Abstract
The role of extracellular matrix (ECM) proteins in the regulation of angiogenesis has been the focus of numerous studies aiming at understanding the interplay of endothelial cells with their microenvironment. Collagens are the most abundant ECM proteins that regulate angiogenesis through complicated, well-orchestrated mechanisms that are not elucidated yet for all collagen types. It seems that collagens can have both stimulatory and inhibitory effects on angiogenic processes, depending on the type of collagen and the presence and activity of the numerous enzymes that act proteolytically and either free growth factors from the ECM or result in the generation of the inhibitory collagen fragments known as matrikines. In the present chapter, we summarize the basic knowledge on the effect of collagens, collagen-degrading enzymes, and collagen fragments on angiogenesis in vitro and in vivo, highlighting the complexity of the described data and the necessity to develop better models to include the heterogeneity of the collagen-related microenvironment for the regulation of vessel growth.
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Kanellopoulou, V.Κ., Xanthopoulos, A., Mikelis, C.M., Papadimitriou, E. (2023). Collagens and Collagen-Degrading Enzymes in the Regulation of Angiogenesis. In: Papadimitriou, E., Mikelis, C.M. (eds) Matrix Pathobiology and Angiogenesis. Biology of Extracellular Matrix, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-031-19616-4_4
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