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Preeclampsia: Early and Long-Term Clinical Considerations

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Biology of Women’s Heart Health

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 26))

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Abstract

Preeclampsia is a hypertensive disorder of pregnancy characterized by new onset of hypertension after 20 weeks gestational age, in the setting of proteinuria and/or other end organ damage. It is a multisystem disorder and is caused by abnormal placentation and release of angiogenic factors with resultant maternal vascular dysfunction. Preeclampsia complicates 5% of pregnancies and the incidence has increased 25% in the last 20 years. Severe forms of preeclampsia can result in dysfunction of maternal neurologic, renal, cardiac, hepatic, pulmonary function, as well as haematologic disturbances and death. Fetal complications include severe growth restriction, preterm birth and stillbirth/neonatal death. Screening, timely diagnosis and management of preeclampsia are integral to optimizing outcomes, with definitive therapy being delivery of the fetus. However, preeclampsia may also be diagnosed in the postpartum period, highlighting the need for post-partum assessment. Though much work has been done in the antepartum diagnosis and management of preeclampsia, a growing body of evidence has shown an increased risk of long-term cardiovascular disease in patients who develop preeclampsia. Not only must healthcare providers be able to diagnose and manage preeclampsia, providers must also understand the role that preeclampsia plays in the lifelong cardiovascular risk of their patients.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada

    Sarah Gibbs

  2. Department of Obstetrics, Gynecology and Reproductive Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Rachelle Govia

  3. Department of Internal Medicine, Section of General Internal Medicine, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Jessica Cudmore & Laura Chisick

  4. Department of Internal Medicine, Section of Cardiology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Robin Ducas

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  1. Sarah Gibbs
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  2. Rachelle Govia
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  3. Jessica Cudmore
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  4. Laura Chisick
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  5. Robin Ducas
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Correspondence to Robin Ducas .

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Editors and Affiliations

  1. The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada

    Lorrie Kirshenbaum

  2. The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada

    Inna Rabinovich-Nikitin

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Gibbs, S., Govia, R., Cudmore, J., Chisick, L., Ducas, R. (2023). Preeclampsia: Early and Long-Term Clinical Considerations. In: Kirshenbaum, L., Rabinovich-Nikitin, I. (eds) Biology of Women’s Heart Health. Advances in Biochemistry in Health and Disease, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-031-39928-2_6

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