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Flexibility in the Design of Nanomedicine Using Biomimetic Immunomodulatory

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Nanovaccinology

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Abstract

Significant increase in immunological diseases has globally attracted attention of researchers to develop molecules able to modulate the immune response. Nanoparticle-based drug delivery systems synthesised from wide array of material based on biomimetic engineering is one such approach to achieve targeted drug delivery by actively engaging and communicating with biological milieu. Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. The current chapter emphasises the relationship between biomimetic nanoparticles and the immune system, drawing attention to the role of tuning the nano-bio interface in the immunomodulation of diseases.

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Bibliography

  • Albanese, A., Tang, P. S., & Chan, W. C. W. (2012). Annual Review of Biomedical Engineering, 14, 1–16.

    Article  CAS  Google Scholar 

  • Angsantikul, P., Thamphiwatana, S., Gao, W., & Zhang, L. (2015). Vaccine, 3, 814–828.

    Article  CAS  Google Scholar 

  • Angsantikul, P., Thamphiwatana, S., Zhang, Q., Spiekermann, K., Zhuang, J., Fang, R. H., Gao, W., Obonyo, M., & Zhang, L. (2018). Advances in Therapy, 1, 1800016.

    Article  Google Scholar 

  • Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., Weissman, I. L., Hamann, A., & Butcher, E. C. (1993). Cell, 74, 185–195.

    Article  CAS  Google Scholar 

  • Bishop, C. J., Kozielski, K. L., & Green, J. J. (2015). Journal of Controlled Release, 219, 488–499.

    Article  CAS  Google Scholar 

  • Boada, C., Zinger, A., Tsao, C., Zhao, P., Martinez, J. O., Hartman, K., Naoi, T., Sukhovershin, R., Sushnitha, M., Molinaro, R., Trachtenberg, B., Cooke, J. P., & Tasciotti, E. (2020). Circulation Research, 126, 25–37.

    Article  CAS  Google Scholar 

  • Bobryshev, Y. V., Ivanova, E. A., Chistiakov, D. A., Nikiforov, N. G., & Orekhov, A. N. (2016). BioMed Research International, 2016, 1–13.

    Article  Google Scholar 

  • Casey, L. M., Kakade, S., Decker, J. T., Rose, J. A., Deans, K., Shea, L. D., & Pearson, R. M. (2019). Biomaterials, 218, 119333.

    Article  CAS  Google Scholar 

  • Castón, J. R., & Carrascosa, J. L. (2013). In M. G. Mateu (Ed.), Structure and physics of viruses (Vol. 68, pp. 53–75). Springer Netherlands.

    Chapter  Google Scholar 

  • Chahal, J. S., Khan, O. F., Cooper, C. L., McPartlan, J. S., Tsosie, J. K., Tilley, L. D., Sidik, S. M., Lourido, S., Langer, R., Bavari, S., Ploegh, H. L., & Anderson, D. G. (2016). Proceedings of the National Academy of Sciences, 113(29), E4133–E4142. https://doi.org/10.1073/pnas.1600299113

    Article  CAS  Google Scholar 

  • Champion, C. I., Kickhoefer, V. A., Liu, G., Moniz, R. J., Freed, A. S., Bergmann, L. L., Vaccari, D., Raval-Fernandes, S., Chan, A. M., Rome, L. H., & Kelly, K. A. (2009). PLoS One, 4, e5409.

    Article  Google Scholar 

  • Chen, W. C., Kawasaki, N., Nycholat, C. M., Han, S., Pilotte, J., Crocker, P. R., & Paulson, J. C. (2012). PLoS One, 7, e39039.

    Article  CAS  Google Scholar 

  • Chen, T., Shen, H.-M., Deng, Z.-Y., Yang, Z.-Z., Zhao, R.-L., Wang, L., Feng, Z.-P., Liu, C., Li, W.-H., & Liu, Z.-J. (2017). Molecular Medicine Reports, 15, 2057–2066.

    Article  CAS  Google Scholar 

  • Copp, J. A., Fang, R. H., Luk, B. T., Hu, C.-M. J., Gao, W., Zhang, K., & Zhang, L. (2014). Proceedings of the National Academy of Sciences, 111, 13481–13486.

    Article  CAS  Google Scholar 

  • Corbo, C., Molinaro, R., Parodi, A., Toledano Furman, N. E., Salvatore, F., & Tasciotti, E. (2016). Nanomedicine, 11, 81–100.

    Article  CAS  Google Scholar 

  • Corbo, C., Molinaro, R., Taraballi, F., Toledano Furman, N. E., Hartman, K. A., Sherman, M. B., De Rosa, E., Kirui, D. K., Salvatore, F., & Tasciotti, E. (2017a). ACS Nano, 11, 3262–3273.

    Article  CAS  Google Scholar 

  • Corbo, C., Cromer, W. E., Molinaro, R., Toledano Furman, N. E., Hartman, K. A., De Rosa, E., Boada, C., Wang, X., Zawieja, D. C., Agostini, M., Salvatore, F., Abraham, B. P., & Tasciotti, E. (2017b). Nanoscale, 9, 14581–14591.

    Article  CAS  Google Scholar 

  • Corbo, C., Molinaro, R., Tabatabaei, M., Farokhzad, O. C., & Mahmoudi, M. (2017c). Biomaterials Science, 5, 378–387.

    Article  CAS  Google Scholar 

  • Delano, M. J., & Ward, P. A. (2016). Immunological Reviews, 274, 330–353.

    Article  CAS  Google Scholar 

  • Ding, J., Xiao, C., Li, Y., Cheng, Y., Wang, N., He, C., Zhuang, X., Zhu, X., & Chen, X. (2013). Journal of Controlled Release, 169, 193–203.

    Article  CAS  Google Scholar 

  • Fang, R. H., Luk, B. T., Hu, C.-M. J., & Zhang, L. (2015). Advanced Drug Delivery Reviews, 90, 69–80.

    Article  CAS  Google Scholar 

  • Faraji, A. H., & Wipf, P. (2009). Bioorganic & Medicinal Chemistry, 17, 2950–2962.

    Article  CAS  Google Scholar 

  • Feig, J. E., Hewing, B., Smith, J. D., Hazen, S. L., & Fisher, E. A. (2014). Circulation Research, 114, 205–213.

    Article  CAS  Google Scholar 

  • Feng, X., Xu, W., Li, Z., Song, W., Ding, J., & Chen, X. (2019). Advancement of Science, 6, 1900101.

    Google Scholar 

  • Fitzgerald, J. R., Foster, T. J., & Cox, D. (2006). Nature Reviews. Microbiology, 4, 445–457.

    Article  CAS  Google Scholar 

  • Friedman, A., Claypool, S., & Liu, R. (2013). Current Pharmaceutical Design, 19, 6315–6329.

    Article  CAS  Google Scholar 

  • Gao, W., Hu, C.-M. J., Fang, R. H., Luk, B. T., Su, J., & Zhang, L. (2013). Advanced Materials, 25, 3549–3553.

    Article  CAS  Google Scholar 

  • Gao, M., Liang, C., Song, X., Chen, Q., Jin, Q., Wang, C., & Liu, Z. (2017). Advanced Materials, 29, 1701429.

    Article  Google Scholar 

  • Gao, S., Tang, G., Hua, D., Xiong, R., Han, J., Jiang, S., Zhang, Q., & Huang, C. (2019). Journal of Materials Chemistry B, 7, 709–729.

    Article  CAS  Google Scholar 

  • Golia, E., Limongelli, G., Natale, F., Fimiani, F., Maddaloni, V., Pariggiano, I., Bianchi, R., Crisci, M., D’Acierno, L., Giordano, R., Di Palma, G., Conte, M., Golino, P., Russo, M. G., Calabrò, R., & Calabrò, P. (2014). Current Atherosclerosis Reports, 16, 435.

    Article  Google Scholar 

  • Gordon, J. R., Ma, Y., Churchman, L., Gordon, S. A., & Dawicki, W. (2014). Frontiers in Immunology, 5. https://doi.org/10.3389/fimmu.2014.00007

  • He, W., Frueh, J., Wu, Z., & He, Q. (2016). ACS Applied Materials & Interfaces, 8, 4407–4415.

    Article  CAS  Google Scholar 

  • He, H., Guo, C., Wang, J., Korzun, W. J., Wang, X.-Y., Ghosh, S., & Yang, H. (2018). Nano Letters, 18, 6164–6174.

    Article  CAS  Google Scholar 

  • Hu, C.-M. J., Fang, R. H., & Zhang, L. (2012). Advanced Healthcare Materials, 1, 537–547.

    Article  CAS  Google Scholar 

  • Hu, C.-M. J., Fang, R. H., Copp, J., Luk, B. T., & Zhang, L. (2013). Nature Nanotechnology, 8, 336–340.

    Article  CAS  Google Scholar 

  • Hu, Q., Sun, W., Qian, C., Wang, C., Bomba, H. N., & Gu, Z. (2015a). Advanced Materials, 27, 7043–7050.

    Article  CAS  Google Scholar 

  • Hu, C.-M. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., Carpenter, C., Ramesh, M., Qu, V., Patel, S. H., Zhu, J., Shi, W., Hofman, F. M., Chen, T. C., Gao, W., Zhang, K., Chien, S., & Zhang, L. (2015b). Nature, 526, 118–121.

    Article  CAS  Google Scholar 

  • Kaczmarczyk, S. J., Sitaraman, K., Young, H. A., Hughes, S. H., & Chatterjee, D. K. (2011). Proceedings of the National Academy of Sciences, 108, 16998–17003.

    Article  CAS  Google Scholar 

  • Kang, S. M., Pushko, P., Bright, R. A., Smith, G., & Compans, R. W. (2009). In R. W. Compans & W. A. Orenstein (Eds.), Vaccines for pandemic influenza (Vol. 333, pp. 269–289). Springer Berlin Heidelberg.

    Chapter  Google Scholar 

  • Kim, Y.-C., Park, J.-H., & Prausnitz, M. R. (2012). Advanced Drug Delivery Reviews, 64, 1547–1568.

    Article  CAS  Google Scholar 

  • Kim, H., Niu, L., Larson, P., Kucaba, T. A., Murphy, K. A., James, B. R., Ferguson, D. M., Griffith, T. S., & Panyam, J. (2018). Biomaterials, 164, 38–53.

    Article  CAS  Google Scholar 

  • Kinlough-Rathbone, R. L., Packham, M. A., & Mustard, J. F. (1983). Arterioscler. Official Journal of the American Heart Association Inc, 3, 529–546.

    CAS  Google Scholar 

  • Kroll, A. V., Fang, R. H., Jiang, Y., Zhou, J., Wei, X., Yu, C. L., Gao, J., Luk, B. T., Dehaini, D., Gao, W., & Zhang, L. (2017). Advanced Materials, 29, 1703969.

    Article  Google Scholar 

  • Lerner, A., Jeremias, P., & Matthias, T. (2016). International Journal of Celiac Disease, 3, 151–155.

    Article  Google Scholar 

  • Li, S., Rizzo, M., Bhattacharya, S., & Huang, L. (1998). Gene Therapy, 5, 930–937.

    Article  CAS  Google Scholar 

  • Li, J., Ai, Y., Wang, L., Bu, P., Sharkey, C. C., Wu, Q., Wun, B., Roy, S., Shen, X., & King, M. R. (2016). Biomaterials, 76, 52–65.

    Article  CAS  Google Scholar 

  • Li, S., Feng, X., Wang, J., He, L., Wang, C., Ding, J., & Chen, X. (2018). Nano Research, 11, 5769–5786.

    Article  CAS  Google Scholar 

  • Liu, X.-Q., & Tang, R.-Z. (2017). Drug Delivery, 24, 1–15.

    Google Scholar 

  • Liu, Z., Tabakman, S., Welsher, K., & Dai, H. (2009). Nano Research, 2, 85–120.

    Article  CAS  Google Scholar 

  • Lv, W., Xu, J., Wang, X., Li, X., Xu, Q., & Xin, H. (2018). ACS Nano, 12, 5417–5426.

    Article  CAS  Google Scholar 

  • Martinez, J. O., Molinaro, R., Hartman, K. A., Boada, C., Sukhovershin, R., De Rosa, E., Kuri, D., Zhang, S., Evangelopoulos, M., Carter, A. M., Bibb, J. A., Cooke, J. P., & Tasciotti, E. (2018). Theranostics, 8, 1131–1145.

    Article  CAS  Google Scholar 

  • Mirza, A. Z., & Siddiqui, F. A. (2014). International Nano Letters, 4, 94.

    Article  Google Scholar 

  • Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001). Pharmacological Reviews, 53, 283–318.

    CAS  Google Scholar 

  • Molinaro, R., Pastò, A., Corbo, C., Taraballi, F., Giordano, F., Martinez, J. O., Zhao, P., Wang, X., Zinger, A., Boada, C., Hartman, K. A., & Tasciotti, E. (2019). Nanoscale, 11, 13576–13586.

    Article  CAS  Google Scholar 

  • Molinaro, R., Martinez, J. O., Zinger, A., De Vita, A., Storci, G., Arrighetti, N., De Rosa, E., Hartman, K. A., Basu, N., Taghipour, N., Corbo, C., & Tasciotti, E. (2020). Biomaterials Science, 8, 333–341.

    Article  CAS  Google Scholar 

  • Moon, J. J., Suh, H., Polhemus, M. E., Ockenhouse, C. F., Yadava, A., & Irvine, D. J. (2012). PLoS One, 7, e31472.

    Article  CAS  Google Scholar 

  • Mout, R., Moyano, D. F., Rana, S., & Rotello, V. M. (2012). Chemical Society Reviews, 41, 2539.

    Article  CAS  Google Scholar 

  • Musetti, S., & Huang, L. (2018). ACS Nano, 12, 11740–11755.

    Article  CAS  Google Scholar 

  • Naahidi, S., Jafari, M., Edalat, F., Raymond, K., Khademhosseini, A., & Chen, P. (2013). Journal of Controlled Release, 166, 182–194.

    Article  CAS  Google Scholar 

  • Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009). Nature Materials, 8, 543–557.

    Article  CAS  Google Scholar 

  • Netea, M. G., Quintin, J., & van der Meer, J. W. M. (2011). Cell Host & Microbe, 9, 355–361.

    Article  CAS  Google Scholar 

  • Pancer, Z., & Cooper, M. D. (2006). Annual Review of Immunology, 24, 497–518.

    Article  CAS  Google Scholar 

  • Park, J. H., Dehaini, D., Zhou, J., Holay, M., Fang, R. H., & Zhang, L. (2020). Nanoscale Horizons, 5, 25–42.

    Article  CAS  Google Scholar 

  • Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., Brown, B. S., Khaled, S. Z., Yazdi, I. K., Enzo, M. V., Isenhart, L., Ferrari, M., & Tasciotti, E. (2013). Nature Nanotechnology, 8, 61–68.

    Article  CAS  Google Scholar 

  • Perera, A. S., & Coppens, M.-O. (2019). Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 377, 20180268.

    Article  CAS  Google Scholar 

  • Rambukwella, M., Sakthivel, N. A., Delcamp, J. H., Sementa, L., Fortunelli, A., & Dass, A. (2018). Frontiers in Chemistry, 6, 330.

    Article  Google Scholar 

  • Rao, M. (2013). Tissue Engineering Regenerative Medicine, 10, 223–229.

    Article  CAS  Google Scholar 

  • Schmid, D., Park, C. G., Hartl, C. A., Subedi, N., Cartwright, A. N., Puerto, R. B., Zheng, Y., Maiarana, J., Freeman, G. J., Wucherpfennig, K. W., Irvine, D. J., & Goldberg, M. S. (2017). Nature Communications, 8, 1747.

    Article  Google Scholar 

  • Shen, Y., Hao, T., Ou, S., Hu, C., & Chen, L. (2018). MedChemComm, 9, 226–238.

    Article  CAS  Google Scholar 

  • Speck, O., & Speck, T. (2019). Biomimetics, 4, 26.

    Article  CAS  Google Scholar 

  • Steenblock, E. R., & Fahmy, T. M. (2008). Molecular Therapy, 16, 765–772.

    Article  CAS  Google Scholar 

  • Stewart, J., Manmathan, G., & Wilkinson, P. (2017). JRSM Cardiovascular Disease, 6, 204800401668721.

    Article  Google Scholar 

  • Sun, H., Su, J., Meng, Q., Yin, Q., Chen, L., Gu, W., Zhang, P., Zhang, Z., Yu, H., Wang, S., & Li, Y. (2016). Advanced Materials, 28, 9581–9588.

    Article  CAS  Google Scholar 

  • Sushnitha, M., Evangelopoulos, M., Tasciotti, E., & Taraballi, F. (2020). Frontiers in Bioengineering and Biotechnology, 8, 627.

    Article  Google Scholar 

  • Tang, J., Lobatto, M. E., Hassing, L., van der Staay, S., van Rijs, S. M., Calcagno, C., Braza, M. S., Baxter, S., Fay, F., Sanchez-Gaytan, B. L., Duivenvoorden, R., Sager, H. B., Astudillo, Y. M., Leong, W., Ramachandran, S., Storm, G., Pérez-Medina, C., Reiner, T., Cormode, D. P., Strijkers, G. J., Stroes, E. S. G., Swirski, F. K., Nahrendorf, M., Fisher, E. A., Fayad, Z. A., & Mulder, W. J. M. (2015). Science Advances, 1, e1400223.

    Article  Google Scholar 

  • Tang, J., Su, T., Huang, K., Dinh, P.-U., Wang, Z., Vandergriff, A., Hensley, M. T., Cores, J., Allen, T., Li, T., Sproul, E., Mihalko, E., Lobo, L. J., Ruterbories, L., Lynch, A., Brown, A., Caranasos, T. G., Shen, D., Stouffer, G. A., Gu, Z., Zhang, J., & Cheng, K. (2018). Nature Biomedical Engineering, 2, 17–26.

    Article  CAS  Google Scholar 

  • Tazaki, T., Tabata, K., Ainai, A., Ohara, Y., Kobayashi, S., Ninomiya, T., Orba, Y., Mitomo, H., Nakano, T., Hasegawa, H., Ijiro, K., Sawa, H., Suzuki, T., & Niikura, K. (2018). RSC Advances, 8, 16527–16536.

    Article  CAS  Google Scholar 

  • Theofilopoulos, A. N., Kono, D. H., & Baccala, R. (2017). Nature Immunology, 18, 716–724.

    Article  CAS  Google Scholar 

  • Vijayan, V., Uthaman, S., & Park, I.-K. (2018). Polymers, 10, 983.

    Article  Google Scholar 

  • Wang, E. C., & Wang, A. Z. (2014). Integrative Biology, 6, 9–26.

    Article  CAS  Google Scholar 

  • Wang, L., Wang, F.-S., & Gershwin, M. E. (2015). Journal of Internal Medicine, 278, 369–395.

    Article  CAS  Google Scholar 

  • Wei, X., Gao, J., Wang, F., Ying, M., Angsantikul, P., Kroll, A. V., Zhou, J., Gao, W., Lu, W., Fang, R. H., & Zhang, L. (2017). Advanced Materials, 29, 1701644.

    Article  Google Scholar 

  • Wei, X., Zhang, G., Ran, D., Krishnan, N., Fang, R. H., Gao, W., Spector, S. A., & Zhang, L. (2018). Advanced Materials, 30, 1802233.

    Article  Google Scholar 

  • Wei, X., Ran, D., Campeau, A., Xiao, C., Zhou, J., Dehaini, D., Jiang, Y., Kroll, A. V., Zhang, Q., Gao, W., Gonzalez, D. J., Fang, R. H., & Zhang, L. (2019). Nano Letters, 19, 4760–4769.

    Article  CAS  Google Scholar 

  • Wu, C.-Y., Yeh, Y.-C., Chan, J.-T., Yang, Y.-C., Yang, J.-R., Liu, M.-T., Wu, H.-S., & Hsiao, P.-W. (2012). PLoS One, 7, e42363.

    Article  CAS  Google Scholar 

  • Xu, W., Ding, J., Li, L., Xiao, C., Zhuang, X., & Chen, X. (2015). Chemical Communications, 51, 6812–6815.

    Article  CAS  Google Scholar 

  • Xu, W., Ding, J., & Chen, X. (2017). Biomacromolecules, 18, 3291–3301.

    Article  CAS  Google Scholar 

  • Yang, H.-W., Ye, L., Guo, X. D., Yang, C., Compans, R. W., & Prausnitz, M. R. (2017). Advanced Healthcare Materials, 6, 1600750.

    Article  Google Scholar 

  • Yatim, K. M., & Lakkis, F. G. (2015). Clinical Journal of the American Society of Nephrology, 10, 1274–1281.

    Article  CAS  Google Scholar 

  • Yoo, J.-W., Chambers, E., & Mitragotri, S. (2010). Current Pharmaceutical Design, 16, 2298–2307.

    Article  CAS  Google Scholar 

  • Zhang, Y., Cai, L., Li, D., Lao, Y.-H., Liu, D., Li, M., Ding, J., & Chen, X. (2018a). Nano Research, 11, 4806–4822.

    Article  CAS  Google Scholar 

  • Zhang, X., Wang, C., Wang, J., Hu, Q., Langworthy, B., Ye, Y., Sun, W., Lin, J., Wang, T., Fine, J., Cheng, H., Dotti, G., Huang, P., & Gu, Z. (2018b). Advanced Materials, 30, 1707112.

    Article  Google Scholar 

  • Zhang, Y., Chen, Y., Lo, C., Zhuang, J., Angsantikul, P., Zhang, Q., Wei, X., Zhou, Z., Obonyo, M., Fang, R. H., Gao, W., & Zhang, L. (2019). Angewandte Chemie, International Edition, 58, 11404–11408.

    Article  CAS  Google Scholar 

  • Zhou, Y., & Dai, Z. (2018). Chemistry–An Asian Journal, 13, 3333–3340.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutics, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, India

    Archana S. Patil & Rajashree S. Masareddy

  2. Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, India

    Priyanka P. Patil

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  1. University Centre for Research and Development (UCRD)Chandigarh University, Punjab, India

    Kaushik Pal

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Patil, A.S., Masareddy, R.S., Patil, P.P. (2023). Flexibility in the Design of Nanomedicine Using Biomimetic Immunomodulatory. In: Pal, K. (eds) Nanovaccinology. Springer, Cham. https://doi.org/10.1007/978-3-031-35395-6_9

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