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The Enzymatic Core of Snakes

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XLV Mexican Conference on Biomedical Engineering (CNIB 2022)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 86))

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Abstract

The snake’s venom conformation consists of several enzymes and other proteins which all contribute to the envenomation phenomena. Our objective consists in finding an enzymatic core along a snake-population study in order to achieve a better understanding of the role played by these enzymes. Such identification will build up our hypothesis that all venomous organisms share an enzymatic core. For enzymes identification, transcriptomic data available from selected snake species was processed, followed by an intersection analysis. An enzymatic core composed by 50 enzyme classes was found with an overall high presence of hydrolases. Unexpectedly, among the core components, an elevated amount of serine endopeptidases was identified and associated to the enhancement of the venom’s action in its host, which has been described in the properties of Furin in Loxosceles’ venom. Evidence was found of a correlation between previously described scorpion’s enzymatic core and snake’s enzymatic core described herein, supporting the idea of a shared enzymatic core among all venomous animals.

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Authors and Affiliations

  1. Translational Bioengineering Department, Exact Sciences and Engineering University Center, Universidad de Guadalajara, 44430, Guadalajara, Mexico

    Leonardo Juárez-Zucco, Victor Alvarado-Aparicio, Teresa Romero-Gutiérrez & Ernesto Borrayo

Authors
  1. Leonardo Juárez-Zucco
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  2. Victor Alvarado-Aparicio
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  3. Teresa Romero-Gutiérrez
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  4. Ernesto Borrayo
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Corresponding author

Correspondence to Ernesto Borrayo .

Editor information

Editors and Affiliations

  1. Instituto Nacional de Rehabilitación-LGII, Mexico, Mexico

    Citlalli Jessica Trujillo-Romero

  2. Departamento de Ingeniería Eléctrica y Computación, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Mexico

    Rafael Gonzalez-Landaeta

  3. Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Mexico

    Christian Chapa-González

  4. Facultad de Ciencias Campus Pedregal, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Guadalupe Dorantes-Méndez

  5. Universidad Autónoma de Baja California, Ensenada, Mexico

    Dora-Luz Flores

  6. Conacyt-Instituto Tecnológico de Orizaba, Orizaba, Mexico

    J. J. Agustin Flores Cuautle

  7. Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana Iztapalapa, Mexico, Mexico

    Martha R. Ortiz-Posadas

  8. Departamento de Bioingeniería Traslacional, Universidad de Guadalajara, Guadalajara, Mexico

    Ricardo A. Salido Ruiz

  9. Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, Mexico

    Esmeralda Zuñiga-Aguilar

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Juárez-Zucco, L., Alvarado-Aparicio, V., Romero-Gutiérrez, T., Borrayo, E. (2023). The Enzymatic Core of Snakes. In: Trujillo-Romero, C.J., et al. XLV Mexican Conference on Biomedical Engineering. CNIB 2022. IFMBE Proceedings, vol 86. Springer, Cham. https://doi.org/10.1007/978-3-031-18256-3_26

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  • DOI: https://doi.org/10.1007/978-3-031-18256-3_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-18255-6

  • Online ISBN: 978-3-031-18256-3

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