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In Vivo Mechanistic Study of Superparamagnetic Materials

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Superparamagnetic Materials for Cancer Medicine

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

The recent, fast track advancements in the field of nanotechnology have encouraged the use of nanoparticles as nanomedicine in the biomedical field. Especially, the special class of magnetic materials such as superparamagnetic nanomaterials are highly recommended in cancer theranostics (diagnosis and therapeutics). Mechanistic studies of these superparamagnetic nanomaterials mean the biological processes associated with the nanomaterials coming in contact with the biological environment. The biological environment quickly interacts with the nanomaterials, remodels their structure i.e. formation of protein corona results in changes in their physicochemical properties which is responsible for their biodistribution, biotransformation, potential toxicity and fate. The biodistribution and fate of superparamagnetic nanomaterials determines the effectiveness and safety of the cancer nanomedicine. In order to use the cancer nanomedicine very efficiently it is important to understand the mechanistic studies very well. The chapter involves the understanding of mechanistic studies of superparamagnetic nanomaterials. The main focus is on the biodistribution, biotransformation, toxicity and fate or elimination pathways followed by nanomaterials after their short term and long term exposure. Although, the use of nanomedicine is highly advanced, the mechanistic studies from exposure to long term fate of newly synthesized nanomaterials must be cautiously evaluated prior actual clinical use. Current understanding of the adverse effects and the exact fate of the nanomaterials inside the human body is very inadequate.

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Acknowledgements

The author is thankful to Director, Directorate of Forensic Science Laboratories, Kalina, Mumbai and Deputy Director, Regional Forensic Science Laboratory, Nashik, Home Department, M.S. for their constant encouragement, motivation, valuable and kind support. N.D.T. acknowledges funding under the Science Foundation Ireland and Irish Research Council (SFI-IRC) pathway program (21/PATH-S/9634).

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Authors and Affiliations

  1. Regional Forensic Science Laboratory, Home Department, Nashik, 422003, MS, India

    Rakesh M. Patil

  2. Krishna Institute of Allied Sciences, Krishna Vishwa Vidtapeeth (Deemed to Be University), Karad, 415539, MS, India

    Prajakta B. Shete

  3. Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA

    Prabhanjan S. Giram

  4. School of Materials Engineering, Purdue University, West Lafayette, 47907, USA

    Sandeep B. Somvanshi

  5. Nuffield Department of Women’s and Reproductive Health, Medical Sciences Division, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK

    Nanasaheb D. Thorat

  6. Department of Physics, Bernal Institute and Limerick Digital Cancer Research Centre (LDCRC), University of Limerick, Limerick, Ireland

    Nanasaheb D. Thorat

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  1. Rakesh M. Patil
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  2. Prajakta B. Shete
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  3. Prabhanjan S. Giram
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  4. Sandeep B. Somvanshi
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  5. Nanasaheb D. Thorat
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Correspondence to Nanasaheb D. Thorat .

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  1. Limerick Digital Cancer Research Centre, Department of Physics and Bernal Institute, University of Limerick, Limerick, Ireland

    Nanasaheb Thorat

  2. Centre for Nanotechnology Research, Vellore Institute of Technology, Tamil Nadu, India

    Niroj Kumar Sahu

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Patil, R.M., Shete, P.B., Giram, P.S., Somvanshi, S.B., Thorat, N.D. (2023). In Vivo Mechanistic Study of Superparamagnetic Materials. In: Thorat, N., Sahu, N.K. (eds) Superparamagnetic Materials for Cancer Medicine. Nanomedicine and Nanotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-031-37287-2_11

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