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Radiobiology

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Basic Radiation Oncology

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Abstract

Radiobiology, in general terms, is the science that evaluates the effects of radiation in living organisms. In the field of radiation oncology, it is defined as the science that investigates the interactions between ionizing radiation and living systems and the consequences of these interactions.

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References

  1. de Pouplana LR (ed.) (2005) The genetic code and the origin of life. Springer, pp 75–91

    Google Scholar 

  2. Pollard TD, Earnshaw WC (2007) Cell biology. Saunders, pp 20–47

    Google Scholar 

  3. Sobti RC, Obe G (eds.) (2002) Some aspects of chromosome structure and function. Springer, pp 112–115

    Google Scholar 

  4. Moeller SJ,Sheaff RJ (2006) G1phase: components, conundrums, context. In: Kaldis P (ed.). Cell cycle regulation. Springer, pp 1–29

    Google Scholar 

  5. Hartwell LH, Culotti J, Pringle JR et al (1974) Genetic control of the cell division cycle in yeast. Science 183:46

    CAS  PubMed  Google Scholar 

  6. Harper JW, Adams PD (2001) Cyclin-dependent kinases. Chem Rev 101:2511

    CAS  PubMed  Google Scholar 

  7. Zinkel SS, Korsmeyer SJ (2005) Apoptosis. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: principles & practice of oncology, 7th edn. Lippincott Williams & Wilkins, Philadelphia, pp 95–98

    Google Scholar 

  8. Jékely G (Ed.) (2007) Eukaryotic membranes and cytoskeleton. Springer, pp 35–40

    Google Scholar 

  9. Lenhard Rudolph K (2007) Telomere shortening induces cell intrinsic checkpoints and environmental alterations limiting adult stem cell function. In: Gutierrez LG, Ju Z. Telomeres and telomerase in ageing, disease, and cancer, part II. Springer, pp 161–80

    Google Scholar 

  10. Bignold L, Coghlan B, Jersmann H (2006) Cancer morphology, carcinogenesis and genetic instability: a background. In: Bignold LP (ed.) Cancer: cell structures, carcinogens and genomic instability. Springer, pp 1–25

    Google Scholar 

  11. Bodansky D (2007) Effects of radiation exposures. In: Bodansky D (ed.) Nuclear energy. Springer, pp 85–121

    Google Scholar 

  12. Kaul A, Becker D (eds.) (2005) Radiological protection. Springer, pp 5–40

    Google Scholar 

  13. Reith W (2016) Radiation biology and radiation protection. In: Vogl T, Reith W, Rummeny E (eds) Diagnostic and interventional radiology. Springer, Berlin, p 13

    Google Scholar 

  14. Lewanski CR, Gullick WJ (2001) Radiotherapy and cellular signaling. Lancet Oncol 2:366

    CAS  PubMed  Google Scholar 

  15. Podgorsak EB (2005) Radiation oncology physics: a handbook for teachers and students. International Atomic Energy Agency, Vienna, p 486

    Google Scholar 

  16. Saw CB, Celi JC, Saiful HM (2006) Therapeutic radiation physics primer. Hematol Oncol Clin North Am 20(1):25–43. Review

    PubMed  Google Scholar 

  17. Michael G (2008) Stabin: quantities and units in radiation protection. In: Stabin MG (ed.) Radiation protection and dosimetry. Springer, pp 67–74

    Google Scholar 

  18. Podgorsak EB (2005) Radiation oncology physics: a handbook for teachers and students. International Atomic Energy Agency, Vienna, p 556

    Google Scholar 

  19. Joseph M (2005) Galy Jean radioactivity, radionuclides, radiation. Springer, pp 117–123

    Google Scholar 

  20. Goitein M (2008) Radiation oncology: a physicist’s—eye view. Springer, pp 5–6

    Google Scholar 

  21. Beck-Bornholdt HP (1993) Quantification of relative biological effectiveness, dose modificationfactor and therapeutic gain factor. Strahlenther Onkol 169(1):42–47

    CAS  PubMed  Google Scholar 

  22. Joseph M (2005) Galy Jean radioactivity radionuclides radiation. Springer, pp 102–3

    Google Scholar 

  23. Katz R, Cucinotta FA (1999) Tracks to therapy. Radiat Meas 31(1–6):379–388. Review

    CAS  PubMed  Google Scholar 

  24. Blackstock A, McMullen K (2005) Radiotherapy and chemotherapy. In: Jeremic B (ed.) Advances in radiation oncology in lung cancer. Springer, p 158

    Google Scholar 

  25. Hobbie RK, Roth BJ (2007) Intermediate physics for medicine and biology. Springer, p 463

    Google Scholar 

  26. Bond VP (1995) Dose, effect severity, and imparted energy in assessing biological effects. Stem Cells 13(Suppl 1):21–29. Review

    PubMed  Google Scholar 

  27. Podgorsak EB (2005) Radiation oncology physics: a handbook for teachers and students. International Atomic Energy Agency, Vienna, p 492

    Google Scholar 

  28. Michael G (2008) Stabin: quantities and units in radiation protection. In: Stabin MG (ed.) Radiation protection and dosimetry. Springer, pp 100–2

    Google Scholar 

  29. Fowler JF (2006) Practical time-dose evaluations, or how to stop worrying and learn to love linear quadratics. In: Levitt SH, Purdy JA, Perez CA, Vijayakumar S (eds.) Technical basis of radiation therapy, 4th rev. edn. Springer, pp 444–46

    Google Scholar 

  30. Strandqvist M (1944) Studien uber die cumulative Wirkung der Rontgenstrahlen bei Fraktionierung. Erfahrungen aus dem Radiumhemmet an 280 Haut und Lippenkarzinomen. Acta Radiol 55(Suppl):1–300

    Google Scholar 

  31. Thames HD Jr (1988) Early fractionation methods and the origins of the NSD concept. Acta Oncol 27(2):89–103. Review

    PubMed  Google Scholar 

  32. Ellis F (1969) Dose, time and fractionation: a clinical hypothesis. Clin Radiol 20:1–7

    CAS  PubMed  Google Scholar 

  33. Goitein M (2008) Radiation oncology: a physicist’s—eye view. Springer, pp 3–4

    Google Scholar 

  34. Podgorsak EB (2005) Radiation oncology physics: a handbook for teachers and students. International Atomic Energy Agency, Vienna, pp 485–491

    Google Scholar 

  35. Dan Garwood L, Cho C, Choy H (2006) Clinical principles and applications of chemoirradiation. In: Levitt SH, Purdy JA, Perez CA, Vijayakumar S (eds.) Technical basis of radiation therapy, 4th rev. edn. Springer, pp 40–41

    Google Scholar 

  36. Little JB, Hahn GM, Frindel E, Tubiana M (1973) Repair of potentially lethal radiation damage in vitro and in vivo. Radiology 106:689

    CAS  PubMed  Google Scholar 

  37. The effect of oxygen on impairment of the proliferative capacity of human cells in culture by ionizing radiations of different LET. Int J Radiat Biol Relat Stud Phys Chem Med 1966;10(4):317–2

    Google Scholar 

  38. Grdina DJ, Murley JS, Kataoka Y (2002) Radioprotectants: current status and new directions. Oncology 63(Suppl 2):2–10

    CAS  PubMed  Google Scholar 

  39. Thomas CT, Ammar A, Farrell JJ, Elsaleh H (2006) Radiation modifiers: treatment overview and future investigations. Hematol Oncol Clin North Am 20(1):119–139

    CAS  PubMed  Google Scholar 

  40. Bergonie J, Tribondeau L (1906) Interprétation de quelques résultats de la radiothérapie et essaide fixation d’une technique rationelle. C R Acad Sci 143:983–985

    Google Scholar 

  41. Michalowski AS (1992) Post-irradiation modification of normal-tissue injury: lessons from the clinic. BJR Suppl 24:183–186. Review

    CAS  PubMed  Google Scholar 

  42. Ancel P, Vintemberger P (1928) C R Soc Biol 99, 832

    Google Scholar 

  43. Rubin P, Casarett GW (1968) Clinical radiation pathology as applied to curative radiotherapy. Cancer 22(4):767–778

    CAS  PubMed  Google Scholar 

  44. Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21(1):109–122

    CAS  PubMed  Google Scholar 

  45. Withers HR, Taylor JM, Maciejewski B (1988) Treatment volume and tissue tolerance. Int J Radiat Oncol Biol Phys 14(4):751–759

    CAS  PubMed  Google Scholar 

  46. Awwad HK (2005) Normal tissue radiosensitivity: prediction on deterministic or stochastic basis? J Egypt Natl Canc Inst 17(4):221–230. Review

    PubMed  Google Scholar 

  47. Willers H, Held KD (2006) Introduction to clinical radiation biology. Hematol Oncol Clin North Am 20(1):1–24. Review

    PubMed  Google Scholar 

  48. Baumann M, Petersen C, Krause M (2005) TCP and NTCP in preclinical and clinical research in Europe. Rays 30(2):121–126. Review

    PubMed  Google Scholar 

  49. Baumann M, Petersen C (2005) TCP and NTCP: a basic introduction. Rays 30(2):99–104. Review

    PubMed  Google Scholar 

  50. Lyman JT (1992) Normal tissue complication probabilities: variable dose per fraction. Int J Radiat Oncol Biol Phys 22(2):247–250

    CAS  PubMed  Google Scholar 

  51. Niemierko A (1997) Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med Phys 24(1):103–110

    CAS  PubMed  Google Scholar 

  52. Coutard H (1937) The result and methods of treatment of cancer by radiation. Ann Surg 106(4):584–598

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Tubiana M, Dutreix J, Wambersie A (1990) Introduction to radiobiology. Taylor & Francis, London, pp 119-123-131-135

    Google Scholar 

  54. Baumann M, Dörr W, Petersen C et al (2003) Repopulation during fractionated radiotherapy: much has been learned, even more is open. Int J Radiat Biol 79(7):465–467

    CAS  PubMed  Google Scholar 

  55. Baumann M, Liertz C, Baisch H et al (1994) Impact of overall treatment time of fractionated irradiation on local control of human FaDu squamous cell carcinoma in nude mice. Radiother Oncol 32(2):137–143

    CAS  PubMed  Google Scholar 

  56. Willers H, Dahm-Daphi J, Powell SN (2004) Repair of radiation damage to DNA. Br J Cancer 90(7):1297–1301

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Trott KR (1982) Experimental results and clinical implications of the four R’s in fractionated radiotherapy. Radiat Environ Biophys 20(3):159–170. Review

    CAS  PubMed  Google Scholar 

  58. Popple RA, Ove R, Shen S (2002) Tumor control probability for selective boosting of hypoxic subvolumes, including the effect of reoxygenation. Int J Radiat Oncol Biol Phys 54:921–927

    PubMed  Google Scholar 

  59. Podgorsak EB (2005) Radiation oncology physics: a handbook for teachers and students. International Atomic Energy Agency, Vienna, pp 499–505

    Google Scholar 

  60. Lee CK (2006) Evolving role of radiation therapy for hematologic malignancies. Hematol Oncol Clin North Am 20(2):471–503. Review

    PubMed  Google Scholar 

  61. Thames HD, Ang KK (1998) Altered fractionation: radiobiological principles, clinical results, and potential for dose escalation. Cancer Treat Res 93:101–128

    CAS  PubMed  Google Scholar 

  62. ICRP (2006) Assessing dose of the representative person for the purpose of radiation protection of the public. ICRP publication 101. Approved by the Commission in September 2005. Ann ICRP. 36(3):vii–viii, 5–62

    Google Scholar 

  63. Prasad KN, Cole WC, Haase GM (2004) Radiation protection in humans: extending the concept of as low as reasonably achievable (ALARA) from dose to biological damage. Br J Radiol 77(914):97–99. Review

    CAS  PubMed  Google Scholar 

  64. Song CW, Kim MS, Cho LC, Dusenbery K, Sperduto PW (2014) Radiobiological basis of SBRT and SRS. Int J Clin Oncol 19(4):570–578. https://doi.org/10.1007/s10147-014-0717-z. Epub 2014 Jul 5

    Article  CAS  PubMed  Google Scholar 

  65. Mole RH (1953) Whole body irradiation; radiobiology or medicine? Br J Radiol 26(305):234–241

    CAS  PubMed  Google Scholar 

  66. Nobler MP (1969) The abscopal effect in malignant lymphoma and its relationship to lymphocyte circulation. Radiology 93:410–412

    CAS  PubMed  Google Scholar 

  67. Demaria S, Ng B, Devitt ML et al (2004) Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 58:862–870

    PubMed  Google Scholar 

  68. Kepp O, Senovilla L, Vitale I et al (2014) Consensus guidelines for the detection of immunogenic cell death. Onco Targets Ther 3:e955691

    Google Scholar 

  69. Marin A, Martin M, Linan O et al (2015) Bystander effects and radiotherapy. Rep Pract Oncol Radiother 20(1):12–21

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Gulhane Faculty of Medicine, Department of Radiation Oncology, University of Health Sciences Turkey, Ankara, Turkey

    Murat Beyzadeoglu

  2. Department of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Gokhan Ozyigit

  3. Department of Radiation Oncology, Tepecik Training and Research Hospital, University of Health Sciences Turkey, Izmir, Turkey

    Cüneyt Ebruli

Authors
  1. Murat Beyzadeoglu
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  2. Gokhan Ozyigit
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  3. Cüneyt Ebruli
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Beyzadeoglu, M., Ozyigit, G., Ebruli, C. (2022). Radiobiology. In: Basic Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-87308-0_2

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  • DOI: https://doi.org/10.1007/978-3-030-87308-0_2

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