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Benign Spinal Tumors

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Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1405))

Abstract

Benign spinal intradural tumors are relatively rare and include intramedullary tumors with a favorable histology such as low-grade astrocytomas and ependymomas, as well as intradural extramedullary tumors such as meningiomas and schwannomas. The effect on the neural tissue is usually a combination of mass effect and neuronal involvement in cases of infiltrative tumors. The new understanding of molecular profiling of different tumors allowed us to better define central nervous system tumors and tailor treatment accordingly. The mainstay of management of many intradural spinal tumors is maximal safe surgical resection. This goal is more achievable with intradural extramedullary tumors; yet, with a meticulous surgical approach, many of the intramedullary tumors are amenable for safe gross-total or near-total resection. The nature of these tumors is benign; hence, a different way to measure outcome success is pursued and usually depends on functional rather than oncological or survival outcomes.

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Abbreviations

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

DA:

Diffuse infiltrative astrocytoma

GTR:

Gross-total resection

LGG:

Low-grade glioma

MISME:

Multiple inherited schwannomas, meningiomas, and ependymomas

MRI:

Magnetic resonance imaging

OS:

Overall survival

PFS:

Progression-free survival

RT:

Radiation therapy

SBRT:

Stereotactic body radiation therapy

SEER:

Surveillance, Epidemiology, and End Results

SRS:

Stereotactic radiosurgery

STR:

Sub-total resection

T1WI:

T1-weighted images

VHL:

Von Hippel-Lindau

WHO:

World Health Organization

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Authors and Affiliations

  1. Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA

    Mohammad Hassan A. Noureldine

  2. Institute for Brain Protection Sciences, Johns Hopkins University School of Medicine, Johns Hopkins All Children’s Hospital, Saint Petersburg, FL, USA

    Mohammad Hassan A. Noureldine

  3. Institute of Neuroscience, Geisinger Medical Center, Geisinger Commonwealth School of Medicine, Danville, PA, USA

    Nir Shimony

  4. Institute for Brain Protections Sciences, Johns Hopkins All Children’s Hospital, Saint Petersburg, FL, USA

    Nir Shimony

  5. Institute for Brain Protections Sciences, Johns Hopkins All Children’s Hospital, Saint Petersburg, FL, USA

    George I. Jallo

  6. Department of Surgery, St Jude Children’s Research Hospital, Memphis, USA

    Nir Shimony

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  1. Mohammad Hassan A. Noureldine
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  3. George I. Jallo
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Correspondence to George I. Jallo .

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  1. Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  2. Tehran University of Medical Sciences, Tehran, Iran

    Sara Hanaei

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Noureldine, M.H.A., Shimony, N., Jallo, G.I. (2023). Benign Spinal Tumors. In: Rezaei, N., Hanaei, S. (eds) Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2. Advances in Experimental Medicine and Biology, vol 1405. Springer, Cham. https://doi.org/10.1007/978-3-031-23705-8_23

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