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Hybrid Cardiac Imaging for the Invasive Cardiologist

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Hybrid Cardiac Imaging for Clinical Decision-Making

Abstract

For decades Coronary Angiography (CA) has represented the gold standard for the diagnosis and management of coronary artery disease (CAD). Today, invasive cardiologists can overcome the limits of such a binary approach, based on the definition of obstructive or nonobstructive stenosis, and go deeply into the characterization of individual coronary atherosclerosis. Indeed, several auxiliary imaging techniques allow a more accurate definition of global coronary atherosclerotic burden and single plaque composition. These techniques, integrating CA “luminal” data, assure a better definition of CAD pathophysiology and detection of vulnerable lesions, resulting in improved stratification of individual cardiovascular risk. Furthermore, this hybrid invasive approach can be used to monitor the response to specific intensive pharmacotherapy aiming to reduce atherosclerosis progression. This chapter reviews the main characteristics of imaging modalities currently available to invasive cardiologists, summarizes clinical evidence supporting their use, and illustrates possible future medical implications.

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References

  1. Brown BG, Bolson E, Frimer M, Dodge HT. Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation. Circulation. 1977;55:329–37.

    Article  CAS  PubMed  Google Scholar 

  2. Burton JR, Teo KK, Buller CE, Plante S, Catellier D, Tymchak W, Taylor D, Dzavik V, Montague TJ. Effects of long term cholesterol lowering on coronary atherosclerosis in patient risk factor subgroups: the Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT). Can J Cardiol. 2003;19(5):487–91.

    CAS  PubMed  Google Scholar 

  3. Berry C, L’Allier PL, Gregoire J, Lesperance J, Levesque S, Ibrahim R, Tardif JC. Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression. Circulation. 2007;115(14):1851–7.

    Article  PubMed  Google Scholar 

  4. Mortensen MB, Dzaye O, Steffensen FH, Bøtker HE, Jensen JM, Rønnow Sand NP, Kragholm KH, Sørensen HT, Leipsic J, Mæng M, Blaha MJ, Nørgaard BL. Impact of plaque burden versus stenosis on ischemic events in patients with coronary atherosclerosis. J Am Coll Cardiol. 2020;76(24):2803–13.

    Article  PubMed  Google Scholar 

  5. Task Force Members, Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Sabaté M, Senior R, Taggart DP, van der Wall EE, Vrints CJ, ESC Committee for Practice Guidelines, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Document Reviewers, Knuuti J, Valgimigli M, Bueno H, Claeys MJ, Donner-Banzhoff N, Erol C, Frank H, Funck-Brentano C, Gaemperli O, Gonzalez-Juanatey JR, Hamilos M, Hasdai D, Husted S, James SK, Kervinen K, Kolh P, Kristensen SD, Lancellotti P, Maggioni AP, Piepoli MF, Pries AR, Romeo F, Rydén L, Simoons ML, Sirnes PA, Steg PG, Timmis A, Wijns W, Windecker S, Yildirir A, Zamorano JL. 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34(38):2949–3003.

    Article  Google Scholar 

  6. Tonino PA, Fearon WF, De Bruyne B, Oldroyd KG, Leesar MA, Ver Lee PN, Maccarthy PA, Van’t Veer M, Pijls NH. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol. 2010;55(25):2816–21.

    Article  PubMed  Google Scholar 

  7. Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.

    Article  PubMed  Google Scholar 

  8. Yong AS, Ng AC, Brieger D, Lowe HC, Ng MK, Kritharides L. Threedimensional and two-dimensional quantitative coronary angiography, and their prediction of reduced fractional flow reserve. Eur Heart J. 2011;32:345–53.

    Article  PubMed  Google Scholar 

  9. Bourantas CV, Tweddel AC, Papafaklis MI, Karvelis PS, Fotiadis DI, Katsouras CS, Michalis LK. Comparison of quantitative coronary angiography with intracoronary ultrasound. Can quantitative coronary angiography accurately estimate the severity of a luminal stenosis? Angiology. 2009;60(2):169–79.

    Article  PubMed  Google Scholar 

  10. Tu S, Xu L, Ligthart J, Xu B, Witberg K, Sun Z, Koning G, Reiber JH, Regar E. In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography. Int J Cardiovasc Imaging. 2012;28(6):1315–27.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, Parise H, Templin B, White R, Zhang Z, Serruys PW, PROSPECT Investigators. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364(3):226–35.

    Article  CAS  PubMed  Google Scholar 

  12. Waksman R, Di Mario C, Torguson R, Ali ZA, Singh V, Skinner WH, Artis AK, Cate TT, Powers E, Kim C, Regar E, Wong SC, Lewis S, Wykrzykowska J, Dube S, Kazziha S, van der Ent M, Shah P, Craig PE, Zou Q, Kolm P, Brewer HB, Garcia-Garcia HM, LRP Investigators. Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study. Lancet. 2019;394(10209):1629–37.

    Article  CAS  PubMed  Google Scholar 

  13. Prati F, Romagnoli E, Gatto L, La Manna A, Burzotta F, Ozaki Y, Marco V, Boi A, Fineschi M, Fabbiocchi F, Taglieri N, Niccoli G, Trani C, Versaci F, Calligaris G, Ruscica G, Di Giorgio A, Vergallo R, Albertucci M, Biondi-Zoccai G, Tamburino C, Crea F, Alfonso F, Arbustini E. Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study. Eur Heart J. 2020;41(3):383–91.

    PubMed  Google Scholar 

  14. Finn AV, Nakano M, Narula J, Kolodgie FD, Virmani R. Concept of vulnerable/unstable plaque. Arterioscler Thromb Vasc Biol. 2010;30(7):1282–92.

    Article  CAS  PubMed  Google Scholar 

  15. Falk E, Nakano M, Bentzon JF, Finn AV, Virmani R. Update on acute coronary syndromes: the pathologists’ view. Eur Heart J. 2013;34(10):719–28.

    Article  CAS  PubMed  Google Scholar 

  16. Janoudi A, Shamoun FE, Kalavakunta JK, Abela GS. Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque. Eur Heart J. 2016;37(25):1959–67.

    Article  CAS  PubMed  Google Scholar 

  17. Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006;47(8 Suppl):C13–8.

    Article  CAS  PubMed  Google Scholar 

  18. Chang HJ, Lin FY, Lee SE, Andreini D, Bax J, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic J, Maffei E, Marques H, Plank F, Pontone G, Raff GL, van Rosendael AR, Villines TC, Weirich HG, Al’Aref SJ, Baskaran L, Cho I, Danad I, Han D, Heo R, Lee JH, Rivzi A, Stuijfzand WJ, Gransar H, Lu Y, Sung JM, Park HB, Berman DS, Budoff MJ, Samady H, Shaw LJ, Stone PH, Virmani R, Narula J, Min JK. Coronary atherosclerotic precursors of acute coronary syndromes. J Am Coll Cardiol. 2018;71(22):2511–22.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ozaki Y, Garcia-Garcia HM, Beyene SS, Hideo-Kajita A, Kuku KO, Kolm P, Waksman R. Effect of statin therapy on fibrous cap thickness in coronary plaque on optical coherence tomography—review and meta-analysis. Circ J. 2019;83(7):1480–8.

    Article  CAS  PubMed  Google Scholar 

  20. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106(17):2200–6.

    Article  PubMed  Google Scholar 

  21. Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, Kauffman CR, Shishkov M, Kang DH, Halpern EF, Tearney GJ. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002;106(13):1640–5.

    Article  PubMed  Google Scholar 

  22. Nudi F, Lotrionte M, Biasucci LM, Peruzzi M, Marullo AGM, Frati G, Valenti V, Giordano A, Biondi-Zoccai G. Comparative safety and effectiveness of coronary computed tomography: systematic review and meta-analysis including 11 randomized controlled trials and 19,957 patients. Int J Cardiol. 2016;222:352–8.

    Article  PubMed  Google Scholar 

  23. D’Ascenzo F, Agostoni P, Abbate A, Castagno D, Lipinski MJ, Vetrovec GW, Frati G, Presutti DG, Quadri G, Moretti C, Gaita F, Zoccai GB. Atherosclerotic coronary plaque regression and the risk of adverse cardiovascular events: a metaregression of randomized clinical trials. Atherosclerosis. 2013;226:178–85.

    Article  PubMed  CAS  Google Scholar 

  24. Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, Pinto FJ, Rosenfield K, Siegel RJ, Tuzcu EM, Yock PG. American College of Cardiology Clinical Expert Consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound studies (IVUS). A report of the American College of Cardiology Task Force on clinical expert consensus documents. J Am Coll Cardiol. 2001;37(5):1478–92.

    Article  CAS  PubMed  Google Scholar 

  25. Briguori C, Tobis J, Nishida T, Vaghetti M, Albiero R, Di Mario C, Colombo A. Discrepancy between angiography and intravascular ultrasound when analysing small coronary arteries. Eur Heart J. 2002;23(3):247–54.

    Article  CAS  PubMed  Google Scholar 

  26. Choi JW, Vardi GM, Meyers SN, Parker MA, Goodreau LM, Davidson CJ. Role of intracoronary ultrasound after high-pressure stent implantation. Am Heart J. 2000;139(4):643–8.

    Article  CAS  PubMed  Google Scholar 

  27. Jang JS, Song YJ, Kang W, Jin HY, Seo JS, Yang TH, Kim DK, Cho KI, Kim BH, Park YH, Je HG, Kim DS. Intravascular ultrasound-guided implantation of drug-eluting stents to improve outcome: a meta-analysis. JACC Cardiovasc Interv. 2014;7(3):233–43.

    Article  PubMed  Google Scholar 

  28. Bruining N, Verheye S, Knaapen M, Somers P, Roelandt JR, Regar E, Heller I, de Winter S, Ligthart J, Van Langenhove G, de Feijter PJ, Serruys PW, Hamers R. Three-dimensional and quantitative analysis of atherosclerotic plaque composition by automated differential echogenicity. Catheter Cardiovasc Interv. 2007;70(7):968–78.

    Article  PubMed  Google Scholar 

  29. Hodgson JM, Reddy KG, Suneja R, Nair RN, Lesnefsky EJ, Sheehan HM. Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty. J Am Coll Cardiol. 1993;21(1):35–44.

    Article  CAS  PubMed  Google Scholar 

  30. Amano T, Matsubara T, Uetani T, Kato M, Kato B, Yoshida T, Harada K, Kumagai S, Kunimura A, Shinbo Y, Ishii H, Murohara T. Lipid-rich plaques predict non-target-lesion ischemic events in patients undergoing percutaneous coronary intervention. Circ J. 2011;75(1):157–66.

    Article  PubMed  Google Scholar 

  31. Calvert PA, Obaid DR, O’Sullivan M, Shapiro LM, McNab D, Densem CG, Schofield PM, Braganza D, Clarke SC, Ray KK, West NE, Bennett MR. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) study. JACC Cardiovasc Imaging. 2011;4(8):894–901.

    Article  PubMed  Google Scholar 

  32. Nair A, Margolis MP, Kuban BD, Vince DG. Automated coronary plaque characterisation with intravascular ultrasound backscatter: ex vivo validation. EuroIntervention. 2007;3(1):113–20.

    PubMed  Google Scholar 

  33. Brugaletta S, Cola C, Martin-Yuste V, Vilahur G, Oriol J, Padro T, Guerra JM, Borras R, Badimon L, Sabate M. Qualitative and quantitative accuracy of ultrasound-based virtual histology for detection of necrotic core in human coronary arteries. Int J Cardiovasc Imaging. 2014;30(3):469–76.

    Article  PubMed  Google Scholar 

  34. Campos CM, Fedewa RJ, Garcia-Garcia HM, Vince DG, Margolis MP, Lemos PA, Stone GW, Serruys PW, Nair A. Ex vivo validation of 45 MHz intravascular ultrasound backscatter tissue characterization. Eur Heart J Cardiovasc Imaging. 2015;16(10):1112–9.

    Article  PubMed  Google Scholar 

  35. Kawasaki M, Takatsu H, Noda T, Ito Y, Kunishima A, Arai M, Nishigaki K, Takemura G, Morita N, Minatoguchi S, Fujiwara H. Noninvasive quantitative tissue characterization and two-dimensional color-coded map of human atherosclerotic lesions using ultrasound integrated backscatter: comparison between histology and integrated backscatter images. J Am Coll Cardiol. 2001;38(2):486–92.

    Article  CAS  PubMed  Google Scholar 

  36. Sano K, Kawasaki M, Ishihara Y, Okubo M, Tsuchiya K, Nishigaki K, Zhou X, Minatoguchi S, Fujita H, Fujiwara H. Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2006;47(4):734–41.

    Article  PubMed  Google Scholar 

  37. Okubo M, Kawasaki M, Ishihara Y, Takeyama U, Yasuda S, Kubota T, Tanaka S, Yamaki T, Ojio S, Nishigaki K, Takemura G, Saio M, Takami T, Fujiwara H, Minatoguchi S. Tissue characterization of coronary plaques: comparison of integrated backscatter intravascular ultrasound with virtual histology intravascular ultrasound. Circ J. 2008;72(10):1631–9.

    Article  PubMed  Google Scholar 

  38. Kawasaki M, Bouma BE, Bressner J, Houser SL, Nadkarni SK, MacNeill BD, Jang IK, Fujiwara H, Tearney GJ. Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques. J Am Coll Cardiol. 2006;48(1):81–8.

    Article  PubMed  Google Scholar 

  39. Bourantas CV, Papafaklis MI, Athanasiou L, Kalatzis FG, Naka KK, Siogkas PK, Takahashi S, Saito S, Fotiadis DI, Feldman CL, Stone PH, Michalis LK. A new methodology for accurate 3-dimensional coronary artery reconstruction using routine intravascular ultrasound and angiographic data: implications for widespread assessment of endothelial shear stress in humans. EuroIntervention. 2013;9(5):582–93.

    Article  PubMed  Google Scholar 

  40. Stone PH, Maehara A, Coskun AU, Maynard CC, Zaromytidou M, Siasos G, Andreou I, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Lansky AJ, Mintz GS, Serruys PW, Feldman CL, Stone GW. Role of low endothelial shear stress and plaque characteristics in the prediction of nonculprit major adverse cardiac events: the PROSPECT study. JACC Cardiovasc Imaging. 2018;11(3):462–47.

    Article  PubMed  Google Scholar 

  41. Bourantas CV, Räber L, Sakellarios A, Ueki Y, Zanchin T, Koskinas KC, Yamaji K, Taniwaki M, Heg D, Radu MD, Papafaklis MI, Kalatzis F, Naka KK, Fotiadis DI, Mathur A, Serruys PW, Michalis LK, Garcia-Garcia HM, Karagiannis A, Windecker S. Utility of multimodality intravascular imaging and the local hemodynamic forces to predict atherosclerotic disease progression. JACC Cardiovasc Imaging. 2020;13(4):1021–32.

    Article  PubMed  Google Scholar 

  42. Stone PH, Saito S, Takahashi S, Makita Y, Nakamura S, Kawasaki T, Takahashi A, Katsuki T, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S, Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI, Feldman CL, PREDICTION Investigators. Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION study. Circulation. 2012;126(2):172–81.

    Article  PubMed  Google Scholar 

  43. Samady H, Eshtehardi P, McDaniel MC, Suo J, Dhawan SS, Maynard C, Timmins LH, Quyyumi AA, Giddens DP. Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Circulation. 2011;124(7):779–88.

    Article  CAS  PubMed  Google Scholar 

  44. Timmins LH, Molony DS, Eshtehardi P, McDaniel MC, Oshinski JN, Giddens DP, Samady H. Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease. J R Soc Interface. 2017;14(127):20160972.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  45. Cheng JM, Garcia-Garcia HM, de Boer SP, Kardys I, Heo JH, Akkerhuis KM, Oemrawsingh RM, van Domburg RT, Ligthart J, Witberg KT, Regar E, Serruys PW, van Geuns RJ, Boersma E. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Eur Heart J. 2014;35(10):639–47.

    Article  PubMed  Google Scholar 

  46. Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA, Crowe T, Howard G, Cooper CJ, Brodie B, Grines CL, DeMaria AN, REVERSAL Investigators. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA. 2004;291(9):1071–80.

    Article  CAS  PubMed  Google Scholar 

  47. Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, Raichlen JS, Uno K, Borgman M, Wolski K, Nissen SE. Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med. 2011;365(22):2078–87.

    Article  CAS  PubMed  Google Scholar 

  48. Räber L, Taniwaki M, Zaugg S, Kelbæk H, Roffi M, Holmvang L, Noble S, Pedrazzini G, Moschovitis A, Lüscher TF, Matter CM, Serruys PW, Jüni P, Garcia-Garcia HM, Windecker S, IBIS 4 (Integrated Biomarkers and Imaging Study-4) Trial Investigators (NCT00962416). Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study. Eur Heart J. 2015;36(8):490–500.

    Article  PubMed  Google Scholar 

  49. Sipahi I, Tuzcu EM, Schoenhagen P, Wolski KE, Nicholls SJ, Balog C, Crowe TD, Nissen SE. Effects of normal, pre-hypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis. J Am Coll Cardiol. 2006;48(4):833–8.

    Article  PubMed  Google Scholar 

  50. Hong MK, Park DW, Lee CW, Lee SW, Kim YH, Kang DH, Song JK, Kim JJ, Park SW, Park SJ. Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis. JACC Cardiovasc Interv. 2009;2(7):679–88.

    Article  PubMed  Google Scholar 

  51. Serruys PW, Garcia-Garcia HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, Botker HE, von Birgelen C, D’Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der Steen AF, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A, Integrated Biomarker and Imaging Study-2 Investigators. Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque. Circulation. 2008;118(11):1172–82.

    Article  CAS  PubMed  Google Scholar 

  52. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, Fujimoto JG. Optical coherence tomography. Science. 1991;254(5035):1178–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Barlis P, Gonzalo N, Di Mario C, Prati F, Buellesfeld L, Rieber J, Dalby MC, Ferrante G, Cera M, Grube E, Serruys PW, Regar E. A multicentre evaluation of the safety of intracoronary optical coherence tomography. EuroIntervention. 2009;5(1):90–5.

    Article  PubMed  Google Scholar 

  54. Takano M, Jang IK, Inami S, Yamamoto M, Murakami D, Okamatsu K, Seimiya K, Ohba T, Mizuno K. In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics. Am J Cardiol. 2008;101(4):471–6.

    Article  PubMed  Google Scholar 

  55. Romagnoli E, Paoletti G, Marco V, Gatto L, Calligaris G, Fabbiocchi F, Fineschi M, Boi A, Albertucci M, Nicholls SJ, Prati F. Comparison between different approaches to evaluate fibrous cap thickness in sequential OCT studies. Minerva Cardioangiol. 2020. https://doi.org/10.23736/S0026-4725.20.05237-8. Epub ahead of print.

  56. Tearney GJ, Yabushita H, Houser SL, Aretz HT, Jang IK, Schlendorf KH, Kauffman CR, Shishkov M, Halpern EF, Bouma BE. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation. 2003;107(1):113–9.

    Article  PubMed  Google Scholar 

  57. Tian J, Hou J, Xing L, Kim SJ, Yonetsu T, Kato K, Lee H, Zhang S, Yu B, Jang IK. Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study. Heart. 2012;98(20):1504–9.

    Article  PubMed  Google Scholar 

  58. Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, Bouma B, Bruining N, Cho JM, Chowdhary S, Costa MA, de Silva R, Dijkstra J, Di Mario C, Dudek D, Falk E, Feldman MD, Fitzgerald P, Garcia-Garcia HM, Gonzalo N, Granada JF, Guagliumi G, Holm NR, Honda Y, Ikeno F, Kawasaki M, Kochman J, Koltowski L, Kubo T, Kume T, Kyono H, Lam CC, Lamouche G, Lee DP, Leon MB, Maehara A, Manfrini O, Mintz GS, Mizuno K, Morel MA, Nadkarni S, Okura H, Otake H, Pietrasik A, Prati F, Räber L, Radu MD, Rieber J, Riga M, Rollins A, Rosenberg M, Sirbu V, Serruys PW, Shimada K, Shinke T, Shite J, Siegel E, Sonoda S, Suter M, Takarada S, Tanaka A, Terashima M, Thim T, Uemura S, Ughi GJ, van Beusekom HM, van der Steen AF, van Es GA, van Soest G, Virmani R, Waxman S, Weissman NJ, Weisz G, International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT). Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012;59(12):1058–72.

    Article  PubMed  Google Scholar 

  59. Vergallo R, Crea F. Atherosclerotic plaque healing. N Engl J Med. 2020;383(9):846–57.

    Google Scholar 

  60. Kume T, Akasaka T, Kawamoto T, Watanabe N, Toyota E, Neishi Y, Sukmawan R, Sadahira Y, Yoshida K. Assessment of coronary intima-media thickness by optical coherence tomography: comparison with intravascular ultrasound. Circ J. 2005;69(8):903–7.

    Article  PubMed  Google Scholar 

  61. Narula J, Nakano M, Virmani R, Kolodgie FD, Petersen R, Newcomb R, Malik S, Fuster V, Finn AV. Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques. J Am Coll Cardiol. 2013;61(10):1041–51.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Tian J, Ren X, Vergallo R, Xing L, Yu H, Jia H, Soeda T, McNulty I, Hu S, Lee H, Yu B, Jang IK. Distinct morphological features of ruptured culprit plaque for acute coronary events compared to those with silent rupture and thin-cap fibroatheroma: a combined optical coherence tomography and intravascular ultrasound study. J Am Coll Cardiol. 2014;63(21):2209–16.

    Article  PubMed  Google Scholar 

  63. Komukai K, Kubo T, Kitabata H, Matsuo Y, Ozaki Y, Takarada S, Okumoto Y, Shiono Y, Orii M, Shimamura K, Ueno S, Yamano T, Tanimoto T, Ino Y, Yamaguchi T, Kumiko H, Tanaka A, Imanishi T, Akagi H, Akasaka T. Effect of atorvastatin therapy on fibrous cap thickness in coronary atherosclerotic plaque as assessed by optical coherence tomography: the EASY-FIT study. J Am Coll Cardiol. 2014;64(21):2207–17.

    Article  CAS  PubMed  Google Scholar 

  64. Rieber J, Meissner O, Babaryka G, Reim S, Oswald M, Koenig A, Schiele TM, Shapiro M, Theisen K, Reiser MF, Klauss V, Hoffmann U. Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens: a comparison with histology. Coron Artery Dis. 2006;17(5):425–30.

    Article  PubMed  Google Scholar 

  65. Manfrini O, Mont E, Leone O, Arbustini E, Eusebi V, Virmani R, Bugiardini R. Sources of error and interpretation of plaque morphology by optical coherence tomography. Am J Cardiol. 2006;98(2):156–9.

    Article  PubMed  Google Scholar 

  66. Xu C, Schmitt JM, Carlier SG, Virmani R. Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography. J Biomed Opt. 2008;13(3):034003.

    Article  PubMed  Google Scholar 

  67. Kume T, Akasaka T, Kawamoto T, Ogasawara Y, Watanabe N, Toyota E, Neishi Y, Sukmawan R, Sadahira Y, Yoshida K. Assessment of coronary arterial thrombus by optical coherence tomography. Am J Cardiol. 2006;97(12):1713–7.

    Article  PubMed  Google Scholar 

  68. Kubo T, Imanishi T, Takarada S, Kuroi A, Ueno S, Yamano T, Tanimoto T, Matsuo Y, Masho T, Kitabata H, Tsuda K, Tomobuchi Y, Akasaka T. Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol. 2007;50(10):933–9.

    Article  PubMed  Google Scholar 

  69. Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, Kato K, Yonetsu T, Vergallo R, Hu S, Tian J, Lee H, Park SJ, Jang YS, Raffel OC, Mizuno K, Uemura S, Itoh T, Kakuta T, Choi SY, Dauerman HL, Prasad A, Toma C, McNulty I, Zhang S, Yu B, Fuster V, Narula J, Virmani R, Jang IK. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62(19):1748–58.

    Article  PubMed  Google Scholar 

  70. Di Vito L, Agozzino M, Marco V, Ricciardi A, Concardi M, Romagnoli E, Gatto L, Calogero G, Tavazzi L, Arbustini E, Prati F. Identification and quantification of macrophage presence in coronary atherosclerotic plaques by optical coherence tomography. Eur Heart J Cardiovasc Imaging. 2015;16(7):807–13.

    Article  PubMed  Google Scholar 

  71. Phipps JE, Vela D, Hoyt T, Halaney DL, Mancuso JJ, Buja LM, Asmis R, Milner TE, Feldman MD. Macrophages and intravascular OCT bright spots: a quantitative study. JACC Cardiovasc Imaging. 2015;8(1):63–72.

    Article  PubMed  Google Scholar 

  72. Nidorf SM, Fiolet A, Abela GS. Viewing atherosclerosis through a crystal lens: How the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability. J Clin Lipidol. 2020;14(5):619–30.

    Google Scholar 

  73. Abela GS, Aziz K, Vedre A, Pathak DR, Talbott JD, Dejong J. Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes. Am J Cardiol. 2009;103(7):959–68.

    Article  CAS  PubMed  Google Scholar 

  74. Vorpahl M, Nakano M, Virmani R. Small black holes in optical frequency domain imaging matches intravascular neoangiogenesis formation in histology. Eur Heart J. 2010;31:1889.

    Article  PubMed  Google Scholar 

  75. Kume T, Okura H, Yamada R, Koyama T, Fukuhara K, Kawamura A, Imai K, Neishi Y, Uemura S. Detection of plaque neovascularization by optical coherence tomography: ex vivo feasibility study and in vivo observation in patients with angina pectoris. J Invasive Cardiol. 2016;28(1):17–22.

    PubMed  Google Scholar 

  76. Papafaklis MI, Bourantas CV, Yonetsu T, Vergallo R, Kotsia A, Nakatani S, Lakkas LS, Athanasiou LS, Naka KK, Fotiadis DI, Feldman CL, Stone PH, Serruys PW, Jang IK, Michalis LK. Anatomically correct three-dimensional coronary artery reconstruction using frequency domain optical coherence tomographic and angiographic data: head-to-head comparison with intravascular ultrasound for endothelial shear stress assessment in humans. EuroIntervention. 2015;11(4):407–15.

    Article  PubMed  Google Scholar 

  77. Athanasiou LS, Bourantas CV, Siogkas PK, Sakellarios AI, Exarchos TP, Naka KK, Papafaklis MI, Michalis LK, Prati F, Fotiadis DI. 3D reconstruction of coronary arteries using frequency domain optical coherence tomography images and biplane angiography. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2647–50.

    CAS  Google Scholar 

  78. Torii R, Stettler R, Räber L, Zhang YJ, Karanasos A, Dijkstra J, Patel K, Crake T, Hamshere S, Garcia-Garcia HM, Tenekecioglu E, Ozkor M, Baumbach A, Windecker S, Serruys PW, Regar E, Mathur A, Bourantas CV. Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions. Int J Cardiol. 2018;272:7–12.

    Article  PubMed  Google Scholar 

  79. Vergallo R, Papafaklis MI, Yonetsu T, Bourantas CV, Andreou I, Wang Z, Fujimoto JG, McNulty I, Lee H, Biasucci LM, Crea F, Feldman CL, Michalis LK, Stone PH, Jang IK. Endothelial shear stress and coronary plaque characteristics in humans: combined frequency-domain optical coherence tomography and computational fluid dynamics study. Circ Cardiovasc Imaging. 2014;7(6):905–11.

    Article  PubMed  Google Scholar 

  80. Slager CJ, Wentzel JJ, Gijsen FJ, Thury A, van der Wal AC, Schaar JA, et al. The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications. Nat Clin Pract Cardiovasc Med. 2005;2:456–64.

    Article  CAS  PubMed  Google Scholar 

  81. Fukumoto Y, Hiro T, Fujii T, Hashimoto G, Fujimura T, Yamada J, et al. Localized elevation of shear stress is related to coronary plaque rupture: a 3-dimensional intravascular ultrasound study with in-vivo color mapping of shear stress distribution. J Am Coll Cardiol. 2008;51:645–50.

    Article  PubMed  Google Scholar 

  82. van Ditzhuijzen NS, Karanasos A, Bruining N, van den Heuvel M, Sorop O, Ligthart J, Witberg K, Garcia-Garcia HM, Zijlstra F, Duncker DJ, van Beusekom HM, Regar E. The impact of Fourier-domain optical coherence tomography catheter induced motion artefacts on quantitative measurements of a PLLA-based bioresorbable scaffold. Int J Cardiovasc Imaging. 2014;30(6):1013–26.

    Article  PubMed  Google Scholar 

  83. Li Y, Gutiérrez-Chico JL, Holm NR, Yang W, Hebsgaard L, Christiansen EH, Mæng M, Lassen JF, Yan F, Reiber JH, Tu S. Impact of side branch modeling on computation of endothelial shear stress in coronary artery disease: coronary tree reconstruction by fusion of 3D angiography and OCT. J Am Coll Cardiol. 2015;66(2):125–35.

    Article  PubMed  Google Scholar 

  84. Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y. Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques. Eur Heart J. 2012;33(1):78–85.

    Article  PubMed  Google Scholar 

  85. Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK. Clinical significance of lipid-rich plaque detected by optical coherence tomography: a 4-year follow-up study. J Am Coll Cardiol. 2017;69(20):2502–13.

    Article  PubMed  Google Scholar 

  86. Cassis LA, Lodder RA. Near-IR imaging of atheromas in living arterial tissue. Anal Chem. 1993;65(9):1247–56.

    Article  CAS  PubMed  Google Scholar 

  87. Gardner CM, Tan H, Hull EL, Lisauskas JB, Sum ST, Meese TM, Jiang C, Madden SP, Caplan JD, Burke AP, Virmani R, Goldstein J, Muller JE. Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system. JACC Cardiovasc Imaging. 2008;1(5):638–48.

    Article  PubMed  Google Scholar 

  88. Waxman S, Dixon SR, L'Allier P, Moses JW, Petersen JL, Cutlip D, Tardif JC, Nesto RW, Muller JE, Hendricks MJ, Sum ST, Gardner CM, Goldstein JA, Stone GW, Krucoff MW. In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study. JACC Cardiovasc Imaging. 2009;2(7):858–68.

    Article  PubMed  Google Scholar 

  89. Kang SJ, Mintz GS, Pu J, Sum ST, Madden SP, Burke AP, Xu K, Goldstein JA, Stone GW, Muller JE, Virmani R, Maehara A. Combined IVUS and NIRS detection of fibroatheromas: histopathological validation in human coronary arteries. JACC Cardiovasc Imaging. 2015;8(2):184–94.

    Article  PubMed  Google Scholar 

  90. Inaba S, Mintz GS, Burke AP, Stone GW, Virmani R, Matsumura M, Parvataneni R, Puri R, Nicholls SJ, Maehara A. Intravascular ultrasound and near-infrared spectroscopic characterization of thin-cap fibroatheroma. Am J Cardiol. 2017;119(3):372–8.

    Article  PubMed  Google Scholar 

  91. Bourantas CV, Jaffer FA, Gijsen FJ, van Soest G, Madden SP, Courtney BK, Fard AM, Tenekecioglu E, Zeng Y, van der Steen AFW, Emelianov S, Muller J, Stone PH, Marcu L, Tearney GJ, Serruys PW. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology. Eur Heart J. 2017;38(6):400–12.

    Article  PubMed  Google Scholar 

  92. Kuku KO, Singh M, Ozaki Y, Dan K, Chezar-Azerrad C, Waksman R, Garcia-Garcia HM. Near-infrared spectroscopy intravascular ultrasound imaging: state of the art. Front Cardiovasc Med. 2020;7:107.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Schuurman AS, Vroegindewey M, Kardys I, Oemrawsingh RM, Cheng JM, de Boer S, Garcia-Garcia HM, van Geuns RJ, Regar ES, Daemen J, van Mieghem NM, Serruys PW, Boersma E, Akkerhuis KM. Near-infrared spectroscopy-derived lipid core burden index predicts adverse cardiovascular outcome in patients with coronary artery disease during long-term follow-up. Eur Heart J. 2018;39(4):295–302.

    Article  PubMed  Google Scholar 

  94. Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR. Role of biomechanical forces in the natural history of coronary atherosclerosis. Nat Rev Cardiol. 2016;13(4):210–20.

    Article  PubMed  Google Scholar 

  95. Hartman EMJ, De Nisco G, Kok AM, Hoogendoorn A, Coenen A, Mastik F, Korteland SA, Nieman K, Gijsen FJH, van der Steen AFW, Daemen J, Wentzel JJ. Lipid-rich plaques detected by near-infrared spectroscopy are more frequently exposed to high shear stress. J Cardiovasc Transl Res. 2021;14(3):416–25. https://doi.org/10.1007/s12265-020-10072-x.

    Article  PubMed  Google Scholar 

  96. Shishikura D, Sidharta SL, Honda S, Takata K, Kim SW, Andrews J, Montarello N, Delacroix S, Baillie T, Worthley MI, Psaltis PJ, Nicholls SJ. The relationship between segmental wall shear stress and lipid core plaque derived from near-infrared spectroscopy. Atherosclerosis. 2018;275:68–73.

    Article  CAS  PubMed  Google Scholar 

  97. Goldstein JA, Maini B, Dixon SR, Brilakis ES, Grines CL, Rizik DG, Powers ER, Steinberg DH, Shunk KA, Weisz G, Moreno PR, Kini A, Sharma SK, Hendricks MJ, Sum ST, Madden SP, Muller JE, Stone GW, Kern MJ. Detection of lipid-core plaques by intracoronary near-infrared spectroscopy identifies high risk of periprocedural myocardial infarction. Circ Cardiovasc Interv. 2011;4(5):429–37.

    Article  PubMed  Google Scholar 

  98. de Boer S, Baran Y, Garcia-Garcia HM, Eskin I, Lenzen MJ, Kleber ME, Regar E, de Jaegere PJ, Ligthart JM, van Geuns RJ, Lehtimäki T, Laaksonen R, Boersma E, Marz W, Halperin E, Serruys PW, Koenig W. The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis—Intravascular Ultrasound (ATHEROREMO-IVUS) study. EuroIntervention. 2018;14(2):194–203.

    Article  PubMed  Google Scholar 

  99. Raghunathan D, Abdel-Karim AR, Papayannis AC, daSilva M, Jeroudi OM, Rangan BV, Banerjee S, Brilakis ES. Relation between the presence and extent of coronary lipid core plaques detected by near-infrared spectroscopy with postpercutaneous coronary intervention myocardial infarction. Am J Cardiol. 2011;107(11):1613–8.

    Article  PubMed  Google Scholar 

  100. Kini AS, Baber U, Kovacic JC, Limaye A, Ali ZA, Sweeny J, Maehara A, Mehran R, Dangas G, Mintz GS, Fuster V, Narula J, Sharma SK, Moreno PR. Changes in plaque lipid content after short-term intensive versus standard statin therapy: the YELLOW trial (reduction in yellow plaque by aggressive lipid-lowering therapy). J Am Coll Cardiol. 2013;62(1):21–9.

    Article  CAS  PubMed  Google Scholar 

  101. Kini AS, Vengrenyuk Y, Shameer K, Maehara A, Purushothaman M, Yoshimura T, Matsumura M, Aquino M, Haider N, Johnson KW, Readhead B, Kidd BA, Feig JE, Krishnan P, Sweeny J, Milind M, Moreno P, Mehran R, Kovacic JC, Baber U, Dudley JT, Narula J, Sharma S. Intracoronary imaging, cholesterol efflux, and transcriptomes after intensive statin treatment: the YELLOW II study. J Am Coll Cardiol. 2017;69(6):628–40.

    Article  CAS  PubMed  Google Scholar 

  102. Boogers MJ, Broersen A, van Velzen JE, de Graaf FR, El-Naggar HM, Kitslaar PH, Dijkstra J, Delgado V, Boersma E, de Roos A, Schuijf JD, Schalij MJ, Reiber JH, Bax JJ, Jukema JW. Automated quantification of coronary plaque with computed tomography: comparison with intravascular ultrasound using a dedicated registration algorithm for fusion-based quantification. Eur Heart J. 2012;33(8):1007–16.

    Article  PubMed  Google Scholar 

  103. Kruk M, Wardziak Ł, Mintz GS, Achenbach S, Pręgowski J, Rużyłło W, Dzielińska Z, Demkow M, Witkowski A, Kępka C. Accuracy of coronary computed tomography angiography vs intravascular ultrasound for evaluation of vessel area. J Cardiovasc Comput Tomogr. 2014;8(2):141–8.

    Article  PubMed  Google Scholar 

  104. Takahashi S, Kawasaki M, Miyata S, Suzuki K, Yamaura M, Ido T, Aoyama T, Fujiwara H, Minatoguchi S. Feasibility of tissue characterization of coronary plaques using 320-detector row computed tomography: comparison with integrated backscatter intravascular ultrasound. Heart Vessel. 2016;31(1):29–37.

    Article  Google Scholar 

  105. Voros S, Rinehart S, Qian Z, Vazquez G, Anderson H, Murrieta L, Wilmer C, Carlson H, Taylor K, Ballard W, Karmpaliotis D, Kalynych A, Brown C 3rd. Prospective validation of standardized, 3-dimensional, quantitative coronary computed tomographic plaque measurements using radiofrequency backscatter intravascular ultrasound as reference standard in intermediate coronary arterial lesions: results from the ATLANTA (assessment of tissue characteristics, lesion morphology, and hemodynamics by angiography with fractional flow reserve, intravascular ultrasound and virtual histology, and noninvasive computed tomography in atherosclerotic plaques) I study. JACC Cardiovasc Interv. 2011;4(2):198–208.

    Article  PubMed  Google Scholar 

  106. Otsuka K, Fukuda S, Tanaka A, Nakanishi K, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M. Napkin-ring sign on coronary CT angiography for the prediction of acute coronary syndrome. JACC Cardiovasc Imaging. 2013;6(4):448–57.

    Article  PubMed  Google Scholar 

  107. Versteylen MO, Kietselaer BL, Dagnelie PC, Joosen IA, Dedic A, Raaijmakers RH, Wildberger JE, Nieman K, Crijns HJ, Niessen WJ, Daemen MJ, Hofstra L. Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary syndrome. J Am Coll Cardiol. 2013;61(22):2296–305.

    Article  PubMed  Google Scholar 

  108. Motoyama S, Ito H, Sarai M, Kondo T, Kawai H, Nagahara Y, Harigaya H, Kan S, Anno H, Takahashi H, Naruse H, Ishii J, Hecht H, Shaw LJ, Ozaki Y, Narula J. Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up. J Am Coll Cardiol. 2015;66(4):337–46.

    Article  PubMed  Google Scholar 

  109. van der Giessen AG, Schaap M, Gijsen FJ, Groen HC, van Walsum T, Mollet NR, Dijkstra J, van de Vosse FN, Niessen WJ, de Feyter PJ, van der Steen AF, Wentzel JJ. 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study. Int J Cardiovasc Imaging. 2010;26(7):781–96.

    Article  PubMed  Google Scholar 

  110. Hoogendoorn A, Kok AM, Hartman EMJ, de Nisco G, Casadonte L, Chiastra C, Coenen A, Korteland SA, Van der Heiden K, Gijsen FJH, Duncker DJ, van der Steen AFW, Wentzel JJ. Multidirectional wall shear stress promotes advanced coronary plaque development: comparing five shear stress metrics. Cardiovasc Res. 2020;116(6):1136–46.

    Article  CAS  PubMed  Google Scholar 

  111. Ferencik M, Mayrhofer T, Bittner DO, Emami H, Puchner SB, Lu MT, Meyersohn NM, Ivanov AV, Adami EC, Patel MR, Mark DB, Udelson JE, Lee KL, Douglas PS, Hoffmann U. Use of high-risk coronary atherosclerotic plaque detection for risk stratification of patients with stable chest pain: a secondary analysis of the PROMISE randomized clinical trial. JAMA Cardiol. 2018;3(2):144–52.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Williams MC, Moss AJ, Dweck M, Adamson PD, Alam S, Hunter A, Shah ASV, Pawade T, Weir-McCall JR, Roditi G, van Beek EJR, Newby DE, Nicol ED. Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study. J Am Coll Cardiol. 2019;73(3):291–301.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Brown AJ, Obaid DR, Costopoulos C, Parker RA, Calvert PA, Teng Z, Hoole SP, West NE, Goddard M, Bennett MR. Direct comparison of virtual-histology intravascular ultrasound and optical coherence tomography imaging for identification of thin-cap fibroatheroma. Circ Cardiovasc Imaging. 2015;8(10):e003487.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Fujii K, Hao H, Shibuya M, Imanaka T, Fukunaga M, Miki K, Tamaru H, Sawada H, Naito Y, Ohyanagi M, Hirota S, Masuyama T. Accuracy of OCT, grayscale IVUS, and their combination for the diagnosis of coronary TCFA: an ex vivo validation study. JACC Cardiovasc Imaging. 2015;8(4):451–60.

    Article  PubMed  Google Scholar 

  115. Taniwaki M, Radu MD, Garcia-Garcia HM, Heg D, Kelbæk H, Holmvang L, Moschovitis A, Noble S, Pedrazzini G, Saunamäki K, Dijkstra J, Landmesser U, Wenaweser P, Meier B, Stefanini GG, Roffi M, Lüscher TF, Windecker S, Räber L. Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy. Int J Cardiovasc Imaging. 2015;31(5):915–26.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

    Enrico Romagnoli, Francesco Burzotta, Cristina Aurigemma & Carlo Trani

  2. Università Cattolica del Sacro Cuore, Rome, Italy

    Francesco Burzotta & Carlo Trani

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  1. Enrico Romagnoli
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  2. Francesco Burzotta
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  3. Cristina Aurigemma
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  4. Carlo Trani
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Editors and Affiliations

  1. Service of Hybrid Cardio Imaging, Madonna della Fiducia Clinic, Rome, Lazio, Italy

    Francesco Nudi

  2. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Lazio, Italy

    Orazio Schillaci

  3. Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Lazio, Italy

    Giuseppe Biondi-Zoccai

  4. Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA

    Ami E. Iskandrian

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Romagnoli, E., Burzotta, F., Aurigemma, C., Trani, C. (2022). Hybrid Cardiac Imaging for the Invasive Cardiologist. In: Nudi, F., Schillaci, O., Biondi-Zoccai, G., Iskandrian, A.E. (eds) Hybrid Cardiac Imaging for Clinical Decision-Making. Springer, Cham. https://doi.org/10.1007/978-3-030-99391-7_6

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