubMed  Google Scholar 

  • Davignon, M. N., Qian, Y., Massolo, M., & Croen, L. A. (2018). Psychiatric and medical conditions in transition-aged individuals with ASD. Pediatrics, 141(Suppl 4), S335–S345.

    Article  PubMed  Google Scholar 

  • Durand, V. M. (2014). Sleep better: A guide to improving sleep for children with special needs. Brooks Publshing.

    Google Scholar 

  • Earl, R. K., Ward, T., Gerdts, J., Eichler, E. E., Bernier, R. A., & Hudac, C. M. (2021). Sleep problems in children with ASD and gene disrupting mutations. Journal of Genetic Psychology, 182(5), 317–334.

    Article  PubMed  Google Scholar 

  • Eilenberg, J. S., Paff, M., Harrison, A. J., & Long, K. A. (2019). Disparities based on race, ethnicity, and socioeconomic status over the transition to adulthood among adolescents and young adults on the autism spectrum: A systematic review. Current Psychiatry Reports, 21(5), 32.

    Article  PubMed  Google Scholar 

  • Eisenberg, L., & Kanner, L. (1956). Childhood schizophrenia symposium 1955. VI infantile autism. American Journal of Orthopsychiatry, 26, 556–566.

    Article  PubMed  Google Scholar 

  • Elsabbagh, M., et al. (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5, 160–179.

    Article  PubMed  PubMed Central  Google Scholar 

  • Farley, M., & McMahon, B. (2014). Range of outcomes and challenges in middle and later life. In Adolescents and adults with autism spectrum disorders (pp. 211–238). Springer Science + Business Media.

    Chapter  Google Scholar 

  • Fein, D., Barton, M., Eigsti, I. M., Kelley, E., Naigles, L., Schultz, R. T., Stevens, M., Helt, M., Orinstein, A., Rosenthal, M., Troyb, E., & Tyson, K. (2013). Optimal outcome in individuals with a history of autism. Journal of Child Psychology & Psychiatry & Allied Disciplines, 54(2), 195–205.

    Article  Google Scholar 

  • Fenikilé, T. S., Ellerbeck, K., Filippi, M. K., & Daley, C. M. (2015). Barriers to autism screening in family medicine practice: a qualitative study. Primary Health Care Research & Development, 16(4), 356–366, https://doi.org/10.1017/s1463423614000449

  • Foldi, C. J., Eyles, D. W., McGrath, J. J., & Burne, T. H. J. (2019). Increasing paternal age alters anxiety-related behaviour in adult mice. Genes, Brain, & Behavior, 18(2), e12522.

    Article  Google Scholar 

  • Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology & Psychiatry & Allied Disciplines, 18(4), 297–321.

    Article  Google Scholar 

  • Fuentes-Biggi, J., Ferrari-Arroyo, M. J., Boada-Munoz, L., Tourino-Aguilera, E., Artigas-Pallares, J., Belinchon-Carmona, M., Munoz-Yunta, J. A., Hervas-Zuniga, A., Canal-Bedia, R., Hernandez, J. M., Diez-Cuervo, A., Idiazabal-Aletxa, M. A., Mulas, F., Palacios, S., Tamarit, J., Martos-Perez, J., Posada-De la Paz, M., & E. Grupo de Estudio de los Trastornos del Espectro Autista del Instituto de Salud Carlos Iii. Ministerio de Sanidad y Consumo. (2006). Good practice guidelines for the treatment of autistic spectrum disorders. Revista de Neurologia, 43(7), 425–438.

    PubMed  Google Scholar 

  • Gauthier-Boudreault, C., Gallagher, F., Trepanier, J., Corbin, F., & Couture, M. (2020). Factors impacting the transition to adulthood of youth with fragile X syndrome and their families: Facilitators, obstacles and needs. Research in Developmental Disabilities, 103, 103674.

    Article  PubMed  Google Scholar 

  • Gerhardt, P. F., Cicero, F., & Mayville, E. (2014). Employment and related services for adults with autism spectrum disorders. In Adolescents and adults with autism spectrum disorders (pp. 105–119). Springer Science + Business Media.

    Chapter  Google Scholar 

  • Gilbertson, K. E., Jackson, H. L., Dziuban, E. J., Sherman, S. L., Berry-Kravis, E. M., Erickson, C. A., & Valdez, R. (2019). Preventive care services and health behaviors in children with fragile X syndrome. Disability & Health Journal, 12(4), 564–573.

    Article  Google Scholar 

  • Gillberg, C., & Coleman, M. (1996). Autism and medical disorders: A review of the literature. Developmental Medicine & Child Neurology, 38(3), 191–202.

    Article  Google Scholar 

  • Gillette, M. L., Stough, C. O., Beck, A. R., Maliszewski, G., Best, C. M., Gerling, J. K., & Summar, S. (2014). Outcomes of a weight management clinic for children with special needs. Journal of Developmental & Behavioral Pediatrics, 35(4), 266–273.

    Article  Google Scholar 

  • Grondhuis, S. N., & Aman, M. G. (2014). Overweight and obesity in youth with developmental disabilities: A call to action. Journal of Intellectual Disability Research, 58(9), 787–799.

    Article  PubMed  Google Scholar 

  • Hagerman, P. J., & Hagerman, R. (2021). Fragile X syndrome. Current biology: CB, 31(6), R273–R275. https://doi.org/10.1016/j.cub.2021.01.043

    Article  PubMed  Google Scholar 

  • Hall, J. P., & Kurth, N. K. (2019). National Survey on Health and Disability. Retrieved February 10, 2020, from https://ihdps.ku.edu/collaborative-health-reform-and-independent-living-chril

  • Hall, J. P., et al. (2020). Health disparities among sexual and gender minorities with autism spectrum disorder. Journal of Autism and Developmental Disorders, 50(8), 3071–3077.

    Article  PubMed  Google Scholar 

  • Halstead, E., Sullivan, E., Zambelli, Z., Ellis, J. G., & Dimitriou, D. (2021). The treatment of sleep problems in autistic adults in the United Kingdom. Autism, 25(8), 2412–2417.

    Article  PubMed  Google Scholar 

  • Hellstrand, K., Rogers, S. C., DiVietro, S., Clough, M., & Sturm, J. (2021). Prevalence of cyberbullying in patients presenting to the pediatric emergency department. Pediatric Emergency Care, 37(6), e334–e338.

    Article  PubMed  Google Scholar 

  • Hernandez, J. M., Artigas-Pallares, J., Martos-Perez, J., Palacios-Anton, S., Fuentes-Biggi, J., Belinchon-Carmona, M., Canal-Bedia, R., Diez-Cuervo, A., Ferrari-Arroyo, M. J., Hervas-Zuniga, A., Idiazabal-Alecha, M. A., Mulas, F., Munoz-Yunta, J. A., Tamarit, J., Valdizan, J. R., Posada-De la Paz, M., & C. Grupo de Estudio de los Trastornos del Espectro Autista del Instituto de Salud, III. (2005). Best practice guidelines for the early detection of Autistic Spectrum Disorders (I). Revista de Neurologia, 41(4), 237–245.

    PubMed  Google Scholar 

  • Howlin, P. (2021). Adults with autism: Changes in understanding since DSM-111. Journal of Autism & Developmental Disorders, 20, 20.

    Google Scholar 

  • Hyman, S. L., Stewart, P. A., Foley, J., Cain, U., Peck, R., Morris, D. D., Wang, H., & Smith, T. (2015). The gluten-free/casein-free diet: A double-blind challenge trial in children with autism. No Pagination Specified.

    Google Scholar 

  • Jackson, S. L. J., Hart, L., Brown, J. T., & Volkmar, F. R. (2018). Brief report: Self-reported academic, social, and mental health experiences of post-secondary students with autism Spectrum disorder. Journal of Autism & Developmental Disorders, 48(3), 643–650.

    Article  Google Scholar 

  • Jokiranta-Olkoniemi, E., Gyllenberg, D., Sucksdorff, D., Suominen, A., Kronstrom, K., Chudal, R., & Sourander, A. (2021). Risk for premature mortality and intentional self-harm in autism spectrum disorders. Journal of Autism & Developmental Disorders, 51(9), 3098–3108.

    Article  Google Scholar 

  • Kanner, L. (1971). Follow-up study of eleven autistic children originally reported in 1943. Journal of Autism & Childhood Schizophrenia, 1(2), 119–145.

    Article  Google Scholar 

  • Kinnear, S. H., et al. (2016). Understanding the experience of stigma for parents of children with autism spectrum disorder and the role stigma plays in families’ lives. Journal of Autism and Developmental Disorders, 46(3), 942–953.

    Article  PubMed  Google Scholar 

  • Kuddo, T., & Nelson, K. B. (2003). How common are gastrointestinal disorders in children with autism? Current Opinion in Pediatrics, 15(3), 339–343.

    Article  PubMed  Google Scholar 

  • Lake, J. K., Balogh, R., & Lunsky, Y. (2012). Polypharmacy profiles and predictors among adults with autism spectrum disorders. Research in Autism Spectrum Disorders, 6(3), 1142–1149.

    Article  Google Scholar 

  • Lamy, M., & Erickson, C. A. (2018). Pharmacological management of behavioral disturbances in children and adolescents with autism spectrum disorders. Current Problems in Pediatric & Adolescent Health Care, 48(10), 250–264.

    Article  Google Scholar 

  • Lau, D. C. W., Douketis, J. D., Morrison, K. M., Hramiak, I. M., Sharma, A. M., Ur, E., & P. Obesity Canada Clinical Practice Guidelines Expert. (2007). 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. [comment]. CMAJ Canadian Medical Association Journal, 176(8), S1–S13.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lavelle, T. A., et al. (2014). Economic burden of childhood autism spectrum disorders. Pediatrics, 133(3), e520–e529.

    Article  PubMed  Google Scholar 

  • Levy, S. E., Giarelli, E., Lee, L. C., Schieve, L. A., Kirby, R. S., Cunniff, C., et al. (2010). Autism spectrum disorder and co-occurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States. [Research support, U.S. Gov’t, P.H.S.]. Journal of Developmental & Behavioral Pediatrics, 31(4), 267–275. https://doi.org/10.1097/DBP.0b013e3181d5d03b

    Article  Google Scholar 

  • Lofthouse, N., Hendren, R., Hurt, E., Arnold, L. E., & Butter, E. (2012). A review of complementary and alternative treatments for autism spectrum disorders. Autism Research & Treatment Print, 2012, 870391.

    Google Scholar 

  • Lohr, W. D., Creel, L., Feygin, Y., Stevenson, M., Smith, M. J., Myers, J., Woods, C., Liu, G., & Davis, D. W. (2018). Psychotropic polypharmacy among children and youth receiving medicaid, 2012–2015. Journal of Managed Care & Specialty Pharmacy, 24(8), 736–744.

    Article  Google Scholar 

  • Lorimer, P. A., Simpson, R. L., Myles, B. S., & Ganz, J. B. (2002). The use of social stories as a preventative behavioral intervention in a home setting with a child with autism. Journal of Positive Behavior Interventions, 4(1), 53–60. https://doi.org/10.1177/109830070200400109

    Article  Google Scholar 

  • Lugnegard, T., Hallerback, M. U., & Gillberg, C. (2011). Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. [Research support, non-U.S. Gov’t]. Research in Developmental Disabilities, 32(5), 1910–1917. https://doi.org/10.1016/j.ridd.2011.03.025

    Article  PubMed  Google Scholar 

  • Lunsky, Y., Lai, M. C., Balogh, R., Chung, H., Durbin, A., Jachyra, P., Tint, A., Weiss, J., & Lin, E. (2022). Premature mortality in a population-based cohort of autistic adults in Canada. Autism research: Official Journal of the International Society for Autism Research, 15(8), 1550–1559.

    Article  PubMed  Google Scholar 

  • Malik-Soni, N., Shaker, A., Luck, H., Mullin, A. E., Wiley, R. E., Lewis, M., Fuentes, J., & Frazier, T. W. (2022). Tackling healthcare access barriers for individuals with autism from diagnosis to adulthood. Pediatric Research, 91(5), 1028–1035. https://doi.org/10.1038/s41390-021-01465-y

    Article  PubMed  Google Scholar 

  • Matin, B. K., et al. (2022). Contributing factors to healthcare costs in individuals with autism spectrum disorder: A systematic review. BMC Health Services Research, 22(1), 1–20.

    Article  Google Scholar 

  • Mazurek, M. O., et al. (2019). ECHO autism STAT: Accelerating early access to autism diagnosis. Journal of Autism and Developmental Disorders, 49(1), 127–137.

    Article  PubMed  Google Scholar 

  • McClure, I. (2014). Developing and implementing practice guidelines. In N. J. Hoboken (Ed.), Handbook of autism and pervasive developmental disorders, volume 2: Assessment, interventions, and policy (pp. 1014–1035). Wiley.

    Google Scholar 

  • McDonald, T. A. M., & Scudder, A. (2023). Mind the NIH-funding gap: Structural discrimination in physical health-related research for cognitively able autistic adults. Journal of Autism & Developmental Disorders. https://doi.org/10.1007/s10803-022-05856-w

  • McLaughlin, L., Keim, S. A., & Adesman, A. (2018). Wandering by children with autism spectrum disorder: Key clinical factors and the role of schools and pediatricians. Journal of Developmental & Behavioral Pediatrics, 39(7), 538–546.

    Article  Google Scholar 

  • Millward, C., Ferriter, M., Calver, S., & Connell-Jones, G. (2008). Gluten- and casein-free diets for autistic spectrum disorder. [Update of Cochrane database Syst rev. 2004;(2):CD003498; PMID: 15106205]. Cochrane Database of Systematic Reviews, 2, CD003498.

    Google Scholar 

  • Miot, S., Akbaraly, T., Michelon, C., Couderc, S., Crepiat, S., Loubersac, J., Picot, M. C., Pernon, E., Gonnier, V., Jeandel, C., Blain, H., & Baghdadli, A. (2019). Comorbidity burden in adults with autism Spectrum disorders and intellectual disabilities-a report from the EFAAR (frailty assessment in ageing adults with autism spectrum and intellectual disabilities) study. Frontiers in psychiatry Frontiers Research Foundation, 10, 617.

    Article  Google Scholar 

  • Morgan, B., Nageye, F., Masi, G., & Cortese, S. (2019). Sleep in adults with autism Spectrum disorder: A systematic review and meta-analysis of subjective and objective studies. Sleep Medicine, 65, 113–120.

    Article  PubMed  Google Scholar 

  • Mouridsen, S. E., Bronnum-Hansen, H., Rich, B., & Isager, T. (2008). Mortality and causes of death in autism spectrum disorders: An update. Autism, 12(4), 403–414.

    Article  PubMed  Google Scholar 

  • Myles, B. S., Gagnon, E., Moyer, S. A., & Trautman, M. L. (2004). Asperger syndrome. In F. M. Kline & L. B. Silver (Eds.), The educator’s guide to mental health issues in the classroom (pp. 75–100). Paul H Brookes Publishing.

    Google Scholar 

  • Nahar, A., Thippeswamy, H., Shanker Reddy, M. S., Kishore, M. T., & Chaturvedi, S. K. (2019). Psychiatric comorbidity in persons with high-functioning autism spectrum disorders: Findings from a tertiary care neuropsychiatric hospital. Asian Journal of Psychiatry, 41, 50–53.

    Article  PubMed  Google Scholar 

  • NICE. (2012). http://www.nice.org.uk/guidance/cg142/chapter/1-recommendations.\

  • Pederson, C. T., Reisert, H., & Adesman, A. (2021). Wandering behavior in children with autism spectrum disorder and other developmental disabilities. Current Opinion in Pediatrics, 33(4), 464–470.

    Article  Google Scholar 

  • Piven, J., Rabins, P., & Autism-in-Older Adults Working, G. (2011). Autism spectrum disorders in older adults: Toward defining a research agenda. Journal of the American Geriatrics Society, 59(11), 2151–2155. https://doi.org/10.1111/j.1532-5415.2011.03632.x

    Article  PubMed  Google Scholar 

  • Raja, M., & Azzoni, A. (2001). Asperger’s disorder in the emergency psychiatric setting. General Hospital Psychiatry, 23(5), 285–293.

    Article  PubMed  Google Scholar 

  • Rast, J. E., Shattuck, P. T., Roux, A. M., Anderson, K. A., & Kuo, A. (2018). The medical home and health care transition for youth with autism. Pediatrics, 141(Suppl 4), S328–S334.

    Article  PubMed  Google Scholar 

  • Reiss, S., Levitan, G. W., & Szyszko, J. (1982). Emotional disturbance and mental retardation: Diagnostic overshadowing. American Journal of Mental Deficiency, 86(6), 567–574.

    PubMed  Google Scholar 

  • Rigles, B. (2017). The relationship between adverse childhood events, resiliency and health among children with autism. Journal of Autism and Developmental Disorders, 47(1), 187–202. https://doi.org/10.1007/s10803-016-2905-3

    Article  PubMed  Google Scholar 

  • Ritter, C., Hewitt, K., & McMorris, C. A. (2021). Psychotropic polypharmacy among children and youth with autism: A systematic review. Journal of Child & Adolescent Psychopharmacology, 31(4), 244–258.

    Article  Google Scholar 

  • Rutter, M., Bailey, A., Bolton, P., & Le Couter, A. (1994). Autism and known medical conditions: Myth and substance. Journal of Child Psychology & Psychiatry & Allied Disciplines, 35(2), 311–322.

    Article  Google Scholar 

  • Rydzewska, E., Dunn, K., & Cooper, S. A. (2021). Umbrella systematic review of systematic reviews and meta-analyses on comorbid physical conditions in people with autism spectrum disorder. British Journal of Psychiatry, 218(1), 10–19.

    Article  Google Scholar 

  • Schaefer, G. B., Mendelsohn, N. J., Professional, P., & Guidelines, C. (2013). Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions. [Erratum appears in Genet Med. 2013 Aug;15(8):669]. Genetics in Medicine, 15(5), 399–407.

    Article  PubMed  Google Scholar 

  • Schoufour, J. D., Oppewal, A., van der Maarl, H. J. K., Hermans, H., Evenhuis, H. M., Hilgenkamp, T. I. M., & Festen, D. A. (2018). Multimorbidity and polypharmacy are independently associated with mortality in older people with intellectual disabilities: A 5-year follow-up from the HA-ID study. American Journal on Intellectual & Developmental Disabilities, 123(1), 72–82.

    Article  Google Scholar 

  • Sharp, W. G., Burrell, T. L., & Jaquess, D. L. (2014). The autism MEAL plan: A parent-training curriculum to manage eating aversions and low intake among children with autism. Autism, 18(6), 712–722.

    Article  PubMed  Google Scholar 

  • Shavelle, R. M., & Strauss, D. (1998). Comparative mortality of persons with autism in California, 1980–1996. Journal of Insurance Medicine (Seattle), 30(4), 220–225.

    Google Scholar 

  • Shavelle, R. M., Strauss, D. J., & Pickett, J. (2001). Causes of death in autism. Journal of Autism & Developmental Disorders, 31(6), 569–576.

    Article  Google Scholar 

  • Shehi, E., Shah, H., Singh, A., Pampana, V. S., & Kaur, G. (2022). The linkage between autism spectrum disorder and Dup15q syndrome: A case report. Cureus, 14(4), e24205.

    PubMed  PubMed Central  Google Scholar 

  • Shmaya, Y., Eilat-Adar, S., Leitner, Y., Reif, S., & Gabis, L. (2015). Nutritional deficiencies and overweight prevalence among children with autism spectrum disorder. Research in Developmental Disabilities, 38, 1–6.

    Article  PubMed  Google Scholar 

  • Smith, T., Oakes, L., Selver, K., Volkmar, F. R., Paul, R., Rogers, S. J., & Pelphrey, K. A. (2014). Alternative treatments. In Handbook of autism and pervasive developmental disorders (4th ed.). Wiley.

    Google Scholar 

  • Solomon, C. (2020). Autism and employment: Implications for employers and adults with ASD. Journal of Autism & Developmental Disorders, 15(11), 15.

    Google Scholar 

  • Srinivasan, S. M., Pescatello, L. S., & Bhat, A. N. (2014). Current perspectives on physical activity and exercise recommendations for children and adolescents with autism spectrum disorders. Physical Therapy, 94(6), 875–889.

    Article  PubMed  PubMed Central  Google Scholar 

  • Starkstein, S., Gellar, S., Parlier, M., Payne, L., & Piven, J. (2015). High rates of parkinsonism in adults with autism. Journal of Neurodevelopmental Disorders, 7(1), 29. https://doi.org/10.1186/s11689-015-9125-6

    Article  PubMed  PubMed Central  Google Scholar 

  • Sturm, A., & Kasari, C. (2019). Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender. Autism Research: No Pagination Specified.

    Google Scholar 

  • Sylvester, C. J., & Forman, S. F. (2008). Clinical practice guidelines for treating restrictive eating disorder patients during medical hospitalization. [comment]. Current Opinion in Pediatrics, 20(4), 390–397.

    Article  PubMed  Google Scholar 

  • Tammimies, K., Marshall, C. R., Walker, S., Kaur, G., Thiruvahindrapuram, B., Lionel, A. C., Yuen, R. K., Uddin, M., Roberts, W., Weksberg, R., Woodbury-Smith, M., Zwaigenbaum, L., Anagnostou, E., Wang, Z., Wei, J., Howe, J. L., Gazzellone, M. J., Lau, L., Sung, W. W., Whitten, K., Vardy, C., Crosbie, V., Tsang, B., D'Abate, L., Tong, W. W., Luscombe, S., Doyle, T., Carter, M. T., Szatmari, P., Stuckless, S., Merico, D., Stavropoulos, D. J., Scherer, S. W., & Fernandez, B. A. (2015). Molecular diagnostic yield of chromosomal microarray analysis and whole-exome sequencing in children with autism spectrum disorder. JAMA, 314(9), 895–903.

    Article  PubMed  Google Scholar 

  • Tan, B. W., Pooley, J. A., & Speelman, C. P. (2016). A meta-analytic review of the efficacy of physical exercise interventions on cognition in individuals with autism Spectrum disorder and ADHD. Journal of Autism & Developmental Disorders, 46(9), 3126–3143.

    Article  Google Scholar 

  • Tolliver, S., Smith, Z. I., & Silverberg, N. (2022). The genetics and diagnosis of pediatric neurocutaneous disorders: Neurofibromatosis and tuberous sclerosis complex. Clinics in Dermatology, 4, 04.

    Google Scholar 

  • van Schalkwyk, G. I., & Volkmar, F. R. (2017). Autism spectrum disorders: Challenges and opportunities for transition to adulthood. Child & Adolescent Psychiatric Clinics of North America, 26(2), 329–339.

    Article  Google Scholar 

  • van Schalkwyk, G., Smith, I. C., Silverman, W. K., & Volkmar, F. R. (2018). Brief report: Bullying and anxiety in high-functioning adolescents with ASD. Journal of Autism & Developmental Disorders, 48(5), 1819–1824.

    Article  Google Scholar 

  • Vivanti, G., Yerys, B. E., & Salomone, E. (2019). Psychological factors in autism spetrum disorders. In F. Volkmar (Ed.), Autism and the pervasive developmental disorders (pp. 61–89). Cambridge University Press.

    Chapter  Google Scholar 

  • Vohra, R., Madhavan, S., Sambamoorthi, U., StPeter, C., Poe, S., Dwibedi, N., & Ajmera, M. (2016). Prescription drug use and polypharmacy among Medicaid-enrolled adults with autism: A retrospective cross-sectional analysis. Drugs Real World Outcomes, 3(4), 409–425.

    Article  PubMed  PubMed Central  Google Scholar 

  • Volkmar, F. R., & Nelson, D. S. (1990). Seizure disorders in autism. Journal of the American Academy of Child & Adolescent Psychiatry, 29(1), 127–129.

    Article  Google Scholar 

  • Volkmar, F. R., & Wiesner, L. (2017). Essential guide to understanding and treating autism. Wiley-Blackwell.

    Book  Google Scholar 

  • Volkmar, F. R., & Wiesner, L. A. (2021). A practical guide to autism. Wiley.

    Book  Google Scholar 

  • Walsh, C., et al. (2021). A systematic review of interventions to improve healthcare experiences and access in autism. Review. Journal of Autism and Developmental Disorders, 1–18.

    Google Scholar 

  • Wang, L. W., Tancredi, D. J., & Thomas, D. W. (2011). The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Journal of Developmental & Behavioral Pediatrics, 32(5), 351–360.

    Article  Google Scholar 

  • White, S. W., Elias, R., Capriola-Hall, N. N., Smith, I. C., Conner, C. M., Asselin, S. B., Howlin, P., Getzel, E. E., & Mazefsky, C. A. (2017). Development of a college transition and support program for students with autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(10), 3072–3078.

    Article  PubMed  PubMed Central  Google Scholar 

  • White, S. W., Smith, I. C., Miyazaki, Y., Conner, C. M., Elias, R., & Capriola-Hall, N. N. (2021). Improving transition to adulthood for students with autism: A randomized controlled trial of STEPS. Journal of Clinical Child & Adolescent Psychology, 50(2), 187–201.

    Article  Google Scholar 

  • White, S. W., Smith, I., & Brewe, A. M. (2022). Brief report: The influence of autism severity and depression on self-determination among young adults with autism spectrum disorder. Journal of Autism & Developmental Disorders, 52(6), 2825–2830.

    Article  Google Scholar 

  • Whitney, D. G., Schmidt, M., Peterson, M. D., & Haapala, H. (2020). Polypharmacy among privately insured adults with cerebral palsy: A retrospective cohort study. Journal of Managed Care & Specialty Pharmacy, 26(9), 1153–1161.

    Article  Google Scholar 

  • Williams, Z. J., & Gotham, K. O. (2022). Current and lifetime somatic symptom burden among transition-aged autistic young adults. Autism research: Official Journal of the International Society for Autism Research, 15(4), 761–770.

    Article  PubMed  Google Scholar 

  • Yuenn, R. K. C., Szatmari, P., & Vorstman, J. A. S. (2019). The genetics of autism Spectrum disorders. In Autism and the Pervasive Developmental Disorders. F. R. Volkmar (pp. 112–128). Cambridge University Press.

    Chapter  Google Scholar 

  • Zuckerman, K. E., Hill, A. P., Guion, K., Voltolina, L., & Fombonne, E. (2014). Overweight and obesity: Prevalence and correlates in a large clinical sample of children with autism spectrum disorder. [Research support, N.I.H., extramural research support, non-U.S. Gov’t research support, U.S. Gov’t, P.H.S.]. Journal of Autism & Developmental Disorders, 44(7), 1708–1719. https://doi.org/10.1007/s10803-014-2050-9

    Article  Google Scholar 

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Authors and Affiliations

  1. Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA

    Cristofer Zillo

  2. Yale Child Study Center, Yale University, New Haven, CT, USA

    Fred R. Volkmar

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  1. Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA

    Fred R. Volkmar

  2. A.J. Pappanikou Center for Excellence in Developmental Disabilities, UConn Health, University of Connecticut, Farmington, CT, USA

    Brian Reichow

  3. Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA

    James C. McPartland

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Zillo, C., Volkmar, F.R. (2024). Medical Care and Common Medical Comorbidities in ASD. In: Volkmar, F.R., Reichow, B., McPartland, J.C. (eds) Adolescents and Adults with Autism Spectrum Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-46463-8_12

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