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Metal Nanoparticles in Tuberculosis

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Tubercular Drug Delivery Systems

Abstract

Tuberculosis (TB) is a bacterial illness that affects a number of human organs, predominantly the lungs but also the liver, spleen, and spine. It causes fever, fatigue, and a chronic cough, among other symptoms, and can be fatal if not treated effectively. Every year, ten million people contract active tuberculosis, with an estimated 1.3 million deaths. Oral administration of a combination of first-line anti-TB medicines for at least 6 months is recommended by current treatment guidelines. Patient compliance is poor due to extensive treatment times and poor pharmacokinetics, as well as side effects of drugs, which have accelerated the emergence of multidrug-resistant (MDR) organisms. All of this, together with the scarcity of novel TB drugs to treat MDR-TB and shorten typical treatment times, has underlined the need for new targeted drug delivery methods. In this regard, there has recently been a focus on nanotechnology to construct organic or/and metal, bi-metal nanoparticles loaded with TB drugs for targeted delivery via the inhaled route to improve their efficacy. This chapter identifies recent studies that have employed metal nanoparticles to provide a reliable diagnostic system and an inhaled drug delivery system to more effectively treat TB.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India

    Nilayan Guha & Md. Kamaruz Zaman

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  1. Nilayan Guha
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Correspondence to Md. Kamaruz Zaman .

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    Ranjita Shegokar

  2. Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant Pathak

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Guha, N., Zaman, M.K. (2023). Metal Nanoparticles in Tuberculosis. In: Shegokar, R., Pathak, Y. (eds) Tubercular Drug Delivery Systems. Springer, Cham. https://doi.org/10.1007/978-3-031-14100-3_3

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