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Genetics and Otitis Media

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Textbook of Otitis Media

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Abstract

Otitis media (OM) is a complex disease of multifactorial etiology with a strong genetic component as evidenced by heritability studies and previously identified rare and common variants that confer susceptibility to OM. Recent scientific and technological advancements have helped propel our understanding of OM in the genetic context, with numerous genetic loci and genes brought into focus. Many of these genes relate the immune system and craniofacial development to OM susceptibility. Findings have also highlighted the complexity of OM pathogenesis with the implication of gene–environment interactions and changes to the microbiota of the middle ear and nasopharynx due to genetic variants. Using the latest genetic tools, the identification of OM-pathogenic variants in diverse populations will further increase our knowledge of OM pathophysiology, which can then be used to optimize prevention and treatment of OM.

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Acknowledgments

This work was supported by the National Institutes of Health (NIH)—the National Institute on Deafness and Other Communication Disorders (NIDCD) via grants R01 DC015004 and R01 DC019642 (to RS-C). NKL was supported by the T32 DC012280 grant from NIH-NIDCD (to Sue C. Kinnamon and Herman A. Jenkins). The contents of this chapter are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

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  1. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Nam K. Lee & Regie Lyn P. Santos-Cortez

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Correspondence to Regie Lyn P. Santos-Cortez .

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Editors and Affiliations

  1. Department of Otolaryngology, Clínica Universidad de Los Andes, Santiago, Chile, USA

    Marcos V. Goycoolea

  2. Otolaryngology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sady Selaimen da Costa

  3. Department of Otolaryngology, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Chris de Souza

  4. Paparella Ear Head & Neck Institute, University of Minnesota, Minneapolis, MN, USA

    Michael M. Paparella

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Lee, N.K., Santos-Cortez, R.L.P. (2023). Genetics and Otitis Media. In: Goycoolea, M.V., Selaimen da Costa, S., de Souza, C., Paparella, M.M. (eds) Textbook of Otitis Media. Springer, Cham. https://doi.org/10.1007/978-3-031-40949-3_10

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  • DOI: https://doi.org/10.1007/978-3-031-40949-3_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-40948-6

  • Online ISBN: 978-3-031-40949-3

  • eBook Packages: MedicineMedicine (R0)

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