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Sepsis and Fever in the Neuro-Critical Care Unit (NCCU)

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Procedures and Protocols in the Neurocritical Care Unit

Abstract

The exact incidence of sepsis in the Neuro-Critical Care Unit (NCCU) is unknown to date. The diagnosis of sepsis is confounded by multiple factors in acute neurologic patients. Low Glasgow Coma Score (GCS), underlying cranial nerve weakness leading to impaired speech and swallow, impaired ability to clear one’s secretions, prolonged bed-bound status, multiple indwelling iatrogenic devices, etc. all put the patient at a high risk of sepsis. Greater than 50% of the patients end up in short term or long-term rehabilitation centers. This contributes to an additional septic burden to the patient. Central nervous system and spinal tract infections require prolonged broad-spectrum antibiotics due to difficult penetration. Drug toxicity and superinfection is another complication of sepsis in the NCCU. The focus of the current chapter is to describe the causes of sepsis and its diagnostic criteria, systematic approach, management protocol and choice of appropriate antibiotics for the patient with sepsis, the role of various laboratory parameters and briefly describe non-infectious causes of fever in Intensive Care Unit (ICU).

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  1. Department of Neurocritical Care, University of Missouri, Columbia, MO, USA

    Chandra Shekar Pingili

  2. Department of Neurology- Neurocriticalcare unit, University of Missouri, Columbia, MO, USA

    Niraj Arora

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    Niraj Arora

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Pingili, C.S., Arora, N. (2022). Sepsis and Fever in the Neuro-Critical Care Unit (NCCU). In: Arora, N. (eds) Procedures and Protocols in the Neurocritical Care Unit. Springer, Cham. https://doi.org/10.1007/978-3-030-90225-4_16

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