Abstract
For a long time, animals have been employed in research and studies. Even in affluent countries with Judeo-Christian ethical foundations, unambiguous ethical principles and relevant legislation were only enacted in the last several decades. We address the fundamentals of animal research ethics, ethical review and compliance criteria for animal experiments around the world, “our” fundamentals of institutional animal research ethics instruction and emerging alternatives to animal research in a concise manner. This book was painstakingly put together for scientists who are interested in or participating in animal research. We will go over some of the most important animal ethics ideas in this chapter. Even though ethical review and compliance guidelines for animal experiments are similar across industrialized nations, ethical review and compliance guidelines for animal experimentation vary.
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References
Advisory Committee on Dangerous Pathogens (ACDP). (2004). The approved list of biological agents. Health and Safety Executive.
Arango, M. T., Quintero, R. P., Castiblanco, J., et al. (2013). Cell culture and cell analysis. Rosario University Press.
Bauer, K., Taub, S., & Parsi, K. (2004). Ethical issues in tissue banking for research: a brief review of existing organizational policies. Theoretical Medicine and Bioethics, 25(2), 113–142.
British Association of Tissue Banking. General Standards for Tissue Banking. (September 29, 1999)
Brown, W. M. (2003). Intellectual property law: a primer for scientists. Molecular Biotechnology, 23(3), 213–224.
Cebo, D. (2019). Public opinion about stem cell research and human cloning – The bioethics of stem cell research and therapy. Global Journal of Community Medicine
Cornish, W. R. (1989). Intellectual property: Patents, copyright, trade marks, and allied rights (2nd ed.). Sweet & Maxwell.
Corral-Vázquez, C., Aguilar-Quesada, R., Catalina, P., Lucena-Aguilar, G., Ligero, G., Miranda, B., & Carrillo-Ávila, J. A. (2017). Cell lines authentication and mycoplasma detection as minimun quality control of cell lines in biobanking. Cell and Tissue Banking, 18, 271–280.
Coté, R. J. (2001). Aseptic technique for cell culture. Current Protocols in Cell Biology.
Dennert, K., & Kumar, R. (2021). Traceability methods for cell line authentication and mycoplasma detection. SLAS Technology, 26, 630–636.
Drexler, H. G., & Matsuo, Y. (1999). Guidelines for the characterization and publication of human malignant hematopoietic cell lines. Leukemia, 13, 835–842.
Geraghty, R. J., Capes-Davis, A., Davis, J. M., Downward, J., Freshney, R. I., Knezevic, I., et al. (2014). Guidelines for the use of cell lines in biomedical research. British Journal of Cancer, 111, 1021–1046.
How can stem cells advance medicine? (2007). Nature Reports Stem Cells.
Hu, P., Zhang, W., Xin, H., & Deng, G. (2016). Single cell isolation and analysis. Frontiers in Cell and Developmental Biology, 4, 116.
Isasi, R., Knoppers, B. M., Andrews, P. W., Bredenoord, A., Colman, A., Hin, L. E., & Zeng, F. (2012). Disclosure and management of research findings in stem cell research and banking: Policy statement. Regenerative Medicine, 7, 439.
Josefson, D. (2000). Human tissue for sale: what are the costs? The Western Journal of Medicine, 173, 302–303.
Karlsson, J. O., & Toner, M. (1996). Long-term storage of tissues by cryopreservation: critical issues. Biomaterials, 17, 243–256.
Karpowicz, P., Cohen, C. B., & van der Kooy, D. (2004). It is ethical to transplant human stem cells into nonhuman embryos. Nature Medicine, 10, 331–335.
Langer, R., & Vacanti, J. P. (1993). Tissue engineering. Science, 260(5110), 920–926.
Le Douarin, N., Dieterlen-Lièvre, F., Creuzet, S., & Teillet, M. A. (2008). Quail-chick transplantations. Methods in Cell Biology, 19–58.
McKeehan, W. L., Barnes, D., Reid, L., Stanbridge, E., Murakami, H., & Sato, G. H. (1990). Frontiers in mammalian cell culture. In Vitro Cellular & Developmental Biology, 9–23.
Merten, O.- W. (2015). Advances in cell culture: Anchorage dependence. Philosophical Transactions of the Royal Society of London 20140040-20140040.
Moysidou, C.-M., Barberio, C., & Owens, R. M. (2021). Advances in engineering human tissue models. Frontiers in Bioengineering and Biotechnology, 8, 620962.
Muth, D., Corman, V. M., Roth, H., Binger, T., Dijkman, R., Gottula, L. T., et al. (2018). Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission. Scientific Reports, 8, 15177.
National Research Council (US) Committee on Hazardous Biological Substances in the Laboratory. Biosafety In The Laboratory: Prudent Practices for the Handling and Disposal of Infectious Materials. Appendix A, Biosafety in Microbiological and Biomedical Laboratories. (1989). Washington (DC): Washington (DC): National Academies Press (US)
Naveca, F., Nascimentio, V., Souza, V., et al. (2021). Phylogenetic relationship of SARS-CoV-2 sequences from Amazonas with emerging Brazilian variants harboring mutations E484K and N501Y in the Spike protein.
Pegg, D. E. (2007). Principles of cryopreservation. Methods in Molecular Biology, 368, 39–57.
Poticha, D., & Duncan, M. W. (2019). Intellectual property-the foundation of innovation: a scientist’s guide to intellectual property. Journal of Mass Spectrometry, 54, 288–300.
Raj, G. M., Priyadarshini, R., & Mathaiyan, J. (2015). Drug patents and intellectual property rights. European Journal of Clinical Pharmacology, 71, 403–409.
Segeritz, C.–. P., & Vallier, L. (2017). Cell culture: Growing cells as model systems in vitro. Basic Science Methods for Clinical Researchers, 151–172.
Singh, B., Mal, G., Gautam, S. K., & Mukesh, M. (2019). Intellectual property rights in animal biotechnology. Advances in Animal Biotechnology, 527–530.
Srour, E., Zanjani, E., Brandt, J., Leemhuis, T., Briddell, R., Heerema, N., & Hoffman, R. (1992). Sustained human hematopoiesis in sheep transplanted in utero during early gestation with fractionated adult human bone marrow cells. Blood, 79, 1404–1412.
Stacey, G. N. (2011). Cell culture contamination. Methods in Molecular Biology, 731, 79–91.
Verma, A., Verma, M., & Singh, A. (2020). Animal tissue culture principles and applications. Animal Biotechnology, 269–293.
Voss, T., Paranjpe, A. S., Cook, T. G., & Garrison, N. D. W. (2017). A short introduction to intellectual property rights. Techniques in Vascular and Interventional Radiology, 20, 116–120.
Webber, P. M. (2003). A guide to drug discovery. Protecting your inventions: the patent system. Nature Reviews. Drug Discovery, 2, 823–830.
WHO. (2021). COVID-19 new variants: knowledge gaps and research. WHO R&D Blueprint.
Yang, L., Li, C., Chen, L., & Li, Z. (2009). An agarose-gel based method for transporting cell lines. Current Chemical Genomics, 3, 50–53.
Zhang, W., Davis, B. D., Chen, S. S., Sincuir Martinez, J. M., Plummer, J. T., & Vail, E. (2021). Emergence of a novel SARS-CoV-2 variant in Southern California. JAMA, 325, 1324–1326.
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Jindal, D., Vaishanavi, Singh, M. (2023). Ethical Issues in Animal Cell Culture. In: Animal Cell Culture: Principles and Practice. Techniques in Life Science and Biomedicine for the Non-Expert. Springer, Cham. https://doi.org/10.1007/978-3-031-19485-6_20
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DOI: https://doi.org/10.1007/978-3-031-19485-6_20
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