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Enterovirus Infections in Children and Hearing Loss

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Hearing Loss in Congenital, Neonatal and Childhood Infections

Part of the book series: Comprehensive ENT ((CENT))

Abstract

Enteroviruses (EVs) belong to the Picornaviridae family and consist of coxsackieviruses (CVs), rhinoviruses, polioviruses, and echoviruses. Enteroviruses constitute one of the most common causes of infections in humans worldwide, affecting all age groups and causing a diverse range of diseases, including the common cold, polio, and aseptic meningitis. Enteroviral infections are often self-limiting, though EVs can lead to significant morbidity and economic burden [1].

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References

  1. Sinclair W, Omar M. Enterovirus. In: StatPearls. Treasure Island, FL: StatPearls; 2022; https://www.ncbi.nlm.nih.gov/books/NBK562330/. Accessed 21 Oct 2022.

    Google Scholar 

  2. de Crom SCM, Rossen JW, van Furth AM, Obihara CC. Enterovirus and parechovirus infection in children: a brief overview. Eur J Pediatr. 2016;175:1023–9.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Modlin JF. Enterovirus and parechovirus infections: Epidemiology and pathogenesis. In: Hirsch MS, editor. UpToDate. Waltham, MA: UpToDate; 2022. s.

    Google Scholar 

  4. Zhou H, Guo SZ, Zhou H, Zhu YF, Zhang LJ, Zhang W. Clinical characteristics of hand, foot and mouth disease in Harbin and the prediction of severe cases. Chin Med J. 2012;125:261–5.

    Google Scholar 

  5. Zou XN, Zhang XZ, Wang B, Qiu YT. Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. Braz J Infect Dis. 2012;16:457–65.

    Article  PubMed  Google Scholar 

  6. Öncel EK, Nar I, Özsürekçi Y, et al. Demographic and clinical findings in children with enteroviral infection outbreak. J Pediatr Inf. 2013;7:97–101.

    Article  Google Scholar 

  7. Chen BS, Lee HC, Lee KM, Gong YN, Shih SR. Enterovirus and encephalitis. Front Microbiol. 2020;11:261.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Lu CY, Lee CY, Kao CL, et al. Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan. J Med Virol. 2002;67:217–23.

    Article  PubMed  Google Scholar 

  9. Lugo D, Krogstad P. EVs in the early 21st century: new manifestations and challenges. Curr Opin Pediatr. 2016;28:107–13.

    Article  PubMed  PubMed Central  Google Scholar 

  10. American Academy of Pediatrics. Enterovirus (nonpoliovirus). In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, editors. Red book: 2021–2024 report of the committee on infectious diseases. 32nd ed. Itasca, IL: American Academy of Pediatrics; 2021. p. 315–8.

    Google Scholar 

  11. Modlin JF. Enterovirus and parechovirus infections: clinical features, laboratory diagnosis, treatment, and prevention. In: Hirsch MS, Edwards MS, editors. UpToDate. Waltham, MA: UpToDate; 2022; https://www.uptodate.com/contents/enterovirus-and-parechovirus-infections-clinical-features-laboratory-diagnosis-treatment-and-prevention. Accessed 21 Oct 2022.

    Google Scholar 

  12. Harvala H, Broberg E, Benschop K, et al. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. J Clin Virol. 2018;101:11–7.

    Article  CAS  PubMed  Google Scholar 

  13. Lee KY. Enterovirus 71 infection and neurological complications. Korean J Pediatr. 2016;59:395–401.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Chang LY, Lin HY, Gau SS, et al. Enterovirus A71 neurologic complications and long-term sequelae. J Biomed Sci. 2019;26(1):57.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Uprety P, Graf EH. Enterovirus infection and acute flaccid myelitis. Curr Opin Virol. 2020;40:55–60.

    Article  CAS  PubMed  Google Scholar 

  16. Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52:851–7.

    Article  CAS  PubMed  Google Scholar 

  17. Kadambari S, Braccio S, Ribeiro S, et al. Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric surveillance unit study. Arch Dis Child. 2019;104:552–7.

    Article  PubMed  Google Scholar 

  18. Aswathyraj S, Arunkumar G, Alidjinou EK, Hober D. Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy. Med Microbiol Immunol. 2016;205:397–407.

    Article  CAS  PubMed  Google Scholar 

  19. Jones E, Pillay TD, Liu F, et al. Outcomes following severe hand foot and mouth disease: a systematic review and meta-analysis. Eur J Paediatr Neurol. 2018;22(5):763–73.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Huang J, Liao Q, Ooi MH, et al. Epidemiology of recurrent hand, foot and mouth disease, China, 2008-2015. Emerg Infect Dis. 2018;24:432–42.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Del Giudice P. Enterovirus A71 infection and neurologic disease, Madrid, Spain, 2016. Emerg Infect Dis. 2020;26(7):1638.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Cherry JD. Cutaneous manifestations of systemic infections. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry's textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 539–59.

    Google Scholar 

  23. Bhatt A. Ocular infections. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry's textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 578–97.

    Google Scholar 

  24. Cherry JD, Krogstad P. EVs, parechoviruses, and Saffold viruses. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry's textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 1499–544.

    Google Scholar 

  25. McKinney RE Jr, Katz SL, Wilfert CM. Chronic enteroviral meningoencephalitis in agammaglobulinemic patients. Rev Infect Dis. 1987;9:334–56.

    Article  PubMed  Google Scholar 

  26. Pyykkö I, Kentala E, Zou J. Do viruses cause inner ear disturbances? ORL J Otorhinolaryngol Relat Spec. 2008;70:32–40.

    Article  PubMed  Google Scholar 

  27. Schattner A, Halperin D, Wolf D, Zimhony O. EVs and sudden deafness. CMAJ. 2003;168:1421–3.

    PubMed  PubMed Central  Google Scholar 

  28. Bachor E, Karmody CS. Neural hearing loss in a child with poliomyelitis: a histopathological study. J Laryngol Otol. 2001;115:243–6.

    Article  CAS  PubMed  Google Scholar 

  29. Mentel R, Kaftan H, Wegner U, Reissmann A, Gürtler L. Are enterovirus infections a co-factor in sudden hearing loss? J Med Virol. 2004;72:625–9.

    Article  PubMed  Google Scholar 

  30. Gross M, Wolf DG, Elidan J, Eliashar R. Enterovirus, cytomegalovirus, and Epstein-Barr virus infection screening in idiopathic sudden sensorineural hearing loss. Audiol Neurootol. 2007;12:179–82.

    Article  PubMed  Google Scholar 

  31. Balasubramanian H, Wagh D, Rao S, Keil AD, McMichael J. Developmental outcomes in cerebrospinal fluid proven enteroviral meningitis in neonates > 32 weeks of gestation. J Paediatr Child Health. 2016;52:327–32.

    Article  PubMed  Google Scholar 

  32. Biaukula VL, Tikoduadua L, Azzopardi K, Seduadua A, et al. Meningitis in children in Fiji: etiology, epidemiology, and neurological sequelae. Int J Infect Dis. 2012;16:e289–95.

    Article  PubMed  Google Scholar 

  33. Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol. 2020;30:e2083.

    Article  PubMed  Google Scholar 

  34. Tekin B, Boire N, Shah K, Hanson J, Bridges AG. Viral panniculitis in a patient with disseminated opportunistic enterovirus infection. J Cutan Pathol. 2021;48:434–8.

    Article  PubMed  Google Scholar 

  35. Muller WJ. Treatment of perinatal viral infections to improve neurologic outcomes. Pediatr Res. 2017;81:162–9.

    Article  PubMed  Google Scholar 

  36. Abzug MJ, Cloud G, Bradley J, et al. Double-blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J. 2003;22:335–41.

    Article  PubMed  Google Scholar 

  37. Lin JY, Kung YA, Shih SR. Antivirals and vaccines for enterovirus A71. J Biomed Sci. 2019;26(1):65.

    Article  PubMed  PubMed Central  Google Scholar 

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Belet, N., Erdeniz, E.H., Tenenbaum, T. (2023). Enterovirus Infections in Children and Hearing Loss. In: Arısoy, A.E., Arısoy, E.S., Bayar Muluk, N., Cingi, C., Correa, A.G. (eds) Hearing Loss in Congenital, Neonatal and Childhood Infections. Comprehensive ENT. Springer, Cham. https://doi.org/10.1007/978-3-031-38495-0_53

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  • DOI: https://doi.org/10.1007/978-3-031-38495-0_53

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