Gut Microbiome in Dyslipidemia and Atherosclerosis

Puetz, Andreas; Kappel, Ben A.

doi:10.1007/978-3-031-35064-1_10

Andreas Puetz⁵ &
Ben A. Kappel⁵

Part of the book series: Endocrinology ((ENDOCR))

184 Accesses

Abstract

Classical risk factors for cardiovascular disease, such as dyslipidemia, arterial hypertension, obesity, diabetes mellitus, smoking, and genetic predisposition, are well-studied, and their impacts on the pathogenesis of atherosclerotic disease remain beyond question. Recently, intestinal microbiota became of more interest in cardiovascular research. Their crucial role in the pathogenesis of obesity has been elucidated previously. Over the last two decades new scientific findings indicate a further influence of the gut microbiome on lipid metabolism and atherosclerosis. Alterations in the microbiota composition can be observed in patients with dyslipidemia as well as with atherosclerosis. The intestinal microbiota influence lipid metabolism and also directly contribute to atherosclerosis. Here, microbiota-derived metabolites, such as TMAO or short chain fatty acids (SCFA), are of particular interest as mediators in the crosstalk between microbiome and host. An impact on adaptive and innate immune response and inflammatory pathways linked to atherosclerosis has also been described. This chapter will enlighten interactions of the intestinal microbiome with lipid metabolism, atherosclerosis, and subsequently cardiovascular disease.

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Department of Internal Medicine 1, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
Andreas Puetz & Ben A. Kappel

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Correspondence to Ben A. Kappel .

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Department of Systems Medicine, University of Tor Vergata, Rome, Italy
Massimo Federici
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Rossella Menghini

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Puetz, A., Kappel, B.A. (2024). Gut Microbiome in Dyslipidemia and Atherosclerosis. In: Federici, M., Menghini, R. (eds) Gut Microbiome, Microbial Metabolites and Cardiometabolic Risk. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-031-35064-1_10

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DOI: https://doi.org/10.1007/978-3-031-35064-1_10
Published: 02 February 2024
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-35063-4
Online ISBN: 978-3-031-35064-1
eBook Packages: MedicineReference Module Medicine

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