Abstract
Surgical scars can have significant physical and psychosocial effects on patients. Clinical trials have identified a limited number of interventions that are associated with proven reductions in scar size and improved appearance. Few pre-operative measures have proven benefits but may include managing patient stress levels, body warming, and possibly vitamin E application. Intra-operatively, good planning and prevention of blood loss and infection are essential; suture material and size may be less important. Although surgical denervation can hinder wound repair, perioperative botulinum neurotoxin injection around the surgical site is among the most useful interventions for improved scarring. Post-operatively, there is also good evidence to support the use of hypochlorous acid, silicone dressings and gels, and laser treatment. As the remodelling phase of healing can last for up to a year, some such interventions may need to continue well beyond the immediate perioperative period. Many other methods offer potential for post-operative benefit, including platelet-rich plasma, micro-needling, and various wound dressings and topical preparations. Further studies are required. In the future, approaches that redirect wound healing towards a more ‘foetal’ type of process might make truly scarless surgery a possibility.
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References
Brown BC, McKenna SP, Siddhi K, et al. The hidden cost of skin scars: quality of life after skin scarring. J Plast Reconstr Aesthet Surg. 2008;61:1049–58.
Jourdan M, Madfes DC, Lima E, et al. Skin care management for medical and aesthetic procedures to prevent scarring. Clin Cosmet Investig Dermatol. 2019;12:799–804.
Yarbus AL. Eye movements during the examination of complicated objects. Biofizika. 1961;6:52–6.
Lebonvallet N, Laverdet B, Misery L, et al. New insights into the roles of myofibroblasts and innervation during skin healing and innovative therapies to improve scar innervation. Exp Dermatol. 2018;27:950–8.
Shirakami E, Yamakawa S, Hayashida K. Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence. Burns Trauma. 2020;8:tkz003.
Coger V, Million N, Rehbock C, et al. Tissue concentrations of zinc, iron, copper, and magnesium during the phases of full thickness wound healing in a rodent model. Biol Trace Elem Res. 2019;191:167–76.
Gauglitz GG, Korting HC, Pavicic T, et al. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011;17:113–25.
Amadeu T, Braune A, Mandarim-de-Lacerda C, et al. Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. Pathol Res Pract. 2003;199:469–73.
Bowden LG, Byrne HM, Maini PK, Moulton DE. A morphoelastic model for dermal wound closure. Biomech Model Mechanobiol. 2016;15:663–81.
Baumann LS, Spencer J. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg. 1999;25:311–5.
Zampieri N, Zuin V, Burro R, et al. A prospective study in children: pre- and post-surgery use of vitamin E in surgical incisions. J Plast Reconstr Aesthet Surg. 2010;63:1474–8.
Tanaydin V, Conings J, Malyar M, et al. The role of topical vitamin E in scar management: a systematic review. Aesthet Surg J. 2016;36:959–65.
Geers NC, Zegel M, Huybregts JGJ, Niessen FB. The influence of preoperative interventions on postoperative surgical wound healing in patients without risk factors: a systematic review. Aesthet Surg J. 2018;38:1237–49.
Rao RM, Nagendra HR, Raghuram N, et al. Influence of yoga on postoperative outcomes and wound healing in early operable breast cancer patients undergoing surgery. Int J Yoga. 2008;1:33–41.
Broadbent E, Kahokehr A, Booth RJ, et al. A brief relaxation intervention reduces stress and improves surgical wound healing response: a randomised trial. Brain Behav Immun. 2012;26:212–7.
Ginandes C, Brooks P, Sando W, et al. Can medical hypnosis accelerate post-surgical wound healing? Results of a clinical trial. Am J Clin Hypn. 2003;45:333–51.
Pereira L, Figueiredo-Braga M, Carvalho IP. Preoperative anxiety in ambulatory surgery: the impact of an empathic patient-centered approach on psychological and clinical outcomes. Patient Educ Couns. 2016;99:733–8.
Melling AC, Ali B, Scott EM, Leaper DJ. Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial. Lancet. 2001;358:876–80.
Künzli BM, Liebl F, Nuhn P, et al. Impact of preoperative local water-filtered infrared A irradiation on postoperative wound healing: a randomized patient- and observer-blinded controlled clinical trial. Ann Surg. 2013;258:887–94.
Lee Peng G, Kerolus JL. Management of surgical scars. Facial Plast Surg Clin North Am. 2019;27:513–7.
Kelly AP. Update on the management of keloids. Semin Cutan Med Surg. 2009;28:71–6.
Murthy R, Roos JCP, Goldberg RA. Periocular hyaluronic acid fillers: applications, implications, complications. Curr Opin Ophthalmol. 2019;30:395–400.
Gill JF, Yu SS, Neuhaus IM. Tobacco smoking and dermatologic surgery. J Am Acad Dermatol. 2013;68:167–72.
Commander SJ, Chamata E, Cox J, et al. Update on postsurgical scar management. Semin Plast Surg. 2016;30:122–8.
Huang C, Ogawa R. The link between hypertension and pathological scarring: does hypertension cause or promote keloid and hypertrophic scar pathogenesis? Wound Repair Regen. 2014;22:462–6.
Ogawa R, Akaishi S. Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis—keloids and hypertrophic scars may be vascular disorders. Med Hypotheses. 2016;96:51–60.
Waisbren E, Rosen H, Bader AM, et al. Percent body fat and prediction of surgical site infection. J Am Coll Surg. 2010;210:381–9.
Long M, Cai L, Li W, et al. DPP-4 inhibitors improve diabetic wound healing via direct and indirect promotion of epithelial-mesenchymal transition and reduction of scarring. Diabetes. 2018;67:518–31.
Suwanai H, Watanabe R, Sato M, et al. DPP-4 inhibitor reduces the risk of developing hypertrophic scars and keloids following median sternotomy in diabetic patients: a nationwide retrospective cohort study using the National Database of Health Insurance Claims of Japan. Plast Reconstr Surg. 2020;146:83–9.
Wagner J, Lock JF, Kastner C, et al. Perioperative management of anticoagulant therapy. Innov Surg Sci. 2019;4:144–51.
Hirsch GE, Viecili PRN, de Almeida AS, et al. Natural products with antiplatelet action. Curr Pharm Des. 2017;23:1228–46.
Di Minno A, Frigerio B, Spadarella G, et al. Old and new oral anticoagulants: food, herbal medicines and drug interactions. Blood Rev. 2017;31:193–203.
Malhotra U, Hasday M, Romanos GE, Javed F. Assessment of routine diet (garlic consumption) as a pre- and postoperative protocol in oral and maxillofacial surgical interventions: an evidence-based literature review. Nutr Health. 2020;26:135–9.
Palmieri B, Vadalà M, Laurino C. Nutrition in wound healing: investigation of the molecular mechanisms, a narrative review. J Wound Care. 2019;28:683–93.
Vaxman F, Olender S, Lambert A, et al. Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial. Eur Surg Res. 1995;27:158–66.
Vaxman F, Olender S, Lambert A, et al. Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. Eur Surg Res. 1996;28:306–14.
Akintoye E, Sethi P, Harris WS. Fish oil and perioperative bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584.
Razzaghi R, Pidar F, Momen-Heravi M, et al. Magnesium supplementation and the effects on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Biol Trace Elem Res. 2018;181:207–15.
Momen-Heravi M, Barahimi E, Razzaghi R, et al. The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Wound Repair Regen. 2017;25:512–20.
Soleimani Z, Hashemdokht F, Bahmani F, et al. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. J Diabetes Complicat. 2017;31:1394–400.
Afzali H, Jafari Kashi AH, Momen-Heravi M, et al. The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Wound Repair Regen. 2019;27:277–84.
Mohseni S, Bayani M, Bahmani F, et al. The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Diabetes Metab Res Rev. 2018;34:e2970.
Chopra K, Calva D, Sosin M, et al. A comprehensive examination of topographic thickness of skin in the human face. Aesthet Surg J. 2015;35:1007–13.
Sukeik M, Alshryda S, Powell J, Haddad FS. The effect of tranexamic acid on wound complications in primary total hip arthroplasty: a meta-analysis. Surgeon. 2020;18:53–61.
Emmerson E. Efficient healing takes some nerve: electrical stimulation enhances innervation in cutaneous human wounds. J Invest Dermatol. 2017;137:543–5.
Parfejevs V, Debbache J, Shakhova O, et al. Injury-activated glial cells promote wound healing of the adult skin in mice. Nat Commun. 2018;9:236.
Zheng Z, Wan Y, Liu Y, et al. Sympathetic denervation accelerates wound contraction but inhibits reepithelialization and pericyte proliferation in diabetic mice. J Diabetes Res. 2017;2017:7614685.
Sebastian A, Volk SW, Halai P, et al. Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation. J Invest Dermatol. 2017;137:737–47.
Moody BR, McCarthy JE, Linder J, Hruza GJ. Enhanced cosmetic outcome with running horizontal mattress sutures. Dermatol Surg. 2005;31:1313–6.
Khansa I, Harrison B, Janis JE. Evidence-based scar management: how to improve results with technique and technology. Plast Reconstr Surg. 2016;138:165S–78S.
Liu KY, Silvestri B, Marquez J, Huston TL. Secondary intention healing after Mohs surgical excision as an alternative to surgical repair: evaluation of wound characteristics and esthetic outcomes. Ann Plast Surg. 2020;85:S28–32.
Eisen DB, Zhuang AR, Hasan A, et al. 5-0 polypropylene versus 5-0 fast absorbing plain gut for cutaneous wound closure: a randomized evaluator blind trial. Arch Dermatol Res. 2020;312:179–85.
Moran B, Humphrey S, Seal A, et al. Photographic assessment of post-surgical facial scars epidermally sutured with rapidly absorbable polyglactin 910 or nylon: a randomized clinical trial. J Am Acad Dermatol. 2020;83:1395–9.
Gillanders SL, Anderson S, Mellon L, Heskin L. A systematic review and meta-analysis: do absorbable or non-absorbable suture materials differ in cosmetic outcomes in patients requiring primary closure of facial wounds? J Plast Reconstr Aesthet Surg. 2018;71:1682–92.
Wade RG, Wormald JC, Figus A. Absorbable versus non-absorbable sutures for skin closure after carpal tunnel decompression surgery. Cochrane Database Syst Rev. 2018;2:CD011757.
Motosko CC, Zakhem GA, Saadeh PB, Hazen A. The implications of barbed sutures on scar aesthetics: a systematic review. Plast Reconstr Surg. 2018;142:337–43.
Pourang A, Crispin MK, Clark AK, et al. Use of 5-0 fast absorbing gut versus 6-0 fast absorbing gut during cutaneous wound closure on the head and neck: a randomized evaluator-blinded split-wound comparative effectiveness trial. J Am Acad Dermatol. 2019;81:213–8.
Sklar LR, Pourang A, Armstrong AW, et al. Comparison of running cutaneous suture spacing during linear wound closures and the effect on wound cosmesis of the face and neck: a randomized clinical trial. JAMA Dermatol. 2019;155:321–6.
Jenkins LE, Davis LS. Comprehensive review of tissue adhesives. Dermatol Surg. 2018;44:1367–72.
Dumville JC, Coulthard P, Worthington HV, et al. Tissue adhesives for closure of surgical incisions. Cochrane Database Syst Rev. 2014;11:CD004287.
Zhuang AR, Beroukhim K, Armstrong AW, et al. Comparison of 2-octylcyanoacrylate versus 5-0 fast-absorbing gut during linear wound closures and the effect on wound cosmesis. Dermatol Surg. 2020;46:628–34.
Ben Safta Y, Maatouk M, Bouzidi MT, et al. A randomised clinical trial to compare octyl cyanoacrylate with absorbable monofilament sutures for the closure of laparoscopic cholecystectomy port incisions. Int Wound J. 2020;17:449–54.
Jain R, Wairkar S. Recent developments and clinical applications of surgical glues: an overview. Int J Biol Macromol. 2019;137:95–106.
Bao Z, Gao M, Sun Y, et al. The recent progress of tissue adhesives in design strategies, adhesive mechanism and applications. Mater Sci Eng C Mater Biol Appl. 2020;111:110796.
Pirazzini M, Rossetto O, Eleopra R, Montecucco C. Botulinum neurotoxins: biology, pharmacology, and toxicology. Pharmacol Rev. 2007;69:200–35.
Wang Y, Wang J, Zhang J, et al. Effectiveness and safety of botulinum toxin type A injection for scar prevention: a systematic review and meta-analysis. Aesthet Plast Surg. 2019;43:1241–9.
Xiao Z, Zhang F, Lin W, et al. Effect of botulinum toxin type a on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report. Aesthet Plast Surg. 2010;34:424–7.
Shuo L, Ting Y, KeLun W. Efficacy and possible mechanisms of botulinum toxin treatment of oily skin. J Cosmet Dermatol. 2019;18:451–7.
Guo X, Song G, Zhang D, Jin X. Efficacy of botulinum toxin type A in improving scar quality and wound healing: a systematic review and meta-analysis of randomized controlled trials. Aesthet Surg J. 2020;40:NP273–85.
Yang W, Li G. The safety and efficacy of botulinum toxin type A injection for postoperative scar prevention: a systematic review and meta-analysis. J Cosmet Dermatol. 2020;19:799–808.
Ziade M, Domergue S, Batifol D, et al. Use of botulinum toxin type A to improve treatment of facial wounds: a prospective randomised study. J Plast Reconstr Aesthet Surg. 2013;66:209–14.
Kruse CR, Singh M, Targosinski S, et al. The effect of pH on cell viability, cell migration, cell proliferation, wound closure, and wound reepithelialization: in vitro and in vivo study. Wound Repair Regen. 2017;25:260–9.
Nuutila K, Yang L, Broomhead M, et al. Novel negative pressure wound therapy device without foam or gauze is effective at −50 mmHg. Wound Repair Regen. 2019;27:162–9.
Junker JP, Kamel RA, Caterson EJ, Eriksson E. Clinical impact upon wound healing and inflammation in moist, wet, and dry environments. Adv Wound Care (New Rochelle). 2013;2:348–56.
Mir M, Ali MN, Barakullah A, et al. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater. 2018;7:1–21.
Barnes LA, Marshall CD, Leavitt T, et al. Mechanical forces in cutaneous wound healing: emerging therapies to minimize scar formation. Adv Wound Care. 2018;7:47–56.
Kuhn MA, Moffit MR, Smith PD, et al. Silicone sheeting decreases fibroblast activity and downregulates TGFbeta2 in hypertrophic scar model. Int J Surg Invest. 2001;2:467–74.
Choi J, Lee EH, Park SW, Chang H. Regulation of transforming growth factor β1, platelet-derived growth factor, and basic fibroblast growth factor by silicone gel sheeting in early-stage scarring. Arch Plast Surg. 2015;42:20–7.
Wang F, Li X, Wang X, Jiang X. Efficacy of topical silicone gel in scar management: a systematic review and meta-analysis of randomised controlled trials. Int Wound J. 2020;17:765–73.
O’Brien L, Jones DJ. Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2013;9:CD003826.
Lim AF, Weintraub J, Kaplan EN. The embrace device significantly decreases scarring following scar revision surgery in a randomized controlled trial. Plast Reconstr Surg. 2014;133:398–405.
Longaker MT, Rohrich RJ, Greenberg L, et al. A randomized controlled trial of the embrace advanced scar therapy device to reduce incisional scar formation. Plast Reconstr Surg. 2014;134:536–46.
Perez JL, Rohrich RJ. Optimizing your post-surgical scars: a systematic review on best practices in preventative scar management. Plast Reconstr Surg. 2017;140:782e–93e.
Rosengren H, Askew DA, Heal C, et al. Does taping torso scars following dermatologic surgery improve scar appearance? Dermatol Pract Concept. 2013;3:75–83.
Atkinson JA, McKenna KT, Barnett AG, et al. A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer’s skin tension lines. Plast Reconstr Surg. 2005;116:1648–56.
Liu B, Liu Y, Wang L, et al. The effects of pressure intervention on wound healing and scar formation in a Bama minipig model. Burns. 2019;45:413–22.
Schmitz L, Hessam S, Scholl L. Wound care with a porcine extracellular matrix after surgical treatment of rhinophyma. J Cutan Med Surg. 2020;24:253–8.
Jafari A, Amirsadeghi A, Hassanajili S, Azarpira N. Bioactive antibacterial bilayer PCL/gelatin nanofibrous scaffold promotes full-thickness wound healing. Int J Pharm. 2020;583:119413.
Trookman NS, Rizer RL, Weber T. Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model. J Am Acad Dermatol. 2011;64:S8–15.
Lee N, Wong CK, Chan MCW, et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: a randomized controlled trial. Antivir Res. 2017;144:48–56.
Moore AL, desJardins-Park HE, Duoto BA. Doxycycline reduces scar thickness and improves collagen architecture. Ann Surg. 2020;272:183–93.
Gold MH, Andriessen A, Bhatia AC, et al. Topical stabilized hypochlorous acid: the future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol. 2020;19:270–7.
Steinsapir KD, Woodward JA. Chlorhexidine keratitis: safety of chlorhexidine as a facial antiseptic. Dermatol Surg. 2017;43:1–6.
Kong CG, Kim GH, Kim DW, In Y. The effect of topical scar treatment on postoperative scar pain and pruritus after total knee arthroplasty. Arch Orthop Trauma Surg. 2014;134:555–9.
Shirazi M, Mohammadi AA, Shamohammadi I, et al. Efficacy of silicone gel in reducing scar formation after hypospadias repair: a randomized placebo-controlled trial. Res Rep Urol. 2019;11:291–8.
Ruan QZ, Chen AD, Tran BNN, et al. Integrative medicine in plastic surgery: a systematic review of our literature. Ann Plast Surg. 2019;82:459–68.
Song T, Kim KH, Lee KW. Randomised comparison of silicone gel and onion extract gel for post-surgical scars. J Obstet Gynaecol. 2018;38:702–7.
Malhotra R, Ziahosseini K, Poitelea C, et al. Effect of manuka honey on eyelid wound healing: a randomized controlled trial. Ophthalmic Plast Reconstr Surg. 2017;33:268–72.
Kosmadaki M, Katsambas A. Topical treatments for acne. Clin Dermatol. 2017;35:173–8.
Leyden J, Stein-Gold L, Weiss J. Why topical retinoids are mainstay of therapy for acne. Dermatol Ther (Heidelb). 2017;7:293–304.
Kwon SY, Park SD, Park K. Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars. J Eur Acad Dermatol Venereol. 2014;28:1025–33.
Totonchi A, Guyuron B. A randomized, controlled comparison between arnica and steroids in the management of postrhinoplasty ecchymosis and edema. Plast Reconstr Surg. 2007;120:271–4.
Simsek G, Sari E, Kilic R, Muluk NB. Topical application of arnica and mucopolysaccharide polysulfate attenuates periorbital edema and ecchymosis in open rhinoplasty: a randomized controlled clinical study. Plast Reconstr Surg. 2016;137:530e–5e.
Lueangarun S, Srituravanit A, Tempark T. Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: a split-face, double-blinded, randomized, controlled trial. J Cosmet Dermatol. 2019;18:1751–7.
Loo YL, Goh BLK, Jeffery S. An overview of the use of bromelain-based enzymatic debridement (Nexobrid®) in deep partial and full thickness burns: appraising the evidence. J Burn Care Res. 2018;39:932–8.
Kim J, Kim J, Lee YI, et al. Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation. J Cosmet Dermatol. 2020;19:2576–82.
Wan Ishak WM, Katas H, Yuen NP, et al. Topical application of omega-3-, omega-6-, and omega-9-rich oil emulsions for cutaneous wound healing in rats. Drug Deliv Transl Res. 2019;9:418–33.
Ang LF, Darwis Y, Koh RY, et al. Wound healing property of curcuminoids as a microcapsule-incorporated cream. Pharmaceutics. 2019;11:205.
Koga AY, Felix JC, Silvestre RGM, et al. Evaluation of wound healing effect of alginate film containing aloe vera gel and cross-linked with zinc chloride. Acta Cir Bras. 2020;35:e202000507.
Han B, Fang WH, Zhao S, et al. Zinc sulfide nanoparticles improve skin regeneration. Nanomedicine. 2020;29:102263.
Betarbet U, Blalock TW. Keloids: a review of etiology, prevention, and treatment. J Clin Aesthet Dermatol. 2020;13:33–43.
Meseci E, Kayatas S, Api M, et al. Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the Pfannenstiel scar prevention—a randomized controlled trial. Ginekol Pol. 2017;88:591–8.
Singla A, Qureshi R, Chen DQ, et al. Risk of surgical site infection and mortality following lumbar fusion surgery in patients with chronic steroid usage and chronic methicillin-resistant Staphylococcus aureus infection. Spine. 2019;44:E408–13.
Haddad AL, Matos LF, Brunstein F, et al. A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma. Int J Dermatol. 2003;42:153–6.
Yin NC, McMichael AJ. Acne in patients with skin of color: practical management. Am J Clin Dermatol. 2014;15:7–16.
Pariser D, Spencer J, Berman B, et al. Using a hydroquinone/tretinoin-based skin care system before and after electrodesiccation and curettage of superficial truncal basal cell carcinoma: a multicenter, randomized, investigator-blind, controlled study of short-term healing. J Clin Aesthet Dermatol. 2009;2:38–43.
Reinholz M, Heppt M, Tietze JK, et al. Photoletter to the Editor: Topical 0.5% brimonidine gel to camouflage redness of immature scars. J Dermatol Case Rep. 2015;9:87–8.
Bandral MR, Padgavankar PH, Japatti SR, et al. Clinical evaluation of microneedling therapy in the management of facial scar: a prospective randomized study. J Maxillofac Oral Surg. 2019;18:572–8.
Alster TS, Li MK. Microneedling of scars: a large prospective study with long-term follow-up. Plast Reconstr Surg. 2020;145:358–64.
Casabona GR, Giacomo TB. Improving the appearance of surgical facial scars with incobotulinumtoxina and microneedling. J Drugs Dermatol. 2020;19:611–5.
Kent RA, Shupp J, Fernandez S, et al. Effectiveness of early laser treatment in surgical scar minimization: a systematic review and meta-analysis. Dermatol Surg. 2020;46:402–10.
Karmisholt KE, Haerskjold A, Karlsmark T, et al. Early laser intervention to reduce scar formation—a systematic review. J Eur Acad Dermatol Venereol. 2018;32:1099–110.
Behrouz-Pirnia A, Liu H, Peternel S, et al. Early laser intervention to reduce scar formation in wound healing by primary intention: a systematic review. J Plast Reconstr Aesthet Surg. 2020;73:528–36.
Andia I. Platelet rich plasma therapies: a great potential to be harnessed. Muscles Ligaments Tendons J. 2014;4:1–2.
Rivers JK. Platelet-rich plasma: should we wait for the verdict? J Cutan Med Surg. 2014;18:147–8.
Hausauer AK, Humphrey S. The physician’s guide to platelet-rich plasma in dermatologic surgery part II: clinical evidence. Dermatol Surg. 2020;46:447–56.
Fang Z, Yang X, Wu G, et al. The use of autologous platelet-rich plasma gel increases wound healing and reduces scar development in split-thickness skin graft donor sites. J Plast Surg Hand Surg. 2019;53:356–60.
Refahee SM, Aboulhassan MA, Abdel Aziz O, et al. Is PRP effective in reducing the scar width of primary cleft lip repair? A randomized controlled clinical study. Cleft Palate Craniofac J. 2020;57:581–8.
Ofstead CL, Buro BL, Hopkins KM, Eiland JE. The impact of continuous electrical microcurrent on acute and hard-to-heal wounds: a systematic review. J Wound Care. 2020;29:S6–15.
Shin TM, Bordeaux JS. The role of massage in scar management: a literature review. Dermatol Surg. 2012;38:414–23.
Erickson JR, Echeverri K. Learning from regeneration research organisms: the circuitous road to scar free wound healing. Dev Biol. 2018;433:144–54.
Ud-Din S, Volk SW, Bayat A. Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives. Exp Dermatol. 2014;23:615–9.
Walmsley GG, Maan ZN, Wong VW, et al. Scarless wound healing: chasing the holy grail. Plast Reconstr Surg. 2015;135:907–17.
Li H, Roos JC, Rose GE, et al. Eyelid and sternum fibroblasts differ in their contraction potential and responses to inflammatory cytokines. Plast Reconstr Surg Glob Open. 2015;3:e448.
Han X, Deng Y, Yu J, et al. Acarbose accelerates wound healing via Akt/eNOS signaling in db/db mice. Oxidative Med Cell Longev. 2017;2017:7809581.
Tang ZM, Zhai XX, Ding JC. Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention. Mol Med Rep. 2017;15:2546–50.
Wells AR, Leung KP. Pirfenidone attenuates the profibrotic contractile phenotype of differentiated human dermal myofibroblasts. Biochem Biophys Res Commun. 2020;521:646–51.
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Murthy, R., Ryder, T., Roos, J.C.P. (2024). Prevention of Post-surgical Scarring. In: Quaranta Leoni, F.M., Verity, D.H., Paridaens, D. (eds) Oculoplastic, Lacrimal and Orbital Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-39634-2_24
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