Skip to main content

Psychosocial Recovery-Oriented Interventions in Schizophrenia

  • Chapter
  • First Online:
Recovery and Major Mental Disorders

Abstract

From the deinstitutionalization of the second half of the twentieth century, the Mental Health Care System has focused on outpatient care and community-based services. The goal is reaching recovery in patients with severe mental illness, that means improving symptoms and allowing patients to develop their cognitive, emotional and social skills in order to live in the community. In this new scenario, psychosocial interventions find an important role in improving functioning in schizophrenia. Some psychosocial interventions based on multiple randomized controlled trials demonstrated to be effective at improving the outcome of schizophrenia, whereas others led to promising findings. In this chapter we will focus on evidence-based psychosocial practices to achieve recovery in schizophrenia, such as psychoeducation, cognitive behavioural therapy for psychosis, cognitive remediation and on interventions which led to potential benefits in this population, such as healthy lifestyle interventions, physical exercise and integrated treatments for co-occurring substance use disorder. Despite international guidelines recommend psychosocial interventions as supportive treatments alongside pharmaceutic or psychotherapeutic ones, until now only a minority of patients received a person-centred evidence-based psychiatric rehabilitation intervention. It is necessary to redesign services on the principles of recovery and to implement services that deliver interventions supported by scientific evidence.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rössler W, Drake RE. Psychiatric rehabilitation in Europe. Epidemiol Psychiatr Sci. 2017;26(3):1–7. https://doi.org/10.1017/S2045796016000858.

    Article  Google Scholar 

  2. Mueser KT, Deavers F, Penn DL, Cassisi JE. Psychosocial treatments for schizophrenia. Annu Rev Clin Psychol. 2013;9:465–97. https://doi.org/10.1146/annurev-clinpsy-050212-185620.

    Article  PubMed  Google Scholar 

  3. Vita A, Corrivetti G, Mannu J, Semisa D, Vigano C. Psychosocial rehabilitation in Italy today. Int J Ment Health. 2016;45:15–23. https://doi.org/10.1080/00207411.2015.1119375.

    Article  Google Scholar 

  4. Vita A, Barlati S. Recovery from schizophrenia: is it possible? Curr Opin Psychiatry. 2018;31(3):246–55. https://doi.org/10.1097/YCO.0000000000000407.

    Article  PubMed  Google Scholar 

  5. Morin L, Franck N. Rehabilitation interventions to promote recovery from schizophrenia: a systematic review. Front Psych. 2017;8:100. https://doi.org/10.3389/fpsyt.2017.00100.

    Article  Google Scholar 

  6. Harvey PD, Strassnig M. Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status. World Psychiatry. 2012;11(2):73–9. https://doi.org/10.1016/j.wpsyc.2012.05.004.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ventura J, Hellemann GS, Thames AD, Koellner V, Nuechterlein KH. Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophr Res. 2009;113(2–3):189–99. https://doi.org/10.1016/j.schres.2009.03.035.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ventriglio A, Ricci F, Magnifico G, Chumakov E, Torales J, Watson C, Castaldelli-Maia JM, Petito A, Bellomo A. Psychosocial interventions in schizophrenia: focus on guidelines. Int J Soc Psychiatry. 2020;66(8):735–47. https://doi.org/10.1177/0020764020934827.

    Article  PubMed  Google Scholar 

  9. Drake RE, Rosenberg SD, Teague GB, Bartels SJ, Torrey WC. Fundamental principles of evidence-based medicine applied to mental health care. Psychiatr Clin North Am 2003;26(4):811–20, vii. doi: https://doi.org/10.1016/s0193-953x(03)00063-7.

  10. Drake RE, Goldman HH, Leff HS, Lehman AF, Dixon L, Mueser KT, Torrey WC. Implementing evidence-based practices in routine mental health service settings. Psychiatr Serv. 2001;52(2):179–82. https://doi.org/10.1176/appi.ps.52.2.179.

    Article  CAS  PubMed  Google Scholar 

  11. Shean GD. Evidence-based psychosocial practices and recovery from schizophrenia. Psychiatry. 2009;72(4):307–20. https://doi.org/10.1521/psyc.2009.72.4.307.

    Article  PubMed  Google Scholar 

  12. Lehman AF, Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB, Goldberg R, Green-Paden LD, et al. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003. Schizophr Bull. 2004;30(2):193–217. https://doi.org/10.1093/oxfordjournals.schbul.a007071.

    Article  PubMed  Google Scholar 

  13. Kern RS, Glynn SM, Horan WP, Marder SR. Psychosocial treatments to promote functional recovery in schizophrenia. Schizophr Bull. 2009;35(2):347–61. https://doi.org/10.1093/schbul/sbn177.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Fleischhacker WW, Arango C, Arteel P, Barnes TR, Carpenter W, Duckworth K, Galderisi S, Halpern L, Knapp M, Marder SR, Moller M, Sartorius N, Woodruff P. Schizophrenia—time to commit to policy change. Schizophr Bull. 2014;40(Suppl 3):S165–94. https://doi.org/10.1093/schbul/sbu006.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Vita A, Barlati S. The implementation of evidence-based psychiatric rehabilitation: challenges and opportunities for mental health services. Front Psych. 2019;10:147. https://doi.org/10.3389/fpsyt.2019.00147.

    Article  Google Scholar 

  16. Rummel-Kluge C, Kissling W. Psychoeducation in schizophrenia: new developments and approaches in the field. Curr Opin Psychiatry. 2008;21(2):168–72. https://doi.org/10.1097/YCO.0b013e3282f4e574.

    Article  PubMed  Google Scholar 

  17. Atadokht A, Hajloo N, Karimi M, Narimani M. The role of family expressed emotion and perceived social support in predicting addiction relapse. Int J High Risk Behav Addict. 2015;4(1):e21250. https://doi.org/10.5812/ijhrba.21250.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Koutra K, Triliva S, Roumeliotaki T, Basta M, Simos P, Lionis C, Vgontzas AN. Impaired family functioning in psychosis and its relevance to relapse: a two-year follow-up study. Compr Psychiatry. 2015;62:1–12. https://doi.org/10.1016/j.comppsych.2015.06.006.

    Article  PubMed  Google Scholar 

  19. Lyman DR, Braude L, George P, Dougherty RH, Daniels AS, Ghose SS, Delphin-Rittmon ME. Consumer and family psychoeducation: assessing the evidence. Psychiatr Serv. 2014;65(4):416–28. https://doi.org/10.1176/appi.ps.201300266.

    Article  PubMed  Google Scholar 

  20. Cohen AN, Glynn SM, Murray-Swank AB, Barrio C, Fischer EP, McCutcheon SJ, Perlick DA, Rotondi AJ, Sayers SL, Sherman MD, Dixon LB. The family forum: directions for the implementation of family psychoeducation for severe mental illness. Psychiatr Serv. 2008;59(1):40–8. https://doi.org/10.1176/ps.2008.59.1.40.

    Article  PubMed  Google Scholar 

  21. Pharoah F, Mari J, Rathbone J, Wong W. Family intervention for schizophrenia. Cochrane Database Syst Rev. 2010;(12):CD000088. https://doi.org/10.1002/14651858.CD000088.pub2.

  22. Morgan AJ, Reavley NJ, Ross A, Too LS, Jorm AF. Interventions to reduce stigma towards people with severe mental illness: systematic review and meta-analysis. J Psychiatr Res. 2018;103:120–33. https://doi.org/10.1016/j.jpsychires.2018.05.017.

    Article  PubMed  Google Scholar 

  23. Ashcroft K, Kim E, Elefant E, Benson C, Carter JA. Meta-analysis of caregiver-directed psychosocial interventions for schizophrenia. Community Ment Health J. 2018;54(7):983–91. https://doi.org/10.1007/s10597-018-0289-x.

    Article  PubMed  Google Scholar 

  24. Ivezić SŠ, Sesar MA, Mužinić L. Effects of a group psychoeducation program on self-stigma, empowerment and perceived discrimination of persons with schizophrenia. Psychiatr Danub. 2017;29(1):66–73.

    Article  Google Scholar 

  25. Xia J, Merinder LB, Belgamwar MR. Psychoeducation for schizophrenia. Cochrane Database Syst Rev. 2011;2011(6):CD002831. https://doi.org/10.1002/14651858.CD002831.pub2.

    Article  PubMed Central  Google Scholar 

  26. National Institute for Health and Care Excellence. Rehabilitation for adults with complex psychosis. London, UK; 2020.

    Google Scholar 

  27. SIGN guideline, Management of Schizophrenia. 2013.

    Google Scholar 

  28. Galletly C, Castle D, Dark F, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders. Aust N Z J Psychiatry. 2016;50(5):410–72.

    Article  Google Scholar 

  29. Keepers GA, Fochtmann LJ, Anzia JM, Benjamin S, Lyness JM, Mojtabai R, Servis M, et al. The American Psychiatric Association Practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry. 2020;177(9):868–72. https://doi.org/10.1176/appi.ajp.2020.177901.

    Article  PubMed  Google Scholar 

  30. Beck AT. Successful outpatient psychotherapy of a chronic schizophrenic with a delusion based on borrowed guilt. Psychiatry. 1952;15(3):305–12. https://doi.org/10.1080/00332747.1952.11022883.

    Article  CAS  PubMed  Google Scholar 

  31. Morrison AP, Renton JC, Dunn H, Williams S, Bentall RP. Cognitive therapy for psychosis: a case formulation approach. Brighton: Psychology Press Ltd; 2003.

    Google Scholar 

  32. Turkington D, Kingdon D, Weiden PJ. Cognitive behavior therapy for schizophrenia. Am J Psychiatry. 2006;163(3):365–73. https://doi.org/10.1176/appi.ajp.163.3.365.

    Article  PubMed  Google Scholar 

  33. Kopelowicz A, Liberman RP, Zarate R. Recent advances in social skills training for schizophrenia. Schizophr Bull. 2006;32(Suppl 1):S12–23. https://doi.org/10.1093/schbul/sbl023.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Beck AT, Rector NA. Cognitive approaches to schizophrenia: theory and therapy. Annu Rev Clin Psychol. 2005;1:577–606. https://doi.org/10.1146/annurev.clinpsy.1.102803.144205.

    Article  PubMed  Google Scholar 

  35. Mander H, Kingdon D. The evolution of cognitive-behavioral therapy for psychosis. Psychol Res Behav Manag. 2015;8:63–9. https://doi.org/10.2147/PRBM.S52267.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Wykes T, Steel C, Everitt B, Tarrier N. Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor. Schizophr Bull. 2008;34(3):523–37. https://doi.org/10.1093/schbul/sbm114.

    Article  PubMed  Google Scholar 

  37. Dixon LB, Dickerson F, Bellack AS, Bennett M, Dickinson D, Goldberg RW, Lehman A, et al. Schizophrenia Patient Outcomes Research Team (PORT). The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statements. Schizophr Bull. 2010;36(1):48–70. https://doi.org/10.1093/schbul/sbp115.

    Article  PubMed  Google Scholar 

  38. Jauhar S, McKenna PJ, Radua J, Fung E, Salvador R, Laws KR. Cognitive-behavioural therapy for the symptoms of schizophrenia: systematic review and meta-analysis with examination of potential bias. Br J Psychiatry. 2014;204(1):20–9. https://doi.org/10.1192/bjp.bp.112.116285.

    Article  CAS  PubMed  Google Scholar 

  39. Laws KR, Darlington N, Kondel TK, McKenna PJ, Jauhar S. Cognitive behavioural therapy for schizophrenia—outcomes for functioning, distress and quality of life: a meta-analysis. BMC Psychol. 2018;6(1):32. https://doi.org/10.1186/s40359-018-0243-2.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Bellack AS, Mueser KT. Psychosocial treatment for schizophrenia. Schizophr Bull. 1993;19(2):317–36. https://doi.org/10.1093/schbul/19.2.317.

    Article  CAS  PubMed  Google Scholar 

  41. Rector NA, Beck AT. Cognitive therapy for schizophrenia: from conceptualization to intervention. Can J Psychiatr. 2002;47(1):39–48.

    Article  Google Scholar 

  42. Pilling S, Bebbington P, Kuipers E, Garety P, Geddes J, Martindale B, Orbach G, et al. Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation. Psychol Med. 2002;32(5):783–91. https://doi.org/10.1017/s0033291702005640.

    Article  CAS  PubMed  Google Scholar 

  43. Mueser KT, Penn DL. Meta-analysis examining the effects of social skills training on schizophrenia. Psychol Med. 2004;34(7):1365–7. https://doi.org/10.1017/s0033291704213848.

    Article  PubMed  Google Scholar 

  44. Pfammatter M, Junghan UM, Brenner HD. Efficacy of psychological therapy in schizophrenia: conclusions from meta-analyses. Schizophr Bull. 2006;32(Suppl 1):S64–80. https://doi.org/10.1093/schbul/sbl030.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Kurtz MM, Mueser KT. A meta-analysis of controlled research on social skills training for schizophrenia. J Consult Clin Psychol. 2008;76(3):491–504. https://doi.org/10.1037/0022-006X.76.3.491.

    Article  PubMed  Google Scholar 

  46. Silverstein SM, Spaulding WD, Menditto AA, Savitz A, Liberman RP, Berten S, Starobin H. Attention shaping: a reward-based learning method to enhance skills training outcomes in schizophrenia. Schizophr Bull. 2009;35(1):222–32. https://doi.org/10.1093/schbul/sbm150.

    Article  PubMed  Google Scholar 

  47. Turner DT, McGlanaghy E, Cuijpers P, van der Gaag M, Karyotaki E, MacBeth A. A meta-analysis of social skills training and related interventions for psychosis. Schizophr Bull. 2018;44(3):475–91. https://doi.org/10.1093/schbul/sbx146.

    Article  PubMed  Google Scholar 

  48. Leff J, Warner R. Social inclusion of people with mental illness. Cambridge University Press; 2006.

    Book  Google Scholar 

  49. Mueser KT, Becker DR, Torrey WC, Xie H, Bond GR, Drake RE, Dain BJ. Work and nonvocational domains of functioning in persons with severe mental illness: a longitudinal analysis. J Nerv Ment Dis. 1997;185(7):419–26. https://doi.org/10.1097/00005053-199707000-00001.

    Article  CAS  PubMed  Google Scholar 

  50. Gold PB, Waghorn G. Supported employment for people with severe mental illness. Lancet. 2007;370(9593):1108–9. https://doi.org/10.1016/S0140-6736(07)61491-3.

    Article  PubMed  Google Scholar 

  51. Bond GB. Vocational rehabilitation, Handbook of psychiatric rehabilitation; 1992. p. 244–25.

    Google Scholar 

  52. Hoffmann H, Jäckel D, Glauser S, Kupper Z. A randomised controlled trial of the efficacy of supported employment. Acta Psychiatr Scand. 2012;125(2):157–67. https://doi.org/10.1111/j.1600-0447.2011.01780.

    Article  CAS  PubMed  Google Scholar 

  53. Lehman AF, Goldberg R, Dixon LB, McNary S, Postrado L, Hackman A, McDonnell K. Improving employment outcomes for persons with severe mental illnesses. Arch Gen Psychiatry. 2002;59(2):165–72. https://doi.org/10.1001/archpsyc.59.2.165.

    Article  PubMed  Google Scholar 

  54. Becker DR, Drake RE. A working life for people with severe mental illness. Oxford University Press; 2003.

    Book  Google Scholar 

  55. Frederick DE, VanderWeele TJ. Supported employment: meta-analysis and review of randomized controlled trials of individual placement and support. PLoS One. 2019;14(2):e0212208. https://doi.org/10.1371/journal.pone.0212208.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Heinrichs RW, Miles AA, Ammari N, Muharib E. Cognition as a central illness feature in schizophrenia. In: Harvey PD, editor. Cognitive impairment in schizophrenia: characteristics, assessment and treatment. Cambridge University Press; 2013. p. 1–23. https://doi.org/10.1017/CBO9781139003872.002.

    Chapter  Google Scholar 

  57. Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, et al. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiatry. 2007;64(6):633–47. https://doi.org/10.1001/archpsyc.64.6.633.

    Article  CAS  PubMed  Google Scholar 

  58. Kambeitz-Ilankovic L, Betz LT, Dominke C, Haas SS, Subramaniam K, Fisher M, Vinogradov S, Koutsouleris N, Kambeitz J. Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: revisiting the relevance of human coaching and elucidating interplay between multiple outcomes. Neurosci Biobehav Rev. 2019;107:828–45. https://doi.org/10.1016/j.neubiorev.2019.09.031.

    Article  PubMed  PubMed Central  Google Scholar 

  59. McGurk SR, Mueser KT, Covell NH, Cicerone KD, Drake RE, Silverstein SM, Medialia A, et al. Mental health system funding of cognitive enhancement interventions for schizophrenia: summary and update of the New York Office of Mental Health expert panel and stakeholder meeting. Psychiatr Rehabil J. 2013;36(3):133–45. https://doi.org/10.1037/prj0000020.

    Article  PubMed  Google Scholar 

  60. Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011;168(5):472–85. https://doi.org/10.1176/appi.ajp.2010.10060855.

    Article  PubMed  Google Scholar 

  61. Bowie CR, Bell MD, Fiszdon JM, Johannesen JK, Lindenmayer JP, McGurk SR, Medalia AA, et al. Cognitive remediation for schizophrenia: an expert working group white paper on core techniques. Schizophr Res. 2020;215:49–53. https://doi.org/10.1016/j.schres.2019.10.047.

    Article  PubMed  Google Scholar 

  62. McGurk SR, Twamley EW, Sitzer DI, McHugo GJ, Mueser KT. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry. 2007;164(12):1791–802. https://doi.org/10.1176/appi.ajp.2007.07060906.

    Article  PubMed  PubMed Central  Google Scholar 

  63. DeTore NR, Mueser KT, Byrd JA, McGurk SR. Cognitive functioning as a predictor of response to comprehensive cognitive remediation. J Psychiatr Res. 2019;113:117–24. https://doi.org/10.1016/j.jpsychires.2019.03.012.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Van Duin D, de Winter L, Oud M, Kroon H, Veling W, van Weeghel J. The effect of rehabilitation combined with cognitive remediation on functioning in persons with severe mental illness: systematic review and meta-analysis. Psychol Med. 2019;49(9):1414–25. https://doi.org/10.1017/S003329171800418X.

    Article  PubMed  Google Scholar 

  65. McGurk SR, Mueser KT, Pascaris A. Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophr Bull. 2005;31(4):898–909. https://doi.org/10.1093/schbul/sbi037.

    Article  PubMed  Google Scholar 

  66. Hogarty GE, Flesher S, Ulrich R, Carter M, Greenwald D, Pogue-Geile M, Kechavan M, et al. Cognitive enhancement therapy for schizophrenia: effects of a 2-year randomized trial on cognition and behavior. Arch Gen Psychiatry. 2004;61(9):866–76. https://doi.org/10.1001/archpsyc.61.9.866.

    Article  PubMed  Google Scholar 

  67. Pukrop R, Schultze-Lutter F, Ruhrmann S, Brockhaus-Dumke A, Tendolkar I, Bechdolf A, Matuschek E, et al. Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first- and multiple-episode schizophrenia. J Clin Exp Neuropsychol. 2006;28(8):1388–407. https://doi.org/10.1080/13803390500434425.

    Article  PubMed  Google Scholar 

  68. Lin A, Wood SJ, Nelson B, Brewer WJ, Spiliotacopoulos D, Bruxner A, Broussard C, et al. Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Schizophr Res. 2011;132(1):1–7. https://doi.org/10.1016/j.schres.2011.06.014.

    Article  CAS  PubMed  Google Scholar 

  69. Ruhrmann S, Schultze-Lutter F, Klosterkötter J. Intervention in the at-risk state to prevent transition to psychosis. Curr Opin Psychiatry. 2009;22(2):177–83. https://doi.org/10.1097/YCO.0b013e328324b687.

    Article  PubMed  Google Scholar 

  70. Barlati S, Deste G, De Peri L, Ariu C, Vita A. Cognitive remediation in schizophrenia: current status and future perspectives. Schizophr Res Treatment. 2013;2013:156084. https://doi.org/10.1155/2013/156084.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Pinkham AE, Hopfinger JB, Pelphrey KA, Piven J, Penn DL. Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophr Res. 2008;99(1–3):164–75. https://doi.org/10.1016/j.schres.2007.10.024.

    Article  PubMed  Google Scholar 

  72. Pinkham AE, Penn DL. Neurocognitive and social cognitive predictors of interpersonal skill in schizophrenia. Psychiatry Res. 2006;143(2–3):167–78. https://doi.org/10.1016/j.psychres.2005.09.005.

    Article  PubMed  Google Scholar 

  73. Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: a review. Schizophr Bull. 2006;32(Suppl 1):S44–63. https://doi.org/10.1093/schbul/sbl029.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Fett AK, Viechtbauer W, Dominguez MD, Penn DL, van Os J, Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev. 2011;35(3):573–88. https://doi.org/10.1016/j.neubiorev.2010.07.001.

    Article  PubMed  Google Scholar 

  75. Fiszdon JM. Introduction to social cognitive treatment approaches for schizophrenia. In: Roberts DL, Penn DL, editors. Social cognition in schizophrenia: from evidence to treatment. Oxford University Press; 2013. p. 285–310. https://doi.org/10.1093/med:psych/9780199777587.003.0012.

    Chapter  Google Scholar 

  76. Roder V, Mueller DR, Schmidt SJ. Effectiveness of integrated psychological therapy (IPT) for schizophrenia patients: a research update. Schizophr Bull. 2011;37(Suppl 2):S71–9. https://doi.org/10.1093/schbul/sbr072.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Lindenmayer JP, Khan A, McGurk SR, Kulsa MKC, Ljuri I, Ozog V, Fregenti S, et al. Does social cognition training augment response to computer-assisted cognitive remediation for schizophrenia? Schizophr Res. 2018;201:180–6. https://doi.org/10.1016/j.schres.2018.06.012.

    Article  PubMed  Google Scholar 

  78. Horan WP, Kern RS, Tripp C, Hellemann G, Wynn JK, Bell M, Marder SR, et al. Efficacy and specificity of social cognitive skills training for outpatients with psychotic disorders. J Psychiatr Res. 2011;45(8):1113–22. https://doi.org/10.1016/j.jpsychires.2011.01.015.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Kurtz MM, Richardson CL. Social cognitive training for schizophrenia: a meta-analytic investigation of controlled research. Schizophr Bull. 2012;38(5):1092–104. https://doi.org/10.1093/schbul/sbr036.

    Article  PubMed  Google Scholar 

  80. Lysaker PH, Shea AM, Buck KD, Dimaggio G, Nicolò G, Procacci M, Salvatore G, Rand KL. Metacognition as a mediator of the effects of impairments in neurocognition on social function in schizophrenia spectrum disorders. Acta Psychiatr Scand. 2010;122(5):405–13. https://doi.org/10.1111/j.1600-0447.2010.01554.x.

    Article  PubMed  Google Scholar 

  81. Ottavi P, D’Alia D, Lysaker P, Kent J, Popolo R, Salvatore G, Dimaggio G. Metacognition-oriented social skills training for individuals with long-term schizophrenia: methodology and clinical illustration. Clin Psychol Psychother. 2014;21(5):465–73. https://doi.org/10.1002/cpp.1850.

    Article  PubMed  Google Scholar 

  82. Inchausti F, García-Poveda NV, Ballesteros-Prados A, Ortuño-Sierra J, Sánchez-Reales S, Prado-Abril J, Aldaz-Armendáriz JA, Mole J, Dimaggio G, Ottavi P, Fonseca-Pedrero E. The effects of metacognition-oriented social skills training on psychosocial outcome in schizophrenia-spectrum disorders: a randomized controlled trial. Schizophr Bull. 2018;44(6):1235–44. https://doi.org/10.1093/schbul/sbx168.

    Article  PubMed  Google Scholar 

  83. Moritz S, Woodward TS. Metacognitive training in schizophrenia: from basic research to knowledge translation and intervention. Curr Opin Psychiatry. 2007;20(6):619–25. https://doi.org/10.1097/YCO.0b013e3282f0b8ed.

    Article  PubMed  Google Scholar 

  84. Moritz S, Andreou C, Schneider BC, Wittekind CE, Menon M, Balzan RP, Woodward TS. Sowing the seeds of doubt: a narrative review on metacognitive training in schizophrenia. Clin Psychol Rev. 2014;34(4):358–66. https://doi.org/10.1016/j.cpr.2014.04.004.

    Article  PubMed  Google Scholar 

  85. Liu YC, Tang CC, Hung TT, Tsai PC, Lin MF. The efficacy of metacognitive training for delusions in patients with schizophrenia: a meta-analysis of randomized controlled trials informs evidence-based practice. Worldviews Evid-Based Nurs. 2018;15(2):130–9. https://doi.org/10.1111/wvn.12282.

    Article  PubMed  Google Scholar 

  86. Philipp R, Kriston L, Lanio J, Kühne F, Härter M, Moritz S, Meister R. Effectiveness of metacognitive interventions for mental disorders in adults—a systematic review and meta-analysis (METACOG). Clin Psychol Psychother. 2019;26(2):227–40. https://doi.org/10.1002/cpp.2345.

    Article  PubMed  Google Scholar 

  87. Laursen TM. Life expectancy among persons with schizophrenia or bipolar affective disorder. Schizophr Res. 2011;131(1–3):101–4. https://doi.org/10.1016/j.schres.2011.06.008.

    Article  PubMed  Google Scholar 

  88. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand. 2007;116(5):317–33. https://doi.org/10.1111/j.1600-0447.2007.01095.x.

    Article  CAS  PubMed  Google Scholar 

  89. The Schizophrenia Commission. The abandoned illness: a report from the Schizophrenia Commission. London: Rethink Mental Illness; 2012.

    Google Scholar 

  90. Thornicroft G. Physical health disparities and mental illness: the scandal of premature mortality. Br J Psychiatry. 2011;199(6):441–2. https://doi.org/10.1192/bjp.bp.111.092718.

    Article  PubMed  Google Scholar 

  91. Vancampfort D, Rosenbaum S, Schuch F, Ward PB, Richards J, Mugisha J, Probst M, et al. Cardiorespiratory fitness in severe mental illness: a systematic review and meta-analysis. Sports Med. 2017;47(2):343–52. https://doi.org/10.1007/s40279-016-0574-1.

    Article  PubMed  Google Scholar 

  92. Hutchison SL, Terhorst L, Murtaugh S, Gross S, Kogan JN, Shaffer SL. Effectiveness of a staff promoted wellness program to improve health in residents of a mental health long-term care facility. Issues Ment Health Nurs. 2016;37(4):257–64. https://doi.org/10.3109/01612840.2015.1126774.

    Article  PubMed  Google Scholar 

  93. Gill KJ, Zechner M, Zambo Anderson E, Swarbrick M, Murphy A. Wellness for life: a pilot of an interprofessional intervention to address metabolic syndrome in adults with serious mental illnesses. Psychiatr Rehabil J. 2016;39(2):147–53. https://doi.org/10.1037/prj0000172.

    Article  PubMed  Google Scholar 

  94. Looijmans A, Jörg F, Bruggeman R, Schoevers RA, Corpeleijn E. Multimodal lifestyle intervention using a web-based tool to improve cardiometabolic health in patients with serious mental illness: results of a cluster randomized controlled trial (LION). BMC Psychiatry. 2019;19(1):339. https://doi.org/10.1186/s12888-019-2310-5.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Sabe M, Kaiser S, Sentissi O. Physical exercise for negative symptoms of schizophrenia: systematic review of randomized controlled trials and meta-analysis. Gen Hosp Psychiatry. 2020;62:13–20. https://doi.org/10.1016/j.genhosppsych.2019.11.002.

    Article  PubMed  Google Scholar 

  96. Firth J, Cotter J, Elliott R, French P, Yung AR. A systematic review and meta-analysis of exercise interventions in schizophrenia patients. Psychol Med. 2015;45(7):1343–61. https://doi.org/10.1017/S0033291714003110.

    Article  CAS  PubMed  Google Scholar 

  97. Leutwyler H, Hubbard EM, Jeste DV, Miller B, Vinogradov S. Associations of schizophrenia symptoms and neurocognition with physical activity in older adults with schizophrenia. Biol Res Nurs. 2014;16(1):23–30. https://doi.org/10.1177/1099800413500845.

    Article  PubMed  Google Scholar 

  98. McEwen SC, Hardy A, Ellingson BM, Jarrahi B, Sandhu N, Subotnik KL, Ventura J, et al. Prefrontal and hippocampal brain volume deficits: role of low physical activity on brain plasticity in first-episode schizophrenia patients. J Int Neuropsychol Soc. 2015;21(10):868–79. https://doi.org/10.1017/S1355617715000983.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Kimhy D, Vakhrusheva J, Bartels MN, Armstrong HF, Ballon JS, Khan S, Chang RW, et al. Aerobic fitness and body mass index in individuals with schizophrenia: implications for neurocognition and daily functioning. Psychiatry Res. 2014;220(3):784–91. https://doi.org/10.1016/j.psychres.2014.08.052.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, Elliott R, et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull. 2017;43(3):546–56. https://doi.org/10.1093/schbul/sbw115.

    Article  PubMed  Google Scholar 

  101. Maurus I, Röh A, Falkai P, Malchow B, Schmitt A, Hasan A. Nonpharmacological treatment of dyscognition in schizophrenia: effects of aerobic exercise. Dialogues Clin Neurosci. 2019;21(3):261–9. https://doi.org/10.31887/DCNS.2019.21.3/aschmitt.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Bond GR, Drake RE, Mueser KT, et al. Assertive community treatment for people with severe mental illness. Dis-Manage-Health-Outcomes. 2001;9:141–59. https://doi.org/10.2165/00115677-200109030-00003.

    Article  Google Scholar 

  103. Latimer EA. Economic impacts of assertive community treatment: a review of the literature. Can J Psychiatr. 1999;44(5):443–54. https://doi.org/10.1177/070674379904400504.

    Article  CAS  Google Scholar 

  104. Latimer E. Economic considerations associated with assertive community treatment and supported employment for people with severe mental illness. J Psychiatry Neurosci. 2005;30(5):355–9.

    PubMed  PubMed Central  Google Scholar 

  105. Monroe-DeVita M, Teague GB, Moser LL. The TMACT: a new tool for measuring fidelity to assertive community treatment. J Am Psychiatr Nurses Assoc. 2011;17(1):17–29. https://doi.org/10.1177/1078390310394658.

    Article  PubMed  Google Scholar 

  106. Tarrier N, Wittkowski A, Kinney C, McCarthy E, Morris J, Humphreys L. Durability of the effects of cognitive-behavioural therapy in the treatment of chronic schizophrenia: 12-month follow-up. Br J Psychiatry. 1999;174:500–4. https://doi.org/10.1192/bjp.174.6.500.

    Article  CAS  PubMed  Google Scholar 

  107. Mueser KT, Corrigan PW, Hilton DW, Tanzman B, Schaub A, Gingerich S, Essock SM, et al. Illness management and recovery: a review of the research. Psychiatr Serv. 2002;53(10):1272–84. https://doi.org/10.1176/appi.ps.53.10.1272.

    Article  PubMed  Google Scholar 

  108. Gingerich S, Mueser KT. Illness management and recovery: personalized skills and strategies for those with mental illness. Centre City, MN: Hazelden; 2011.

    Google Scholar 

  109. Lean M, Fornells-Ambrojo M, Milton A, Lloyd-Evans B, Harrison-Stewart B, Yesufu-Udechuku A, Kendall T, et al. Self-management interventions for people with severe mental illness: systematic review and meta-analysis. Br J Psychiatry. 2019;214(5):260–8. https://doi.org/10.1192/bjp.2019.54.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Valencia M, Fresan A, Juárez F, Escamilla R, Saracco R. The beneficial effects of combining pharmacological and psychosocial treatment on remission and functional outcome in outpatients with schizophrenia. J Psychiatr Res. 2013;47(12):1886–92. https://doi.org/10.1016/j.jpsychires.2013.09.006.

    Article  CAS  PubMed  Google Scholar 

  111. Guo X, Zhai J, Liu Z, Fang M, Wang B, Wang C, Hu B, et al. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch Gen Psychiatry. 2010;67(9):895–904. https://doi.org/10.1001/archgenpsychiatry.2010.105.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Menezes NM, Arenovich T, Zipursky RB. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychol Med. 2006;36(10):1349–62. https://doi.org/10.1017/S0033291706007951.

    Article  CAS  PubMed  Google Scholar 

  113. Linden M, Pyrkosch L, Hundemer HP. Frequency and effects of psychosocial interventions additional to olanzapine treatment in routine care of schizophrenic patients. Soc Psychiatry Psychiatr Epidemiol. 2008;43(5):373–9. https://doi.org/10.1007/s00127-008-0318-0.

    Article  PubMed  Google Scholar 

  114. Sato S, Iwata K, Furukawa S, Matsuda Y, Hatsuse N, Ikebuchi E. The effects of the combination of cognitive training and supported employment on improving clinical and working outcomes for people with schizophrenia in Japan. Clin Pract Epidemiol Ment Health. 2014;10:18–27. https://doi.org/10.2174/1745017901410010018.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophr Res. 2015;162(1–3):35–41. https://doi.org/10.1016/j.schres.2015.01.020.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Nibbio G, Barlati S, Cacciani P, Corsini P, Mosca A, Ceraso A, Deste G, et al. Evidence-based integrated intervention in patients with schizophrenia: a pilot study of feasibility and effectiveness in a real-world rehabilitation setting. Int J Environ Res Public Health. 2020;17(10):3352. https://doi.org/10.3390/ijerph17103352.

    Article  CAS  PubMed Central  Google Scholar 

  117. Kukla M, Bell MD, Lysaker PH. A randomized controlled trial examining a cognitive behavioral therapy intervention enhanced with cognitive remediation to improve work and neurocognition outcomes among persons with schizophrenia spectrum disorders. Schizophr Res. 2018;197:400–6. https://doi.org/10.1016/j.schres.2018.01.012.

    Article  PubMed  Google Scholar 

  118. Chien WT, Yip AL. Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments. Neuropsychiatr Dis Treat. 2013;9:1311–32. https://doi.org/10.2147/NDT.S37485.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Addington J, Penn D, Woods SW, Addington D, Perkins DO. Social functioning in individuals at clinical high risk for psychosis. Schizophr Res. 2008;99(1–3):119–24. https://doi.org/10.1016/j.schres.2007.10.001.

    Article  PubMed  Google Scholar 

  120. Lieberman JA, Perkins D, Belger A, Chakos M, Jarskog F, Boteva K, Gilmore J. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry. 2001;50(11):884–97. https://doi.org/10.1016/s0006-3223(01)01303-8. Erratum in: Biol Psychiatry 2002 Feb 15;51(4):346.

    Article  CAS  PubMed  Google Scholar 

  121. Fusar-Poli P, Byrne M, Valmaggia L, Day F, Tabraham P, Johns L, McGuire P, et al. Social dysfunction predicts two years clinical outcome in people at ultra high risk for psychosis. J Psychiatr Res. 2010;44(5):294–301. https://doi.org/10.1016/j.jpsychires.2009.08.016.

    Article  CAS  PubMed  Google Scholar 

  122. Santesteban-Echarri O, Rice S, González-Blanch C, Alvarez-Jimenez M. Chapter 18: Promoting psychosocial functioning and recovery in schizophrenia spectrum and other psychotic disorders. In: Johanna C, editor. A clinical introduction to psychosis: foundations for clinical psychologists and neuropsychologist; 2019. https://doi.org/10.1016/B978-0-12-815012-2.00018-3.

    Chapter  Google Scholar 

  123. Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161(3):473–9. https://doi.org/10.1176/appi.ajp.161.3.473.

    Article  PubMed  Google Scholar 

  124. Jaracz K, Górna K, Kiejda J, Grabowska-Fudala B, Jaracz J, Suwalska A, Rybakowski JK. Psychosocial functioning in relation to symptomatic remission: a longitudinal study of first episode schizophrenia. Eur Psychiatry. 2015;30(8):907–13. https://doi.org/10.1016/j.eurpsy.2015.08.001.

    Article  CAS  PubMed  Google Scholar 

  125. Bird V, Premkumar P, Kendall T, Whittington C, Mitchell J, Kuipers E. Early intervention services, cognitive-behavioural therapy and family intervention in early psychosis: systematic review. Br J Psychiatry. 2010;197(5):350–6. https://doi.org/10.1192/bjp.bp.109.074526.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Grawe RW, Falloon IR, Widen JH, Skogvoll E. Two years of continued early treatment for recent-onset schizophrenia: a randomised controlled study. Acta Psychiatr Scand. 2006;114(5):328–36. https://doi.org/10.1111/j.1600-0447.2006.00799.x.

    Article  CAS  PubMed  Google Scholar 

  127. Bosanac P, Patton GC, Castle DJ. Early intervention in psychotic disorders: faith before facts? Psychol Med. 2010;40(3):353–8. https://doi.org/10.1017/s0033291709990341.

    Article  CAS  PubMed  Google Scholar 

  128. Mueser KT, Penn DL, Addington J, Brunette MF, Gingerich S, Glynn SM, Lynde DW, et al. The NAVIGATE program for first-episode psychosis: rationale, overview, and description of psychosocial components. Psychiatr Serv. 2015;66(7):680–90. https://doi.org/10.1176/appi.ps.201400413.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Bechdolf A, Wagner M, Ruhrmann S, Harrigan S, Putzfeld V, Pukrop R, Brockhaus-Dumke A, et al. Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry. 2012;200(1):22–9. https://doi.org/10.1192/bjp.bp.109.066357.

    Article  CAS  PubMed  Google Scholar 

  130. Miklowitz DJ, O’Brien MP, Schlosser DA, Addington J, Candan KA, Marshall C, Domingues I, Walsh BC, Zinberg JL, De Silva SD, Friedman-Yakoobian M, Cannon TD. Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial. J Am Acad Child Adolesc Psychiatry. 2014;53(8):848–58. https://doi.org/10.1016/j.jaac.2014.04.020.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Worthington MA, Miklowitz DJ, O’Brien M, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, et al. Selection for psychosocial treatment for youth at clinical high risk for psychosis based on the North American Prodrome Longitudinal Study individualized risk calculator. Early Interv Psychiatry. 2021;15(1):96–103. https://doi.org/10.1111/eip.12914.

    Article  PubMed  Google Scholar 

  132. Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC. Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry. 1997;54(4):313–21. https://doi.org/10.1001/archpsyc.1997.01830160031005.

    Article  CAS  PubMed  Google Scholar 

  133. Schmidt LM, Hesse M, Lykke J. The impact of substance use disorders on the course of schizophrenia—a 15-year follow-up study: dual diagnosis over 15 years. Schizophr Res. 2011;130(1–3):228–33. https://doi.org/10.1016/j.schres.2011.04.011.

    Article  PubMed  Google Scholar 

  134. Barrowclough C, Haddock G, Wykes T, Beardmore R, Conrod P, Craig T, Davies L, et al. Integrated motivational interviewing and cognitive behavioural therapy for people with psychosis and comorbid substance misuse: randomised controlled trial. BMJ. 2010;341:c6325. https://doi.org/10.1136/bmj.c6325.

    Article  PubMed  PubMed Central  Google Scholar 

  135. Brunette MF, Mueser KT, Drake RE. A review of research on residential programs for people with severe mental illness and co-occurring substance use disorders. Drug Alcohol Rev. 2004;23(4):471–81. https://doi.org/10.1080/09595230412331324590.

    Article  PubMed  Google Scholar 

  136. Brunette MF, Mueser KT. Psychosocial interventions for the long-term management of patients with severe mental illness and co-occurring substance use disorder. J Clin Psychiatry. 2006;67(Suppl 7):10–7.

    PubMed  Google Scholar 

  137. Drake RE, Essock SM. The science-to-service gap in real-world schizophrenia treatment: the 95% problem. Schizophr Bull. 2009;35(4):677–8. https://doi.org/10.1093/schbul/sbp047.

    Article  PubMed  PubMed Central  Google Scholar 

  138. Liberman RP. Recovery from schizophrenia: form follows functioning. World Psychiatry. 2012;11(3):161–2. https://doi.org/10.1002/j.2051-5545.2012.tb00118.x.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Deegan PE. The importance of personal medicine: a qualitative study of resilience in people with psychiatric disabilities. Scand J Public Health Suppl. 2005;66:29–35. https://doi.org/10.1080/14034950510033345.

    Article  PubMed  Google Scholar 

  140. Bond GR, Drake RE. New directions for psychiatric rehabilitation in the USA. Epidemiol Psychiatr Sci. 2017;26(3):223–7. https://doi.org/10.1017/S2045796016000834.

    Article  CAS  PubMed  Google Scholar 

  141. Williamson A, Makkar SR, McGrath C, Redman S. How can the use of evidence in mental health policy be increased? A systematic review. Psychiatr Serv. 2015;66(8):783–97. https://doi.org/10.1176/appi.ps.201400329.

    Article  PubMed  Google Scholar 

  142. Farkas M, Gagne C, Anthony W, Chamberlin J. Implementing recovery oriented evidence based programs: identifying the critical dimensions. Community Ment Health J. 2005;41(2):141–58. https://doi.org/10.1007/s10597-005-2649-6.

    Article  PubMed  Google Scholar 

  143. Winsper C, Crawford-Docherty A, Weich S, Fenton SJ, Singh SP. How do recovery-oriented interventions contribute to personal mental health recovery? A systematic review and logic model. Clin Psychol Rev. 2020;76:101815. https://doi.org/10.1016/j.cpr.2020.101815.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Antonio Vita .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Barlati, S. et al. (2022). Psychosocial Recovery-Oriented Interventions in Schizophrenia. In: Carpiniello, B., Vita, A., Mencacci, C. (eds) Recovery and Major Mental Disorders. Comprehensive Approach to Psychiatry, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-030-98301-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-98301-7_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-98300-0

  • Online ISBN: 978-3-030-98301-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics