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Vit B6 (Pyridoxine)

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Androgenetic Alopecia From A to Z
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Abstract

Vit B6 is a water-soluble vitamin, but the name refers to a group of at least ten chemically similar pyridine derivatives (vitamers), which can be interconverted in biological systems.

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References

  1. György P. Vitamin B2 and the pellagra-like dermatitis of rats. Nature. 1934;133(3361):498–9.

    Google Scholar 

  2. Coburn SP, Lewis DL, Fink WJ, Mahuren JD, Schaltenbrand WE, Costill DL. Human vitamin B-6 pools estimated through muscle biopsies. Am J Clin Nutr. 1988;48(2):291–4.

    CAS  PubMed  Google Scholar 

  3. Percudani R, Peracchi A. The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families. BMC Bioinform. 2009;1(10):273.

    Google Scholar 

  4. Combs GF, McClung JP. The vitamins: fundamental aspects in nutrition and health. 5th ed. San Diego: Elsevier; 2017.

    Google Scholar 

  5. Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, editors. Modern nutrition in health and disease. 9th ed. Baltimore: Williams and Wilkins; 1999. p. 413–21.

    Google Scholar 

  6. Chandra RK, Sudhakaran L. Regulation of immune responses by vitamin B6. Ann N Y Acad Sci. 1990;585:404–23.

    CAS  PubMed  Google Scholar 

  7. Trakatellis A, Dimitriadou A, Trakatelli M. Pyridoxine deficiency: new approaches in immunosuppression and chemotherapy. Postgrad Med J. 1997;73(864):617–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Oka T. Modulation of gene expression by vitamin B6. Nutr Res Rev. 2001;14(2):257–66.

    CAS  PubMed  Google Scholar 

  9. Shibata K, Mushiage M, Kondo T, Hayakawa T, Tsuge H. Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin. Biosci Biotechnol Biochem. 1995;59(11):2060–3.

    CAS  PubMed  Google Scholar 

  10. Mahfouz MM, Zhou SQ, Kummerow FA. Vitamin B6 compounds are capable of reducing the superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells in culture. Int J Vitam Nutr Res. 2009;79(4):218–29.

    CAS  PubMed  Google Scholar 

  11. Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem. 1997;249(1):239–47.

    CAS  PubMed  Google Scholar 

  12. Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988;119(5):627–32.

    CAS  PubMed  Google Scholar 

  13. Allgood VE, Cidlowski JA. Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily. J Biol Chem. 1992;267(6):3819–24.

    CAS  PubMed  Google Scholar 

  14. Kniewald Z, Zechner V, Kniewald J. Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives. Endocr Regul. 1992;26(1):47–51.

    CAS  PubMed  Google Scholar 

  15. Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J. 1994;8(3):343–9.

    CAS  PubMed  Google Scholar 

  16. Symes EK, Bender DA, Bowden JF, Coulson WF. Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat. J Steroid Biochem. 1984;20(5):1089–93.

    CAS  PubMed  Google Scholar 

  17. Bender DA, Ghartey-Sam K, Singh A. Effects of vitamin B6 deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats. Br J Nutr. 1989;61(3):619–28.

    CAS  PubMed  Google Scholar 

  18. Brzezinska-Wcislo L. Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women. Wiad Lek. 2001;54(1–2):11–8.

    CAS  PubMed  Google Scholar 

  19. U.S. Department of Agriculture, Agricultural Research Service. USDA Nutrient Database for Standard Reference, Release. Nutrient Data Laboratory. 1999. http://www.nal.usda.gov/fnic/foodcomp. Search the database online.

  20. Sareen G, Stepnick A, Smith JL, Groff JL. Advanced nutrition and human metabolism. Australia: Wadsworth/Cengage Learning; 2009.

    Google Scholar 

  21. Institute of Medicine. Food and nutrition board. Dietary reference intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press; 1998.

    Google Scholar 

  22. Henríquez-Sánchez P, Sánchez-Villegas A, Doreste-Alonso J, Ortiz-Andrellucchi A, Pfrimer K, Serra-Majem L. Dietary assessment methods for micronutrient intake: a systematic review on vitamins. Br J Nutr. 2009;102(Suppl 1):S10–37.

    PubMed  Google Scholar 

  23. Hunt AD Jr, Stokes J Jr, McCrory WW, Stroud HH. Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics. 1954;13(2):140–5.

    CAS  PubMed  Google Scholar 

  24. Massé PG, Boudreau J, Tranchant CC, Ouellette R, Ericson KL. Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood. Appl Physiol Nutr Metab. 2012;37(1):167–75.

    PubMed  Google Scholar 

  25. Spannuth CL Jr, Warnock LG, Wagner C, Stone WJ. Increased plasma clearance of pyridoxal 5′-phosphate in vitamin B6 deficient uremic man. J Lab Clin Med. 1977 Oct;90(4):632–7.

    CAS  PubMed  Google Scholar 

  26. Mitchell D, Wagner C, Stone WJ, Wilkinson GR, Schenker S. Abnormal regulation of plasma pyridoxal 5′-phosphate in patients with liver disease. Gastroenterology. 1976;71(6):1043–9.

    CAS  PubMed  Google Scholar 

  27. DiLorenzo PA. Pellagra-like syndrome associated with isoniazid therapy. Acta Derm Venereol. 1967;47(5):318–22.

    CAS  PubMed  Google Scholar 

  28. Raskin NH, Fishman RA. Pyridoxine-deficiency neuropathy due to hydralazine. N Engl J Med. 1965;273(22):1182–5.

    CAS  PubMed  Google Scholar 

  29. Gershoff SN. Vitamin B6. In: Hegsted DM, Chichester CO, Darby WJ, McNutt KW, Stalvey RM, Stotz EH, editors. Present knowledge in nutrition. Washington: The Nutrition Foundation; 1976. p. 149–61.

    Google Scholar 

  30. Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican health study. Am J Clin Nutr. 2010;91(2):337–42.

    CAS  PubMed  Google Scholar 

  31. Ulvik A, Midttun Ø, Pedersen ER, Eussen SJ, Nygård O, Ueland PM. Evidence for increased catabolism of vitamin B-6 during systemic inflammation. Am J Clin Nutr. 2014;100(1):250–5.

    CAS  PubMed  Google Scholar 

  32. Rall LC, Meydani SN. Vitamin B6 and immune competence. Nutr Rev. 1993;51(8):217–25.

    CAS  PubMed  Google Scholar 

  33. György P. Developments leading to the metabolic role of vitamin B 6. Am J Clin Nutr. 1971;24(10):1250–6.

    PubMed  Google Scholar 

  34. György P. The history of vitamin B6. Introductory remarks. Vitam Horm. 1964;22:361–5.

    Google Scholar 

  35. Prasad R, Lakshmi AV, Bamji MS. Impaired collagen maturity in vitamins B2 and B6 deficiency—probable molecular basis of skin lesions. Biochem Med. 1983 Dec;30(3):333–41.

    CAS  PubMed  Google Scholar 

  36. Malouf R, Grimley EJ. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;4:CD004393.

    Google Scholar 

  37. Spinneker A, Sola R, Lemmen V, Castillo MJ, Pietrzik K, González-Gross M. Vitamin B6 status, deficiency and its consequences--an overview. Nutr Hosp. 2007;22(1):7–24.

    CAS  PubMed  Google Scholar 

  38. Selhub J, Jacques PF, Bostom AG, D’Agostino RB, Wilson PW, Belanger AJ, O’Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med. 1995;332(5):286–91.

    CAS  PubMed  Google Scholar 

  39. Thompson IR, Osei-Lah A, Blackburn A. Disequilibrium due to a vitamin B6 megadose supplement. Age Ageing. 2007 Sep;36(5):597.

    PubMed  Google Scholar 

  40. Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM. The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017;44:206–12.

    CAS  PubMed  Google Scholar 

  41. Dalton K, Dalton MJ. Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand. 1987;76(1):8–11.

    CAS  PubMed  Google Scholar 

  42. Bhagavan HN, Brin M. Drug—vitamin B6 interaction. Curr Concepts Nutr. 1983;12:1–12.

    CAS  PubMed  Google Scholar 

  43. Tamura T, Aiso K, Johnston KE, Black L, Faught E. Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy. EpilepsyRes. 2000;40(1):7–15.

    CAS  Google Scholar 

  44. Brasky TM, White E, Chen CL. Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the vitamins and lifestyle (VITAL) cohort. J Clin Oncol. 2017;35(30):3440–8.

    CAS  PubMed  PubMed Central  Google Scholar 

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Anastassakis, K. (2022). Vit B6 (Pyridoxine). In: Androgenetic Alopecia From A to Z . Springer, Cham. https://doi.org/10.1007/978-3-031-08057-9_32

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  • DOI: https://doi.org/10.1007/978-3-031-08057-9_32

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