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Cardamonin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

  • Living reference work entry
  • First Online:
Handbook of Dietary Flavonoids

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Abstract

Cardamonin (2′, 4′-dihydroxy-6′-methoxychalcone) is a naturally occurring flavonoid (chalcone) abundantly present in plants. Cardamonin has been identified in many plant species used in traditional medicine, such as Boesenbergia rotunda, Alpinia raffleflesiana, Elettaria cardamomum, etc. Several studies have documented that cardamonin exerts a broad spectrum of biological activities against many diseases, e.g., type 2-diabetes (T2DM), neurodegenerative diseases, cancer, cardiovascular diseases (CVDs), rheumatoid arthritis, anti-microbial, Sjogren’s syndrome, anti-inflammatory, inflammatory bowel disease (IBD), and others. Moreover, in vitro and in vivo studies have proven the low bioavailability and bioaccessibility of cardamonin. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) of cardamonin also need further study. This current book chapter focuses on cardamonin regarding its resources, biosynthesis pathway, bioavailability, bioactivity, and its proposed role in human health.

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Acknowledgments

This work was supported by Jiangsu Specially-Appointed Professor Program (19TPJS-002) and Senior Talent Startup Fund of Jiangsu University (4111360002) to X. Chen.

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Authors and Affiliations

  1. School of Food and Biological Engineering, Jiangsu University, Jingkou District, Zhenjiang, Jiangsu, People’s Republic of China

    Arshad Mehmood, Yu Sun & Xiumin Chen

  2. Institute of Food Physical Processing, Jiangsu University, Jingkou District, Zhenjiang, Jiangsu, People’s Republic of China

    Xiumin Chen

  3. International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu University, Zhenjiang, China

    Xiumin Chen

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  1. Arshad Mehmood
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  2. Yu Sun
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  3. Xiumin Chen
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Correspondence to Xiumin Chen .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Mehmood, A., Sun, Y., Chen, X. (2023). Cardamonin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_93-1

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