Abstract
Erysipelothrix rhusiopathiae is a generalist, opportunistic, and zoonotic bacterium with a global distribution and wide host range that spans vertebrates and invertebrates. It is best known as a cause of production loss in the domestic swine and poultry industries but has been recently recognized as a significant disease-causing pathogen in arctic mammals. There are three main clades of E. rhusiopathiae, with isolates from Clade 3 dominating in arctic terrestrial mammals. The bacterium is also an important occupational pathogen of people. Given the broad host range and opportunistic nature of E. rhusiopathiae, increased efforts to better understand its epidemiology and significance in the changing arctic ecosystem are warranted.
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References
Alley MR, Gartrell BD, Mack HJ, McInnes CM (2005) Erysipelothrix rhusiopathiae septicaemia in translocated kakapo (Strigops habroptilus). N Z Vet J 53(1):94–94. https://doi.org/10.1080/00480169.2005.36481
Atyabi N, Youssefi R, Javdani G, Tavasoli A, Vojgani M, Gharegozloo F (2012) Isolation of Erysipelothrix rhusiopathiae from aborted lambs in Iran: a case report. Iran J Vet Med 6(2):129–132
Baker AS, Ruoff KL, Madoff S (1998) Isolation of Mycoplasma species from a patient with seal finger. Clin Infect Dis 27(5):1168–1170. https://doi.org/10.1086/514980
Beck B, Smith TG (1976) Letter: seal finger: an unsolved medical problem in Canada. Can Med Assoc J 115(2):105–106
Bender JS, Kinyon JM, Kariyawasam S, Halbur PG, Opriessnig T (2009) Comparison of conventional direct and enrichment culture methods for Erysipelothrix spp. from experimentally and naturally infected swine. J Vet Diagn Investig 21(6):863–868. https://doi.org/10.1177/104063870902100617
Blyde DJ, Woods R (1999) Erysipelas in malleefowl. Aust Vet J 77(7):434–435. https://doi.org/10.1111/j.1751-0813.1999.tb12084.x
Bobrek K, Gaweł A, Mazurkiewicz M (2013) Infections with Erysipelothrix rhusiopathiae in poultry flocks. Worlds Poult Sci J 69(4):803–812. https://doi.org/10.1017/S0043933913000822
Bondo KJ, Macbeth B, Schwantje H, Orsel K, Culling D, Culling B, Tryland M, Nymo IH, Kutz S (2019) Health survey of boreal caribou (Rangifer tarandus caribou) in northeastern British Columbia, Canada. J Wildl Dis 55(3):544–562. https://doi.org/10.7589/2018-01-018
Bossart GD, Eimstad EA (1988) Erysipelothrix vesicular glossitis in a killer whale (Orcinus orca). J Zoo Anim Med 19(1/2):42–47. https://doi.org/10.2307/20094851
Brooke CJ, Riley TV (1999) Erysipelothrix rhusiopathiae: bacteriology, epidemiology and clinical manifestations of an occupational pathogen. J Med Microbiol 48(9):789–799. https://doi.org/10.1099/00222615-48-9-789
Bruner JA, Griffith RW, Greve JH, Wood RL (1984) Erysipelothrix rhusiopathiae serotype 5 isolated from a white-tailed deer in Iowa. J Wildl Dis 20(3):235–236. https://doi.org/10.7589/0090-3558-20.3.235
Butkus CE, Allender MC, Phillips CA, Adamovicz LA (2017) Detection of ranavirus using bone marros harvested from mortality events in eastern box turtles (Terrapene carolina carolina). J Zoo Wildl Med 48(4):1210–1214. https://doi.org/10.1638/2017-0098.1
Calle PP, Kenny DE, Cook RA (1993) Successful treatment of suspected erysipelas septicemia in a beluga whale (Delphinapterus leucas). Zoo Biol 12(5):483–490. https://doi.org/10.1002/zoo.1430120510
Campbell GD, Addison EM, Barker IK, Rosendal S (1994) Erysipelothrix rhusiopathiae, serotype septicemia in moose (Alces alces) from Algonquin Park, Ontario. J Wildl Dis 30(3):436–438
Chong RS-M, Shinwari MW, Amigh MJ, Aravena-Roman M, Riley TV (2015) First report of Erysipelothrix rhusiopathiae-associated septicaemia and histologic changes in cultured Australian eels, Anguilla reinhardtii (Steindachner, 1867) and A. australis (Richardson, 1841). J Fish Dis 38(9):839–847. https://doi.org/10.1111/jfd.12293
Clark AE (2015) The occupational opportunist: an update on Erysipelothrix rhusiopathiae infection, disease pathogenesis, and microbiology. Clin Microbiol Newsl 37(18):143–151. https://doi.org/10.1016/j.clinmicnews.2015.09.001
CWHC (2016) Report CWHC # 124628. Canadian Wildlife Health Cooperative
Domenis L, Spedicato R, Orusa R, Robetto S (2017) Erysipelothrix rhusiopathiae infection in an Alpine ibex (Capra ibex). J Comp Pathol 156(1):101
Fiorito CD, Bentancor A, Lombardo D, Bertellotti M (2016) Erysipelothrix rhusiopathiae isolated from gull-inflicted wounds in southern right whale calves. Dis Aquat Org 121(1):67–73. https://doi.org/10.3354/dao03041
Forde T, Biek R, Zadoks R, Workentine ML, De Buck J, Kutz S, Opriessnig T, Trewby H, van der Meer F, Orsel K (2016a) Genomic analysis of the multi-host pathogen Erysipelothrix rhusiopathiae reveals extensive recombination as well as the existence of three generalist clades with wide geographic distribution. BMC Genomics 17(1):461. https://doi.org/10.1186/s12864-016-2643-0
Forde TL, Orsel K, Zadoks RN, Biek R, Adams LG, Checkley SL, Davison T, De Buck J, Dumond M, Elkin BT, Finnegan L, Macbeth BJ, Nelson C, Niptanatiak A, Sather S, Schwantje HM, van der Meer F, Kutz SJ (2016b) Bacterial genomics reveal the complex epidemiology of an emerging pathogen in Arctic and Boreal ungulates. Front Microbiol 7:1759. https://doi.org/10.3389/fmicb.2016.01759
Forde TL, Kollanandi Ratheesh N, Harvey WT, Thomson JR, Williamson S, Biek R, Opriessnig T (2020) Genomic and immunogenic protein diversity of Erysipelothrix rhusiopathiae isolated from pigs in Great Britain: implications for vaccine protection. Front Microbiol 11:418. https://doi.org/10.3389/fmicb.2020.00418
Franson JC, Galbreath EJ, Wiemeyer SN, Abell JM (1994) Erysipelothrix rhusiopathiae infection in a captive bald eagle (Haliaeetus leucocephalus). J Zoo Wildl Med 25(3):446–448
Fthenakis GC, Christodoulopoulos G, Leontides L, Tzora A (2006) Abortion in ewes associated with Erysipelothrix rhusiopathiae. Small Rumin Res 63(1):183–188. https://doi.org/10.1016/j.smallrumres.2005.01.017
Gartrell BD, Alley MR, Mack H, Donald J, McInnes K, Jansen P (2005) Erysipelas in the critically endangered kakapo (Strigops habroptilus). Avian Pathol 34(5):383–387. https://doi.org/10.1080/03079450500268583
Giménez-Lirola LG, Xiao CT, Halbur PG, Opriessnig T (2012) Development of a novel fluorescent microbead-based immunoassay and comparison with three enzyme-linked immunoassays for detection of anti-Erysipelothrix spp. IgG antibodies in pigs with known and unknown exposure. J Microbiol Methods 91(1):73–79. https://doi.org/10.1016/j.mimet.2012.07.014
Goerttler V, Hubrig T, Others (1960) Pathogenesis of swine erysipelas. Zentralbl Veterinaermed 7:364–391
Groeschel M, Forde T, Turvey S, Joffe AM, Hui C, Naidu P, Mavrot F, Kutz S, Singh AE (2019) An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source. BMC Infect Dis 19(1):282. https://doi.org/10.1186/s12879-019-3913-7
Hassanein R, Sawada T, Kataoka Y, Itoh K, Suzuki Y (2001) Serovars of Erysipelothrix species isolated from the tonsils of healthy cattle in Japan. Vet Microbiol 82(1):97–100. https://doi.org/10.1016/s0378-1135(01)00379-0
Hillenbrand FKM (1953) Whale finger and seal finger; their relation to erysipeloid. Lancet 1(6762):680–681. https://doi.org/10.1016/s0140-6736(53)91807-8
Janßen T, Voss M, Kühl M, Semmler T, Philipp H-C, Ewers C (2015) A combinational approach of multilocus sequence typing and other molecular typing methods in unravelling the epidemiology of Erysipelothrix rhusiopathiae strains from poultry and mammals. Vet Res 46:84. https://doi.org/10.1186/s13567-015-0216-x
Jensen WI, Cotter SE, Fish and Wildlife Service US (1976) An outbreak of erysipelas in eared grebes (Podiceps nigricollis). J Wildl Dis 12:583–586
Jones MP, Orosz SE, Finnegan MV, Sleeman JM, Bemis DA (1999) Erysipelothrix rhusiopathiae infection in an emu (Dromaius novaehollandiae). J Avian Med Surg 13(2):104–107
Kucsera G (1973) Proposal for standardization of the designations used for serotypes of Erysipelothrix rhusiopathiae (migula) Buchanan. Int J Syst Bacteriol 23(2):184–188. https://doi.org/10.1099/00207713-23-2-184
Kutz S, Bollinger T, Branigan M, Checkley S, Davison T, Dumond M, Elkin B, Forde T, Hutchins W, Niptanatiak A, Orsel K (2015) Erysipelothrix rhusiopathiae associated with recent widespread muskox mortalities in the Canadian Arctic. Can Vet J 56(6):560–563
Lamont MH (1979) Erysipelothrix rhusiopathiae: epidemiology and infection in sheep. Vet Bull 49:479–495
Langford EV, Dorward WJ (1977) Erysipelothrix insidiosa recovered from sylvatic mammals in northwestern Canada during examinations for rabies and anthrax. Can Vet J 18(4):101–104
Livingston M, Fidler A, Mellor D, de Kloet S, Eason D, Elliott G, Moorhouse R (2013) Prevalence of IgY antibodies against Erysipelothrix rhusiopathiae in a critically endangered parrot (kakapo, Strigops habroptilus) and associated responses to vaccination. Avian Pathol 42(5):502–507. https://doi.org/10.1080/03079457.2013.832146
Mass DP, Newmeyer WL, Kilgore ES Jr (1981) Seal finger. J Hand Surg Am 6(6):610–612. https://doi.org/10.1016/s0363-5023(81)80144-x
Mavrot F, Orsel K, Hutchins W, Adams LG, Beckmen K, Blake JE, Checkley SL, Davison T, Di Francesco J, Elkin B, Leclerc L-M, Schneider A, Tomaselli M, Kutz SJ (2020) Novel insights into serodiagnosis and epidemiology of Erysipelothrix rhusiopathiae, a newly recognized pathogen in muskoxen (Ovibos moschatus). PLoS One 15(4):e0231724. https://doi.org/10.1371/journal.pone.0231724
McLelland JM, Gartrell BD, Roe WD (2011) A retrospective study of post-mortem examination findings in takahe (Porphyrio hochstetteri). N Z Vet J 59(4):160–165. https://doi.org/10.1080/00480169.2011.579243
Melero M, Rubio-Guerri C, Crespo JL, Arbelo M, Vela AI, GarcÃa-Párraga D, Sierra E, DomÃnguez L, Sánchez-VizcaÃno JM (2011) First case of erysipelas in a free-ranging bottlenose dolphin (Tursiops truncatus) stranded in the Mediterranean Sea. Dis Aquat Org 97(2):167–170. https://doi.org/10.3354/dao02412
Nakato H, Shinomiya K, Mikawa H (1987) Adhesion of Erysipelothrix rhusiopathiae to cultured rat aortic endothelial cells. Role of bacterial neuraminidase in the induction of arteritis. Pathol Res Pract 182(2):255–260. https://doi.org/10.1016/S0344-0338(87)80114-0
Nollens HH, Giménez-Lirola LG, Robeck TR, Schmitt TL, DiRocco S, Opriessnig T (2016) Evaluation of anti-Erysipelothrix rhusiopathiae IgG response in bottlenose dolphins Tursiops truncatus to a commercial pig vaccine. Dis Aquat Org 121(3):249–256. https://doi.org/10.3354/dao03061
Ogawa Y, Ooka T, Shi F, Ogura Y, Nakayama K, Hayashi T, Shimoji Y (2011) The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism’s intracellular adaptations. J Bacteriol 193(12):2959–2971. https://doi.org/10.1128/JB.01500-10
Ogawa Y, Shiraiwa K, Ogura Y, Ooka T, Nishikawa S, Eguchi M, Hayashi T, Shimoji Y (2017) Clonal lineages of Erysipelothrix rhusiopathiae responsible for acute swine erysipelas in Japan identified by using genome-wide single-nucleotide polymorphism analysis. Appl Environ Microbiol 83(11):e00130–e001317. https://doi.org/10.1128/AEM.00130-17
Opriessnig T, Coutinho TA (2019) Erysipelas. In: Zimmerman J (ed) Diseases of swine. Wiley, Boca Raton, FL, pp 835–843
Opriessnig T, Shen HG, Bender JS, Boehm JR, Halbur PG (2013) Erysipelothrix rhusiopathiae isolates recovered from fish, a harbour seal (Phoca vitulina) and the marine environment are capable of inducing characteristic cutaneous lesions in pigs. J Comp Pathol 148(4):365–372. https://doi.org/10.1016/j.jcpa.2012.08.004
Pal N, Bender JS, Opriessnig T (2010) Rapid detection and differentiation of Erysipelothrix spp. by a novel multiplex real-time PCR assay. J Appl Microbiol 108(3):1083–1093. https://doi.org/10.1111/j.1365-2672.2009.04560.x
Pewsner M, Origgi FC, Frey J, Ryser-Degiorgis M-P (2017) Assessing fifty years of general health surveillance of roe deer in Switzerland: a retrospective analysis of necropsy reports. PLoS One 12(1):e0170338. https://doi.org/10.1371/journal.pone.0170338
Proctor DM, Richardson IM (1954) A report on 235 cases of erysipeloid in Aberdeen. Br J Ind Med 11(3):175–179. https://doi.org/10.1136/oem.11.3.175
Ramsay EC, Baumeister BM (1986) Isolation of Erysipelothrix rhusiopathiae from lesions of distal extremity necrosis in a captive king vulture. J Wildl Dis 22(3):430–431. https://doi.org/10.7589/0090-3558-22.3.430
Reboli AC, Farrar WE (1989) Erysipelothrix rhusiopathiae: an occupational pathogen. Clin Microbiol Rev 2(4):354–359. https://doi.org/10.1128/cmr.2.4.354
Rouquet P, Froment J-M, Bermejo M, Kilbourn A, Karesh W, Reed P, Kumulungui B, Yaba P, Délicat A, Rollin PE, Leroy EM (2005) Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003. Emerg Infect Dis 11(2):283–290. https://doi.org/10.3201/eid1102.040533
Sauvé CC, Hernández-Ortiz A, Jenkins E, Mavrot F, Schneider A, Kutz S, Saliki JT, Daoust P-Y (2020) Exposure of the Gulf of St. Lawrence grey seal Halichoerus grypus population to potentially zoonotic infectious agents. Dis Aquat Org 142:105–118. https://doi.org/10.3354/dao03536
Shiraiwa K, Ogawa Y, Nishikawa S, Eguchi M, Shimoji Y (2018) Identification of serovar 1a, 1b, 2, and 5 strains of Erysipelothrix rhusiopathiae by a conventional gel-based PCR. Vet Microbiol 225:101–104. https://doi.org/10.1016/j.vetmic.2018.09.014
Silva AP, Cooper G, Blakey J, Jerry C, Shivaprasad HL, Stoute S (2020) Retrospective summary of Erysipelothrix rhusiopathiae diagnosed in avian species in California (2000–19). Avian Dis 64(4):499–506. https://doi.org/10.1637/aviandiseases-d20-00038
Spraker TR, White PA (2017) Shaggy Lame Fox Syndrome in Pribilof Island Arctic Foxes (Alopex lagopus pribilofensis), Alaska. Vet Pathol 54(2):258–268. https://doi.org/10.1177/0300985816660745
Stephenson EH, Berman DT (1978) Isolation of Erysipelothrix rhusiopathiae from tonsils of apparently normal swine by two methods. Am J Vet Res 39(1):187–188
Stickdorn H (1936) Versuche zur Übertragung von Rotlaufbakterien durch die Schweinelaus (Haematopinus suis). Z Parasitenkd 8(4):492–503. https://doi.org/10.1007/bf02163070
Sudlovenick E (2019) A serological survey and Inuit Qaujimajatuqangit of Ringed seals (Nattiit) in Frobisher Bay, Nunavut. Masters Thesis, University of Prince Edward Island
Suer LD, Vedros NA, Schroeder JP, Dunn JL (1988) Erysipelothrix rhusiopathiae. I. Isolation and characterization from pinnipeds and bite/abrasion wounds in humans. Dis Aquat Org 5:1–5
Tomaselli M, Kutz S, Gerlach C, Checkley S (2018) Local knowledge to enhance wildlife population health surveillance: conserving muskoxen and caribou in the Canadian Arctic. Biol Conserv 217:337–348. https://doi.org/10.1016/j.biocon.2017.11.010
Tryland M, Nesbakken T, Robertson L, Grahek-Ogden D, Lunestad BT (2014) Human pathogens in marine mammal meat – a northern perspective. Zoonoses Public Health 61(6):377–394. https://doi.org/10.1111/zph.12080
Ugochukwu ICI, Samuel F, Orakpoghenor O, Nwobi OC, Anyaoha CO, Majesty-Alukagberie LO, Ugochukwu MO, Ugochukwu EI (2019) Erysipelas, the opportunistic zoonotic disease: history, epidemiology, pathology, and diagnosis–a review. Comp Clin Pathol 28(3):853–859. https://doi.org/10.1007/s00580-018-2856-5
Waltzek TB, Cortés-Hinojosa G, Wellehan JFX Jr, Gray GC (2012) Marine mammal zoonoses: a review of disease manifestations. Zoonoses Public Health 59(8):521–535. https://doi.org/10.1111/j.1863-2378.2012.01492.x
Wang Q, Chang BJ, Riley TV (2010) Erysipelothrix rhusiopathiae. Vet Microbiol 140(3–4):405–417. https://doi.org/10.1016/j.vetmic.2009.08.012
Westley BP, Horazdovsky RD, Michaels DL, Brown DR (2016) Identification of a novel Mycoplasma species in a patient with septic arthritis of the hip and seal finger. Clin Infect Dis 62(4):491–493. https://doi.org/10.1093/cid/civ875
White CP, Jewer DD (2009) Seal finger: a case report and review of the literature. Can J Plast Surg 17(4):133–135. https://doi.org/10.1177/229255030901700415
Wolcott MJ (2007) Erysipelas. In: Hunter NJ, Hunter DB, Atkinson CT (eds) Infectious diseases of wild birds. Blackwell, New York, pp 332–340
Wood RL (1973) Survival of Erysipelothrix rhusiopathiae in soil under various environmental conditions. Cornell Vet 63(3):390–410
Wood RL (1974) Isolation of pathogenic Erysipelothrix rhusiopathiae from feces of apparently healthy swine. Am J Vet Res 35(1):41–43
Wood RL (1975) Erysipelothrix infection. In: Hubbert WT (ed) Diseases transmitted from animals to man, 6th edn. Thomas, Springfield, IL
Wood RL (1994) Erysipelothrix infections. In: Beran GW (ed) Handbook of zoonoses. Section A: bacterial, rickettsial, chlamydial, and mycotic, 2nd edn. CRC Press, Boca Raton, FL
Woodbine M (1950) Erysipelothrix rhusiopathiae. Bacteriology and chemotherapy. Bacteriol Rev 14(2):161–178
Zhu W, Cai C, Wang Y, Li J, Wu C, Kang C, Sun X, Jin M (2017) Characterization of roles of SpaA in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells. Microb Pathog 113:176–180. https://doi.org/10.1016/j.micpath.2017.10.020
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Mavrot, F., Aleuy, O.A., Forde, T., Kutz, S.J. (2022). Erysipelas in Arctic and Northern Regions. In: Tryland, M. (eds) Arctic One Health. Springer, Cham. https://doi.org/10.1007/978-3-030-87853-5_16
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