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ERβ and Inflammation

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Nuclear Receptors in Human Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1390))

Abstract

Estrogen, through the regulation of cytokine production, can act both as pro-inflammatory and anti-inflammatory signals dependent on the tissue context. In breast cancer cells, ERα is known to modulate inflammatory signaling through interaction with NFκB. Whether ERβ has a role in inflammation is less explored. Low levels of ERβ have been corroborated in several immune-related organs and, for example, in colonic epithelial cells. Specifically, an impact of ERβ on colitis and colitis-associated colorectal cancer (CRC) is experimentally supported, using ERβ-selective agonists, full-body ERβ knockout mice and, most recently, intestinal epithelial-specific knockout mice. An intricate crosstalk between ERβ and TNFα/NFκB signaling in the colon is supported, and ERβ activation appears to reduce macrophage infiltration also during high fat diet (HFD)-induced colon inflammation. Finally, the gut microbiota plays a fundamental role in the pathogenesis of colitis and ERβ has been indicated to modulate the microbiota diversity during colitis and colitis-induced CRC. ERβ is thus proposed to protect against colitis, by modulating NFκB signaling, immune cell infiltration, and/or microbiota composition. Selective activation of ERβ may therefore constitute a suitable preventative approach for the treatment of for example colitis-associated CRC.

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Acknowledgements

This work was supported by the Swedish Cancer Society (21 1632 Pj), Swedish Research Council (2017-01658), and Stockholm County Council (RS2021-0316).

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Authors and Affiliations

  1. SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna, Sweden

    Linnea Hases, Amena Archer & Cecilia Williams

  2. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

    Linnea Hases, Amena Archer & Cecilia Williams

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  1. Linnea Hases
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  2. Amena Archer
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  3. Cecilia Williams
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Correspondence to Cecilia Williams .

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Editors and Affiliations

  1. College of Pharmacy, The Ohio State University, Columbus, OH, USA

    Moray J. Campbell

  2. Department of Surgery & Cancer, Imperial College London, London, UK

    Charlotte L. Bevan

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Hases, L., Archer, A., Williams, C. (2022). ERβ and Inflammation. In: Campbell, M.J., Bevan, C.L. (eds) Nuclear Receptors in Human Health and Disease. Advances in Experimental Medicine and Biology, vol 1390. Springer, Cham. https://doi.org/10.1007/978-3-031-11836-4_12

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