Abstract
As the population ages, the number of individuals who live for 100 years or more is increasing. While cognitive impairment is more common as we grow older, it is not necessarily an inevitable component of the aging process. Research has shown that although certain key characteristics of being a centenarian enjoying cognitive health, such as genetic factors, cannot be modified, positive lifestyle choices play an important role in preserving cognitive health. For example, maintaining a Mediterranean diet and regular exercise regimen, as well as engaging in social activities may improve our chances of preserving a healthy brain.
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References
2020 Alzheimer’s disease facts and figures. Alzheimer’s Dement., 16: 391–460.
Arosio, B., et al. (2017). Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess. Mechanisms of Ageing and Development, 185–194.
Beker, N., et al. (2020). Longitudinal maintenance of cognitive health in centenarians in the 100-plus study. JAMA Network Open, e200094.
Beker, N., et al. (2021). Association of Cognitive Function Trajectories in centenarians with postmortem neuropathology, physical health, and other risk factors for cognitive decline. JAMA Network Open, 4(1), e2031654.
Biau, D. J., Kerneis, S., & Porcher, R. (2008). Statistics in brief: The importance of sample size in the planning and interpretation of medical research. Clinical Orthopaedics and Related Research, 466(9), 2282–2288.
Brodaty, H., et al. (2016). ICC-dementia (international centenarian consortium – dementia): An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurology, 16, 52.
Buettner, D., & Skemp, S. (2016). Blue zones: Lessons from the World’s longest lived. American Journal of Lifestyle Medicine, 10(5), 318–321.
Calvert, J. F., Jr., et al. (2006). Dementia-free survival among centenarians: An evidence-based review. The Journals of Gerontology: Series A., 61, 951–956.
Centers for Disease Control. (2019). What is Dementia? Available from: https://www.cdc.gov/aging/dementia/index.html
Davey, A., et al. (2013). Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis. Experimental Aging Research, 39(2), 125–144.
Feng, L., et al. (2022). Malnutrition is positively associated with cognitive decline in centenarians and oldest-old adults: A cross-sectional study. eClinicalMedicine, 47.
Folstein, M. F., Folstein, S. E., & Mchugh, P. R. (1975). “Mini-mental state” a practical method for grading the cognitive state of patients for the clinician*. Journal of Psychiatric Research, Pergamon Press, 189–198.
Fratiglioni, L., & Hui-Xin, W. (2007). Brain reserve hypothesis in dementia. Journal of Alzheimer’s Disease, 12(1), 11–22.
Fries, B. E., et al. (2000). Accelerated dysfunction among the very oldest-old in nursing homes. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 55(6), M336–M341.
Hai, S., et al. (2017). Association between nutrition status and cognitive impairment among Chinese nonagenarians and centenarians. International Journal of Gerontology, 11(4), 215–219.
Hernández-Vicente, A., et al. (2019). Physical activity and sedentary behavior at the end of the human lifespan. Journal of Aging and Physical Activity, 27(4), 899–905.
Huang, J. (2021). Alzheimer disease – Neurologic disorders. Available from: https://www.merckmanuals.com/professional/neurologic-disorders/delirium-and-dementia/alzheimer-disease#
Huang, J. Dementia – Neurologic Disorders. 2021 [cited 2022 December 01]. Available from: https://www.merckmanuals.com/professional/neurologic-disorders/delirium-and-dementia/dementia
Ishioka, Y. L., et al. (2016). Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians. Age, 38(5–6), 495–503.
James, B. D., et al. (2016). TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia. Brain, 139(11), 2983–2993.
Jopp, D. S., et al. (2016). Physical, cognitive, social and mental health in near-centenarians and centenarians living in New York City: Findings from the Fordham centenarian study. BMC Geriatrics, 16(1), 1.
Kliegel, M., Zimprich, D., & Rott, C. (2004). Life-long intellectual activities mediate the predictive effect of early education on cognitive impairment in centenarians: A retrospective study. Aging & Mental Health, 8(5), 430–437.
Leitão, C., et al. (2022). The effect of nutrition on aging – A systematic review focusing on aging-related biomarkers. Nutrients, 14(3), 554.
MacDonald, M. (2007). Social support for centenarians’ health, psychological well-being, and longevity. Annual Review of Gerontology and Geriatrics, 27(1), 107–127.
Ozaki, A., et al. (2007). The Japanese centenarian study: Autonomy was associated with health practices as well as physical status. Journal of the American Geriatrics Society, 55(1), 95–101.
Panza, F., et al. (2004). Mediterranean diet and cognitive decline. Public Health Nutrition, 7(7), 959–963.
Perls, T. (2004). Dementia-free centenarians. Experimental Gerontology, 39(11–12), 1587–1593.
Poon, L. W., et al. (2012). Understanding dementia prevalence among centenarians. The Journals of Gerontology: Series A., 67A, 358–365.
Qiu, C., & Fratiglioni, L. (2018). Aging without dementia is achievable: Current evidence from epidemiological research. Journal of Alzheimer’s Disease., 62, 933–942.
Ravaglia, G., et al. (1999). Prevalence and severity of dementia among northern Italian centenarians. Neurology, 53(2), 416–418.
Rosenthal, T. C., & Fox, C. (2000). Access to health care for the rural elderly. JAMA, 284(16), 2034–2036.
Samuelsson, S. M., et al. (1997). The Swedish centenarian study: A multidisciplinary study of five consecutive cohorts at the age of 100. International Journal of Aging and Human Development, Baywood Publishing Inc., 223–253.
Scheltens, P., et al. (2021). Alzheimer’s disease. Lancet, 397(10284), 1577–1590.
Sebastiani, P., et al. (2019a). A serum protein signature of APOE genotypes in centenarians. Aging Cell, 18(6), e13023.
Sebastiani, P., et al. (2019b). APOE alleles and extreme human longevity. The Journals of Gerontology: Series A, 74(1), 44–51.
Slavin, M. J., Brodaty, H., & Sachdev, P. S. (2013). Challenges of diagnosing dementia in the oldest old population. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 68(9), 1103–1111.
Sommerlad, A., et al. (2019). Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. PLoS Medicine, 16(8), e1002862.
Song, R., et al. (2021). Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study. Alzheimer’s & Dementia, 17(12), 1914–1922.
Stefanacci, R. G. (2022). Overview of aging – Older People’s health issues. Merck Manuals Consumer Version; Available from: https://www.merckmanuals.com/home/older-people%E2%80%99s-health-issues/the-aging-body/overview-of-aging
Tanprasertsuk, J., et al. (2021). Carotenoid-rich brain nutrient pattern is positively correlated with higher cognition and lower depression in the oldest old with no dementia. Frontiers in Nutrition, 8, 704691.
Terry, D. F., et al. (2003). Cardiovascular advantages among the offspring of centenarians. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 58(5), M425–M431.
Terry, D. F., et al. (2004). Lower all-cause, cardiovascular, and cancer mortality in centenarians’ offspring. Journal of the American Geriatrics Society, 52(12), 2074–2076.
Toepper, M. (2017). Dissociating Normal aging from Alzheimer’s disease: A view from cognitive neuroscience. Journal of Alzheimer’s Disease, 57(2), 331–352.
Van Patten, R., & Tremont, G. (2020). Public knowledge of late-life cognitive decline and dementia in an international sample. Dementia (London), 19(6), 1758–1776.
Wang, B., He, P., & Dong, B. (2015). Associations between social networks, social contacts, and cognitive function among Chinese nonagenarians/centenarians. Archives of Gerontology and Geriatrics, 60(3), 522–527.
Wang, C., et al. (2022). Sardinian dietary analysis for longevity: A review of the literature. Journal of Ethnic Foods, 9(1), 33.
Willcox, B. J., et al. (2006a). Siblings of Okinawan centenarians share lifelong mortality advantages. The Journals of Gerontology: Series A, 61(4), 345–354.
Willcox, D. C., et al. (2006b). Genetic determinants of exceptional human longevity: Insights from the Okinawa centenarian study. Age, 28(4), 313–332.
Wu, T., et al. (2017). Factors associated with activities of daily life disability among centenarians in rural Chongqing, China: A cross-sectional study. International Journal of Environmental Research and Public Health, 14(11), 1364.
Xiang, Q., et al. (2021). Studying the interplay between apolipoprotein E and education on cognitive decline in centenarians using Bayesian Beta regression. Frontiers in Genetics, 11, 606831.
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Acknowledgement to Arianne Fritts, MS for editing support.
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End of Chapter Questions
End of Chapter Questions
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1.
What is the most common cause of dementia?
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(a)
Lewy-body disease
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(b)
Alzheimer’s disease
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(c)
Pick’s disease
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(d)
Cardiovascular disease
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(a)
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2.
How can dementia be diagnosed clinically?
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(a)
Taking a medical history & performing a neurological examination
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(b)
Neuroimaging methods (ie. PET scan)
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(c)
Neuropsychologic testing
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(d)
All the above
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(a)
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3.
What is the strongest risk factor for the development of dementia?
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(a)
Diabetes
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(b)
Family history
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(c)
Age
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(d)
Smoking
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(a)
Answers: b, d, c
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Crull, J., Barlis, K., Brawman-Mintzer, O., Blasy, C., Mintzer, J. (2023). Do Centenarians Get Dementia?. In: Kheirbek, R.E., Llorente, M.D. (eds) Current Perspectives on Centenarians. International Perspectives on Aging, vol 36. Springer, Cham. https://doi.org/10.1007/978-3-031-30915-1_5
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