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Timeline and Infectious Disease Evaluation of Candidates to New Therapies

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Infectious Complications in Biologic and Targeted Therapies

Abstract

Patients on biologic and targeted therapies have a higher risk of developing life-threatening infectious diseases. Most of these infections can be avoided by a correct prophylactic treatment and a carefully planned follow-up. A thorough medical history before starting treatment is required. The physician must take into account the mechanism of action of the biologic agent and the expected impact on the infection risk. Moreover, the physician should also consider the patient’s underlying diseases, prior and concurrent immunosuppressive treatments, and the patient’s birthplace and countries where he or she has lived. It is important to address all these factors so that biologic and targeted therapies are safely used.

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References

  1. Fernandez-Ruiz M, Meije Y, Manuel O, Akan H, Carratala J, Aguado JM, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (introduction). Clin Microbiol Infect. 2018;24(Suppl 2):S2–9.

    Article  PubMed  Google Scholar 

  2. Godfrey MS, Friedman LN. Tuberculosis and biologic therapies: anti-tumor necrosis factor-alpha and beyond. Clin Chest Med. 2019;40(4):721–39.

    Article  PubMed  Google Scholar 

  3. Cantini F, Niccoli L, Goletti D. Adalimumab, etanercept, infliximab, and the risk of tuberculosis: data from clinical trials, national registries, and postmarketing surveillance. J Rheumatol Suppl. 2014;91:47–55.

    Article  CAS  PubMed  Google Scholar 

  4. Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors). Clin Microbiol Infect. 2018;24(Suppl 2):S21–40.

    Article  CAS  PubMed  Google Scholar 

  5. Nolfi-Donegan D, Konar M, Vianzon V, MacNeil J, Cooper J, Lurie P, et al. Fatal nongroupable Neisseria meningitidis disease in vaccinated patient receiving eculizumab. Emerg Infect Dis. 2018;24(8)

    Google Scholar 

  6. Crew PE, Abara WE, McCulley L, Waldron PE, Kirkcaldy RD, Weston EJ, et al. Disseminated gonococcal infections in patients receiving eculizumab: a case series. Clin Infect Dis. 2019;69(4):596–600.

    Article  PubMed  Google Scholar 

  7. Multani A, Ho DY. JC polyomavirus infection potentiated by biologics. Infect Dis Clin N Am. 2020;34(2):359–88.

    Article  Google Scholar 

  8. Mills EA, Mao-Draayer Y. Understanding progressive multifocal leukoencephalopathy risk in multiple sclerosis patients treated with immunomodulatory therapies: a bird’s eye view. Front Immunol. 2018;9:138.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Grebenciucova E, Berger JR. Progressive multifocal leukoencephalopathy. Neurol Clin. 2018;36(4):739–50.

    Article  PubMed  Google Scholar 

  10. Vennegoor A, van Rossum JA, Leurs C, Wattjes MP, Rispens T, Murk JL, et al. High cumulative JC virus seroconversion rate during long-term use of natalizumab. Eur J Neurol. 2016;23(6):1079–85.

    Article  CAS  PubMed  Google Scholar 

  11. Redelman-Sidi G, Michielin O, Cervera C, Ribi C, Aguado JM, Fernandez-Ruiz M, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors). Clin Microbiol Infect. 2018;24(Suppl 2):S95–S107.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mikulska M, Lanini S, Gudiol C, Drgona L, Ippolito G, Fernandez-Ruiz M, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52). Clin Microbiol Infect. 2018;24(Suppl 2):S71–82.

    Article  CAS  PubMed  Google Scholar 

  13. Wolach O, Bairey O, Lahav M. Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature. Medicine (Baltimore). 2010;89(5):308–18.

    Article  Google Scholar 

  14. Ogawa E, Wei MT, Nguyen MH. Hepatitis B virus reactivation potentiated by biologics. Infect Dis Clin N Am. 2020;34(2):341–58.

    Article  Google Scholar 

  15. Ciccullo A, Ponziani FR, Maiolo E, Pallavicini F, Pompili M. Late reactivation of hepatitis B virus after rituximab-containing chemotherapy for mantle cell lymphoma: a case report. Infection. 2019;47(2):313–6.

    Article  PubMed  Google Scholar 

  16. Quiros S, de la Rosa D, Uranga A, Madero R, Amaro R, Bruguera N, et al. Screening for latent tuberculosis infection in patients who are candidate for biological therapies in Spain? A multidisciplinary survey. Arch Bronconeumol. 2018;54(10):510–7.

    Article  PubMed  Google Scholar 

  17. Smith MY, Attig B, McNamee L, Eagle T. Tuberculosis screening in prescribers of anti-tumor necrosis factor therapy in the European Union. Int J Tuberc Lung Dis. 2012;16(9):1168–73.

    Article  CAS  PubMed  Google Scholar 

  18. Benamu E, Montoya JG. Infections associated with the use of eculizumab: recommendations for prevention and prophylaxis. Curr Opin Infect Dis. 2016;29(4):319–29.

    Article  CAS  PubMed  Google Scholar 

  19. Drgona L, Gudiol C, Lanini S, Salzberger B, Ippolito G, Mikulska M. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4). Clin Microbiol Infect. 2018;24(Suppl 2):S83–94.

    Article  PubMed  Google Scholar 

  20. Burza S, Croft SL, Boelaert M. Leishmaniasis. Lancet. 2018;392(10151):951–70.

    Article  PubMed  Google Scholar 

  21. Tektonidou MG, Skopouli FN. Visceral leishmaniasis in a patient with psoriatic arthritis treated with infliximab: reactivation of a latent infection? Clin Rheumatol. 2008;27(4):541–2.

    Article  PubMed  Google Scholar 

  22. Tung Chen Y, Perales C, Lacruz J, Senent L, Salavert M. Visceral leishmaniasis infection during adalimumab therapy: a case report and literature review. Int J Rheum Dis. 2014;17(7):822–4.

    Article  PubMed  Google Scholar 

  23. Casabianca A, Marchetti M, Zallio F, Feyles E, Concialdi E, Ferroglio E, et al. Seronegative visceral leishmaniasis with relapsing and fatal course following rituximab treatment. Infection. 2011;39(4):375–8.

    Article  CAS  PubMed  Google Scholar 

  24. Pitini V, Cascio A, Arrigo C, Altavilla G. Visceral leishmaniasis after alemtuzumab in a patient with chronic lymphocytic leukaemia. Br J Haematol. 2012;156(1):1.

    Article  PubMed  Google Scholar 

  25. Haeseleer C, Martiny D, Van Laethem Y, Cantinieaux B, Martin C. Reactivation of Plasmodium infection during a treatment with infliximab: a case report. Int J Infect Dis. 2020;91:101–3.

    Article  CAS  PubMed  Google Scholar 

  26. Vacas AS, Gomez-Santana LV, Torre AC, Galimberti RL. Reactivation of Chagas-Mazza disease during treatment with infliximab. An Bras Dermatol. 2017;92(6):899–900.

    Article  PubMed  Google Scholar 

  27. Krishnamurthy R, Dincer HE, Whittemore D. Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis after anti-TNF-alpha therapy. J Clin Rheumatol. 2007;13(3):150–2.

    Article  PubMed  Google Scholar 

  28. Umekita K, Hashiba Y, Kariya Y, Kubo K, Miyauchi S, Aizawa A, et al. The time-sequential changes of risk factors for adult T-cell leukemia development in human T-cell leukemia virus-positive patients with rheumatoid arthritis: a retrospective cohort study. Mod Rheumatol. 2019;29(5):795–801.

    Article  CAS  PubMed  Google Scholar 

  29. Swaminathan N, Vinicius JM, Serrins J. Hemophagocytic lymphohistiocytosis (HLH) in a patient with disseminated histoplasmosis. Case Rep Hematol. 2020;2020:5638262.

    PubMed  PubMed Central  Google Scholar 

  30. Geraghty EM, Ristow B, Gordon SM, Aronowitz P. Overwhelming parasitemia with Plasmodium falciparum infection in a patient receiving infliximab therapy for rheumatoid arthritis. Clin Infect Dis. 2007;44(10):e82–4.

    Article  PubMed  Google Scholar 

  31. Norena I, Fernandez-Ruiz M, Aguado JM. Viral infections in the biologic therapy era. Expert Rev Anti-Infect Ther. 2018;16(10):781–91.

    Article  CAS  PubMed  Google Scholar 

  32. Clemente WT, Pierrotti LC, Abdala E, Morris MI, Azevedo LS, Lopez-Velez R, et al. Recommendations for management of endemic diseases and travel medicine in solid-organ transplant recipients and donors: Latin America. Transplantation. 2018;102(2):193–208.

    Article  PubMed  Google Scholar 

  33. Pierrotti LC, Levi ME, Di Santi SM, Segurado AC, Petersen E. Malaria disease recommendations for solid organ transplant recipients and donors. Transplantation. 2018;102(2S Suppl 2):S16–26.

    Article  PubMed  Google Scholar 

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Lopez-Medrano, F., Silva, J.T. (2022). Timeline and Infectious Disease Evaluation of Candidates to New Therapies. In: Cervera, C., Aguado, J.M. (eds) Infectious Complications in Biologic and Targeted Therapies. Springer, Cham. https://doi.org/10.1007/978-3-031-11363-5_2

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  • DOI: https://doi.org/10.1007/978-3-031-11363-5_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-11362-8

  • Online ISBN: 978-3-031-11363-5

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