Skip to main content

Alzheimer’s Detection and Prediction on MRI Scans: A Comparative Study

  • Conference paper
  • First Online:
Multi-disciplinary Trends in Artificial Intelligence (MIWAI 2023)

Abstract

Alzheimer’s disease (AD) is one of the most prevalent medical conditions with no effective medical treatment or cure. The issue lies in the fact that it is also a condition which is chronic, with irreversible effects on the brain, like cognitive impairment. The diagnosis of Alzheimer’s in elderly people is quite difficult and requires a highly discriminative feature representation for classification due to similar brain patterns and pixel intensities. Although we cannot prevent AD from developing, we can try to detect the stages of development of AD. In this paper, we explore and test the various methodologies used to classify Alzheimer’s Disease (AD), Early Mild Cognitive Impairment (EMCI), Late Mild Cognitive Impairment (LMCI), Mild Cognitive Impairment (MCI) and, healthy person (CN) using the Magnetic Resonance Image (MRI)s and Deep Learning techniques. The experiments are performed using ADNI dataset the results are obtained for multiple machine learning and deep learning methods that have been implemented over time. In our proposed work, we take into consideration the different stages of Dementia and Alzheimer’s Disease, and use Deep Learning models on the MRI scans for detecting and predicting which stage of Alzheimer’s or Dementia a person is suffering from.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Helaly, H.A., Badawy, M., Haikal, A.Y.: Deep learning approach for early detection of Alzheimer’s disease. Cogn. Comput. 14, 1711–1727 (2021)

    Article  Google Scholar 

  2. Chandra, A., et al.: Magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment. J. Neurol. 266, 1293–1302 (2019)

    Article  Google Scholar 

  3. Robinson, L., Tang, E., Taylor, J.-P.: Dementia: timely diagnosis and early intervention. Bmj 350 (2015)

    Google Scholar 

  4. Mittal, V.A., Walker, E.F.: Dyskinesias, tics, and psychosis: issues for the next diagnostic and statistical manuel of mental disorders. Psychiatry Res. 189(1), 158 (2011)

    Article  Google Scholar 

  5. Hinrichs, C., et al.: Predictive markers for AD in a multi-modality framework: an analysis of MCI progression in the ADNI population. Neuroimage 55(2), 574–589 (2011)

    Article  Google Scholar 

  6. Suk, H.-I., Shen, D.: Deep learning-based feature representation for AD/MCI classification. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds.) MICCAI 2013. LNCS, vol. 8150, pp. 583–590. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-40763-5_72

    Chapter  Google Scholar 

  7. Li, F., et al.: A robust deep model for improved classification of AD/MCI patients. IEEE J. Biomed. Health Inform. 19(5), 1610–1616 (2015)

    Article  Google Scholar 

  8. Mirzaei, G., Adeli, H.: Machine learning techniques for diagnosis of Alzheimer disease, mild cognitive disorder, and other types of dementia. Biomed. Signal Process. Control 72, 103293 (2022)

    Article  Google Scholar 

  9. Payan, A., Montana, G.: Predicting Alzheimer’s disease: a neuroimaging study with 3D convolutional neural networks. arXiv preprint arXiv:1502.02506 (2015)

  10. Hosseini-Asl, E., Keynton, R., El-Baz, A.: Alzheimer’s disease diagnostics by adaptation of 3D convolutional network. In: 2016 IEEE International Conference on Image Processing (ICIP). IEEE (2016)

    Google Scholar 

  11. Sarraf, S., Tofighi, G.: Classification of Alzheimer’s disease structural MRI data by deep learning convolutional neural networks. arXiv preprint arXiv:1607.06583 (2016)

  12. Wang, Y., et al.: A novel multimodal MRI analysis for Alzheimer’s disease based on convolutional neural network. In: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE (2018)

    Google Scholar 

  13. Bhatkoti, P., Paul, M.: Early diagnosis of Alzheimer’s disease: a multi-class deep learning framework with modified k-sparse autoencoder classification. In: 2016 International Conference on Image and Vision Computing New Zealand (IVCNZ). IEEE (2016)

    Google Scholar 

  14. Gamal, A., Elattar, M., Selim, S.: Automatic early diagnosis of Alzheimer’s disease using 3D deep ensemble approach. IEEE Access 10, 115974–115987 (2022)

    Article  Google Scholar 

  15. Liu, S., et al.: On the design of convolutional neural networks for automatic detection of Alzheimer’s disease. In: Machine Learning for Health Workshop. PMLR (2020)

    Google Scholar 

  16. Parmar, H., et al.: Spatiotemporal feature extraction and classification of Alzheimer’s disease using deep learning 3D-CNN for fMRI data. J. Med. Imaging 7(5), 056001–056001 (2020)

    Article  Google Scholar 

  17. Kumar, L., Sathish, S., et al.: AlexNet approach for early stage Alzheimer’s disease detection from MRI brain images. Mater. Today Proc. 51, 58–65 (2022)

    Article  Google Scholar 

  18. Spasov, S.E., et al.: A multi-modal convolutional neural network framework for the prediction of Alzheimer’s disease. In: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE (2018)

    Google Scholar 

  19. Basaia, S., et al.: Automated classification of Alzheimer’s disease and mild cognitive impairment using a single MRI and deep neural networks. NeuroImage Clin. 21, 101645 (2019)

    Article  Google Scholar 

  20. Pan, D., et al.: Early detection of Alzheimer’s disease using magnetic resonance imaging: a novel approach combining convolutional neural networks and ensemble learning. Front. Neurosci. 14, 259 (2020)

    Article  Google Scholar 

  21. Lundervold, A.S., Lundervold, A.: An overview of deep learning in medical imaging focusing on MRI. Z. Med. Phys. 29(2), 102–127 (2019)

    Article  Google Scholar 

  22. Gong, E., et al.: Deep learning enables reduced gadolinium dose for contrast-enhanced brain MRI. J. Magn. Reson. Imaging 48(2), 330–340 (2018)

    Article  Google Scholar 

  23. Liu, F., et al.: Deep learning MR imaging-based attenuation correction for PET/MR imaging. Radiology 286(2), 676–684 (2018)

    Article  Google Scholar 

  24. Oakden-Rayner, L., et al.: Precision radiology: predicting longevity using feature engineering and deep learning methods in a radiomics framework. Sci. Rep. 7(1), 1648 (2017)

    Article  Google Scholar 

  25. LeCun, Y., et al.: Gradient-based learning applied to document recognition. Proc. IEEE 86(11), 2278–2324 (1998)

    Article  Google Scholar 

  26. O’Shea, K., Nash, R.: An introduction to convolutional neural networks. arXiv preprint arXiv:1511.08458 (2015)

  27. Tan, M., Le, Q.: EfficientNet: rethinking model scaling for convolutional neural networks. In: International Conference on Machine Learning, PMLR (2019)

    Google Scholar 

  28. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Namrata Nair .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Nair, N., Poornachandran, P., Sujadevi, V.G., Aravind, M. (2023). Alzheimer’s Detection and Prediction on MRI Scans: A Comparative Study. In: Morusupalli, R., Dandibhotla, T.S., Atluri, V.V., Windridge, D., Lingras, P., Komati, V.R. (eds) Multi-disciplinary Trends in Artificial Intelligence. MIWAI 2023. Lecture Notes in Computer Science(), vol 14078. Springer, Cham. https://doi.org/10.1007/978-3-031-36402-0_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-36402-0_22

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-36401-3

  • Online ISBN: 978-3-031-36402-0

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics