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Detection and Quantification of Exhaled Breath Condensate and Dyspnea Correlation in Stable COPD: A Proof-of-Concept Study

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GeNeDis 2022 (GeNeDis 2022)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1423))

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References

  1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2022 report, https://goldcopd.org/2022-gold-reports-2/

  2. Hanania N.A. & O'Donnell D.E. (2019). ‘Activity-related dyspnea in chronic obstructive pulmonary disease: physical and psychological consequences, unmet needs, and future directions’. International Journal of Chronic Obstructive Pulmonary Disease; 14: 1127–1138, https://doi.org/10.2147/COPD.S188141

    Article  PubMed  PubMed Central  Google Scholar 

  3. Parshall M.B., Schwartzstein R.M., Adams L., Banzett R.B., Manning H.L., Bourbeau J., Calverley P.M., Gift A.G., Harver A., Lareau S.C., Mahler D.A., Meek P.M. & O’Donnell D.E. (2012). ‘An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea’. American Journal of Respiratory & Critical Care Medicine; 185(4): 435–452, https://doi.org/10.1164/rccm.201111-2042ST

    Article  Google Scholar 

  4. Miravitlles M. & Ribera A. (2017). ‘Understanding the impact of symptoms on the burden of COPD’. Rwspiratory Research; 18(1): 67, https://doi.org/10.1186/s12931-017-0548-3

    Article  Google Scholar 

  5. Kazeminasab S., Emamalizadeh B., Khoubnasabjafari M. & Jouyban A. (2021). ‘Exhaled Breath Condensate: A Non-Invasive Source for Tracking of Genetic and Epigenetic Alterations in Lung Diseases’. Pharmaceutical Sciences; 27(2): 149–161, https://doi.org/10.34172/PS.2020.46

  6. Kostikas K., Papatheodorou G., Psathakis K., Panagou P. & Loukides S. (2003). ‘Oxidative Stress in Expired Breath Condensate of Patients With COPD’. Chest; 124: 1373–1280, https://doi.org/10.1378/chest.124.4.1373

    Article  CAS  PubMed  Google Scholar 

  7. Murata K., Fujimoto K., Kitaguchi Y., Horiuchi T., Kubo K. & Honda T. (2014). ‘Hydrogen Peroxide Content and pH of Expired Breath Condensate from Patients with Asthma and COPD’. COPD Journal of Chronic Obstructive Pulmonary Disease; 11: 81–87, https://doi.org/10.3109/15412555.2013.830094

    Article  PubMed  Google Scholar 

  8. Inonu H., Doruk S., Sahin S., Erkorkmaz U., Celik D., Celikel S. & Seyfikli Z. (2012). ‘Oxidative Stress Levels in Exhaled Breath Condensate Associated With COPD and Smoking’. Respiratory Care; 57(3): 413–419, https://doi.org/10.4187/respcare.01302

    Article  PubMed  Google Scholar 

  9. Makris D., Paraskakis E., Korakas P., Karagiannakis E., Sourvinos G., Siafakas N.M. & Tzanakis N. (2008). ‘Exhaled Breath Condensate 8-Isoprostane, Clinical Parameters, Radiological Indices and Airway Inflammation in COPD’. Respiration; 75: 138–144, https://doi.org/10.1159/000106377

    Article  CAS  PubMed  Google Scholar 

  10. Rahimpour E., Khoubnasabjafari M., Jouyban-Gharamaleki V. & Jouyban A. (2018). ‘Non-volatile compounds in exhaled breath condensate: review of methodological aspects’. Analytical and Bioanalytical Chemistry; 410(25): 6411–6440. https://doi.org/10.1007/s00216-018-1259-4

    Article  CAS  PubMed  Google Scholar 

  11. Horváth I., Barnes P.J., Loukides S., Sterk P.J., Högman M., Olin A.C., Amann A., Antus B., Baraldi E., Bikov A., Boots A.W., Bos L.D., Brinkman P., Bucca C., Carpagnano G.E., Corradi M., Cristescu S., de Jongste J.C., Dinh-Xuan A.T., Dompeling E., Fens N., Fowler S., Hohlfeld J.M., Holz O., Jöbsis Q., Van De Kant K., Knobel H.H., Kostikas K., Lehtimäki L., Lundberg J.O., Montuschi P., Van Muylem A., Pennazza G., Reinhold P., Ricciardolo F.L.M., Rosias P., Santonico M., Van der Schee M.P., Van Schooten F.J., Spanevello A., Tonia T. & Vink T.J. (2017). ‘A European Respiratory Society technical standard: exhaled biomarkers in lung disease’. European Respiratory Journal; 49: 1600965, https://doi.org/10.1183/13993003.00965-2016

    Article  CAS  PubMed  Google Scholar 

  12. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002). ‘ATS statement: guidelines for the six-minute walk test’. American Journal of Respiratory & Critical Care Medicine; 166(1): 111–7, https://doi.org/10.1164/ajrccm.166.1.at1102

  13. Modified Borg dyspnea scale. https://www.physio-pedia.com/Physiopedia:About

  14. COPD Assessment Test user guide. https://www.catestonline.org/content/dam/global/catestonline/documents/CAT_HCP%20User%20Guide.pdf

  15. Maniscalco M., Fuschillo S., Paris D., Cutignano A., Sanduzzi A. & Motta A. (2019). ‘Clinical metabolomics of exhaled breath condensate in chronic respiratory diseases’. Advances in Clinical Chemistry; 88: 121–149, https://doi.org/10.1016/bs.acc.2018.10.002

    Article  CAS  PubMed  Google Scholar 

  16. Lazar Z., Horvath I., Vestbo J. & Bikov A. (2018). ‘Exhaled breath condensate in chronic obstructive pulmonary disease: methodological challenges and clinical application’. Minerva Pneumologica; 57(2): 42–56, https://doi.org/10.23736/S0026-4954.18.01816-3

    Article  Google Scholar 

  17. Lewthwaite H., Jensen D. & Ekström M. (2021). ‘How to Assess Breathlessness in Chronic Obstructive Pulmonary Disease’. International Journal of Chronic Obstructive Pulmonary Disease; 16: 1581–1598, https://doi.org/10.2147/COPD.S277523

    Article  PubMed  PubMed Central  Google Scholar 

  18. Davis M.D., Fowler S.J. & Montpetit A.J. (2019). ‘Exhaled Breath Testing – A Tool for the Clinician and Researcher’. Paediatric Respiratory Reviews; 29: 37–41, https://doi.org/10.1016/j.prrv.2018.05.002

    Article  PubMed  Google Scholar 

  19. Ghio A.J., Madden M.C. & Esther Jr C.R. (2018). ‘Transition and post-transition metals in exhaled breath condensate’. Journal of Breath Research; 12(2): 027112, https://doi.org/10.1088/1752-7163/aaa214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Larstad M., Almstrand A.C., Larsson P., Bake B., Larsson S., Ljungström E., Mirgorodskaya E. & Olin A.C. (2015). ‘Surfactant Protein A in Exhaled Endogenous Particles Is Decreased in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Pilot Study’. PLoS One; 10(12):e0144463, https://doi.org/10.1371/journal.pone.0144463

  21. Schwarz K., Biller H., Windt H., Koch W. & Hohlfeld J.M. (2015). ‘Characterization of Exhaled Particles from the Human Lungs in Airway Obstruction’. Journal of Aerosol Medicine & Pulmonary Drug Delivery; 28(1):52–58, https://doi.org/10.1089/jamp.2013.1104

  22. Seferaj S., Ullah S., Tinglev A., Carlsson S., Winberg J., Stambeck P. & Beck O. (2018). ‘Evaluation of a new simple collection device for sampling of microparticles in exhaled breath’. Journal of Breath Research; 12(3): 036005, https://doi.org/10.1088/1752-7163/aaaf24

  23. Bake B., Larsson P., Ljungkvist G., Ljungström E. & Olin A.C. (2019). ‘Exhaled particles and small airways’. Respiratory Research; 20(1): 8, https://doi.org/10.1186/s12931-019-0970-9

  24. Anzueto A. & Miravitlles M. (2017). ‘Pathophysiology of dyspnea in COPD’. Postgraduate Medicine; 129(3): 366–374, https://doi.org/10.1080/00325481.2017.1301190

  25. Welker R.W. (2012). ‘Size Analysis and Identification of Particles’. Chapter 4th, In R. Kohli & K.L. Mittal (eds), Developments in Surface Contamination and Cleaning. Detection, Characterization, and Analysis of Contaminants, (pp. 179–213). William Andrew, https://doi.org/10.1016/B978-1-4377-7883-0.00004-3

  26. Pawan K.C., Liu F., Zhe J. & Zhang G. (2018). ‘Development and Comparison of Two Immuno-disaggregation Based Bioassays for Cell Secretome Analysis’. Theranostics; 8(2): 328–340, https://doi.org/10.7150/thno.21917

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Authors and Affiliations

  1. General Hospital of Corfu, Corfu, Greece

    S. Patsiris, N. Vaitsis & I. Nasoula

  2. Department of Informatics, Ionian University, Corfu, Greece

    S. Patsiris, T. Exarchos & P. Vlamos

Authors
  1. S. Patsiris
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  2. N. Vaitsis
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  3. I. Nasoula
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  4. T. Exarchos
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  5. P. Vlamos
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Editors and Affiliations

  1. Department of Informatics, Ionian University, Corfu, Greece

    Panagiotis Vlamos

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Patsiris, S., Vaitsis, N., Nasoula, I., Exarchos, T., Vlamos, P. (2023). Detection and Quantification of Exhaled Breath Condensate and Dyspnea Correlation in Stable COPD: A Proof-of-Concept Study. In: Vlamos, P. (eds) GeNeDis 2022. GeNeDis 2022. Advances in Experimental Medicine and Biology, vol 1423. Springer, Cham. https://doi.org/10.1007/978-3-031-31978-5_3

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