Abstract
The Research Domain Criteria (RDoC) is a research framework introduced by the National Institute of Mental Health (NIMH) in 2009 intended to direct mental health-related research and integrate findings from multiple fields of research into a unified model of neurobehavioral functioning and psychopathology. This chapter provides an overview of the theoretical rationale for RDoC’s conception and design, including how RDoC incorporates influences from developmental and environmental factors that impact neurobehavioral functioning. Highlights from RDoC-oriented research are presented, and the ongoing evolution of the RDoC framework is discussed. Throughout the chapter, effort is made to provide examples from clinical child psychology to illustrate the potential strengths of RDoC.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahlen, J., & Ghaderi, A. (2019). Dimension-specific symptom patterns in trajectories of broad anxiety: A longitudinal prospective study in school-aged children. Development and Psychopathology, 32(1), 31–41.
Alexopoulos, G. S., & Arean, P. (2014). A model for streamlining psychotherapy in the RDoC era: The example of ’Engage’. Molecular Psychiatry, 19(1), 14–19. https://doi.org/10.1038/mp.2013.150
Angold, A., Costello, E. J., & Erkanli, A. (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40(1), 57–87. https://www.ncbi.nlm.nih.gov/pubmed/10102726
Barch, D. M., Oquendo, M. A., Pacheco, J., & Morris, S. (2016). Behavioral assessment methods for RDoC contructs: A report by the National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (RDoC). National Institutes of Mental Health.
Baskin-Sommers, A. R., & Foti, D. (2015). Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism. International Journal of Psychophysiology, 98(2 Pt 2), 227–239. https://doi.org/10.1016/j.ijpsycho.2015.01.011
Beeney, J. E., Hallquist, M. N., Ellison, W. D., & Levy, K. N. (2016). Self-other disturbance in borderline personality disorder: Neural, self-report, and performance-based evidence. Personal Disord, 7(1), 28–39. https://doi.org/10.1037/per0000127
Benjamin, S. (2014). A DSM-5 to-do list for adult psychiatry residency directors. Academic Psychiatry, 38(1), 67–71. https://doi.org/10.1007/s40596-013-0008-4
Bhavnani, S., Mukherjee, D., Dasgupta, J., Verma, D., Parameshwaran, D., Divan, G., Sharma, K. K., Thiagarajan, T., & Patel, V. (2019). Development, feasibility and acceptability of a gamified cognitive DEvelopmental assessment on an E-Platform (DEEP) in rural Indian pre-schoolers - a pilot study. Global Health Action, 12(1), 1548005. https://doi.org/10.1080/16549716.2018.1548005
Blair, R. J., Leibenluft, E., & Pine, D. S. (2014a). Conduct disorder and callous-unemotional traits in youth. The New England Journal of Medicine, 371(23), 2207–2216. https://doi.org/10.1056/NEJMra1315612
Blair, R. J., White, S. F., Meffert, H., & Hwang, S. (2014b). Disruptive behavior disorders: Taking an RDoC(ish) approach. Current Topics in Behavioral Neurosciences, 16, 319–336. https://doi.org/10.1007/7854_2013_247
Briggs-Gowan, M. J., Pollak, S. D., Grasso, D., Voss, J., Mian, N. D., Zobel, E., McCarthy, K. J., Wakschlag, L. S., & Pine, D. S. (2015). Attention bias and anxiety in young children exposed to family violence. Journal of Child Psychology and Psychiatry, 56(11), 1194–1201. https://doi.org/10.1111/jcpp.12397
Briggs-Gowan, M. J., Grasso, D., Bar-Haim, Y., Voss, J., McCarthy, K. J., Pine, D. S., & Wakschlag, L. S. (2016). Attention bias in the developmental unfolding of post-traumatic stress symptoms in young children at risk. Journal of Child Psychology and Psychiatry, 57(9), 1083–1091. https://doi.org/10.1111/jcpp.12577
Briscione, M. A., Jovanovic, T., & Norrholm, S. D. (2014). Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors. Frontiers in Psychiatry, 5, 88. https://doi.org/10.3389/fpsyt.2014.00088
Brislin, S. J., Martz, M. E., Cope, L. M., Hardee, J. E., Weigard, A., & Heitzeg, M. M. (2021). Heterogeneity within youth with childhood-onset conduct disorder in the ABCD study. Frontiers in Psychiatry, 12, 701199. https://doi.org/10.3389/fpsyt.2021.701199
Bronfenbrenner, U. (1979a). Contexts of child-rearing – Problems and prospects. American Psychologist, 34(10), 844–850. https://doi.org/10.1037/0003-066x.34.10.844
Bronfenbrenner, U. (1979b). The ecology of human development: Experiments by nature and design. Harvard University Press.
Bufferd, S. J., Dyson, M. W., Hernandez, I. G., & Wakschlag, L. S. (2016). Explicating the “developmental” in preschool psychopathology. In Developmental psychopathology: Maladaptation and psychopathology (Vol. 3, 3rd ed., pp. 152–186). Wiley https://doi.org/10.1002/9781119125556.devpsy305
Cannon, M., Caspi, A., Moffitt, T. E., Harrington, H., Taylor, A., Murray, R. M., & Poulton, R. (2002). Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: Results from a longitudinal birth cohort. Archives of General Psychiatry, 59(5), 449–456. https://doi.org/10.1001/archpsyc.59.5.449
Cardinale, R., O’Donnell, L., Chun, J., Park, J., Kross, E., Kamali, M., McInnis, M., & Deldin, P. (2018). A preliminary study of central nervous system arousal and sleep quality in bipolar disorder. Psychopathology, 51(4), 269–275. https://doi.org/10.1159/000489679
Carpenter, W. T., Jr. (2016). The RDoC controversy: Alternate paradigm or dominant paradigm? The American Journal of Psychiatry, 173(6), 562–563. https://doi.org/10.1176/appi.ajp.2016.16030347
Casey, B. J., Getz, S., & Galvan, A. (2008). The adolescent brain. Developmental Review, 28(1), 62–77. https://doi.org/10.1016/j.dr.2007.08.003
Casey, B. J., Oliveri, M. E., & Insel, T. (2014). A neurodevelopmental perspective on the research domain criteria (RDoC) framework. Biological Psychiatry, 76(5), 350–353. https://doi.org/10.1016/j.biopsych.2014.01.006
Clark, L. A., Cuthbert, B., Lewis-Fernandez, R., Narrow, W. E., & Reed, G. M. (2017). Three approaches to understanding and classifying mental disorder: ICD-11, DSM-5, and the National Institute of Mental Health’s research domain criteria (RDoC). Psychological Science in the Public Interest, 18(2), 72–145. https://doi.org/10.1177/1529100617727266
Clayson, P. E., Kappenman, E. S., Gehring, W. J., Miller, G. A., & Larson, M. J. (2021). A commentary on establishing norms for error-related brain activity during the arrow flanker task among young adults. NeuroImage, 234, 117932. https://doi.org/10.1016/j.neuroimage.2021.117932
Connor, D. F., Ford, J. D., Albert, D. B., & Doerfler, L. A. (2007). Conduct disorder subtype and comorbidity. Annals of Clinical Psychiatry, 19(3), 161–168. https://doi.org/10.1080/10401230701465269
Copeland, W. E., Shanahan, L., Costello, E. J., & Angold, A. (2009). Childhood and adolescent psychiatric disorders as predictors of young adult disorders. Archives of General Psychiatry, 66(7), 764–772. https://doi.org/10.1001/archgenpsychiatry.2009.85
Cozza, E. M., & Shankman, S. A. (2021). Integrating NIMH’s research domain criteria (RDoC) initiative into psychiatry resident training. Academic Psychiatry, 46(4), 522–527. https://doi.org/10.1007/s40596-021-01547-3
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., Dour, H., & Rosenfield, D. (2019). Positive affect treatment for depression and anxiety: A randomized clinical trial for a core feature of anhedonia. Journal of Consulting and Clinical Psychology, 87(5), 457–471. https://doi.org/10.1037/ccp0000396
Cuthbert, B. N. (2020). The role of RDoC in future classification of mental disorders. Dialogues in Clinical Neuroscience, 22(1), 81–85. https://doi.org/10.31887/DCNS.2020.22.1/bcuthbert
Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11, 126. https://doi.org/10.1186/1741-7015-11-126
da Cunha-Bang, S., Fisher, P. M., Hjordt, L. V., Holst, K., & Knudsen, G. M. (2019). Amygdala reactivity to fearful faces correlates positively with impulsive aggression. Social Neuroscience, 14(2), 162–172. https://doi.org/10.1080/17470919.2017.1421262
Damme, K. S. F., Park, J. S., Vargas, T., Walther, S., Shankman, S. A., & Mittal, V. A. (2022). Motor abnormalities, depression risk, and clinical course in adolescence. Biol Psychiatry Glob Open Sci, 2(1), 61–69. https://doi.org/10.1016/j.bpsgos.2021.06.011
Davidson, M. C., Amso, D., Anderson, L. C., & Diamond, A. (2006). Development of cognitive control and executive functions from 4 to 13 years: Evidence from manipulations of memory, inhibition, and task switching. Neuropsychologia, 44(11), 2037–2078. https://doi.org/10.1016/j.neuropsychologia.2006.02.006
Dean, D. J., & Mittal, V. A. (2015). Spontaneous parkinsonisms and striatal impairment in neuroleptic free youth at ultrahigh risk for psychosis. NPJ Schizophrenia, 1. https://doi.org/10.1038/npjschz.2014.6
Dean, D. J., Bernard, J. A., Damme, K. S. F., O’Reilly, R., Orr, J. M., & Mittal, V. A. (2020). Longitudinal assessment and functional neuroimaging of movement variability reveal novel insights into motor dysfunction in clinical high risk for psychosis. Schizophrenia Bulletin, 46(6), 1567–1576. https://doi.org/10.1093/schbul/sbaa072
Diagnostic and statistical manual of mental disorders. (2013). (5th ed.). American Psychiatric Association.
Dubey, I., Bishain, R., Dasgupta, J., Bhavnani, S., Belmonte, M. K., Gliga, T., Mukherjee, D., Estrin, G. L., Johnson, M. H., Chandran, S., Patel, V., Gulati, S., Divan, G., & Chakrabarti, B. (2021). Using mobile health technology to assess childhood autism in low-resource community settings in India: an innovation to address the detection gap. medRxiv, 2021.2006.2024.21259235. https://doi.org/10.1101/2021.06.24.21259235.
Ellard, K. K., Fairholme, C. P., Boisseau, C. L., Farchione, T. J., & Barlow, D. H. (2010). Unified protocol for the Transdiagnostic treatment of emotional disorders: Protocol development and initial outcome data. Cognitive and Behavioral Practice, 17(1), 88–101. https://doi.org/10.1016/j.cbpra.2009.06.002
Etkin, A., & Cuthbert, B. (2014). Beyond the DSM: Development of a transdiagnostic psychiatric neuroscience course. Academic Psychiatry, 38(2), 145–150. https://doi.org/10.1007/s40596-013-0032-4
Evans, S. C., Wei, M. A., Harmon, S. L., & Weisz, J. R. (2021). Modular psychotherapy outcomes for youth with different latent profiles of irritability and emotion dysregulation. Frontiers in Psychiatry, 12, 618455. https://doi.org/10.3389/fpsyt.2021.618455
Fairchild, G., Hawes, D. J., Frick, P. J., Copeland, W. E., Odgers, C. L., Franke, B., Freitag, C. M., & De Brito, S. A. (2019). Conduct disorder. Nature Reviews Disease Primers, 5(1), 43. https://doi.org/10.1038/s41572-019-0095-y
Fanti, K. A. (2018). Understanding heterogeneity in conduct disorder: A review of psychophysiological studies. Neuroscience and Biobehavioral Reviews, 91, 4–20. https://doi.org/10.1016/j.neubiorev.2016.09.022
Fish, B. (1987). Infant predictors of the longitudinal course of schizophrenic development. Schizophrenia Bulletin, 13(3), 395–409. https://doi.org/10.1093/schbul/13.3.395
Fonagy, P., & Luyten, P. (2018). Conduct problems in youth and the RDoC approach: A developmental, evolutionary-based view. Clinical Psychology Review, 64, 57–76. https://doi.org/10.1016/j.cpr.2017.08.010
Frick, P. J., & Nigg, J. T. (2012). Current issues in the diagnosis of attention deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder. Annual Review of Clinical Psychology, 8, 77–107. https://doi.org/10.1146/annurev-clinpsy-032511-143150
Frick, P. J., Lilienfeld, S. O., Ellis, M., Loney, B., & Silverthorn, P. (1999). The association between anxiety and psychopathy dimensions in children. Journal of Abnormal Child Psychology, 27(5), 383–392. https://doi.org/10.1023/a:1021928018403
Gibb, B. E., Schofield, C. A., & Coles, M. E. (2009). Reported history of childhood abuse and young adults’ information-processing biases for facial displays of emotion. Child Maltreatment, 14(2), 148–156. https://doi.org/10.1177/1077559508326358
Gillett, C. B., Bilek, E. L., Hanna, G. L., & Fitzgerald, K. D. (2018). Intolerance of uncertainty in youth with obsessive-compulsive disorder and generalized anxiety disorder: A transdiagnostic construct with implications for phenomenology and treatment. Clinical Psychology Review, 60, 100–108. https://doi.org/10.1016/j.cpr.2018.01.007
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., 3rd, Herman, D. H., Clasen, L. S., Toga, A. W., Rapoport, J. L., & Thompson, P. M. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 8174–8179. https://doi.org/10.1073/pnas.0402680101
Goldstein, S., & Schwebach, A. J. (2004). The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: Results of a retrospective chart review. Journal of Autism and Developmental Disorders, 34(3), 329–339. https://doi.org/10.1023/b:jadd.0000029554.46570.68
Gordon, J. (2020, September 26). RDoC at Ten Years – Part 2: The Next Ten Years. Director’s Messages.
Grabb, M. C., Hillefors, M., & Potter, W. Z. (2020). The NIMH ’Fast-fail trials’ (FAST) initiative: Rationale, promise, and Progress. Pharmaceut Med, 34(4), 233–245. https://doi.org/10.1007/s40290-020-00343-y
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004). Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on alcohol and related conditions. Archives of General Psychiatry, 61(8), 807–816. https://doi.org/10.1001/archpsyc.61.8.807
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010). Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: Associations with first onset of DSM-IV disorders. Archives of General Psychiatry, 67(2), 113–123. https://doi.org/10.1001/archgenpsychiatry.2009.186
Harmon, S. L., Price, M. A., Corteselli, K. A., Lee, E. H., Metz, K., Bonadio, F. T., Hersh, J., Marchette, L. K., Rodriguez, G. M., Raftery-Helmer, J., Thomassin, K., Bearman, S. K., Jensen-Doss, A., Evans, S. C., & Weisz, J. R. (2021). Evaluating a modular approach to therapy for children with anxiety, depression, trauma, or conduct problems (MATCH) in school-based mental health care: Study protocol for a randomized controlled trial. Frontiers in Psychology, 12, 639493. https://doi.org/10.3389/fpsyg.2021.639493
Harrison, L. A., Kats, A., Williams, M. E., & Aziz-Zadeh, L. (2019). The importance of sensory processing in mental health: A proposed addition to the research domain criteria (RDoC) and suggestions for RDoC 2.0. Frontiers in Psychology, 10, 103. https://doi.org/10.3389/fpsyg.2019.00103
Heleniak, C., Jenness, J. L., Stoep, A. V., McCauley, E., & McLaughlin, K. A. (2016). Childhood maltreatment exposure and disruptions in emotion regulation: A Transdiagnostic pathway to adolescent internalizing and externalizing psychopathology. Cognitive Therapy and Research, 40(3), 394–415. https://doi.org/10.1007/s10608-015-9735-z
Henje Blom, E., Duncan, L. G., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Chesney, M., Hecht, F. M., & Yang, T. T. (2014). The development of an RDoC-based treatment program for adolescent depression: “Training for awareness, resilience, and action” (TARA). Frontiers in Human Neuroscience, 8, 630. https://doi.org/10.3389/fnhum.2014.00630
Holmes, S. E., Slaughter, J. R., & Kashani, J. (2001). Risk factors in childhood that lead to the development of conduct disorder and antisocial personality disorder. Child Psychiatry and Human Development, 31(3), 183–193. https://doi.org/10.1023/a:1026425304480
Hui, A. (2020). Exploring the utility of RDoC in differentiating effectiveness amongst antidepressants: A systematic review using proposed psychometrics as the unit of analysis for the negative valence systems domain. PLoS One, 15(12), e0243057. https://doi.org/10.1371/journal.pone.0243057
Hyman, S. E. (2007). Can neuroscience be integrated into the DSM-V? Nature Reviews. Neuroscience, 8(9), 725–732. https://doi.org/10.1038/nrn2218
Hyman, S. E. (2011). Diagnosing the DSM: Diagnostic classification needs fundamental reform. Cerebrum, 2011, 6. https://www.ncbi.nlm.nih.gov/pubmed/23447775.
Imburgio, M. J., Banica, I., Hill, K. E., Weinberg, A., Foti, D., & MacNamara, A. (2020). Establishing norms for error-related brain activity during the arrow flanker task among young adults. NeuroImage, 213, 116694. https://doi.org/10.1016/j.neuroimage.2020.116694
Insel, T. R. (2005). Psychiatry as a clinical neuroscience discipline. JAMA, 294(17), 2221. https://doi.org/10.1001/jama.294.17.2221
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167(7), 748–751. https://doi.org/10.1176/appi.ajp.2010.09091379
Jaffee, S. R., & Price, T. S. (2008). Genotype-environment correlations: Implications for determining the relationship between environmental exposures and psychiatric illness. Psychiatry, 7(12), 496–499. https://doi.org/10.1016/j.mppsy.2008.10.002
Joyner, B., & Beaver, K. M. (2021). Examining the potential link between child maltreatment and callous-unemotional traits in children and adolescents: A multilevel analysis. Child Abuse & Neglect, 122, 105327. https://doi.org/10.1016/j.chiabu.2021.105327
Kelly, S., Guimond, S., Lyall, A., Stone, W. S., Shenton, M. E., Keshavan, M., & Seidman, L. J. (2019). Neural correlates of cognitive deficits across developmental phases of schizophrenia. Neurobiology of Disease, 131, 104353. https://doi.org/10.1016/j.nbd.2018.12.013
Kempes, M., Matthys, W., de Vries, H., & van Engeland, H. (2005). Reactive and proactive aggression in children--a review of theory, findings and the relevance for child and adolescent psychiatry. European Child & Adolescent Psychiatry, 14(1), 11–19. https://doi.org/10.1007/s00787-005-0432-4
Kendler, K. S. P., & Prescott, C. A. (2006). Genes, environment, and psychopathology. The Guilford Press.
Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1992). Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Archives of General Psychiatry, 49(9), 716–722. https://doi.org/10.1001/archpsyc.1992.01820090044008
Klahr, A. M., & Burt, S. A. (2014). Evaluation of the known behavioral heterogeneity in conduct disorder to improve its assessment and treatment. Journal of Child Psychology and Psychiatry, 55(12), 1300–1310. https://doi.org/10.1111/jcpp.12268
Krystal, A. D., Pizzagalli, D. A., Smoski, M., Mathew, S. J., Nurnberger, J., Lisanby, S. H., Iosifescu, D., Murrough, J. W., Yang, H., Weiner, R. D., Calabrese, J. R., Sanacora, G., Hermes, G., Keefe, R. S. E., Song, A., Goodman, W., Szabo, S. T., Whitton, A. E., Gao, K., & Potter, W. Z. (2020). A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia. Nature Medicine, 26(5), 760–768. https://doi.org/10.1038/s41591-020-0806-7
Kwak, Y., & Huettel, S. A. (2016). Prosocial reward learning in children and adolescents. Frontiers in Psychology, 7, 1539. https://doi.org/10.3389/fpsyg.2016.01539
Lewinsohn, P. M., Shankman, S. A., Gau, J. M., & Klein, D. N. (2004). The prevalence and co-morbidity of subthreshold psychiatric conditions. Psychological Medicine, 34(4), 613–622. https://doi.org/10.1017/S0033291703001466
Lewis, D. O., Lewis, M., Unger, L., & Goldman, C. (1984). Conduct disorder and its synonyms: Diagnoses of dubious validity and usefulness. The American Journal of Psychiatry, 141(4), 514–519. https://doi.org/10.1176/ajp.141.4.514
Lijster, J. M., Dierckx, B., Utens, E. M., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S. (2017). The age of onset of anxiety disorders. Canadian Journal of Psychiatry, 62(4), 237–246. https://doi.org/10.1177/0706743716640757
Lozier, L. M., Cardinale, E. M., VanMeter, J. W., & Marsh, A. A. (2014). Mediation of the relationship between callous-unemotional traits and proactive aggression by amygdala response to fear among children with conduct problems. JAMA Psychiatry, 71(6), 627–636. https://doi.org/10.1001/jamapsychiatry.2013.4540
March-Llanes, J., Marques-Feixa, L., Mezquita, L., Fananas, L., & Moya-Higueras, J. (2017). Stressful life events during adolescence and risk for externalizing and internalizing psychopathology: A meta-analysis. European Child & Adolescent Psychiatry, 26(12), 1409–1422. https://doi.org/10.1007/s00787-017-0996-9
Marcus, J., Hans, S. L., Lewow, E., Wilkinson, L., & Burack, C. M. (1985). Neurological findings in high-risk children: Childhood assessment and 5-year followup. Schizophrenia Bulletin, 11(1), 85–100. https://doi.org/10.1093/schbul/11.1.85
Marsh, A. A., Finger, E. C., Mitchell, D. G., Reid, M. E., Sims, C., Kosson, D. S., Towbin, K. E., Leibenluft, E., Pine, D. S., & Blair, R. J. (2008). Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. The American Journal of Psychiatry, 165(6), 712–720. https://doi.org/10.1176/appi.ajp.2007.07071145
Masten, C. L., Guyer, A. E., Hodgdon, H. B., McClure, E. B., Charney, D. S., Ernst, M., Kaufman, J., Pine, D. S., & Monk, C. S. (2008). Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Child Abuse & Neglect, 32(1), 139–153. https://doi.org/10.1016/j.chiabu.2007.09.006
Maughan, A., & Cicchetti, D. (2002). Impact of child maltreatment and interadult violence on children’s emotion regulation abilities and socioemotional adjustment. Child Development, 73(5), 1525–1542. https://doi.org/10.1111/1467-8624.00488
McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010a). Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: Associations with persistence of DSM-IV disorders. Archives of General Psychiatry, 67(2), 124–132. https://doi.org/10.1001/archgenpsychiatry.2009.187
McLaughlin, K. A., Kubzansky, L. D., Dunn, E. C., Waldinger, R., Vaillant, G., & Koenen, K. C. (2010b). Childhood social environment, emotional reactivity to stress, and mood and anxiety disorders across the life course. Depression and Anxiety, 27(12), 1087–1094. https://doi.org/10.1002/da.20762
McLaughlin, K. A., Colich, N. L., Rodman, A. M., & Weissman, D. G. (2020). Mechanisms linking childhood trauma exposure and psychopathology: A transdiagnostic model of risk and resilience. BMC Medicine, 18(1), 96. https://doi.org/10.1186/s12916-020-01561-6
Milojevich, H. M., Norwalk, K. E., & Sheridan, M. A. (2019). Deprivation and threat, emotion dysregulation, and psychopathology: Concurrent and longitudinal associations. Development and Psychopathology, 31(3), 847–857. https://doi.org/10.1017/S0954579419000294
Mittal, V. A., & Wakschlag, L. S. (2017). Research domain criteria (RDoC) grows up: Strengthening neurodevelopment investigation within the RDoC framework. Journal of Affective Disorders, 216, 30–35. https://doi.org/10.1016/j.jad.2016.12.011
North, C., & Yutzy, S. (2018). Goodwin and Guze’s psychiatric diagnosis (7th ed.). Oxford University Press.
Nusslock, R., & Alloy, L. B. (2017). Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective. Journal of Affective Disorders, 216, 3–16. https://doi.org/10.1016/j.jad.2017.02.001
Olino, T. M. (2016). Future research directions in the positive valence systems: Measurement, development, and implications for youth unipolar depression. Journal of Clinical Child and Adolescent Psychology, 45(5), 681–705. https://doi.org/10.1080/15374416.2015.1118694
Oschmann, M., & Gawryluk, J. R. (2020). A longitudinal study of changes in resting-state functional magnetic resonance imaging functional connectivity networks during healthy aging. Brain Connectivity, 10(7), 377–384. https://doi.org/10.1089/brain.2019.0724
Paez, J. G., Janne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., Naoki, K., Sasaki, H., Fujii, Y., Eck, M. J., Sellers, W. R., Johnson, B. E., & Meyerson, M. (2004). EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science, 304(5676), 1497–1500. https://doi.org/10.1126/science.1099314
Perrottelli, A., Giordano, G. M., Brando, F., Giuliani, L., & Mucci, A. (2021). EEG-based measures in at-risk mental state and early stages of schizophrenia: A systematic review. Frontiers in Psychiatry, 12, 653642. https://doi.org/10.3389/fpsyt.2021.653642
Platt, B., Waters, A. M., Schulte-Koerne, G., Engelmann, L., & Salemink, E. (2017). A review of cognitive biases in youth depression: Attention, interpretation and memory. Cognition and Emotion, 31(3), 462–483. https://doi.org/10.1080/02699931.2015.1127215
Pollak, S. D., & Sinha, P. (2002). Effects of early experience on children’s recognition of facial displays of emotion. Developmental Psychology, 38(5), 784–791. https://doi.org/10.1037//0012-1649.38.5.784
Powell, J., Dawkins, L., & Davis, R. E. (2002). Smoking, reward responsiveness, and response inhibition: Tests of an incentive motivational model. Biological Psychiatry, 51(2), 151–163. https://doi.org/10.1016/s0006-3223(01)01208-2
Powers, A., & Casey, B. J. (2015). The adolescent brain and the emergence and peak of psychopathology. Journal of Infant, Child, and Adolescent Psychotherapy, 14(1), 3–15. https://doi.org/10.1080/15289168.2015.1004889
Raine, A. (2018). Antisocial personality as a neurodevelopmental disorder. Annual Review of Clinical Psychology, 14, 259–289. https://doi.org/10.1146/annurev-clinpsy-050817-084819
Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autistic traits in a population-based ADHD twin sample. Journal of Child Psychology and Psychiatry, 48(5), 464–472. https://doi.org/10.1111/j.1469-7610.2006.01720.x
Roepke, S., Vater, A., Preissler, S., Heekeren, H. R., & Dziobek, I. (2012). Social cognition in borderline personality disorder. Frontiers in Neuroscience, 6, 195. https://doi.org/10.3389/fnins.2012.00195
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., Wang, P. S., & Cuthbert, B. N. (2010). Developing constructs for psychopathology research: Research domain criteria. Journal of Abnormal Psychology, 119(4), 631–639. https://doi.org/10.1037/a0020909
Sanislow, C. A., Ferrante, M., Pacheco, J., Rudorfer, M. V., & Morris, S. E. (2019). Advancing translational research using NIMH research domain criteria and computational methods. Neuron, 101(5), 779–782. https://doi.org/10.1016/j.neuron.2019.02.024
Schmidt, U., & Vermetten, E. (2018). Integrating NIMH research domain criteria (RDoC) into PTSD research. Current Topics in Behavioral Neurosciences, 38, 69–91. https://doi.org/10.1007/7854_2017_1
Shackman, J. E., Shackman, A. J., & Pollak, S. D. (2007). Physical abuse amplifies attention to threat and increases anxiety in children. Emotion, 7(4), 838–852. https://doi.org/10.1037/1528-3542.7.4.838
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J. L. (2007). Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19649–19654. https://doi.org/10.1073/pnas.0707741104
Shaw, P., Gilliam, M., Liverpool, M., Weddle, C., Malek, M., Sharp, W., Greenstein, D., Evans, A., Rapoport, J., & Giedd, J. (2011). Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: Support for a dimensional view of attention deficit hyperactivity disorder. The American Journal of Psychiatry, 168(2), 143–151. https://doi.org/10.1176/appi.ajp.2010.10030385
Spitzer, R. L., Williams, J. B., & Skodol, A. E. (1980). DSM-III: The major achievements and an overview. The American Journal of Psychiatry, 137(2), 151–164. https://doi.org/10.1176/ajp.137.2.151
Stevens, E. S., Lieberman, L., Funkhouser, C. J., Correa, K. A., & Shankman, S. A. (2019). Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses. Psychiatry Research, 279, 207–215. https://doi.org/10.1016/j.psychres.2019.02.072
Sullivan, J. A. (2016). Stabilizing constructs through collaboration across different research fields as a way to Foster the integrative approach of the research domain criteria (RDoC) project. Frontiers in Human Neuroscience, 10, 309. https://doi.org/10.3389/fnhum.2016.00309
Sumner, J. A., Powers, A., Jovanovic, T., & Koenen, K. C. (2016). Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 171B(1), 44–64. https://doi.org/10.1002/ajmg.b.32384
Sylvers, P., Lilienfeld, S. O., & LaPrairie, J. L. (2011). Differences between trait fear and trait anxiety: Implications for psychopathology. Clinical Psychology Review, 31(1), 122–137. https://doi.org/10.1016/j.cpr.2010.08.004
Thatcher, R. W., Walker, R. A., & Giudice, S. (1987). Human cerebral hemispheres develop at different rates and ages. Science, 236(4805), 1110–1113. https://doi.org/10.1126/science.3576224
Tummeltshammer, K., Feldman, E. C. H., & Amso, D. (2019). Using pupil dilation, eye-blink rate, and the value of mother to investigate reward learning mechanisms in infancy. Developmental Cognitive Neuroscience, 36, 100608. https://doi.org/10.1016/j.dcn.2018.12.006
Underwood, R., Kumari, V., & Peters, E. (2016). Cognitive and neural models of threat appraisal in psychosis: A theoretical integration. Psychiatry Research, 239, 131–138. https://doi.org/10.1016/j.psychres.2016.03.016
Unick, G. J., Snowden, L., & Hastings, J. (2009). Heterogeneity in comorbidity between major depressive disorder and generalized anxiety disorder and its clinical consequences. The Journal of Nervous and Mental Disease, 197(4), 215–224. https://doi.org/10.1097/NMD.0b013e31819d954f
Urben, S., Habersaat, S., Pihet, S., Suter, M., de Ridder, J., & Stephan, P. (2018). Specific contributions of age of onset, callous-unemotional traits and impulsivity to reactive and proactive aggression in youths with conduct disorders. The Psychiatric Quarterly, 89(1), 1–10. https://doi.org/10.1007/s11126-017-9506-y
van Duijvenvoorde, A. C. K., Westhoff, B., de Vos, F., Wierenga, L. M., & Crone, E. A. (2019). A three-wave longitudinal study of subcortical-cortical resting-state connectivity in adolescence: Testing age- and puberty-related changes. Human Brain Mapping, 40(13), 3769–3783. https://doi.org/10.1002/hbm.24630
Viding, E., Sebastian, C. L., Dadds, M. R., Lockwood, P. L., Cecil, C. A., De Brito, S. A., & McCrory, E. J. (2012). Amygdala response to preattentive masked fear in children with conduct problems: The role of callous-unemotional traits. The American Journal of Psychiatry, 169(10), 1109–1116. https://doi.org/10.1176/appi.ajp.2012.12020191
Walker, E. F. (1994). Developmentally moderated expressions of the neuropathology underlying schizophrenia. Schizophrenia Bulletin, 20(3), 453–480. https://doi.org/10.1093/schbul/20.3.453
Walker, E. F., Savoie, T., & Davis, D. (1994). Neuromotor precursors of schizophrenia. Schizophrenia Bulletin, 20(3), 441–451. https://doi.org/10.1093/schbul/20.3.441
Walther, S., Bernard, J. A., Mittal, V. A., & Shankman, S. A. (2019). The utility of an RDoC motor domain to understand psychomotor symptoms in depression. Psychological Medicine, 49(2), 212–216. https://doi.org/10.1017/S0033291718003033
Weems, C. F. (2008). Developmental trajectories of childhood anxiety: Identifying continuity and change in anxious emotion. Developmental Review, 28(4), 488–502.
Weissman, D. G., Bitran, D., Miller, A. B., Schaefer, J. D., Sheridan, M. A., & McLaughlin, K. A. (2019). Difficulties with emotion regulation as a transdiagnostic mechanism linking child maltreatment with the emergence of psychopathology. Development and Psychopathology, 31(3), 899–915. https://doi.org/10.1017/S0954579419000348
White, S. F., VanTieghem, M., Brislin, S. J., Sypher, I., Sinclair, S., Pine, D. S., Hwang, S., & Blair, R. J. (2016). Neural correlates of the propensity for retaliatory behavior in youths with disruptive behavior disorders. The American Journal of Psychiatry, 173(3), 282–290. https://doi.org/10.1176/appi.ajp.2015.15020250
Whitton, A. E., Kumar, P., Treadway, M. T., Rutherford, A. V., Ironside, M. L., Foti, D., Fitzmaurice, G., Du, F., & Pizzagalli, D. A. (2021). Mapping disease course across the mood disorder Spectrum through a research domain criteria framework. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(7), 706–715. https://doi.org/10.1016/j.bpsc.2021.01.004
Wu, W., Zhang, Y., Jiang, J., Lucas, M. V., Fonzo, G. A., Rolle, C. E., Cooper, C., Chin-Fatt, C., Krepel, N., Cornelssen, C. A., Wright, R., Toll, R. T., Trivedi, H. M., Monuszko, K., Caudle, T. L., Sarhadi, K., Jha, M. K., Trombello, J. M., Deckersbach, T., Adams, P., McGrath, P. J., Weissman, M. M., Fava, M., Pizzagalli, D. A., Arns, M., Trivedi, M. H., & Etkin, A. (2020). An electroencephalographic signature predicts antidepressant response in major depression. Nature Biotechnology, 38(4), 439–447. https://doi.org/10.1038/s41587-019-0397-3
Yager, J., & Feinstein, R. E. (2017). Potential applications of the National Institute of Mental Health’s research domain criteria (RDoC) to clinical psychiatric practice: How RDoC might be used in assessment, diagnostic processes, case formulation, treatment planning, and clinical notes. The Journal of Clinical Psychiatry, 78(4), 423–432. https://doi.org/10.4088/JCP.15nr10476
Zelazo, P. D. (2020). Executive function and psychopathology: A neurodevelopmental perspective. Annual Review of Clinical Psychology, 16, 431–454. https://doi.org/10.1146/annurev-clinpsy-072319-024242
Zimmerman, M., Ellison, W., Young, D., Chelminski, I., & Dalrymple, K. (2015). How many different ways do patients meet the diagnostic criteria for major depressive disorder? Comprehensive Psychiatry, 56, 29–34. https://doi.org/10.1016/j.comppsych.2014.09.007
Zoccolillo, M., Pickles, A., Quinton, D., & Rutter, M. (1992). The outcome of childhood conduct disorder: Implications for defining adult personality disorder and conduct disorder. Psychological Medicine, 22(4), 971–986. https://doi.org/10.1017/s003329170003854x
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Cozza, E., Spring, J., Nabb, C., Shankman, S. (2023). NIMH’s Research Domain Criteria (RDoC) and Clinical Child Psychology. In: Matson, J.L. (eds) Handbook of Clinical Child Psychology. Autism and Child Psychopathology Series. Springer, Cham. https://doi.org/10.1007/978-3-031-24926-6_6
Download citation
DOI: https://doi.org/10.1007/978-3-031-24926-6_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-24925-9
Online ISBN: 978-3-031-24926-6
eBook Packages: Behavioral Science and PsychologyBehavioral Science and Psychology (R0)