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Recent Developments in the Treatment of Bacterial Meningitis

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Abstract

There are 1.2 million cases of bacterial meningitis each year, with about one fifth of these cases resulting in significant morbidity and mortality, usually in lower-resource countries. Early antibiotic treatment has been demonstrated to improve the morbidity and mortality of this disease. Because many organisms can cause bacterial meningitis, empiric antibiotic treatment must remain broad based on the likelihood of the causative organism, which can be estimated by the age of the patient. The most common organisms that cause bacterial meningitis include Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes, and Haemophilus influenzae. Most of the disease burden is concentrated in vulnerable populations, such as the neonatal and geriatric populations as well as immunocompromised individuals. Though there are currently many effective antibiotic therapies for bacterial meningitis, with the increasing issue of antibiotic resistance and remaining significant morbidity and mortality from bacterial meningitis, non-antibiotic therapies are currently being trialed to propel this area forward. In addition to antibiotic therapy, immunotherapy and vaccination show great promise in lessening the disease burden of bacterial meningitis worldwide.

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  1. University of South Florida Morsani College of Medicine, MD Program, Tampa, FL, USA

    Dao Le, Deborah Liaw, Nicole Naterelli & Brian Longbottom

  2. University of South Florida Morsani College of Medicine, Department of Molecular Pharmacology & Physiology, Tampa, FL, USA

    Charles Preuss

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    Ranjita Shegokar

  2. Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant Pathak

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Le, D., Liaw, D., Naterelli, N., Longbottom, B., Preuss, C. (2023). Recent Developments in the Treatment of Bacterial Meningitis. In: Shegokar, R., Pathak, Y. (eds) Infectious Diseases Drug Delivery Systems. Springer, Cham. https://doi.org/10.1007/978-3-031-20521-7_16

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