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Orthostatic Hypotension and Diabetes

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Blood Pressure Disorders in Diabetes Mellitus

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

Abstract

Diabetes mellitus (DM) is associated with the development of premature cardiovascular disease, which relates to the clustering of risk factors among which arterial hypertension stands out. However, the spectrum of blood pressure (BP) alterations in patients with DM not only is limited to a variety of hypertensive phenotypes (i.e., sustained, masked, nocturnal, and white coat hypertension) but also includes the opposite phenomenon represented by hypotension, and in particular, orthostatic hypotension (OH). OH is a dangerous condition whose failure to identify leads to an underestimation of the global cardiovascular risk in the general population and in the hypertensive and diabetic setting.

Thus, this present chapter will review a number of issues concerning OH and its association to DM with particular attention to: (I) pathogenetic mechanisms, (II) prevalence and clinical correlates, (III) prognostic significance, (IV) impact of drugs on orthostatic regulation of BP, and (V) clinical aspects and therapeutic interventions.

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Authors and Affiliations

  1. Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

    Cesare Cuspidi

  2. Department of Clinical Sciences and Community Health, University of Milano and Fondazione Ospedale Maggiore IRCCS Policlinico di Milano, Milan, Italy

    Elisa Gherbesi & Carla Sala

  3. University Clinical Hospital Centre “Dragisa Misovic”, Belgrade, Serbia

    Marijana Tadic

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  1. Cesare Cuspidi
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  2. Elisa Gherbesi
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  3. Carla Sala
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  4. Marijana Tadic
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Correspondence to Cesare Cuspidi .

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Editors and Affiliations

  1. American University of Beirut Medical Center, Beirut, Lebanon

    Adel E. Berbari

  2. University of Milano-Bicocca, Milano, Italy

    Giuseppe Mancia

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Cuspidi, C., Gherbesi, E., Sala, C., Tadic, M. (2023). Orthostatic Hypotension and Diabetes. In: Berbari, A.E., Mancia, G. (eds) Blood Pressure Disorders in Diabetes Mellitus. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-031-13009-0_29

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  • DOI: https://doi.org/10.1007/978-3-031-13009-0_29

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