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Neuropathy

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Transplantation of the Pancreas

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Abstract

Polyneuropathy affecting somatic and autonomic nerves is a common and disabling secondary complication of long-term diabetes mellitus. The vast majority of type 1 diabetic patients undergoing a pancreas transplant (PTx) have already developed moderate-to-severe neuropathy involving all nerve function modalities, as evaluated by neurological examination, motor and sensory nerve conduction, cardiovascular and sudomotor autonomic tests. Our large prospective study with 10 years of follow-up demonstrated that polyneuropathy improved in patients who achieved a normoglycemic state after a successful PTx, in contrast to the progression observed in the control group that was treated with insulin. Improvement was maintained over 10-year follow-up after PTx and was more marked for somatic than for autonomic functions. The improvement of nerve function contributed to a higher level in general life activities, and also correlated with a significant reduction in mortality in transplanted patients.

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Authors and Affiliations

  1. Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, and CIBERNED, Universitat Autònoma de Barcelona, Bellaterra, Spain

    Xavier Navarro

  2. Faculty of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain

    Xavier Navarro

  3. Department of Neurology, University of Minnesota, Minneapolis, MN, USA

    William R. Kennedy

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  1. Xavier Navarro
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  2. William R. Kennedy
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Correspondence to Xavier Navarro .

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Editors and Affiliations

  1. Department of Surgery, State University of New York (SUNY), Downstate Health Sciences University, Brooklyn, NY, USA

    Rainer W. G. Gruessner

  2. Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Angelika C. Gruessner

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Navarro, X., Kennedy, W.R. (2023). Neuropathy. In: Gruessner, R.W.G., Gruessner, A.C. (eds) Transplantation of the Pancreas. Springer, Cham. https://doi.org/10.1007/978-3-031-20999-4_59

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  • DOI: https://doi.org/10.1007/978-3-031-20999-4_59

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