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Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes

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Cardiovascular Signaling in Health and Disease

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Abstract

Calcium signaling in cardiomyocytes regulates muscle contractile function and electrical signal propagation in the heart. While calcium influx in nodal cells controls the rhythmic heartbeat, calcium transients in working cardiomyocytes direct excitation-contraction coupling and energy-dependent diastolic relaxation to maintain beat-to-beat pump function. Calcium dysregulation is a hallmark of the pathophysiology of multiple heart diseases including hypertrophy, heart failure, and arrhythmia. Proper compartmentalization and regulation of intra-cardiomyocyte calcium signaling relies on the organization of key calcium-handling machinery to specific functional microdomains. These microdomains serve as signaling hubs to orchestrate cardiac activities whose disruption can contribute to disease progression. Thus, understanding the structure and function of the calcium signaling microdomains in cardiomyocytes is of great scientific interest and translational significance. In this chapter, we discuss the current knowledge concerning calcium signaling at major cardiomyocyte microdomains, microdomain remodeling in diseases, and targetable approaches for the development of new therapies.

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  1. Jing Li and Bradley Richmond contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA

    Jing Li, Bradley Richmond & TingTing Hong

  2. Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA

    TingTing Hong

  3. Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, USA

    TingTing Hong

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  1. Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Narasimham L. Parinandi

  2. Departments of Biomedical Engineering and Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

    Thomas J. Hund

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Li, J., Richmond, B., Hong, T. (2022). Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes. In: Parinandi, N.L., Hund, T.J. (eds) Cardiovascular Signaling in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-08309-9_2

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