Abstract
The chapter will describe a clinical case where exchange transfusion is indicated for severe hyperbilirubinemia. The chapter will discuss the indications and risks-benefits of exchange transfusion and then will review how to set up and perform an exchange transfusion in a low-resource setting. Additional pearls and references for further learning are provided.
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Abbreviations
- AAP:
-
American Academy of Pediatrics
- ACD:
-
Acid citrate dextrose
- BIND:
-
Bilirubin-induced neurologic dysfunction
- CPD:
-
Citrate phosphate dextrose
- EBT:
-
Exchange blood transfusion
- EDTA:
-
Ethylenediaminetetraacetic acid
- IVIG:
-
Intravenous immunoglobulin
- KSD:
-
Kernicterus spectrum disorder
- NPO:
-
Nil per os
- RhD:
-
Rhesus disease
- TSB:
-
Total serum bilirubin
- UVC:
-
Umbilical venous catheter
References
American Academy of Pediatrics Subcommittee on, H., Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297–316.
Stevenson DK, Maisels MJ, Watchko J. Care of the jaundiced neonate. New York: McGraw-Hill Medical; 2012.
Watchko JF, Tiribelli C. Bilirubin-induced neurologic damage–mechanisms and management approaches. N Engl J Med. 2013;369(21):2021–30.
Pochedly C. History of the exchange transfusion; its use in treatment of erythroblastosis fetalis. Bull Hist Med. 1970;44(5):450–60.
Chen HN, Lee ML, Tsao LY. Exchange transfusion using peripheral vessels is safe and effective in newborn infants. Pediatrics. 2008;122(4):e905–10.
Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev. 2006;4:CD004592.
Manning D, et al. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland. Arch Dis Child Fetal Neonatal Ed. 2007;92(5):F342–6.
McGillivray A, Evans N. Severe neonatal jaundice: is it a rare event in Australia? J Paediatr Child Health. 2012;48(9):801–7.
Ebbesen F, et al. Extreme hyperbilirubinaemia in term and near-term infants in Denmark. Acta Paediatr. 2005;94(1):59–64.
Slusher TM, et al. Burden of severe neonatal jaundice: a systematic review and meta-analysis. BMJ Paediatr Open. 2017;1(1):e000105.
Greco C, et al. Neonatal jaundice in low- and middle-income countries: lessons and future directions from the 2015 Don Ostrow Trieste yellow retreat. Neonatology. 2016;110(3):172–80.
Usman F, Diala U, Shapiro SM, Le Pichon JB, Slusher TM. Acute bilirubin encephalopathy and its progression to kernicterus: current perspective. Res Rep Neonatol. 2017;8:33–44.
Mabogunje CA, Olaifa SM, Olusanya BO. Facility-based constraints to exchange transfusions for neonatal hyperbilirubinemia in resource-limited settings. World J Clin Pediatr. 2016;5(2):182–90.
Bujandric N, Grujic J. Exchange transfusion for severe neonatal hyperbilirubinemia: 17 Years’ experience from Vojvodina, Serbia. Indian J Hematol Blood Transfus. 2016;32(2):208–14.
Bhutani VK, et al. Extreme hyperbilirubinemia and rescue exchange transfusion in California from 2007 to 2012. J Perinatol. 2016;36(10):853–7.
Behjati S, et al. Adverse events associated with neonatal exchange transfusion for hyperbilirubinemia. Indian J Pediatr. 2009;76(1):83–5.
Pius S, Bello M, Mava Y, Djossi S, Ambe JP. Prevalence of exchange blood transfusion in severe hyperbilirubinaemia and outcome at the University of Maiduguri Teaching Hospital Maiduguri, Northeastern Nigeria. Nigerian J Paediatrics. 2017;44(2):50–5.
Owa JA, Ogunlesi TA. Why we are still doing so many exchange blood transfusion for neonatal jaundice in Nigeria. World J Pediatr. 2009;5(1):51–5.
Onyearugha CN, Onyire NB, Ugboma HAA. Neonatal jaundice: prevalence and associated factors as seen in federal medical Centre Abakaliki, Southeast Nigeria. J Clin Med Res. 2011;3(3):40–5.
Ibekwe RC, Ibekwe MU, Muoneke VU. Outcome of exchange blood transfusions done for neonatal jaundice in Abakaliki, South eastern Nigeria. J Clin Neonatol. 2012;1(1):34–7.
Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999;103(1):6–14.
Sabzehei MK, Basiri B, Shokouhi M. Complications of exchange transfusion in hospitalized neonates in two neonatal centers in Hamadan, a five-year experience. J Compr Pediatrics. 2015;6(2):4–8.
Smits-Wintjens VE, et al. Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease. Neonatology. 2013;103(2):141–7.
Kaplan M, Wong R, Eric S, Stevenson DK. Neonatal jaundice and liver disease. In: Fanaroff A, Martin RJ, Walsh MC, editors. Neonatal-perinatal medicine: diseases of the fetus and infant. Mosby (Philadelphia, PA); 2010. p. 1478–81.
Jackson JC. Adverse events associated with exchange transfusion in healthy and ill newborns. Pediatrics. 1997;99(5):E7.
Badiee Z. Exchange transfusion in neonatal hyperbilirubinaemia: experience in Isfahan, Iran. Singapore Med J. 2007;48(5):421–3.
Davutoglu M, et al. The etiology of severe neonatal hyperbilirubinemia and complications of exchange transfusion. Turk J Pediatr. 2010;52(2):163–6.
Ip S, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004;114(1):e130–53.
Patra K, et al. Adverse events associated with neonatal exchange transfusion in the 1990s. J Pediatr. 2004;144(5):626–31.
Radmacher PG, et al. A modified bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting. BMC Pediatr. 2015;15:28.
Lees TPM, Slusher M. SUGARPREP: curricular resources for global health educators. [cited 2021 9/12/2021]; Available from: https://sugarprep.org/videos/#Exchange_Blood_Transfusion.
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Satrom, K., Shwe, D., Usman, F. (2022). Exchange Blood Transfusions for Severe Hyperbilirubinemia in Resource-Limited Settings. In: Slusher, T.M., Bjorklund, A.R., Lauden, S.M. (eds) Pediatric Procedural Adaptations for Low-Resource Settings. Springer, Cham. https://doi.org/10.1007/978-3-030-99955-1_7
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DOI: https://doi.org/10.1007/978-3-030-99955-1_7
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