Skip to main content

Viral Meningitis in Children and Hearing Loss

  • Chapter
  • First Online:
Hearing Loss in Congenital, Neonatal and Childhood Infections

Part of the book series: Comprehensive ENT ((CENT))

  • 194 Accesses

Abstract

Hearing loss (HL) is a common cause of speech, language, and cognition delays. Hearing loss occurs in 1–3 newborns per 1000 births, with clinically significant or permanent HL in 1–2 per 1000 newborns and 2 per 1000 children [1, 2]. Early diagnosis of HL is critical, as improvement in speech and cognitive functions can be achieved with early intervention [3]. Pediatric HL can be categorized as congenital (genetic and non-genetic), acquired or sensorineural, conductive, and mixed [4]. Viral central nervous system (CNS) infections can lead to congenital and acquired HL, mainly sensorineural. This chapter will focus on acquired HL associated with viral meningitis and vaccines against viruses in children.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mehl AL, Thomson V. The Colorado newborn hearing screening project, 1992-1999: on threshold of effective population-based universal newborn hearing screening. Pediatrics. 2002;109:e7.

    Article  PubMed  Google Scholar 

  2. Fortnum HM, Summerfield AQ, Marshall DH, Davis AC, Bamford JM. Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study. BMJ. 2001;323:536–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ching TYC, Dillon H, Button L, et al. Age at intervention for permanent hearing loss and 5-year language outcomes. Pediatrics. 2017;140:e20164274.

    Article  PubMed  Google Scholar 

  4. Erenberg A, Lemons J, Sia C, Trunkel D, Ziring P. Newborn and infant hearing loss: detection and intervention. Academy of Pediatrics Task Force on Newborn and Infant Hearing, 1998-1999. Pediatrics. 1999;103:527–30.

    CAS  PubMed  Google Scholar 

  5. Logan SA, MacMahon E. Viral meningitis. BMJ. 2008;336:36–40.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Shukla B, Aguilera AE, Salazar L, Wootton SH, Kaewpoowat Q, Hasbun R. Aseptic meningitis in adults and children: diagnostic and management challenges. J Clin Virol. 2017;94:110–4.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kohil A, Jemmieh S, Smatti MK, Yassine HM. Viral meningitis: an overview. Arch Virol. 2021;166:335–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Abid FB, Abukhattab A, Ghazouani H, et al. Epidemiology and clinical outcomes of viral central nervous system infections. Int J Infect Dis. 2018;73:85–90.

    Article  PubMed  Google Scholar 

  9. Romero JR. Coxsackieviruses, echoviruses, and numbered enteroviruses (EV-A71, EVD-68, EVD-70). In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 9th ed. Philadelphia: Elsevier; 2020. p. 2227–37.

    Google Scholar 

  10. Michos AG, Syriopoulou VP, Daikos GL, et al. Aseptic meningitis in children: analysis of 506 cases. PLoS One. 2007;2:e674.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hviid A, Melbye M. The epidemiology of viral meningitis hospitalization in childhood. Epidemiology. 2007;18:695–701.

    Article  PubMed  Google Scholar 

  12. Dumaidi K, Al-Jawabreh A. Molecular detection and genotyping of enteroviruses from CSF samples of patients with suspected sepsis-like illness and/or aseptic meningitis from 2012 to 2015 in West Bank, Palestine. PLoS One. 2017;12:e0172357.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kadambari S, Braccio S, Ribeiro S, et al. Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study. Arch Dis Child. 2019;104:552–7.

    Article  PubMed  Google Scholar 

  14. Haydar SM, Hallit SR, Hallit RR, et al. Adherence to international guidelines for the treatment of meningitis infections in Lebanon. Saudi Med J. 2019;40:260–5.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Koyuncu OO, Hogue IB, Enquist LW. Virus infections in the nervous system. Cell Host Microbe. 2013;13:379–93.

    Google Scholar 

  16. Onarecker TR, Romero JR. Aseptic and viral meningitis. In: Long SS, Prober CG, Fischer M, Kimberlin DW, editors. Principles and practice of pediatric infectious diseases. 6th ed. Philadelphia: Elsevier; 2023. p. 310–5.

    Chapter  Google Scholar 

  17. Pinninti SG, Kimberlin DW. Neonatal herpes simplex virus infections. Semin Perinatol. 2018;42:168–75.

    Article  PubMed  Google Scholar 

  18. Hou J, Baker LA, Zhou L, Klein RS. Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers. 2016;4:e1142492.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Cassady KA, Whitley RJ. Pathogenesis and pathophysiology of viral central nervous system infections. In: Scheld WM, Whitley R, Marra MC, editors. Infections of the central nervous system. 3rd ed. Philadelphia: Lippincott-Raven; 2004. p. 57–74.

    Google Scholar 

  20. Bronstein DE, Glaser CA. Aseptic meningitis and viral meningitis. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry’s textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 355–61.

    Google Scholar 

  21. Visintin C, Mugglestone MA, Fields EJ, Jacklin P, Murphy MS, Pollard AJ. Management of bacterial meningitis and meningococcal septicaemia in children and young people: summary of NICE guidance. BMJ. 2010;340:c3209.

    Article  PubMed  Google Scholar 

  22. Mehndiratta M, Rayak N, Garg H, Kumar M, Pandey S. Appraisal of Kernig’s and Brudzinski’s sign in meningitis. Ann Indian Acad Neurol. 2012;15:287–8.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Waghdhare S, Kalantri A, Joshi R, Kalantri S. Accuracy of physical signs for detecting meningitis: a hospital-based diagnostic accuracy study. Clin Neurol Neurosurg. 2010;112:752–7.

    Article  PubMed  Google Scholar 

  24. Iguchi M, Noguchi Y, Yamamoto S, Tanaka Y, Tsujimoto H. Diagnostic test accuracy of jolt accentuation for headache in acute meningitis in the emergency setting. Cochrane Database Syst Rev. 2020;6:CD012824.

    PubMed  Google Scholar 

  25. Romero JR, Newland JG. Viral meningitis and encephalitis: traditional and emerging viral agents. Semin Pediatr Infect Dis. 2003;14:72–82.

    Article  PubMed  Google Scholar 

  26. Pérez Méndez C, Oña Navarro M, Ballesteros García S, et al. Enteroviral meningitis. Clinical and laboratory findings in a series of 60 children. An Esp Pediatr. 2001;55:11–4.

    Article  PubMed  Google Scholar 

  27. Parikh V, Tucci V, Galwankar S. Infections of the nervous system. Int J Crit Illn Inj Sci. 2012;2:82–97.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Irani DN. Aseptic meningitis and viral myelitis. Neurol Clin. 2008;26:635–55.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Chang LY, Huang LM, Gau SS, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007;356:1226–34.

    Article  CAS  PubMed  Google Scholar 

  30. Wu JM, Wang JN, Tsai YC, et al. Cardiopulmonary manifestations of fulminant enterovirus 71 infection. Pediatrics. 2002;109:e26.

    Article  PubMed  Google Scholar 

  31. Pastula DM, Aliabadi N, Haynes AK, et al. Acute neurologic illness of unknown etiology in children—Colorado, August–September 2014. MMWR Morb Mortal Wkly Rep. 2014;63:901–2.

    PubMed  PubMed Central  Google Scholar 

  32. Britton PN, Dale RC, Nissen MD, et al. Parechovirus encephalitis and neurodevelopmental outcomes. Pediatrics. 2016;137:e20152848.

    Article  PubMed  Google Scholar 

  33. Rudolph H, Schroten H, Tenenbaum T. Enterovirus infections of the central nervous system in children an update. Pediatr Infect Dis J. 2016;35:567–9.

    Article  PubMed  Google Scholar 

  34. Bearden D, Collett M, Quan PL, Costa-Carvalho BT, Sullivan KE. Enteroviruses in X-linked agammaglobulinemia: update on epidemiology and therapy. J Allergy Clin Immunol Pract. 2016;4:1059–65.

    Article  PubMed  Google Scholar 

  35. Damsgaard J, Hjerrild S, Andersen H, Leutscher PDC. Long-term neuropsychiatric consequences of aseptic meningitis in adult patients. Infect Dis. 2015;47:357–63.

    Article  Google Scholar 

  36. Schmidt H, Cohrs S, Heineman T, et al. Sleep disorders are long-term sequelae of both bacterial and viral meningitis. J Neurol Neurosurg Psychiatry. 2006;77:554–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol. 2020;300:e2083.

    Article  Google Scholar 

  38. Chang LY, Lin HY, Gau SSF, et al. Enterovirus A71 neurologic complications and long-term sequelae. J Biomed Sci. 2019;26:57.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Buch K, Bodilsen J, Knudsen A, et al. Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study. Infect Dis (Lond). 2018;50:514–21.

    Article  PubMed  Google Scholar 

  40. de Crom SC, van Furth MA, Peeters MF, Rossen JW, Obihara CC. Characteristics of pediatric patients with enterovirus meningitis and no cerebral fluid pleocytosis. Eur J Pediatr. 2012;171:795–800.

    Article  PubMed  Google Scholar 

  41. Alhazmi A, Lazrek M, Alidjinou EK, Descombes G, Engelmann I, Hober D. Paediatric enterovirus meningitis without cerebrospinal fluid pleocytosis. J Infect. 2019;79:612–25.

    Article  PubMed  Google Scholar 

  42. Jaijakul S, Salazar L, Wootton SH, Aguilera E, Hasbun R. The clinical significance of neutrophilic pleocytosis in cerebrospinal fluid in patients with viral central nervous system infections. Int J Infect Dis. 2017;59:77–81.

    Article  PubMed  Google Scholar 

  43. Ohst C, Saschenbrecker S, Stiba K, et al. Reliable serological testing for the diagnosis of emerging ınfectious diseases. In: Hilgenfeld R, Vasudevan SG, editors. Dengue and Zika: control and antiviral treatment strategies, Advances in experimental medicine and biology, vol. 1062. Singapore: Springer; 2018. p. 19–43.

    Chapter  Google Scholar 

  44. Verstrepen WA, Kuhn S, Kockx MM, Van De Vyvere ME, Mertens AH. Rapid detection of enterovirus RNA in cerebrospinal fluid specimens with a novel single-tube real-time reverse transcription-PCR assay. J Clin Microbiol. 2001;39:4093–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Khumalo J, Nicol M, Hardie D, Muloiwa R, Mteshana P, Bamford C. Diagnostic accuracy of two multiplex real-time polymerase chain reaction assays for the diagnosis of meningitis in children in a resource-limited setting. PLoS One. 2017;12:e0173948.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Mintegi S, García S, Martín MJ, et al. Clinical prediction rule for distinguishing bacterial from aseptic meningitis. Pediatrics. 2020;146:e20201126.

    Article  PubMed  Google Scholar 

  47. Gaieski DF, O’Brien NF, Hernandez R. Emergency neurologic life support: meningitis and encephalitis. Neurocrit Care. 2017;27(Suppl 1):124–33.

    Article  PubMed  Google Scholar 

  48. Wall EC, Chan JM, Gil E, Heyderman RS. Acute bacterial meningitis. Curr Opin Neurol. 2021;34:386–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Momméja-Marin H, Lafaurie M, Scieux C, Galicier L, Oksenhendler E, Molina JM. Herpes simplex virus type 2 as a cause of severe meningitis in immunocompromised adults. Clin Infect Dis. 2003;37:1527–33.

    Article  PubMed  Google Scholar 

  50. Kaewpoowat Q, Salazar L, Aguilera E, Wootton SH, Hasbun R. Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes. Infection. 2016;44:337–45.

    Article  CAS  PubMed  Google Scholar 

  51. Hassan STS, Šudomová M, Berchová-Bímová K, Šmejkal K, Echeverría J. Psoromic acid, a lichen-derived molecule, ınhibits the replication of HSV-1 and HSV-2, and inactivates HSV-1 DNA polymerase: shedding light on antiherpetic properties. Molecules. 2019;24:2912.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Desmond RA, Accortt NA, Talley L, et al. Enteroviral meningitis: natural history and outcome of pleconaril therapy. Antimicrob Agents Chemother. 2006;50:2409–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Rorabaugh ML, Berlin LE, Heldrich F, et al. Aseptic meningitis in infants younger than 2 years of age: acute illness and neurologic complications. Pediatrics. 1993;92:206–11.

    Article  CAS  PubMed  Google Scholar 

  54. Rotbart HA. Viral meningitis. Semin Neurol. 2000;20:277–92.

    Article  CAS  PubMed  Google Scholar 

  55. Kaplan MH, Klein SW, McPhee J, Harper RG. Group B coxsackievirus infections in infants younger than three months of age: a serious childhood illness. Rev Infect Dis. 1983;5:1019–32.

    Article  CAS  PubMed  Google Scholar 

  56. Modlin JF. Perinatal echovirus infection: insights from a literature review of 61 cases of serious infection and 16 outbreaks in nurseries. Rev Infect Dis. 1986;8:918–26.

    Article  CAS  PubMed  Google Scholar 

  57. Management of genital herpes in pregnancy. ACOG practice bulletin summary, number 220. Obstet Gynecol. 2020;135:1236–8.

    Google Scholar 

  58. Li ML, Shih SR, Tolbert B, Brewer G. Enterovirus A71 vaccines. Vaccines (Basel). 2021;9:199.

    Article  PubMed  Google Scholar 

  59. Cohen BE, Durstenfeld A, Roehm PC. Viral causes of hearing loss: a review for hearing health professionals. Trends Hear. 2014;18:2331216514541361.

    PubMed  PubMed Central  Google Scholar 

  60. Greco A, Fusconi M, Gallo A, Marinelli C, Macri GF, Vincentiis MD. Sudden sensorineural hearing loss: an autoimmune disease? Autoimmun Rev. 2011;10:756–61.

    Article  CAS  PubMed  Google Scholar 

  61. Smith RJH, Bale JF, White KR. Sensorineural hearing loss in children. Lancet. 2005;365:879–90.

    Article  PubMed  Google Scholar 

  62. Nikolopoulos TP, Dyar D, Gibbin KP. Assessing candidate children for cochlear implantation with the Nottingham Children’s Implant Profile (NChIP): the first 200 children. Int J Pediatr Otorhinolaryngol. 2004;68:127–35.

    Article  PubMed  Google Scholar 

  63. Graham ME, Dedhia K, Park AH. Early detection and diagnosis of infant hearing impairment. In: Flint P, Haughey B, Lund V, et al., editors. Cummings otolaryngology head and neck surgery. 7th ed. Philadelphia: Elsevier; 2021. p. 2887–97.

    Google Scholar 

  64. Kim H, Kim MW, Nam DH, Kang EY, Yang HS. Efficacy of auditory evoked potential follow-up in viral meningitis of infants. Childs Nerv Syst. 2020;3077-3083:3077.

    Article  Google Scholar 

  65. Jiang F, Kuper H, Bright T, Qin WZ. Etiology of childhood bilateral sensorineural hearing loss in Shandong province, China. Am J Audiol. 2020;36:236–43.

    Article  CAS  Google Scholar 

  66. Gupta RK, Best J, MacMahon E. Mumps and the UK epidemic 2005. BMJ. 2005;330:1132–5.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Sanayake SN. Mumps: a resurgent disease with protean manifestations. Med J Aust. 2008;189:456–9.

    Article  Google Scholar 

  68. Bjorvatn B, Wolontis S. Mumps meningoencephalitis in Stockholm, November 1964-July 1971. I. Analysis of a hospitalized study group. Questions of selection and representativity. Scand J Infect Dis. 1973;5:253–60.

    Article  CAS  PubMed  Google Scholar 

  69. Johnstone JA, Ross CA, Dunn M. Meningitis and encephalitis associated with mumps infection. A 10-year survey. Arch Dis Child. 1972;47:647–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Koskiniemi M, Donner M, Pettay O. Clinical appearance and outcome in mumps encephalitis in children. Acta Paediatr Scand. 1983;72:603–9.

    Article  CAS  PubMed  Google Scholar 

  71. Murray HG, Field CM, McLeod WJ. Mumps meningoencephalitis. Br Med J. 1960;1:1850–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Hashimoto H, Fujioka M, Kinumaki H. An office-based prospective study of deafness in mumps. Pediatr Infect Dis J. 2009;28:173–5.

    Article  PubMed  Google Scholar 

  73. Vuori M, Lahikainen EA, Peltonen T. Perceptive deafness in connection with mumps. A study of 298 servicemen suffering from mumps. Acta Otolaryngol. 1962;55:231–6.

    Article  CAS  PubMed  Google Scholar 

  74. Everberg G. Deafness following mumps. Acta Otolaryngol. 1957;48:397–403.

    Article  CAS  PubMed  Google Scholar 

  75. Takagi A, Ohfuji S, Nakano T, Kumihashi H, Kano M, Tanaka T. Incidence of mumps deafness in Japan, 2005-2017: analysis of Japanese ınsurance claims database. J Epidemiol. 2022;32:21–6.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Hviid A, Rubin S, Muhlemann K. Mumps. Lancet. 2008;371:932–44.

    Article  PubMed  Google Scholar 

  77. Kawashima Y, Ihara K, Nakamura M, Nakashima T, Fukuda S, Kitamura K. Epidemiological study of mumps deafness in Japan. Auris Nasus Larynx. 2005;32:125–8.

    Article  PubMed  Google Scholar 

  78. Yanagita N, Murahashi K. A comparative study of mumps deafness and idiopathic profound sudden deafness. Arch Otorhinolaryngol. 1986;243:197–9.

    Article  CAS  PubMed  Google Scholar 

  79. Morita S, Fujiwara K, Fukuda A, et al. The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan. Acta Otolaryngol. 2017;137(sup565):s44–7.

    Article  PubMed  Google Scholar 

  80. Nomura Y. Diagnostic criteria for sudden deafness, mumps deafness and perilymphatic fistula. Acta Otolaryngol Suppl. 1988;456:7–8.

    Article  CAS  PubMed  Google Scholar 

  81. Nomura Y, Harada T, Sakata H, Sugiura A. Sudden deafness and asymptomatic mumps. Acta Otolaryngol Suppl. 1988;456:9–11.

    Article  CAS  PubMed  Google Scholar 

  82. Okamoto M, Shitara T, Nakayama M, et al. Sudden deafness accompanied by asymptomatic mumps. Acta Otolaryngol Suppl. 1994;514:45–8.

    Article  CAS  PubMed  Google Scholar 

  83. Fukuda S, Chida E, Kuroda T, Kashiwamura M, Inuyama Y. An anti-mumps IgM antibody level in the serum of idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx. 2001;28(Suppl):s3–5.

    Article  PubMed  Google Scholar 

  84. Fukuda A, Morita S, Nakamaru Y, et al. Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay: a retrospective, multi-institutional investigation in Hokkaido, Japan. Auris Nasus Larynx. 2018;45:911–5.

    Article  PubMed  Google Scholar 

  85. Galazka AM, Robertson SE, Kraighter A. Mumps and mumps vaccine: a global review. Bull World Health Organ. 1999;77:3–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Lindsay JR. Histopathology of deafness due to postnatal viral disease. Arch Otolaryngol. 1973;98:258–64.

    Article  CAS  PubMed  Google Scholar 

  87. Westmore GA, Pickard BH, Stern H. Isolation of mumps virus from the inner ear after sudden deafness. Br Med J. 1979;1:14–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Katsushika M, Kashio A, Ogata E, et al. Outcomes of cochlear implantations for mumps deafness: a report of four pediatric cases. Int J Pediatr Otorhinolaryngol. 2018;114:76–9.

    Article  PubMed  Google Scholar 

  89. Noda T, Kakazu Y, Komune S. Cochlear implants for mumps deafness: two paediatric cases. J Laryngol Otol. 2015;129(Suppl 2):s38–41.

    Article  PubMed  Google Scholar 

  90. McKenna MJ. Measles, mumps, and sensorineural hearing loss. Ann N Y Acad Sci. 1997;830:291–8.

    Article  CAS  PubMed  Google Scholar 

  91. Suboti R. Histopathological findings in the inner ear caused by measles. J Laryngol Otol. 1976;90:173–81.

    Article  CAS  PubMed  Google Scholar 

  92. Fukuda S, Ishikawa K, Inuyama Y. Acute measles infection in the hamster cochlea. Acta Otolaryngol Suppl. 1994;514:111–6.

    Article  CAS  PubMed  Google Scholar 

  93. Sagar PR, Shah P, Bollampally VC, Alhumaidi N, Malik BH. Otosclerosis and measles: do measles have a role in otosclerosis? A review article. Cureus. 2020;12:e9908.

    PubMed  PubMed Central  Google Scholar 

  94. Noda M, Maeda Y, Kataoka Y, Nishizaki K. Paediatric varicella zoster virus infection causing sudden hearing loss. B-ENT. 2018;14:147–51.

    Google Scholar 

  95. Shao M, Xiong G, Xiang G, Xu S, Zheng Y, Zhang L. Sudden deafness as an initial presentation of varicella: case report and literature review. Ann Palliat Med. 2021;10:5891–6.

    Article  PubMed  Google Scholar 

  96. Schwab J, Ryan M. Varicella zoster virus meningitis in a previously immunized child. Pediatrics. 2004;114:e273–4.

    Article  PubMed  Google Scholar 

  97. Veltri RW, Wilson WR, Sprinkle PM, Rodman SM, Kavesh DA. The implication of viruses in idiopathic sudden hearing loss: primary infection or reactivation of latent viruses? Otolaryngol Head Neck Surg. 1981;89:137–41.

    Article  CAS  PubMed  Google Scholar 

  98. Alsanosi AA, Influenza A. (H1N1): a rare cause of deafness in two children. J Laryngol Otol. 2012;126:1274–5.

    Article  CAS  PubMed  Google Scholar 

  99. Zhang N, Zuo Y, Jiang L, Peng Y, Huang X, Zuo L. Epstein-Barr virus and neurological diseases. Front Mol Biosci. 2022;8:816098.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Wang Y, Yang J, Wen Y. Lessons from Epstein-Barr virus DNA detection in cerebrospinal fluid as a diagnostic tool for EBV-induced central nervous system dysfunction among HIV-positive patients. Biomed Pharmacother. 2022;145:112392.

    Article  CAS  PubMed  Google Scholar 

  101. Kelly MJ, Benjamin LA, Cartwright K, et al. Epstein-Barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis. J Infect Dis. 2012;205:106–10.

    Article  PubMed  Google Scholar 

  102. Kleines M, Schiefer J, Stienen A, Blaum M, Ritter K, Häusler M. Expanding the spectrum of neurological disease associated with Epstein-Barr virus activity. Eur J Clin Microbiol Infect Dis. 2011;30:1561–9.

    Article  CAS  PubMed  Google Scholar 

  103. Miyashita T, Kobayashi Z, Numasawa Y, Akaza M, Ishihara S, Shintani S. Epstein-Barr virus-associated meningitis presenting with hearing impairment. Intern Med. 2012;51:1755–7.

    Article  PubMed  Google Scholar 

  104. Yossepowitch O, Lossos A, Lossos IS. Sudden hearing loss following acute hepatitis. Postgrad Med J. 1999;75:309–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Arslan F, Karagöz E, Beköz HS, Ceylan B, Mert A. Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis presenting with acute sensorineural hearing loss: a case report and review of the literature. Infez Med. 2017;3:277–80.

    Google Scholar 

  106. McBride W, Gill KR, Wiviott L. West Nile virus infection with hearing loss. J Infect. 2006;53:e203–5.

    Article  PubMed  Google Scholar 

  107. Jamison SC, Michaels SR, Ratard R, Sweet JM, Deboisblanc BP. A 41-year-old HIV-positive man with acute onset of quadriplegia after West Nile virus infection. South Med J. 2007;100:1051–3.

    Article  PubMed  Google Scholar 

  108. Casetta I, Ciorba A, Cesnik E, Trevisi P, Tugnoli V, Bovo R. West Nile virus neuroinvasive disease presenting with acute flaccid paralysis and bilateral sensorineural hearing loss. J Neurol. 2011;258:1880–1.

    Article  PubMed  Google Scholar 

  109. Weatherhead JE, Miller VE, Garcia MN, et al. Long-term neurological outcomes in West Nile virus-infected patients: an observational study. Am J Trop Med Hyg. 2015;92:1006–12.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Khalil A, Moutranb H, Corr C, Elias F. A case of West Nile viral encephalitis with reversible hearing loss in an immunocompetent patient. Abstracts/Int J Infect Dis. 2016;53S:4–163.

    Google Scholar 

  111. Parrino D, Brescia G, Trimarchi MV, et al. Cochlear-vestibular impairment due to West Nile virus infection. Ann Otol Rhinol Laryngol. 2019;128:1198–202.

    Article  PubMed  Google Scholar 

  112. Ficenec SC, Percak J, Arguello S, et al. Lassa fever induced hearing loss: the neglected disability of hemorrhagic fever. Int J Infect Dis. 2020;100:82–7.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Ibekwe TS, Okokhere PO, Asogun D, et al. Early-onset sensorineural hearing loss in Lassa fever. Eur Arch Otorhinolaryngol. 2011;268:197–201.

    Article  CAS  PubMed  Google Scholar 

  114. Yun NE, Ronca S, Tamura A, et al. Animal model of sensorineural hearing loss associated with Lassa virus infection. J Virol. 2015;90:2920–7.

    Article  PubMed  Google Scholar 

  115. Okokhere P, Colubri A, Azubike C, et al. Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study. Lancet Infect Dis. 2018;18:684–95.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Okokhere PO, Ibekwe TS, Akpede GO. Sensorineural hearing loss in Lassa fever: two case reports. J Med Case Rep. 2009;3:36.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Grahn A, Bråve A, Lagging M, et al. Imported case of Lassa fever in Sweden with encephalopathy and sensorineural hearing deficit. Open Forum Infect Dis. 2016;3:ofw198.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Mateer EJ, Huang C, Shehu NY, Paessler S. Lassa fever-induced sensorineural hearing loss: a neglected public health and social burden. PLoS Negl Trop Dis. 2018;12:e0006187.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Cashman KA, Wilkinson ER, Zeng X, et al. Immune-mediated systemic vasculitis as the proposed cause of sudden-onset sensorineural hearing loss following Lassa virus exposure in Cynomolgus macaques. MBio. 2018;9:e01896–18.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Edington G, White H. The pathology of Lassa fever: a tribute to the late Dr. J. M. Troup. Trans R Soc Trop Med Hyg. 1972;66:381–9.

    Article  CAS  PubMed  Google Scholar 

  121. Mentel R, Kaftan H, Wegner U, Reissmann A, Gürtler L. Are enterovirus infections a co-factor in sudden hearing loss? J Med Virol. 2004;72:625–9.

    Article  PubMed  Google Scholar 

  122. Schattner A, Halperin D, Wolf D, Zimhony O. Enteroviruses and sudden deafness. CMAJ. 2003;168:1421–3.

    PubMed  PubMed Central  Google Scholar 

  123. Anderson SM, Gold D, Olson G, Pisano J. Chronic aseptic meningitis caused by enterovirus in a humorally immunosuppressed adult patient presenting with sensorineural hearing loss: a case report. BMC Infect Dis. 2022;22:16.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Kenna MA. Acquired hearing loss in children. Otolaryngol Clin N Am. 2015;48:933–53.

    Article  Google Scholar 

  125. Wilson WR. The relationship of the herpesvirus family to sudden hearing loss: a prospective clinical study and literature review. Laryngoscope. 1986;96:870–7.

    Article  CAS  PubMed  Google Scholar 

  126. Chand RP, Jan A, Vyas H. Acute sensorineural deafness following herpes simplex infection. Eur J Pediatr. 1993;152:379.

    Article  CAS  PubMed  Google Scholar 

  127. Al Muhaimeed H, Zakzouk SM. Hearing loss and herpes simplex. J Trop Pediatr. 1997;43:20–4.

    Article  PubMed  Google Scholar 

  128. Nomura Y, Kurata T, Saito K. Cochlear changes after herpes simplex virus infection. Acta Otolaryngol. 1985;99:419–27.

    Article  CAS  PubMed  Google Scholar 

  129. Studahl M, Lindquist L, Eriksson BM, et al. Acute viral infections of the central nervous system in immunocompetent adults: diagnosis and management. Drugs. 2013;73:131–58.

    Article  CAS  PubMed  Google Scholar 

  130. Bentivi JO, de Azevedo CMPES, Lopes MKD, et al. Audiological assessment of children with HIV/AIDS: a meta-analysis. J Pediatr. 2020;96:537–45.

    Article  Google Scholar 

  131. Htapcak S, Kuper H, Bartlett P, et al. Hearing loss in HIV-infected children in Lilongwe, Malawi. PLoS One. 2016;11:e0161421.

    Article  Google Scholar 

  132. Dawood G, Klop D, Olivier E, Elliott H, Pillay M, Grimmer K. Nature and extent of hearing loss in HIV-infected children: a scoping review. Int J Pediatr Otorhinolaryngol. 2020;134:110036.

    Article  PubMed  Google Scholar 

  133. Christopher N, Edward T, Sabrina BK, Agnes N. The prevalence of hearing impairment in the 6 months-5 years HIV/AIDS-positive patients attending paediatric infectious disease clinic at Mulago Hospital. Int J Pediatr Otorhinolaryngol. 2013;77:262–5.

    Article  PubMed  Google Scholar 

  134. Rarey KE. Otologic pathophysiology in patients with human immunodeficiency virus. Am J Otolaryngol. 1990;11:366–9.

    Article  CAS  PubMed  Google Scholar 

  135. Timon CI, Walsh MA. Sudden sensorineural hearing loss as a presentation of HIV infection. J Laryngol Otol. 1989;103:1071–2.

    Article  CAS  PubMed  Google Scholar 

  136. van der Westhuizen Y, Swanepoel de W, Heinze B, Hofmeyr LM. Auditory and otological manifestations in adults with HIV/AIDS. Int J Audiol. 2013;52:37–43.

    Article  PubMed  Google Scholar 

  137. Vincenti V, Pasanisi E, Bacciu A, et al. Cochlear implantation in a human immunodeficiency virus-infected patient. Laryngoscope. 2005;115:1079–81.

    Article  PubMed  Google Scholar 

  138. De Luca P, Scarpa A, Ralli M, et al. Auditory disturbances and SARS-CoV-2 ınfection: brain ınflammation or cochlear affection? Systematic review and discussion of potential pathogenesis. Front Neurol. 2021;12:707207.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Tufatulin GS, Boboshko MY, Garbaruk ES, et al. Hearing function in children after new coronavirus infection (COVID-19). Vestn Otorinolaringol. 2021;86:28–34 [article in Russian, abstract in English].

    PubMed  Google Scholar 

  140. Saki N, Karimi M, Bayat A. Cochlear implant failure following COVID 19: report of two cases. Am J Otolaryngol. 2021;42:102910.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  141. Ghiselli S, Laborai A, Biasucci G, Carvelli M, Salsi D, Cuda D. Auditory evaluation of infants born to COVID19 positive mothers. Am J Otolaryngol. 2022;43:103379.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Nabe-Nielsen J, Walter B. Unilateral total deafness as a complication of the measles-mumps-rubella vaccination. Scand Audiol Suppl. 1988;30:69–70.

    CAS  PubMed  Google Scholar 

  143. Kaga K, Ichimura K, Ihara M. Unilateral total loss of auditory and vestibular function as a complication of mumps vaccination. Int J Pediatr Otorhinolaryngol. 1998;43:73–5.

    Article  CAS  PubMed  Google Scholar 

  144. Rikitake M, Sampei S, Komori M, Sakurai Y, Kojima H. Bilateral deafness as a complication of the vaccination-a case report. Int Tinnitus J. 2018;22:19–22.

    Article  PubMed  Google Scholar 

  145. Murray MW, Lewis MJ. Mumps meningitis after measles, mumps, and rubella vaccination. Lancet. 1989;2:677.

    Article  CAS  PubMed  Google Scholar 

  146. Belyaletdinova IK, Mitrofanova IV, Kozlovskaya LI, Ignatyev GM. Cases of aseptic meningitis after vaccination against mumps in Russia (2009-2019). Public Health. 2020;186:8–11.

    Article  CAS  PubMed  Google Scholar 

  147. Brodsky L, Stanievich J. Sensorineural hearing loss following live measles virus vaccination. Int J Pediatr Otorhinolaryngol. 1985;10:159–63.

    Article  CAS  PubMed  Google Scholar 

  148. Stewart BJ, Prabhu PU. Reports of sensorineural deafness after measles, mumps, and rubella immunisation. Arch Dis Child. 1993;69:153–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  149. Jayajaran V, Sedler PA. Hearing loss following measles vaccination. J Infect. 1995;30:184–5.

    Article  Google Scholar 

  150. Asatryan A, Pool V, Chen RT, Kohl KS, Davis RL, Iskander JK. Live attenuated measles and mumps viral strain containing vaccines and hearing loss: vaccine adverse event reporting system (VAERS), United States, 1990–2003. Vaccine. 2008;26:1166–72.

    Article  CAS  PubMed  Google Scholar 

  151. Huang HH, Huang CC, Hsueh PY, Lee TJ. Bilateral sudden deafness following H1N1 vaccination. Otolaryngol Head Neck Surg. 2010;143:849–50.

    Article  PubMed  Google Scholar 

  152. Kolarov C, Lobermann M, Fritzsche C, Hemmer C, Mlynski R, Reisinger EC. Bilateral deafness two days following influenza vaccination: a case report. Hum Vaccin Immunother. 2019;15:107–8.

    Article  PubMed  Google Scholar 

  153. Orlando MP, Masieri S, Pascarella MA, CiofaloA FF. Sudden hearing loss in childhood consequent to hepatitis B vaccination: a case report. Ann N Y Acad Sci. 1997;830:319–21.

    Article  CAS  PubMed  Google Scholar 

  154. Biacabe B, Erminy M, Bonfils P. A case report of fluctuant sensorineural hearing loss after hepatitis B vaccination. Auris Nasus Larynx. 1997;24:357–60.

    Article  CAS  PubMed  Google Scholar 

  155. Davanipour Z, Stewart CE, McGann DG. Hepatitis B vaccination and asymmetrical tinnitus and hearing loss. Clin Res. 1994;42:341A.

    Google Scholar 

  156. Hemachudha T, Phanuphak P, Johnson RT, Griffin DE, Ratanavongsiri J, Siriprasomsup W. Neurologic complications of Semple-type rabies vaccine: clinical and immunological studies. Neurology. 1987;37:550–6.

    Article  CAS  PubMed  Google Scholar 

  157. Manning SE, Rupprecht CE, Fishbein D, et al. Human rabies prevention-United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2008;57:1–28.

    PubMed  Google Scholar 

  158. World Health Organization. WHO Expert Consultation on Rabies. Second report. World Health Organ Tech Rep Ser. 2013;982:1–139. http://apps.who.int/iris/bitstream/10665/85346/1/9789240690943_eng.pdf. Accessed 30 Dec 2022.

  159. Sabchareon A, Lang J, Attanath P, et al. A new Vero cell rabies vaccine: results of a comparative trial with human diploid cell rabies vaccine in children. Clin Infect Dis. 1999;29:141–9.

    Article  CAS  PubMed  Google Scholar 

  160. Fishbein DB, Dreesen DW, Holmes DF, Teplis CF, Mehta N, Briggs DJ. Human diploid cell rabies vaccine purified by zonal centrifugation: a controlled study of antibody response and side effects following primary and booster pre-exposure immunizations. Vaccine. 1989;7:437–42.

    Article  CAS  PubMed  Google Scholar 

  161. Fishbein DB, Yenne KM, Dreesen DW, et al. Risk factors for systemic hypersensitivity reactions after booster vaccinations with human diploid cell rabies vaccine: a nationwide prospective study. Vaccine. 1993;11:1390–4.

    Article  CAS  PubMed  Google Scholar 

  162. Dreesen DW, Fishbein DB, Kemp DT, Brown J. Two-year comparative trial on the immunogenicity and adverse effects of purified chick embryo cell rabies vaccine for pre-exposure immunization. Vaccine. 1989;7:397–400.

    Article  CAS  PubMed  Google Scholar 

  163. Kulkarni PS, Sapru A, D’Costa PM, et al. Safety and immunogenicity of a new purified Vero cell rabies vaccine (PVRV) administered by intramuscular and intradermal routes in healthy volunteers. Vaccine. 2013;31:2719–22.

    Article  CAS  PubMed  Google Scholar 

  164. Mattner F, Bitz F, Goedecke M, et al. Adverse effects of rabies pre and postexposure prophylaxis in 290 health-care workers exposed to rabies infected organ donor or transplant recipients. Infection. 2007;35:219–24.

    Article  CAS  PubMed  Google Scholar 

  165. Güçlü O, Dereköy FS. Sudden hearing loss after rabies vaccination. Balkan Med J. 2013;30:327–8.

    Article  PubMed  PubMed Central  Google Scholar 

  166. Okhovat S, Fox R, Magill J, Narula A. Sudden onset unilateral sensorineural hearing loss after rabies vaccination. BMJ Case Rep. 2015;2015:bcr2015211977.

    Article  PubMed  PubMed Central  Google Scholar 

  167. Gupta D, Singh G, Tijender. A case report of sudden hearing loss after rabies vaccination. IP J Otorhinolaryngol Allied Sci. 2021;4:139–41.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bülent Kara .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kara, B., Güngör, M., Arısoy, E.S., Demmler-Harrison, G.J. (2023). Viral Meningitis in Children and Hearing Loss. In: Arısoy, A.E., Arısoy, E.S., Bayar Muluk, N., Cingi, C., Correa, A.G. (eds) Hearing Loss in Congenital, Neonatal and Childhood Infections. Comprehensive ENT. Springer, Cham. https://doi.org/10.1007/978-3-031-38495-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-38495-0_24

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38494-3

  • Online ISBN: 978-3-031-38495-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics