Abstract
Pharmaceutical proteins are large, folded structures stabilized by weak physical/chemical forces. An appreciation of the factors that may influence their structure is an absolute requirement when dealing with these complex, fragile compounds.
Sadly, Wim Jiskoot passed away by the time of publication of this sixth edition.
This text is a revised and abbreviated version of the chapter by Tsutomu Arakawa and John S. Pilo in the fourth, edition of this book. The discussion of techniques to physicochemically characterize protein structures was taken out and forms a separate chapter, Chap. 3.
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Further Reading
Buxbaum E (2015) Fundamentals of protein structure and function, 2nd edn. Springer, New York
Creighton TE (ed) (1989) Protein structure: a practical approach. IRL Press, Oxford
Gregory RB (ed) (1994) Protein-solvent interactions. Marcel Dekker, New York
Schulz GE, Schirmer RH (eds) (1979) Principles of protein structure. Springer, New York
Shirley BA (ed) (1995) Protein stability and folding. Humana Press, Totowa
Whitford D (2005) Proteins: structure and function. John Wiley, Hoboken, NJ
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Jiskoot, W., Crommelin, D.J.A. (2024). Biophysical and Biochemical Characteristics of Therapeutic Proteins. In: Crommelin, D.J.A., Sindelar, R.D., Meibohm, B. (eds) Pharmaceutical Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-031-30023-3_2
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DOI: https://doi.org/10.1007/978-3-031-30023-3_2
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