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Emerging Developments in Skull Base Reconstruction

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Skull Base Reconstruction

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Abstract

This chapter describes emerging developments and advances that will potentially impact skull base reconstruction in the future. This chapter discusses laser tissue welding, endoscopic drug delivery to central nervous system, point of care CSF detection, indocyanine green applications, wound healing and biomechanical models, and training via simulations and 3D printed models. Laser tissue welding can offer primary wound closure and prevent CSF leaks by endoscopic sealing of wound edges using a laser and biological solder, although more studies are warranted to investigate the technical feasibility and solder formulation. To overcome limitations of drug delivery to the central nervous system due to the blood brain barrier, novel techniques such as minimally invasive nasal depot or mucosal graft techniques are being introduced with promising potentials. Point-of-care detection of CSF leaks has immense clinical implications; thus, studies to accurately quantify beta-trace protein or beta-2 transferrin, or other targets, using various techniques are reporting great progress. Endoscope-integrated indocyanine green has been recently utilized to evaluate nasoseptal flap perfusion, which can improve postoperative outcomes in the future. Since the reconstruction of skull base defects is a complex topic with various types of techniques and grafts available, we also discuss the emerging healing and biomechanical models that compare different methods. Lastly, we explore the technological developments in the training of skull base surgery and reconstruction such as 3D-printed models and virtual reality simulations.

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Authors and Affiliations

  1. Otolaryngology-Head and Neck Surgery and Neurological Surgery, University of California, Irvine, Irvine, CA, USA

    Khodayar Goshtasbi, Harrison W. Lin, Hamid R. Djalilian & Edward C. Kuan

  2. Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA

    Bobby A. Tajudeen

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  1. Khodayar Goshtasbi
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  2. Bobby A. Tajudeen
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  3. Harrison W. Lin
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  4. Hamid R. Djalilian
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  5. Edward C. Kuan
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Correspondence to Edward C. Kuan .

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Editors and Affiliations

  1. Otolaryngology-Head and Neck Surgery and Neurological Surgery, University of California, Irvine, Irvine, CA, USA

    Edward C. Kuan

  2. Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA

    Bobby A. Tajudeen

  3. Otolaryngology-Head and Neck Surgery and Neurological Surgery, University of California, Irvine, Irvine, CA, USA

    Hamid R. Djalilian

  4. Otolaryngology-Head and Neck Surgery and Neurological Surgery, University of California, Irvine, Irvine, CA, USA

    Harrison W. Lin

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Goshtasbi, K., Tajudeen, B.A., Lin, H.W., Djalilian, H.R., Kuan, E.C. (2023). Emerging Developments in Skull Base Reconstruction. In: Kuan, E.C., Tajudeen, B.A., Djalilian, H.R., Lin, H.W. (eds) Skull Base Reconstruction . Springer, Cham. https://doi.org/10.1007/978-3-031-27937-9_34

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  • DOI: https://doi.org/10.1007/978-3-031-27937-9_34

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