Abstract
In recent years, the Indian pharmaceutical industry has gradually evolved witnessing a major development in this sector. India has become the third largest API (Active pharmaceutical ingredient) merchant and is likely to be among the top three pharmaceutical markets by 2020. Though this will strengthen the economic growth of the country but subsequently it is fuelling the major environmental crisis such as waste generation. The unwanted materials produced at the time of manufacturing can turn out to be hazardous to the environment. Like the ash produced from the boiler furnace, impurities from the extraction unit and chemical waste from the processing unit. Today waste management practices become an integrated approach of waste reduction and recycling in order to enhance sustainable development. Common management practices employed by the pharmaceutical industries in India are Incineration, autoclaving, coagulation, constructed wetlands, and vermicomposting. Also, owing to the lack of proper disposal technique, some manufacturing industries often sell the hazardous/solid waste to the authorized re-processor or end user. This chapter elucidates the possible route of waste generation from pharmaceutical industries. It also shed some light on the current waste management technique used in India and also defines its shortcoming and limitations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Dora, K. N., Kumari, K., Srivatsava, M., & Dalai, N. (2020). A review on various techniques for municipality waste management and product development. Materials Today: Proceedings.
Schnapf, D. (1981). State Hazardous waste programs under the federal resource conservation and recovery act. Environmental Law, 12, 679.
Goodman, L. S. (1996). Goodman and Gilman's the pharmacological basis of therapeutics (Vol. 1549). McGraw-Hill.
Reynolds, J. (1989). Sodium cromoglycate and related anti-allergic agents, the extra pharmacopoeia, 29th edn.
Fick, J., Söderström, H., Lindberg, R. H., Phan, C., Tysklind, M., & Larsson, D. J. (2009). Contamination of surface, ground, and drinking water from pharmaceutical production. Environmental Toxicology and Chemistry, 28(12), 2522–2527.
Baldigo, B. P., George, S. D., Phillips, P. J., Hemming, J. D., Denslow, N. D., & Kroll, K. J. (2015). Potential estrogenic effects of wastewaters on gene expression in Pimephales promelas and fish assemblages in streams of southeastern New York. Environmental Toxicology and Chemistry, 34(12), 2803–2815.
Berninger, J. P., LaLone, C. A., Villeneuve, D. L., & Ankley, G. T. (2016). Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset. Environmental Toxicology and Chemistry, 35(4), 1007–1020.
Wilkinson, J., Hooda, P. S., Barker, J., Barton, S., & Swinden, J. (2017). Occurrence, fate and transformation of emerging contaminants in water: An overarching review of the field. Environmental Pollution, 231, 954–970.
Khan, H. K., Rehman, M. Y. A., & Malik, R. N. (2020). Fate and toxicity of pharmaceuticals in water environment: An insight on their occurrence in South Asia. Journal of Environmental Management, 271, 111030.
Bhangale, V. (2008). Pharma marketing in India: Opportunities, challenges and the way forward. Journal of Medical Marketing, 8(3), 205–210.
Patneedi, C. B., & Prasadu, K. D. (2015). Impact of pharmaceutical wastes on human life and environment. Rasayan Journal of Chemistry, 8(1), 67–70.
Singh, D., & Suthar, S. (2012). Vermicomposting of herbal pharmaceutical industry solid wastes. Ecological Engineering, 39, 1–6.
Suthar, S. (2011). Utilizing livestock waste solids as bioresource for socio-economic sustainability: A report from rural India. Reviews in Environmental Science and Biotechnology. https://doi.org/10.1007/s1157-011-92240-0
Brandon, G. M., Lazcano, C., Lores, M., & Dominguez, J. (2011). Short-term stabilization of grape marc through earthworms. Journal of Hazardous Materials, 187, 291–295.
Hait, S., & Tare, V. (2011). Vermistabilization of primary sewage sludge. Bioresource Technology, 102, 2812–2820.
Dominguez, J., & Edwards, C. A. (2004) Vermicomposting organic wastes: A review. In S. H. S. Hanna, & W. Z. A. Milkhail (Eds.), Soil zoology for sustainable development in the 21st century.
Cheng, H., Xu, W., Liu, J., Wang, H., He, Y., & Chen, G. (2007). Pretreatment of wastewater from triazine manufacturing by coagulation, electrolysis, and internal microelectrolysis. The Journal of Hazardous Materials, 146, 385–392.
Zorita, S., Martensson, L., & Mathiasson, L. (2009). Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden. Science of the Total Environment, 407, 2760–3277.
Batt, A. L., Kim, S., & Aga, D. S. (2007). Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. Chemosphere, 68, 428–435.
Ridder, D., Verberk, D. J., Amya, H. J. Q. J. C., VanDijk, G. L., & JC,. (2012). Zeolites for nitrosamine and pharmaceutical removal from demineralised and surface water: Mechanisms and efficacy. Separation and Purification Technology, 89, 71–77.
Ghauch, A., Tuqan, A., & Assi, H. A. (2009). Antibiotic removal from water: Elimination of amoxicillin and ampicillin by microscale and nanoscale iron particles. Environmental Pollution, 157, 1626–1635.
Grisales-Cifuentes, C. M., Galvis, E. A. S., Porras, J., Flórez, E., Torres-Palma, R. A., & Acelas, N. (2021). Kinetics, isotherms, effect of structure, and computational analysis during the removal of three representative pharmaceuticals from water by adsorption using a biochar obtained from oil palm fiber. Bioresource Technology, 124753.
Hounfodji, J. W., Kanhounnon, W. G., Kpotin, G., Atohoun, G. S., Lainé, J., Foucaud, Y., & Badawi, M. (2021). Molecular insights on the adsorption of some pharmaceutical residues from wastewater on kaolinite surfaces. Chemical Engineering Journal, 407, 127176.
Ashraf, M. I., Ateeb, M., Khan, M. H., Ahmed, N., & Mahmood, Q. (2016). Integrated treatment of pharmaceutical effluents by chemical coagulation and ozonation. Separation and Purification Technology, 158, 383–386.
Hassan, S. S., Abdel-Shafy, H. I., & Mansour, M. S. (2019). Removal of pharmaceutical compounds from urine via chemical coagulation by green synthesized ZnO-nanoparticles followed by microfiltration for safe reuse. Arabian Journal of Chemistry, 12(8), 4074–4083.
Kooijman, G., de Kreuk, M. K., Houtman, C., & van Lier, J. B. (2020). Perspectives of coagulation/flocculation for the removal of pharmaceuticals from domestic wastewater: A critical view at experimental procedures. Journal of Water Process Engineering, 34, 101161.
Pal, P., & Thakura, R. (2017). Pharmaceutical waste treatment and disposal of concentrated rejects: A review. International Journal of Engineering Technology Science and Research, 4(9), 2394–3386.
Zaidi, S., Chaabane, T., Sivasankar, V., Darchen, A., Maachi, R., & Msagati, T. A. M. (2019). Electro-coagulation coupled electro-flotation process: Feasible choice in doxycycline removal from pharmaceutical effluents. Arabian Journal of Chemistry, 12(8), 2798–2809.
Dindaş, G. B., Çalışkan, Y., Celebi, E. E., Tekbaş, M., Bektaş, N., & Yatmaz, H. C. (2020). Treatment of pharmaceutical wastewater by combination of electrocoagulation, electro-fenton and photocatalytic oxidation processes. Journal of Environmental Chemical Engineering, 8(3), 103777.
Karthikeyan, K. G., & Meyer, M. T. (2006). Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Science of the Total Environment, 361, 196–207.
Ávila, C., García-Galán, M. J., Uggetti, E., Montemurro, N., García-Vara, M., Pérez, S., & Postigo, C. (2021). Boosting pharmaceutical removal through aeration in constructed wetlands. Journal of Hazardous Materials, 125231.
Hu, B., Hu, S., Chen, Z., & Vymazal, J. (2020). Employ of arbuscular mycorrhizal fungi for pharmaceuticals ibuprofen and diclofenac removal in mesocosm-scale constructed wetlands. Journal of Hazardous Materials, 124524.
Delgado, N., Bermeo, L., Hoyos, D. A., Peñuela, G. A., Capparelli, A., Marino, D., & Casas-Zapata, J. C. (2020). Occurrence and removal of pharmaceutical and personal care products using subsurface horizontal flow constructed wetlands. Water Research, 187, 116448.
Buonomenna, M. G., & Bae, J. (2015). Organic Solvent Nanofiltration in Pharmaceutical Industry. Separation and Purification Reviews, 44(2), 157–182.
Serna-Galvis, E. A., Silva-Agredo, J., Botero-Coy, A. M., Moncayo-Lasso, A., Hernández, F., & Torres-Palma, R. A. (2019). Effective elimination of fifteen relevant pharmaceuticals in hospital wastewater from Colombia by combination of a biological system with a sonochemical process. Science of the Total Environment, 670, 623–632.
Wang, G., Wang, D., Xu, Y., Li, Z., & Huang, L. (2020). Study on optimization and performance of biological enhanced activated sludge process for pharmaceutical wastewater treatment. Science of The Total Environment, 739, 140166.
Ferrer-Polonio, E., Fernández-Navarro, J., Iborra-Clar, M. I., Alcaina-Miranda, M. I., & Mendoza-Roca, J. A. (2020). Removal of pharmaceutical compounds commonly-found in wastewater through a hybrid biological and adsorption process. Journal of Environmental Management, 263, 110368.
Chakrabortty, S., Pal, M., Roy, M., & Pal, P. (2015). Water treatment in a new flux-enhancing, continuous forward osmosis design: Transport modelling and economic evaluation towards scale up. Desalination, 365, 329–342.
Radjenovic, J., Petrovic, M., & Barcelo, D. (2009). Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Research, 43, 831–884.
Sipma, J., Osuna, B., Collado, N., Monclús, H., Ferrero, G., Comas, J., & Roda, I. R. (2010). Comparison of removal of pharmaceuticals in MBR and activated sludge systems. Desalination, 250, 653–659.
Homayoonfal, M., & Mehrnia, M. R. (2014). Amoxicillin separation from pharmaceutical solution by pH sensitive nanofiltration membranes. Separation and Purification Technology, 130, 74–83.
Basu, S., & Balakrishnan, M. (2017). Polyamide thin film composite membranes containing ZIF-8 for the separation of pharmaceutical compounds from aqueous streams. Separation and Purification Technology, 179, 118–125.
Chakrabortty, S., Nayak, J., Pal, P., Kumar, R., & Chakraborty, P. (2020). Separation of COD, sulphate and chloride from pharmaceutical wastewater using membrane integrated system: Transport modeling towards scale-up. Journal of Environmental Chemical Engineering, 8(5), 104275.
Balakrishnan, B. A., & Gurtoo, A. (2015). Environmental practices in the indian pharmaceutical SMEs: An assessment. Review of Integrative Business and Economics Research, 4(4), 205–224.
Campos-Castillo, C. (2012). Co-presence in virtual environments. Social Compass, 6(5), 425–433.
Singh, M., Brueckner, M., & Padhy, P. K. (2014). Insights into the state of ISO 14001 certification in both small and medium enterprise and industry best companies in India: The case of Delhi and Noida. Journal of Cleaner Production, 69, 225–236.
Sing, N. J., & Bagchi, S. (2013). Applied ecology in India: Scope of science and policy to meet contemporary environmental and socio-ecological challenges. Journal of Applied Ecology, 50, 4–14.
Brahmbhatt, N. C., & Pandya, K. Y. (2015). Performance evaluation of effluent treatment plant and hazardous waste management of pharmaceutical industry of Ankleshwar. Advances in Applied Science Research, 6(4), 157–161.
Tekin, H., Bilkay, O., Ataberk, S. S., Balta, T. H., Ceribasi, I. H., Sanin, F. D., Dilek, F. B., & Yetis, U. (2006). Use of Fenton oxidation to improve the biodegradability of a pharmaceutical wastewater. Journal of Hazardous Materials, 136(2), 258–265.
Chelliapan, S., Wilby, T., & Sallis, P. J. (2006). Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics. Water Research, 40, 507–516.
Melero, J. A., Botas, J. A., Molina, R., Pariente, M. I., & Mart, F. (2009). Heterogeneous catalytic wet peroxide oxidation systems for the treatment of an industrial pharmaceutical wastewater. Water Research, 43(16), 4010–4018.
Kulik, N., Trapido, M., Goi, A., Veressinina, Y., & Munter, R. (2008). Combined chemical treatment of pharmaceutical effluents from medical ointment production. Chemosphere, 70(8), 1525–1531.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Upadhyay, S., Sinha, A. (2022). Waste Management in Indian Pharmaceutical Industries. In: Yadav, S., Negm, A.M., Yadava, R.N. (eds) Environmental Management in India: Waste to Wealth. Springer, Cham. https://doi.org/10.1007/978-3-030-93897-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-93897-0_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-93896-3
Online ISBN: 978-3-030-93897-0
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)