Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research

Hbibi, Abdelhadi; Bouziane, Amal; Lyoussi, Badiaa; Zouhdi, Mimoun; Benazza, Driss

doi:10.1007/978-3-030-96881-6_3

Abdelhadi Hbibi^8,9,
Amal Bouziane¹⁰,
Badiaa Lyoussi¹¹,
Mimoun Zouhdi¹² &
…
Driss Benazza¹³

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1373))

1500 Accesses
2 Citations

Abstract

Aggregatibacter actinomycetemcomitans is a major periodontal pathogen that was identified firstly in actinomycotic lesions and later in advanced forms of periodontal diseases as well as in oral cavity of healthy subjects. The particular pathogenicity of this specie makes it a target for extensive studies both at fundamental and practical scales. The current advances in experimental and clinical research related to this bacterium focus the light on epidemiologic features, virulence, and invasiveness aspects as well as on identification challenges, bacterial susceptibility, and anti-virulence strategies. The present chapter provide to scientists and periodontal researchers a comprehensive overview on the main advances made in this field with a special focus on epidemiologic dissemination, microbial diagnosis, virulence factors and clinical implementations of such progress.

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Abbreviations

A. :: Aggregatibacter
AI-2:: autoinducer-2
bp:: base pair
cdt:: cytolethal distending factor
DNA:: deoxyribonucleic acid
ELISA:: enzyme-linked immunosorbent assay
Ig:: immunoglobulins
LAgP:: localized aggressive periodontitis
LFA-1:: lymphocyte function-associated antigen-1
LJP:: localized juvenile periodontitis
LPS:: lipopolysaccharides
LtxA:: Leukotoxin
MALDI-TOF:: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
MIC:: minimum inhibitory concentration
MMPs:: matrix metallo-proteinases
OMV:: outer membrane vesicles
PACs :: cranberry proanthocyanidins
PBS:: phosphate-buffered saline
PCR :: polymerase chain reaction
RANKL:: Receptor activator of NF-kappaB Ligand
RNA:: ribonucleic acid
rPCR:: rapid PCR;
RS :: Ringer’s solution
RTF:: reduced transport fluid
TNF-α:: tumor necrosis factor α
TSBV:: tryptic soy-serum-bacitracin-vancomycin

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Authors and Affiliations

Research laboratory in oral biology and biotechnology, Faculty of dental medicine, Mohammed V University in Rabat, Rabat, Morocco
Abdelhadi Hbibi
Centre des Soins Dentaires, Hôpital Provincial Moulay Abdellah, Salé, Morocco
Abdelhadi Hbibi
Department of Periodontology, Faculty of Dental Medicine, Biostatistical Clinical and Epidemiological Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco
Amal Bouziane
Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Science, University Sidi Mohammed Ben Abdellah, Fez, Morocco
Badiaa Lyoussi
Department of Microbiology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco
Mimoun Zouhdi
Department of Periodontology, Faculty of Dental Medicine, Mohammed V University in Rabat, Rabat, Morocco
Driss Benazza

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Abdelhadi Hbibi
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Amal Bouziane
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Badiaa Lyoussi
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Mimoun Zouhdi
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Driss Benazza
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Correspondence to Abdelhadi Hbibi .

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Science and Healthcare for Oral Welfare, Toulouse, France
Julien Santi-Rocca

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Hbibi, A., Bouziane, A., Lyoussi, B., Zouhdi, M., Benazza, D. (2022). Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research. In: Santi-Rocca, J. (eds) Periodontitis. Advances in Experimental Medicine and Biology, vol 1373. Springer, Cham. https://doi.org/10.1007/978-3-030-96881-6_3

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DOI: https://doi.org/10.1007/978-3-030-96881-6_3
Published: 26 May 2022
Publisher Name: Springer, Cham
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